臺灣博碩士論文加值系統

這篇文章目的在於提出較無爭議之化學物混合之效用的分解。我們提出此分解之母體主效用及交互作用。在常態分配之假設下我們計算這些作用並且以表格呈列，我們也進一步介紹統計估計方法，並模擬分析其估計效果。

This paper propose new but unambiguous systematic decompositions of the effect of covariates on a response variable into main effect and interaction effects. The population type main effects and interaction effects under the normal distribution are formulated. These effects under some examples of distributional parameter settings are computed and presented. Then, this settings make the study of main effects and interactions available through classical statistical inferences techniques.

中文提要 i
英文提要 ii
誌謝 iii
目錄 iv
1. Introduction 1
2. Decomposition of Total Effect Into Covariate Contributions 3
3. Main Effect and Interaction Formulation Under Normal Distribution 6
4. Statistical Inferences for Interactions 12
5. Appendix 16
References 18

1.Berenbaum, M. C. (1981). Criteria for analyzing interactions between biologically active agents. Advances in Can Research,35,269-335.

2.Charles, G. D., Gennings, C., Zacharewski, T. R., Gollapudi, B. B. and Carney, E. W. (2002). An approach for assessing estrogen receptormediated interactions in mixtures of three chemicals: a pilot study. Toxicological Sciences,68,349-360.

3.Ei-masri, H. A., Reardon, K. F. and Yang, R. S. H. (1997). Integrated approaches for the analysis of toxicologic interactions of chemical mixtures. Critical Reviews in toxicology,27,175-197.

4.Kifley, A., Liew, G., Wang, J. J., Kaushik, S., Smith, W. and Wong, T. Y. (2007). Long-team effects of smoking on retinal microvascular caliber. American Journal of Epidemiolopy,166,1288-1297.

5.Mumtaz, M. M., De rosa, C. T., Groten, J., Feron, V. J., Hansen, H. and Durkin, P. R. (1998). Estimation of toxicity of chemical mixtures through modeling of chemical interactions. Environmental Health Perspectives,106,1353-1360

6.Ponce, N. A., Hoggatt, K. J., Wilhelm, M. and Ritz, B. (2005). Preterm birth: the interaction of traffic-related air pollution with economic hard-ship in Los Angels neighborhoods. Americam journal of Epidemiology,162,140-148.

7.Rider, C. V. and LeBlanc, G. A. (2005). An integrted addition and interaction model for assessing toxicity of chemical mixtures. Toxicological Sciences,87,520-528.