近年來由於科技進步與醫學發達，人類平均壽命增加，伴隨而來的是各種老化造成的疾病，退化性膝關節炎即是一個很好的例子。治療退化性膝關節炎之臨床治療方式有: (1)全膝關節置換術；(2)高位脛骨截骨手術。由於全膝關節置換術為晚期治療方式，且具有不可回復性，早期治療方式較適用於高位脛骨截骨手術。
高位脛骨截骨手術在手術過程中容易造成植入物斷裂的現象，為此而設計出新形骨板來改善此缺點。為在植入物生物力學分析前進行模擬，本研究建立現有高位脛骨截骨手術所用之骨板以及新型設計之骨板，並參考一般人體站立時受力大小及位置，做有限元素分析來探討各種植入物間之剛性位移穩定程度及應力分布情形，藉此來分析出新型骨板是否能夠有較佳的表現，以便做為未來生物力學測試之參考。

Recently, human life became more and more elder because of the advance of scientific technology and the development of medicine. But it accompanies the disease caused by aging. Like the knee osteoarthritis, which the most obvious example is. There are two way to treat the knee osteoarthritis, one is total knee replacement; the other is high tibial osteotomy. Because the total knee replacement is a terminal way for treatment and it can’t return, it is a good way in early time to treat the knee osteoarthritis with high tibial osteotomy.

High tibial osteotomy caused the implant break easily in the process of a surgical operation, so there is the new design of the implant to improve the disadventage. For the implant biomechanical analysis before simulation, the study established the existing bone plate used in high tibial osteotomy and the new design of the bone plate. Using the finite element analysis investigate implant stability of the rigid displacement and the stress value with the reference to the general body in standing force and location. And investigate whether the new bone plate has better performance, so as a reference for future biomechanical testing.

摘 要......................................i
ABSTRACT.....................................ii
致 謝......................................iii
目 錄.......................................iv
圖 目 錄..................................vii
表 目 錄....................................x
一、緒論......................................1
1-1 研究背景..................................1
1-2 研究動機與目的............................1
1-3 文獻回顧..................................2
1-3-1 膝關節之解剖學與生物力學................2
1-3-2 膝關節運動學介紹........................7
1-3-3 退化性膝關節炎簡介.....................12
1-3-4 高位脛骨截骨手術(HTO)簡述..............16
1-3-5 脛骨骨板之力學分析.....................19
1-4 本文架構.................................23
二、材料與方法...............................25
2-1 三維脛骨圖檔之建立.......................25
2-1-1 醫學影像資料之蒐集.....................25
2-1-2 脛骨模型之立體重建.....................28
2-2 三維HTO骨板與骨釘模型之建立..............31
2-2-1 現有HTO骨板模型之建立..................31
2-2-2 新型HTO骨板模型之建立..................35
2-2-3 HTO骨板之骨釘模型建立..................36
2-3 脛骨與骨板之配合及材料性質...............36
2-3-1 脛骨與骨板之配合.......................36
2-3-2 脛骨與骨板之材料性質...................38
2-3-3 脛骨與骨板之結合條件...................38
2-4 受力條件與參數設定.......................39
2-5 網格設定與建立...........................41
2-5-1 網格設定...............................41
2-5-2 網格建立...............................43
2-6 有限元素分析.............................47
三、結果.....................................48
3-1 裂口位移分析結果.........................48
3-2 Von Mises Stress.........................49
四、討論.....................................53
4-1 裂口位移分析討論.........................53
4-2 Von Mises Stress討論.....................55
五、結論與未來展望...........................58
參 考 文 獻..................................59

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