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研究生:陳音戎
研究生(外文):Yin-RongChen
論文名稱:膠原蛋白基質與奈米粒子填充物對玻璃離子體的生物相容性與機械性質之影響
論文名稱(外文):The effect of collagen matrix and nanoparticle fillers to the biocompatibility and mechanical properties of a novel glass ionomer cements
指導教授:謝達斌
指導教授(外文):Dar-Bin Shieh
學位類別:碩士
校院名稱:國立成功大學
系所名稱:口腔醫學研究所
學門:醫藥衛生學門
學類:牙醫學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:英文
論文頁數:57
中文關鍵詞:玻璃離子體奈米氧化鋅膠原蛋白機械性質生物相容性
外文關鍵詞:glass ionomer cementszinc oxide nanoparticlecollagenmechanical propertiesbiocompatibility
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  • 點閱點閱:108
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  • 收藏至我的研究室書目清單書目收藏:0
玻璃離子體為一牙科填補材料,可用於修復牙齒酸蝕或是填補非受力區的齲齒,其甚至可用於牙髓或牙周手術時硬組織的修復。然而,玻璃離子體卻因其相對較差的機械性質而限制了它的臨床應用性;另外,它可能會釋放出鋁離子而造成細胞毒性。因此,許多研究想藉由改良其組成成份來改善上述之缺點。膠原蛋白可以藉由調節多樣化的細胞功能來提高生物相容性,而添加奈米氧化鋅粒子於水泥中則被證實可提高其機械性質。因此,在本篇研究裡試圖去探討添加膠原蛋白及奈米氧化鋅粒子於玻璃離子體中對於其機械性質及生物相容性的影響。在本篇研究裡,利用融膠凝膠法來合成奈米氧化鋅粒子,所得產物會經由SEM,TEM,XRD及FTIR定性。由實驗結果可知,添加重量體積百分濃度為2%的奈米氧化鋅粒子及0.01% 膠原蛋白於玻璃離子體中的確可以增加其對徑抗張強度及抗壓強度,並且此添加可以提升其生物相容性及抗菌性。
Glass ionomer cements were used as filling materials for tooth erosion or caries in non-force bearing area or as hard-tissue repair materials for defects in endodontic and periodontal surgeries. However, their poor mechanical properties limited their clinical applications and their cytotoxicity was attributed to the leakage of chemical ingredients such as aluminium. Many attempts have been made to modify their formulation to prevent these drawbacks. Collagen had been demonstrated to enhance biocompatibility via regulating diverse cellular functions and nano-ZnO particles had been incorporated into the concrete to enhance its mechanical properties. I investigated the effects on the mechanical properties and biocompatibility after incorporating collagen and nano-ZnO particles in the composition of glass ionomer cements in the present study. The sol-gel method was used to fabricate the nano-ZnO particles and the products were under further characterization such as SEM, TEM, XRD and FTIR. In the mechanical properties test, the results showed the glass ionomer cements with incorporation of both 2 wt% nano-ZnO particles and 0.01 wt% collagen exhibited the best diametral tensil strength and compressive strength. Besides, the incorporation enhanced the biocompatibility in the biocompatibility assay and elevated antibacterial properties in the antibacterial test. Therefore, the developed glass ionomer cements with enhanced mechanical properties had the potential to be applied in the clinical practice.
中文摘要 I
Abstract II
誌謝 III
Content IV
List of Tables VI
List of Figures VII
1. Introduction 1
1.1 Dental restorative materials 1
1.2 Glass ionomer cements 1
1.3 Nano-ZnO particles 6
1.4 Collagen 8
1.5 Mechanical properties 10
1-6 Motivation 13
2. Material and method 14
2.1 Synthesis of nano-ZnO particles 14
2-2 Characterization of nano-ZnO particles 14
2-3 Cytotoxicity test of nano-ZnO particles 15
2-4 Manipulation of glass ionomer cements samples 15
2.5 Preparation of nano-ZnO particles containing glass ionomer cements samples 16
2.6 Preparation of glass ionomer cements samples containing nano-ZnO particles and collagen 16
2-7 Diametral tensile strength test and compressive strength test 17
2-8 Biocompatibility assay---direct-contact test 18
2-9 Biocompatibility assay---indirect-contact test 19
2-10 Antibacteria test 20
3. Result 21
3-1 The characterization of synthesized nano-ZnO particles 21
3-2The cytotoxicity of nano-ZnO particles 22
3-3 The mechanical properties of the glass ionomer cements incorporated with different contents of nano-ZnO particles. 23
3-4 The mechanical properties of the glass ionomer cements incorporated with 2 wt% nano-ZnO particles and different concentrations of collagen. 29
3-5 The biocompatibility assay of the glass ionomer cements---direct-contact test 32
3-6 The biocompatibility assay of the glass ionomer cements---indirect-contact test 35
3-7 Antibacterial test 41
4. Discussion 43
5. Conclusion 50
6. References 51
Appendix A 55
Appendix B 56
Appendix C 57

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