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研究生:柯惠如
研究生(外文):hui-ju ke
論文名稱:[6]-薑辣酚抗氧化與美白特性之研究
論文名稱(外文):Study on the antioxidant and whitening properties of [6]-shogaol
指導教授:張聰民張聰民引用關係
指導教授(外文):Tsong-Min Chang
學位類別:碩士
校院名稱:弘光科技大學
系所名稱:化妝品科技研究所
學門:民生學門
學類:美容學類
論文種類:學術論文
畢業學年度:100
語文別:中文
論文頁數:82
中文關鍵詞:[6]-薑辣酚酪胺酸酶黑色素抗氧化
外文關鍵詞:[6]-Shogaoltyrosinasemelaninantioxidant
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[6]-薑辣酚為薑的主要生物活性成分之一,根據研究指出,其具備抗發炎、抗菌、抗氧化、抗癌作用等活性。近年的研究結果發現,薑的藥理活性成分主要為生薑醇(gingerols)及薑辣酚(shogaols)和其衍生物,而其中又以[6]-薑辣酚具有較佳的活性表現。但關於[6]-薑辣酚抑制黑色素的效果和作用機制則不曾有任何研究報告,且[6]-薑辣酚之抗氧化能力也未曾廣泛被探討。為了解[6]-薑辣酚未來開發作為皮膚保養品活性成份的可能性,我們針對[6]-薑辣酚抑制黑色素的合成、可能的作用機制以及抗老化之功效進行研究與分析。在本研究中,[6]-薑辣酚的抗氧化活性經由ABTS+自由基清除能力測定、DPPH自由基清除能力試驗、還原力、Folin–Ciocalteau試驗而被證實,尤其是其ABTS+之自由基清除能力效果顯著。此外,實驗結果顯示[6]-薑辣酚可以有效的抑制B16F10黑色素細胞內酪胺酸酶活性,及降低細胞內黑色素生成量,且效果比熊果素(Arbutin)好。經由西方墨點法的試驗結果指出,[6]-薑辣酚對酪胺酸酶、TRP-1、TRP-2及MITF和MC1R蛋白質的表現量皆有明顯下降的趨勢。此外,[6]-薑辣酚也可以明顯降低B16F10細胞內ROS之含量。
本研究證實[6]-薑辣酚能有效抑制B16F10細胞之酪胺酸酶活性並且降低黑色素生成量,且具備有效之抗氧化活性。因此[6]-薑辣酚可以發展成為一種具備美白與抗氧化雙重功能的化妝品活性成份。

[6]-Shogaol is the main biologically active component of ginger. Previous reports showed [6]-Shogaol express various pharmacological activities such as antioxidative, anti-inflammatory, antimicrobial, and anticarcinogenic properties. In recent years, research results revealed that the pharmacological active ingredients in ginger are gingerols and shogaols and its derivatives, among which the [6]-Shogaol has a better activity in pharmacological performance. However, the effects of [6]-Shogaol on melanogenesis have not been reported. Also, the effects of [6]-Shogaol on scavenging free radicals have not been reported extensively. This study was aimed to evaluate the potential whitening effects and antioxidative activities of [6]-Shogaol. In this study, the antioxidant effects of [6]-Shogaol were in vitro determined by 2,2’-Azino-bis (3-ethylbenzo-thiazline-6-sulfonic acid) (ABTS) radical assay, 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, reducing power assay, Folin–Ciocalteau assay and metal chelating ability assay. In particular, the [6]-Shogaol scavenged ABTS+ radicals significantly. Moreover, the results revealed that [6]-Shogaol effectively suppress murine tyrosinase activity and the amount of melanin, and those effects are stronger than arbutin. Through the Western blot test results pointed out that [6]-Shogaol decrease the protein expression levels of tyrosinase, tyrosinase-related protein 1 (TRP-1), tyrosinase-related protein 2 (TRP-2) , microhptalmia-associated transcriptional factor (MITF) and melanocortin 1 receptor (MC1R). Additionally, [6]-Shogaol significantly reduced the intracellular ROS content in B16F10 cells.
This study concluded that [6]-Shogaol can effectively inhibit the tyrosinase activity and reduce the amount of melanin in B16F10 cells, and exhibit effective antioxidant activities. Thus, [6]-Shogaol could be applied into cosmetic formulations and acts as an active ingredient with the dual function of whitening and antioxidation.
目 錄 Ⅰ
圖目錄 Ⅲ
中文摘要 Ⅳ
Abstract Ⅴ
第壹章、前言 1
第壹節、皮 膚 2
一、表 皮(Epidermis) 3
二、真 皮(Dermis) 5
三、 皮下組織(Hypodermis) 5
第貳節、皮膚與美白 6
一、黑色素細胞(melanocytes) 6
二、黑色素體(melanosomes) 6
三、黑色素之生成 7
四、影響色素沉著之因素 11
五、美白的作用機制 13
第參節、皮膚與老化 15
一、內在老化 15
二、外在老化 15
三、皮膚老化理論與機制 16
第肆節、美白與抗氧化之相關研究 19
第伍節、薑 20
第陸節、薑之藥理活性 21
第柒節、[6]-薑辣酚 21
第捌節、研究動機 22
第貳章、材料與方法 23
一、實驗材料 23
(一)、本實驗所使用之藥品來源 23
(二)、實驗儀器設備 26
二、實驗方法 27
(一)、細胞培養 27
(二)、細胞存活率分析 28
(三)、美白能力分析 29
(四)、抗氧化能力分析 36
(五)、SPSS數據統計分析方法 42
第參章、結果 43
一、[6]-薑辣酚之蕈菇類酪胺酸酶抑制能力測定 43
二、[6]-薑辣酚對B16F10細胞內存活率之影響 43
三、[6]-薑辣酚對B16F10細胞內的黑色素含量之影響 43
四、[6]-薑辣酚對B16F10細胞內的酪胺酸酶活性之影響 44
五、[6]-薑辣酚訊息調節劑對[6]-薑辣酚在B16F10細胞內黑色素含量之影響 44
六、[6]-薑辣酚對B16F10細胞內蛋白質表現量之影響 45
七、[6]-薑辣酚對於DPPH自由基清除能力測定 45
八、[6]-薑辣酚之ABTS+自由基清除能力測定 46
九、[6]-薑辣酚之還原力測定 46
十、[6]-薑辣酚之螯合金屬離子能力之測定 46
十一、[6]-薑辣酚之總酚含量測定 46
十二、[6]-薑辣酚對B16F10細胞內的ROS含量之影響 47
十三、[6]-薑辣酚對B16F10細胞內的RS含量之影響 47
第肆章、討論 48
第伍章、結論 52
第陸章、參考文獻 53
附 錄-圖 64
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