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研究生:蔡豐州
研究生(外文):Feng-Chou Tsai
論文名稱:去神經化 (神經截斷與肉毒桿菌素注射) 動態改變整合素alpha-7 相關訊息傳導與表面顯微構造複雜度
論文名稱(外文):Denervation (neurectomy and botulinum toxin A injection) dynamically regulates integrin alpha-7 signaling pathways, microscopic structures and surface complexities
指導教授:謝銘勳謝銘勳引用關係
學位類別:博士
校院名稱:臺北醫學大學
系所名稱:臨床醫學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:2010
畢業學年度:99
語文別:中文
論文頁數:88
中文關鍵詞:去神經化肌肉整合素細胞凋亡生物數學模型模式
外文關鍵詞:denervationmuscleintegrinapoptosismathematical modelpattern
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生物現象是動態,交互影響的複雜系統。去神經化導致的肌肉萎縮,往往造成不可逆永久傷害(如外傷性脊髓傷害與蘿蔔腿小腿神經阻斷術等) ,或是可逆短暫肌肉萎縮(如肉毒桿菌素注射)。目前除了治療效果面臨瓶頸,機制亦存在許多未解之謎。本研究比較動物實驗兩種去神經化(肉毒桿菌素注射與切神經)長時間(一年)機制之後,除了發現肉毒桿菌素注射的效果與頻率與劑量相關,長期而言還會造成肌肉重量與表面型態[不完全]恢復,這和過去文獻的結論大相逕庭之外; 肉毒桿菌素注射亦比切神經在所有訊息傳導表現較弱,尤其細胞凋亡表現上,有較弱與不持久的細胞凋亡誘發因子(硫胱氨酸蛋白酶-獨立細胞凋亡路徑)。並且,動物實驗的肌肉重量分析與本研究所收集的人類臨床兩種去神經化治療的數據,相吻合一致。選擇性肉毒桿菌素注射與切斷單一肌肉神經的實驗設計,發現代償性肌肉現象,讓肌肉功能迅速恢復至正常的水平,可供臨床上釐清患者對於療程是否會造成肢體失能的恐懼與疑慮。再者,去神經化的存活,細胞凋亡訊息傳導,肌纖維表面複雜度動態長期時間序表現模式,呈現高度的同時與雙相性,也就是逐漸增加到一個時間點後,再逐步下降 (切神經與肉毒桿菌素的高峰時間點分別為第8與4週),這也和過去的短期去神經化文獻研究結論不同。發現去神經化的模式之後,接著,本研究冀望探討扮演與細胞外間質,產生內外雙向聯繫,位置與肌肉收縮傳達有關的整合素,來分析去神經化動態變化是否與整合素高度相關。研究結果確認,與存活訊息相關的整合素與其下游訊息傳導分子也驚人呈現同時,雙相模式。此外,利用電子顯微鏡分析肌纖維內部與表面顯微構造,除了內部構造切神經與肉毒桿菌素分別呈現不可逆與可逆構造崩壞,排列失序的變化之外; 整合素表現量會與肌纖維的表面複雜度成高度正相關。此發現可以協助未來研究組織變化時,簡化觀察複雜訊息系統的窗口。總之,本研究藉由建立動物實驗模式,加上作者近年來蘿蔔腿小腿神經整形手術的經驗,建立更清晰的肌肉動態圖像,同時對於臨床運用與解讀更有益處。

Biosystem is a dynamic, complex and interconnected system. Neurectomy and BoNT-A injection have been found in clinical practice to decrease skeletal muscle mass or activity. The treatment principles for nerve injuries have remained little changed for decades despite major advances in understanding. Comparing both denervated groups, the BoNT-A injection whose effect depends on the dose and frequency, not only induces incomplete long-term muscle weight recovery, but shows not long-lasting AIF mediated caspase-independent apoptosis. Both denervated groups show rapid functional recovery due to the muscle compensation and delicate experimental design by selective neurectomy. Molecular expressions (survival and apoptosis) and surface complexities of myofibers on both denervation procedures demonstrate the coherent and biphasic pattern: initial increase, later decay. The peak on the BoNT-A and neurectomy group is 4 and 8 weeks after denervation respectively. Furthermore, the research verifies that the tissue surface reacts accordingly when biochemical responses change. The inner microscopic structures examined by the transmission electron microscope show the irreversible and reversible alterations including sarcomere disarrangement. The integrin and its downstream signaling molecules (Ras/Raf/Erk1/2, MHC, actin and RhoA) correlate with the survival signaling pathway. The surface textures examined and quantified by the scanning electron microscope are highly correlated with the integrin expressions (CAM-ECM interplay, correlation coefficient r=0.873). The study compares the differences between the BoNT-A injection and neurectomy, and establishes the dynamic pattern of specific mechanism based on in vivo experimental model and human calf surgery experiences.

誌謝 i
縮寫表 (Abbreviations) ii
中文摘要 (Abstract in Chinese) v
英文摘要 (Abstract in English) vi
第一章 緒論 (Introduction) 1
第二章 研究方法與材料 (Materials and Methods) 9
第三章 實驗結果 (Results) 15
第四章 討論 (Discussion) 21
第五章 結論與展望 (Conclusion and Perspectives) 50
第六章 參考文獻 (References) 52
第七章 圖表 (Tables and Figures) 66
附錄 (Appendices) 88


Adhihetty, P.J., O’Leary, M.F.N., Chabi, B. (2007). Effect of denervation on mitochondrially mediated apoptosis in skeletal muscle. J Appl Physiol. 102, 1143-51.
Ahn, K.Y., Kim, S.T. (2007). The change of maximum bite force after botulinum toxin type A injection for treating masseteric hypertrophy. Plast Reconstr Surg. 120, 1662-66.
Andjelkovic, M., Maira, S.M., Cron, P., Parker, P.J., Hemmings B.A. (1999). Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase. Mol Cell Biol. 19, 5061-5072.
Bain, J.R., Mackinnon, S.E., Hunter, R.T. (1989). Functional evaluation of complete sciatic, peroneal and posterior tibial nerve lesions in the rat. Plast Reconstr Surg. 83, 129-38.
Basu, S., Totty, N.F., Irwin, M.S., Sudol, M., Downward, J. (2003). Akt phospholates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Mol Cell. 11, 11-23.
Bodine, S.C., Stitt, T.N., Gonzalez, M., Kline, W.O., Stover, G.L., Bauerlein, R. (2001). Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biology. 3, 1014-19.
Bodine, S.C., Latres, E., Baumhueter, S., et al. (2001). Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 294, 1704-1708.
Boerner, S.A. (2010). Integrin signaling pathway. Science’s STKE (Connections Map). http://stke.sciencemag.org/cgi/cm/CMP_6880.
Borisov, A.B., Carlson, B.M. (2000). Cell death in denervated skeletal muscle is distinct from classical apoptosis. Anat Rec. 258, 305-318.
Cajal, S.R. (1935). Die Neuronenlehre, in Bumke O, Foerster O (eds.). Handbuch der Neurologie. Berlin, Springer. 887-994.
Carlson, B.M., Billington, L., Faulkner, J. (1996). Studies on the regenerative recovery of long-term denervated muscle in rats. Restor Neurol Neurosci. 10, 77-84.
Chen, H.C., Appeddu, P.A., Isoda, H., Guan, J.L. (1996). Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase. J Biol Chem 271, 26329-26334.
Chen, W.S., Xu, P.Z., Gottlob, K., Chen, M.L., Sokol, K., Shiyanova, T. (2001). Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 15, 2203–8.
Chiu, S.M., Xue, L.Y., Usuda, J., Azizuddin, K., Oleinick, N.L. (2003). Bax is essential for mitochondria-mediated apoptosis but not for cell death caused for photodynamic therapy. British J Cancer. 89, 1590-97.
Choi, W.H., Song, C.W., Kim, Y.B., Ha, C.S., Yang, G.H., Woo, H.D., Jung, H.H., Koh, W.S. (2007). Skeletal muscle atrophy induced by intramuscular repeated dose of botulinum toxin type A in rats. Drug Chem Toxicol. 30, 217-27.
Chuang, D.C. (2009). Adult brachial plexus reconstruction with the level of injury: review and personal experience. Plast Reconstr Surg. 124, e359-69.
Cobb, M. (2002). Exorcizing the animal spirits: Jan Swammerdam on nerve function. Nature. 3, 395-400.
Coisy-Quivy, M., Sanquesa-Ferrer, J., Weill, M., et al. (2006). Identification of Rho GTPases implicated in terminal differentiation of muscle cells in ascidia. Biol Cell. 98, 577-88.
Collo, G., Starr, L., Quaranta, V. (1993). A new isoform of the laminin receptor integrin is developmentally regulated in skeletal muscle. J Biol Chem. 268, 19019-19024.
Dai, A.I. (2007). How do we get better outcome with botulinum toxin in the treatment of children with spastic hemiplegia? Eura Medicophys. 43, 296-7.
Datta, S.R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., Greenberg, M.E. (1997). Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 91, 231-241.
Davatz, G.C., Andreo, J.C., Rodrigues, A.C., Rosa Junior, G.M., Moraes, L.H.R. (2007). Apoptosis in denervated skeletal muscle. Int J Morphol. 25, 529-36.
Dedkov, E.I., Kostrominova, T.Y., Borisov, A.B., Carslon, B.M. (2001). Reparative myogenesis in long-term denervated skeletal muscles in adult rats results in a reduction of the satellite cell population. Anat Rec. 263, 139-154.
Feng, J., Park, J., Cron, P., Hess, D., Hemmings B.A. (2004). Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J Biol Chem. 279, 41189-41196.
Ferreira, R., Neuparth, M.J., Vitorino, R., Appell, H.J., Amado, F., Durate, J.A. (2008). Evidences of apoptosis during the early phases of soleus muscle atrophy in hindlimb suspended mice. Physiol Res. 57, 601-11.
Fayard, E., Tintignac, L.A., Baudry, A., Hemmings, B.A. (2005). Protein kinase B/Akt at a glance. J Cell Sci. 118, 5675-5678.
Fong, T.H., Wong, C.H., Lin, J.Y., et al. (2010). Correction of asymmetrical calf hypertrophy with differential selective neurectomy. Aesth Plast Surg. 34, 335-9.
Franke, T.F., Yang, S.I., Chan, T.O. (1995). The protein kinase encoded by the Akt proto-oncogene is a target of PDGF-activated phosphoinositide 3-kinase. Cell. 81, 727-36.
Giancotti, F.G., Ruoslahti, E. (1999). Integrin signaling. Science. 285, 1028-1032.
Glasner, A., Avraham, R., Rosenne, E., Benish, M., Zmora, O., Shemer, S., Meiboom, H., Ben-Eliyahu, S. (2010). Improving survival rates in two models of spontaneous postoperative metastasis in mice by combined administration of a beta-adrenergic antagonist and a cyclooxygenase-2 inhibitor. J Immunol. 184, 2449-2457.
Gu, M., Wang, W., Song, W.K., et al. (1994). Selective modulation of the interaction of integrin with fibronectin and laminin by L-14 lectin during skeletal muscle differentiation. J Cell Sci. 107, 175-181.
Gul, N., Smith, L.A., Ahmed, S.A. (2010). Light chain separated from the rest of the type A botulinum neurotoxin molecule is the most catalytically active form. PLoS One. 5, e12872.
Guo, K., Ma, Q., Wang, L., Hiu, H., Li, J., Zhang, D., Zhang, M. (2009). Norepinephrine-induced invasion by pancreatic cancer cells is inhibited by propranolol. Oncol Rep. 22, 825-830.
Gutmann, E., Vodicka, Z., Zelena, J. (1955). Changes in cross striated muscle after the nerve interruption depending on the length of the nerve stump (Russian). Physiol Bohemoslov. 4, 200-204.
Gutmann, E., ed. (1962). The Denervated Muscle. Publ. House of Czechoslovak Academy of Sciences, Prague.
Hagiwara, H., Fallon, J.R. (2001). Shaping membrane architecture: agrins in and out of the synapse. J Cell Biol. 153, F39-F42.
Harder, T., Simons, K. (1997). Caveolae, DIGs and the dynamics of sphingolipid-cholesterol microdomains. Curr Opin Cell Biol. 9, 534.
Harii, K., Kawashima, M. (2008). A double-blind, randomized, placebo-controlled, two-dose comparative study of botulinum toxin type A for treating glabellar lines in Japanese subjects. Aesthetic Plast Surg. 32, 724-30.
Hatoko, M., Niitsuma, K., Tanaka, A. (2004). Expression of N-Cadherin and N-Catenin in the degeneration/regeneration process of rat skeletal muscle after nerve injury. J Reconstr Microsurg. 20, 267-73.
Hilborn, R.C. (2000). Chaos and nonlinear dynamics. 2nd ed. Oxford University Press.
Hoare, B.J., Wallen, M.A., Imms, C., Villanueva, E., Rawicki, H.B., Carey, L. (2010). Botulinum toxin A as an adjunct to treatment in the management of the upper limb in children with spastic cerebral palsy (UPDATE). Cochrane Database Syst Rev. 20, CD003469.
Hresko, R.C., Mueckler, M. (2005). mTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J Biol Chem. 280, 40406-40416.
Hudlicka O. (1962). Vasomotor mechanism in genesis of denervation atrophy, in Gutmann E (ed.): The Denervated Muscle. Prague, Publ. House of Czechoslovak Academy of Sciences. Pp. 173-202.
Hughes, P.E., Renshaw, M.W., Pfaff, M., et al. (1997). Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Cell. 88, 521-530.
Hynes, R.O. (1992). Integrins: versatility, modulation, and signaling in cell adhesion. Cell. 69, 11-25.
Kerr, J.F., Wyllie, A.H., Currie, A.R. (1972). Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 26, 239-57.
Kim, K.S., Byun, Y.S., Kim, Y.J., Kim, S.T.K. (2009). Muscle weakness after repeated injection of botulinum toxin type A evaluated according to bite force measurement of human masseter muscle? Dermatol Surg. 35, 1902-7.
Kim, N.H., Park, R.H., Park, J.B. (2010). Botulinum toxin type A for the treatment of hypertrophy of the masseter muscle. Plast Reconstr Surg. 125, 1693-1705.
Koog, Y.H., Min, B.II. (2010). Effects of botulinum toxin A on calf muscles in children with cerebral palsy: a systematic review. Clin Rehab. 24, 685-700.
Jackman, R.W., Kandarian, S.C. (2004). The molecular basis of skeletal muscle atrophy. Am J Physiol Cell Physiol. 287, 834-43.
Jakubiec-Puka, A., Catani, C., Carraro, U. (1992). Myosin heavy-chain composition in striated muscle after tenotomy. Biochem J. 282, 237-242.
Jeng, S.F., Rau, C.S., Liliang, P.C., Wu, C.J., Lu, T.H., Chen, Y.H., Lin, C.J., Hsieh, C.H. (2009). Profiling muscle-specific microRNA expression after peripheral denervation and reinnervation in a rat model. J Neurotrauma. 26, 2345-53.
Labreza, C.L., Roque, E.D., Hubiche, T., Boralevi, F., Thambo, J.B., Tajeb, A. (2008). Propanolol for severe hemangiomas of infancy. N Engl J Med. 358, 2649-2651.
Lee, C.J., Kim, S.G., Kim, Y.J., Han, J.Y., Choi, S.H., Lee, S.I. (2007). Electrophysiologic change and facial contour following botulinum toxin A injection in square faces. Plast Reconstr Surg. 120, 769-78.
Lee, H.J., Lee, D.W., Park, Y.H., Cha, M.K., Kim, H.S., Ha, S.J. (2004). Botulinum toxin A for aesthetic contouring of enlarged medial gastrocnemius muscle. Dermatol Surg. 30, 867-71.
Leitinger, B., Hogg, N. (2002). The involvement of lipid rafts in the regulation of integrin function. J Cell Science. 115, 963-972.
Lewis, D.M., Schmalbruch, H. Contractile properties of aneurally regenerated compared with denervated muscles of rat. J Muscle Res Cell Motil. 15, 267-277.
Lewis, J. (2010). From signals to patterns: space, time, amd mathematics in developmental biology. Science. 322, 399-403.
Lim, J.Y., Han, T.R. (2010). Effect of electromyostimulation on apoptosis-related factors in denervation and reinnervation of rat skeletal muscles. Muscle Nerve. 42, 422-430.
Lima, S.C., Caierao, Q.M., Peviani, S.M., Russo, T.I., Somazz, M.C. (2009). Muscle and nerve responses after different intervals of electrical stimulation sessions on denervated rat muscle. Am J Phys Med Rehabil. 88, 126-135.
Liu, J., Burkin, D.J., Kaufman, S.J.. (2008). Increasing integrin promotes muscle proliferation, adhesion, and resistance to apoptosis without changing gene expression. Am J Physiol Cell Physiol. 294, C627-C640.
Lum, J.J., DeBerardinis, R.J., Thompson, C.B. (2005). Autophagy in metazoans: cell survival in the land of plenty. Nat Rev Mol Cell Biol. 6, 439–448.
Lubinska, L. (1964). Axoplasmic streaming in regenerating and in normal nerve fibers, in Singer M, Schade JP (eds.). Mechanisms of Neural Regeneration. Amsterdam, Elsevier, pp1-71.
Ma, J., Elsaidi, G.A., Smith, T.L. (2004). Time course of recovery of juvenile skeletal muscle after botulinum toxin A injection: an animal model study. Am J Phys Med Rehabil. 83, 774-80.
Maier, F., Bornemann, A. (1999). Comparison of the muscle fibre diameter and satellite cell frequency in human muscle biopsies. Muscle Nerve. 22, 578–583.
Marino, J.S., Tausch, B.J., Dearth, C.L., Manacci, M.V., McLoughlin, T.J., Rakyta, S.J., Linsenmayer, M.P., Pizza, F.X. (2008). Beta2-integrins contribute to skeletal muscle hypertrophy. Am J Physiol Cell Physiol 295, C1026-C1036.
Masiero, E., Sandri. M. (2010). Autophagy inhibition induces atrophy and myopathy in adult skeletal muscles. Autophagy. 6, 307-309.
Marsden, M., DeSimone, D.W. (2003). Integrin-ECM interactions regulate cadherin-dependent cell adhesion and are required for convergent extension in Xenopus. Curr Biol. 13, 1182-1191.
Marzetti, E., Hwang, J.C.Y., Lees, H.A. (2010). Mitochondrial death effectors: relevance to sarcopenia and disuse muscle atrophy. Biochim Biophys Acta. 1800, 235-44.
Mayer, U. (2003). Integrins: redundant or important players in skeletal muscle. J Biol Chem 278, 14587-14590.
Murgia M, Serrano AL, Calabria E, et al. (2000). Ras is involved in nerve-activity-dependent regulation of muscle genes. Nat Cell Biol. 2, 142-147.
Mauro, A. (1961). Satellite cell of skeletal muscle fibers. J Biophys Biochem Cytol. 9, 493-495.
Namikawa, K., Honma, M., Abe, K. (2000). Akt/protein kinase B prevents injury induced motoneuron death and accelerates axonal regeneration. J Neurosci. 20, 2875-86.
Nurse, P. (2008). Life, logic and information. Nature. 454, 424-427.
Pandorf, C.E., Haddad, F., Roy, R.R., et al. (2006). Dynamics of myosin heavy chain gene regulation in slow skeletal muscle. J Biol Chem. 281, 38330-38342.
Pardo, J.V., D’Angelo, S, Craig, S.W. (1983). A vinculin containing cortical lattice in skeletal muscle: transverse lattice elements (costameres) mark sites of attachment between myofibrils and sarcolemma. Proc Natl Acad Sci. 80, 1008-1012.
Park, M.Y., Ahn, K.Y., Jung, D.S. (2003). Botulinum toxin type A treatment for contouring of the lower face. Dermatol Surg. 29, 477-83.
Parker, K.C., Kong, S.W., Walsh, R.J., et al. (2009). Fast-twitch sarcomeric and glycolytic enzyme protein in inclusion body myositis. Muscle Nerve. 39, 739–753.
Pe´ ault, B., Rudnicki, M., Torrente, Y., Cossu, G., Tremblay, J.P., Partridge, T. (2007). Stem and progenitor cells in skeletal muscle development, maintenance, and therapy. Mol Ther. 15, 867–877.
Pihut, M., Wisniewska, g., Majewwski, P., Gronkiewicz, K., Majewski, S. (2009). Measurement of occlusal forces in the therapy of functional disorders with the use of botulinum toxin type A. J Physio Pharmacology. 60, 113-116.
Pospisilik, J.A., Knauf, C., Joza, N., Benit, P. (2007). Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell. 131, 476-91.
Reich, T.E., Lindstedt, S.L., LaStayo, P.C., et al. (2000). Is the spring quality of muscle plastic? Am J Physiol Regul Integr Comp Physiol. 278, R1661-R1666.
Rogozhin, A.A., Pang, K.K., Bukharaeva, E., Young, C., Slater, C.R. (2008) Recovery of mouse neuromuscular junctions from single and repeated injections of botulinum neurotoxin A. J Physiol. 586, 3163-82.
Rommel, C., Bodine, S.C., Clarke, B.A., et al. (2001) Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)L/Akt/GSK3 pathways. Nat Cell Biol. 3, 1009-13.
Saher, G., Hildt, E. (1999). Activation of c-Raf-1 kinase signal transduction pathway in integrin-deficient mice. J Biol Chem. 274, 27651-27657.
Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A. (2004). Foxo transcription factors induce the atrophyrelated ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell. 117, 399–412.
Scharrer, E., Scharrer, B. (1954). Hormones produced by neurosecretory cells. Rec Progr Hormone Res. 10, 183-240.
Schmalbruch, H., Lewis, D.M. (2000). Dynamics of nuclei of muscle fibers and connective tissue cells in normal and denervated rat muscles. Muscle Nerve. 23, 617-626.
Schwaiger, F.W., Hager, G., Schmitt, A.B. (2000). Peripheral but not central axotomy induces changes in Janus kinases (JAK) and signal transducers and activators of transcription (STAT). Eur J Neurosci. 12, 1165-76.
Shen, J., Ma, J., Lee, C., Smith, B.P., Smith, T.L., Tan, K.H., Koman, L.A. (2006). How muscles recover from paresis and atrophy after intramuscular injection of botulinum toxin A: study in juvenile rats. J Orthop Res. 24, 1128-35.
Sheu, J.Y., Kulhanek, D.J., Eckenstein, F.P. (2000). Differential patterns of ERK and STAT3 phosphorylation after sciatic nerve transaction in the rat. Exp Neurol. 166, 392-402.
Shi, X., Garry, D.J. (2006). Muscle stem cells in development, regeneration, and disease. Genes Dev. 20, 1692–1708.
Singer, M. (1952). The influence of the nerve in regeneration of the amphibian extremity. Quart Rev Biol. 27, 169-200.
Siu, P.M., Always, S.E. (2005). Mitochondria-associated apoptotic signaling in denervated rat skeletal muscle. J Physiol. 565, 309-23.
Song, Y.H., Li, Y., Du, J., Mitch, W.E., Rosenthal, N., Delafontaine, P. (2005). Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting. J Clin Invest. 115, 451-58.
Stelling, J., Sauer, U., Szallasi, Z., Doyle, F.J., Doyle, J. (2004). Robustness of cellular functions. Cell. 118, 675-685.
Stitt, T.N., Drujan, D., Clarke, B.A., Panaro, F., Timofeyva, Y., Kline, W.O. (2004) The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell. 14, 395–403.
Street, S.F. (1983). Lateral transmission of tension in frog myofibers: a myofibrillar network and transverse cytoskeletal connections are possible transmitters. J Cell Physiol 114, 346-364.
Tang, H., Cheung, W.M.W., Ip, F.C., Ip, N.Y. (2000). Identification and characterization of differentially expressed genes in denervated muscle. Mol Cell Neurosci. 12, 127-40.
Terzis, J.K., Kostopoulos, V.K. (2010). Vascularized nerve grafts for lower extremity nerve reconstruction. Ann Plast Surg. 64, 169-76.
Tews, D.S. (2002). Apoptosis and muscle fiber loss in neuromuscular disorders. Neuromuscul Disord. 12, 613-622.
Troussard, A.A., Mawji, N.M., Ong, C., Mui, A., St-Arnaud, R., Dedhar, S., (2003). Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J Biol Chem. 278, 22374-22378.
Tsai, F.C., Mardini, S., Fong, T.H., Kang, J.H., Chou, C.M. (2008). Selective neurectomy of the gastrocnemius and soleus muscles for calf hypertrophy: an anatomical study and 700 clinical cases. Plast Reconstr Surg. 122, 178-87.
Tsai, F.C., Chen, C.C., Lin, C.Y., Ho, L.Y. (2009). Analysis of the body mass index and leg profiles of Asian women after total leg sculpture. Plast Reconstr Surg. 124, 643-50.
Tsai, F.C., Liu, W.M., Pai, M.H., Hsieh, M.S., Lin, J.Y., Chou, C.M. (2010) Downregulation of the integrin alphav signaling pathway in uterine leiomyomas. Gyncol Obstet Invest. (in press)
Tsai, C.Y., Huang, R.Y., Lee, C.M., Hsiao, W.T., Yang, L.Y. (2010). Morphologic and bony structural changes in the mandible after a unilateral injection of botulinum neurotoxin in adult rats. J Oral Maxillofac Surg. 68, 1081-7.
Turing, A. (1952). The chemical basis of morphogenesis. Phil Trans Roy Soc B. 237, 32.
Turner-Stokes, L., Ashford, S. (2007). Serial injection of botulinum toxin for muscle imbalance due to regional spasticity in the upper limb. Disabil Rehabil. 15, 1806-12.
Vahsen, N., Cande, C., Briere, J.J. (2004). AIF deficiency compromises oxidative phosphorylation. EMBO J. 23, 4679-89.
Velling, T., Stefansson, A., Johansson, S. (2008). EGFR and beta1 integrins utilize different signaling pathways to activate Akt. Exp Cell Res. 314, 309-316.
Viguie, C.A., Lu, D-X., Huang, S-K., Rengen, H., Carlson, B.M. (1997). Quantitative study of the effects of long-term denervation on the extensor digitorum longus muscle of the rat. Anat Rec. 248, 346-354.
Walsh, S., Midha, R. (2009). Use of stem cells to augment nerve injury repair. Neurosurgery. 65, 80-6.
Wei, L., Wang, L., Carson, J.A., et al. (2001). integrin and organized actin filaments facilitate cardiomyocyte-specific RhoA-dependent activation of the skeletal -actin promoter. FASEB J. 15, 785-796.
Weiss, P., Hiscoe, H.B. (1948). Experiments on the mechanism of nerve growth. J Exp Zool. 207, 315-395.
Welser, J., Lange, N., Singer, C., et al. (2007). Loss of the integrin promotes extracellular signal-regulated kinase activation and altered vascular remodeling. Cir Res. 101, 672-681.
White, C.M., Greensmith, L., Vrbova, G. (2000). Repeated stimuli for axonal growth causes motorneuron death in adult rats: the effect of botulinum toxin followed by partial denervation. Neuroscience. 95, 1101-09.
Williamson, D., Gallager, P., Harber, M., et al. (2003). Mitogen-activated protein kinase (MAPK) pathway activation: effects of age and acute exercise on human skeletal muscle. J Physiol. 547, 977-987.
Wissing, S. (2004). An AIF orthologue regulates apoptosis in yeast. J Cell Biol. 166, 969-74.
Xiao, Z., Zhang, F., Lin, W., Zhang, M., Liu, Y. (2010). Effect of botulinum toxin type A on transforming growth factor beta1 in fibroblasts derived from hypertrophic scar: a preliminary report. Aesthetic Plast Surg. 34, 424-427.
Yao, C., Ziober, B.L., Squillace, R.M., et al. (2001). integrin mediates cell motility on laminin. J Biol Chem. 291, 25598-25603.
Zhibo, X., Miaobo, Z. (2009). Intralesional botulinum toxin type A injection as a new treatment measure for keloids. Plast Reconstr Surg. 124, 275e-277e.




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