跳到主要內容

臺灣博碩士論文加值系統

(3.235.174.99) 您好!臺灣時間:2021/07/24 20:18
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

: 
twitterline
研究生:歐陽翊暉
研究生(外文):I-Hui Ou Yang
論文名稱:利用碳穩定同位素追查愷他命與火藥的來源
論文名稱(外文):Tracing of ketamine and gunpowder by carbon stable isotope ratio analysis
指導教授:楊秋和、周素蓮
指導教授(外文):Qiu-Han Yang、Su-Lien Chou
學位類別:碩士
校院名稱:中央警察大學
系所名稱:鑑識科學研究所
學門:軍警國防安全學門
學類:警政學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:中文
論文頁數:70
中文關鍵詞:穩定同位素比質譜儀愷他命火藥δ13C值
外文關鍵詞:Isotope Ratio Mass SpectrometryketamineGunpowderδ13C value
相關次數:
  • 被引用被引用:0
  • 點閱點閱:180
  • 評分評分:
  • 下載下載:19
  • 收藏至我的研究室書目清單書目收藏:0
本研究的目的是探討穩定同位素比質譜儀應用於追蹤濫用藥物與火藥來源的可行性。愷他命是三大約會強暴藥物之一,在台灣的濫用程度有逐年遞增的趨勢,因此其來源的追查值得關切。此外,幫派份子走私、自製槍械彈藥的事件時有耳聞,若能得知火藥的成份來源,則有可能進一步連結相關案件。穩定同位素比質譜儀乃分析化合物中的穩定同位素的含量比值,若化合物是相同來源,則會有相似的同位素比值。
本實驗利用氣相層析同位素比質譜儀探討愷他命與火藥的碳同位素比值,藉以追查其來源。研究結果顯示愷他命的δ13C值可粗略將愷他命樣本分成四組可能來源,並依據判決書記載之各樣品的交易地點,發現δ13C值的分佈與地緣有關。火藥樣品因成份複雜,因此針對主要成份Ethyl Phthalate以及DBP的δ13C值分析,結果發現無法依據單一成分之δ13C值將各廠牌的火藥區分開來,然而若取兩個主要成份,Ethyl Phthalate以及DBP的δ13C值做群集分析則可將樣品做出區別,但無法相當精確,仍有些樣品無法區分。研究亦發現各火藥樣品所含成份與波峰訊號比例值皆不相同,因此無法區分之樣品可依照成份區分;若仍無法區分,再以GC之層析圖譜之成份訊號值比例區分火藥樣品來源。
The purpose of this research is trying to use isotope ratio mass technique (IRMS) to trace the source of abused drugs and gunpowders. Abused drugs include anaesthetic, stimulant, hallucinogen and sedative material. This research focused on ketamine, which is one of the date rape pills. The amount of ketamine that ferreted out by police is increasing yearly. It indicated that ketamine was abused seriously, so it is important to trace the source of ketamine. It is illegal for a person to own or to sell a gun in Taiwan, but many gangsters possess guns secretly. Therefore, there are many shooting fight cases occurred and caused series injuries. These showed that it is important to trace the source of gunpower.
GC-isotope Ratio Mass Spectrometry can be used in analysis the ratio of stable isotope element in compounds. The carbon in specific- compound from the same source will have the similar isotope ratio. In this study, we combined the gas chromatography with isotope ratio mass spectrometry to analyze the carbon isotope ratio of ketamine that were from the court. The result showed that δ13C values of 19 ketamine samples can be classified into four groups. It indicated that the ketamine samples might be sold out from four different sources.
Gunpowder was composed of complicated and some thermal unstable components. Among them, δ13C values of the two thermal stable compounds: Ethyl Phthalate and DBP (Dibutyl Phthalate) were analyzed by GC-IRMS. The data shown that δ13C value of single compound from different sample is not distinguishable, however, we can differentiate them by Cluster Analysis of δ13C value of these two components. Few samples that can’t be distinguished by this method can be accomplished by analysis of the GC chromatogram that was obtained in the GC/IRMS running.
中文摘要 I
Abstract II
目 錄 III
圖目錄 IV
表目錄 VI
第一章 緒論 1
1-1前言 1
1-2研究動機與目的 2
第二章 文獻探討 4
2-1愷他命(Ketamine) 4
2-1-1愷他命的特性 4
2-1-2愷他命的濫用 5
2-1-3濫用藥物在實務上的分析 6
2-2火藥 8
2-2-1火藥的有機成份 8
2-2-2火藥的無機成份 9
2-2-3火藥在實務上的分析 10
2-3氣相層析同位素比質譜儀 11
2-3-1穩定同位素 11
2-3-2氣相層析同位素比質譜儀之原理 13
2-3-3穩定同位素比值 15
2-3-4氣相層析同位素比質譜儀之應用 16
第三章 實驗材料與方法 19
3-1實驗樣品與製備 19
3-2標準品製備 19
3-3實驗確效步驟 20
3-4實驗分析流程 20
第四章 結果與討論 22
4-1愷他命之IRMS分析結果 22
4-1-1愷他命之GC/IRMS分析 22
4-1-2愷他命之來源追蹤 23
4-2火藥之IRMS分析結果 24
4-2-1火藥之GC/IRMS分析 24
4-2-2火藥之來源追蹤 28
第五章 結論 30
第六章 參考文獻 32
1. 趙明海 2011 感應耦合電漿質譜法應用於彈頭包衣碎片、槍管及彈孔周圍射擊殘跡之分析 中央警察大學 鑑識科學研究所 碩士論文
2. 陳鈺芳,鄭惠齡,鄭惠及,鐘如惠,曾柏元及蕭開平 2010 台灣地區非法藥物監控系統與愷他命相關死亡事故 鑑識科學研討會論文集
3. Kocsis B. 2011. Differential role of NR2A and NR2B subunits in n-methyl-d-aspartate receptor antagonist-induced aberrant cortical gamma oscillations. J.biopsych.2011.10.002.
4. Oliveira R.B., Graham B., Howlett M.C.H., Gravina F.S., Oliveira M.W.S., Imtiaz M.S., Callister R.J., Lim R., Brichta A.M. and Helden D.F.. 2010. Ketamine anesthesia helps preserve neuronal viability. Journal of neuroscience methods 189:230-232.
5. Shakya B., Chaturvedi A. and Sah B.P.. 2010. Prophylactic low dose ketamine and ondansetron for prevention of shivering during spinal anaesthesia. J anaesth clin pharmacol 26(4): 465-469.
6. Honarmand A. and Safavi M.R.. 2008. Comparison of prophylactic use of midazolam, ketamine, and ketamine plus midazolam for prevention of shivering during regional anaesthesia: a randomized double-blind placebo controlled trial. British journal of anaesthesia 101 (4): 557-62.
7. Dal D., Kose A., Honca M., Akinci S. B., Basgul E. and Aypar U.. 2005. Efficacy of prophylactic ketamine in preventing postoperative shivering. British journal of anaesthesia 95 (2): 189-92.
8. Shrestha S.K., Bhattarai B. and Singh J.. 2010. Ketamine gargling and postoperative sore throat. JNMA J Nepal Med Assoc. Oct-Dec; 50(180):282-5.
9. Sato C., Okabe T., Nakanishi K. and Sakamoto A.. 2010. A case of cancer pain management by long-term intrathecal PCA. J Nippon Med Sch 77: 333-337.
10. Campbell-Fleming J.M. and Williams A. 2008. The use of ketamine as adjuvant therapy to control severe pain. Clin J Oncol Nurs. 2008 Feb; 12(1):102-7.
11. Visser E. and Schug S.A.. 2006. The role of ketamine in pain management. Biomedicine &; Pharmacotherapy 60:341-348.
12. Cui Y., Nie H., Ma H., Chen L., Zhang L., Wang J. and Ji H.. 2011. Ketamine inhibits lung fluid clearance through reducingalveolar sodium transport. Journal of Biomedicine and Biotechnology Volume 2011, Article ID 460596.
13. Sinner B. and Graf B.M.. 2008. Ketamine. Handb Exp pharmacol (182):313-33.
14. Breier A., Malhotra A.K., Pinals D.A., Weisenfeld N.I. and Pickar D.. 1997. Association of ketamine-induced psychosis with focal activationof the prefrontal cortex in healthy volunteers. Am J. psychiatry 154:805-811.
15. Morgan C.J.A. and Curran H.V.. 2011. Ketamine use: a review. Addiction Jul 21:1360-0443.2011.03576.
16. 衛生署食品藥物管理局 2011 藥物濫用案件暨檢驗統計資料
17. Vroegop M.P., van Dongen R.T., Vantroyen B. and Kramers C.. 2007. Ketamine as a party drug. Ned tijdschr geneeskd Sep 15;151(37):2039-42.
18. 濫用藥物檢驗中心 2006. 標準操作程序 慈濟大學
http://adc.tcu.edu.tw/detail.php?recordID=6 2011/10/22 查詢
19. 陳亭亭,潘日南,許美智及倪戌江 2009 濫用藥物的檢驗分析及認證制度 臺灣警察專科學校警專學報 第四卷第五期:35-46頁
20. Yinon J. and Zitrin S.. 1993. Modern methods and applications in analysis of explosives.
21. MacCrehan W.A., Smith K.D. and Rowe W.F.. 1998. Sampling protocols for the detection of smokeless powder residues using capillary electrophoresis. Journal of forensic sciences Vol.43, p119.
22. Cooper P.W. and Kurowski S.R.. 1966. Introduction to the technology of explosives.
23. Espinoza E. O'N. and Thornton J. I. 1994. Characterization of smokeless gunpowder by means of diphenylamine stabilizer and its nitrated derivates. Analytica Chimica Acta, Vol88, p57.
24. Via J.C. and Taylor L.T.. 1992. Chromatrographic analysis of nonpolymeric single base propellant compoents. Journal of chromatographic science, Vol30, p106.
25. Miyauchi H., Kumihashi M., and Shibayama T. 1998. The contribution of trace elements fromsmokeless powder to post firing residues. Journal of forensic sciences 43:90.
26. Sarkis J.E.S., Neto O.N., Viebig S. and Durrant S.F. 2007. Measurements of gunshot residues by sector field inductively coupled plasma mass spectrometry-further studies with pistols. Forensic Sci. Int. 172:63-66.
27. 孟憲輝 1996. 射擊殘跡之形成與特性 警學叢刊 26. p47-65
28. Booker J.L. 1996. A method for the identification of smokeless powders and their residues by thin-layer chromatography of their minor constituents. Journal of forensic sciences Vol41.
29. Munder A., Christensen R.G., and Wiae S.A.. 1991. Microanalysis of explosives and propellants by on-line supercriical fluid extraction/chromatography with triple detection. Journal of microcolumn separation 3:127
30. Molina D.K., Castorena J.L. and DiMaio V.J.. 2007. Gunshot residue testing in suicides: Part II: Analysis by inductive coupled plasma-atomic emission spectrometry. Am J Forensic Med Pathol. 28(3):191-4.
31. Zeichner A., Ehrlich S., Shoshani E. and Halicz L. 2006. Application of lead isotope analysis in shooting incident investigations. Forensic Sci. Int. 58:52-64.
32. 徐意淳 2008 鈾釷同位素在矽藻殼體中富集機制之探討 國立成功大學 地球科學研究所 碩士論文
33. Benson S., Lennard C., Maynard P. and Roux C.. 2006. Forensic applications of isotope ratio massspectrometry—A review. Forensic science international 157:1–22.
34. 殷裕勝 2006 氣相層析同位素比質譜儀應用於茶葉製造過程及產源鑑定之研究 國立清華大學 化學研究所 碩士論文
35. 葉沛辰 2009 資源回收廠校園易燃廢液安全管理探討 長榮大學 職業安全與衛生學系碩士班 碩士論文
36. 莊偉仁 2010 以穩定同位素質譜法追蹤台灣地區大花鬼針草種子之地理來源 中央警察大學 鑑識科學研究所 碩士論文
37. Marclay F., Pazos D., Dele´mont O., Esseiva P. and Saudan C.. 2010. Potential of IRMS technology for tracing gamma-butyrolactone (GBL). Forensic science international 198:46-52.
38. 邵震茹,Archana deokar及凌永健 2010 穩定性同位素比值分析應用於區分內源性/外源性伽瑪-羥基丁酸 鑑識科學研討會論文集
39. Spangenberg J.E., Lavric J.V., Meisser N. and Serneels V.. 2010. Sulfur isotope analysis of cinnabar from Roman wallpaintings by elemental analysis/isotope ratio massspectrometry-tracking the origin of archaeological redpigments and their authenticity. Rapid communications in mass spectrometry 24(19):2812-2816.
40. Cortes J.E., Rincon J.M., Jaramillo J.M., Philp R.P., Allen J.. 2010. Biomarkers and compound-specific stable carbon isotope of n-alkanes in crude oils from Eastern Llanos Basin, Colombia. Journal of south american earth sciences 29:198-213.
41. Rhodes C.N., Heaton K., Goodall I., and Brereton P.A.. 2009. Gas chromatography carbon isotope ratio mass spectrometry applied to the detetion of neutral alcohol in Scotch whisky: an internal reference approach. Food chemistry 114:697-701.
42. 凌永健,袁玉潔,蔡沛宜及邵震茹 2009 化合物別同位素比質譜術的研發進展-酒品摻假鑑定 科儀新知第三十一卷第二期
43. 蔡沛宜 2009 同位素比質譜術於蜂蜜摻假之判定及甲基安非他命來源追踪之研究 國立清華大學 化學研究所 碩士論文
44. Chou S.L., Yang M.H., Ling Y.C., Giang Y.S.. 2004. Gas chromatography-isotope dilution mass spectrometry preceded by liquid-liquid extraction and chemical derivatization for the determination of ketamine and norketamine in urine. Journal of chromatography B, JCB 799(2004): 37-50.
45. 王強,孫萬賦,唐軍及趙新 2008 裂解氣相色譜-質譜法研究增塑劑鄰苯二甲酸二丁酯的熱降解 質譜學報 Vol. 29 No. 3
連結至畢業學校之論文網頁點我開啟連結
註: 此連結為研究生畢業學校所提供,不一定有電子全文可供下載,若連結有誤,請點選上方之〝勘誤回報〞功能,我們會盡快修正,謝謝!
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top