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研究生:陳星儒
研究生(外文):Shing-Ru Chen
論文名稱:面迴訊磁共振頻譜影像之肝臟脂肪定量分析
論文名稱(外文):Quantitative Analysis of Liver Lipid Using Proton Echo Planar Spectroscopic Imaging (PEPSI)
指導教授:林益如林益如引用關係
指導教授(外文):Yi-Ru Lin
口試委員:林益如
口試日期:2011-07-13
學位類別:碩士
校院名稱:國立臺灣科技大學
系所名稱:醫學工程研究所
學門:工程學門
學類:綜合工程學類
論文種類:學術論文
論文出版年:2011
畢業學年度:99
語文別:英文
論文頁數:68
中文關鍵詞:非酒精性脂肪肝肝臟脂肪定量迴訊磁共振頻譜影像磁共振頻譜影像
外文關鍵詞:Proton echo-planar spectroscopic imaging (PEPSI)Liverlipidnon-alcoholic fatty liver diseases (NAFLD)MR spectroscopic imaging (MRSI)
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由於生活習慣的改變,脂肪肝問題也成為目前最重要的公共衛生議題。從國人十大死因中就可以發現有一成的疾病都與肝臟有關,而非酒精性脂肪肝病從單純脂肪肝,脂肪肝炎,脂肪纖維化,到脂肪肝硬化都包含。脂肪肝定義為肝臟重量中大於5%為脂肪所構成,而診斷上以肝臟切片之組織學診斷為黃金標準,但在一般民眾不同意接受肝臟穿刺檢查的情況下,非侵入式的檢查已成為診斷脂肪肝最重要的方式。這項研究的目的就在調查使用磁共振頻譜影像檢查肝臟脂肪含量的可行性和靈敏度。據我們了解,目前並無磁共振頻譜影像測量脂肪肝的相關研究。利用磁共振頻譜影像,測量脂肪肝可結合核磁共振影像與核磁共振頻譜的所有優點。且測量將是非侵入性、沒有輻射線的。最重要的是,它可以提供精確的不同區域的定量分析信息。由於肝臟會隨著我們呼吸而上下移動,因此我們制訂掃描期間需閉氣,而掃描時序列使用面迴訊磁共振頻譜影像,將磁共振頻譜影像的掃描時間加快,定出合理的掃描時間,使屏氣掃描成功應用到正常人的研究,並能迅速和成功地檢測肝臟脂肪含量。
The study aims to investigate the feasibility and sensitivity of using MR spectroscopic imaging (MRSI) to observe the hepatic steatosis in normal subjects and in subjects with non-alcoholic fatty liver diseases (NAFLD). To our understanding, measuring hepatic steatosis using MRSI techniques has never been reported before. Measuring hepatic steatosis using MRSI techniques will combine all the advantages of MRI and MRS techniques. The measurement will be noninvasive, without radiation hazard. Most important of all, it can provide precise quantification with regional distribution information. The long scan time of MRSI will be shortened by our fast acquisition sequence, proton echo-planar spectroscopic imaging (PEPSI). Since it can be applied to normal subject studies, hepatic MRSI will become a powerful tool for diagnosis of liver diseases. To achieve this goal, we need to investigate post-processing procedure, and quantification method. From the result of investigation, we develop a reasonable time to breath-hold and scan for clinical applications, and can quickly and successfully detect liver lipid contents.
List of Figure I
List of Table II
中文摘要 III
Abstract ..IV
Chapter 1. Introduction 1
1.1 Liver disease 1
1.2 History – NMR to MRS 4
1.3 Chemical Shift 6
Chapter 2. Magnetic resonance spectroscopy 8
2.1 Hepatic 1H-MRS 8
2.2 Single voxel spectroscopy (SVS) 12
2.2.1 Stimulated-Echo Acquisition Mode (STEAM) 12
2.2.2 Point-Resolved Spectroscopy (PRESS) 13
2.3 Magnetic Resonance Spectroscopic Imaging (MRSI) 15
2.4 Proton echo-planar spectroscopic imaging (PEPSI) 17
Chapter 3. Material and Method 21
3.1 Experiments 22
3.2 Processing of the MR Spectra 23
3.3 Frequency Shift Correction 26
3.4 Selection of Regions of interest (ROIs) 29
3.5 Quantification 30
3.5.1 LCModel 30
3.5.2 Lorentzian function 33
3.6 Statistical Analysis 35
Chapter 4. Results 36
4.1 Breath-hold or non-breath-hold 36
4.2 LCModel and Lorentzian function 38
4.3 Comparing the left and right liver 44
Chapter 5. Discussion 49
Chapter 6. Conclusion 55
References 56
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台灣行政院衛生署 衛生統計資訊網
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