跳到主要內容

臺灣博碩士論文加值系統

(3.231.230.177) 您好!臺灣時間:2021/08/04 05:25
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

: 
twitterline
研究生:李婉嘉
研究生(外文):Wan-ChiaLee
論文名稱:自閉症死亡風險分析
論文名稱(外文):Mortality Risk in Autism
指導教授:王榮德王榮德引用關係
指導教授(外文):Jung-Der Wang
學位類別:碩士
校院名稱:國立成功大學
系所名稱:公共衛生研究所
學門:醫藥衛生學門
學類:公共衛生學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:英文
論文頁數:21
中文關鍵詞:自閉症存活分析預期壽命
外文關鍵詞:autism spectrum disordersurvival analysislife expectancy
相關次數:
  • 被引用被引用:0
  • 點閱點閱:137
  • 評分評分:
  • 下載下載:7
  • 收藏至我的研究室書目清單書目收藏:0
背景
全球自閉症患者的盛行率逐漸增加,然而,關於患者死亡的資訊卻相當有限。本研究利用存活分析及外推計算方法,推估自閉症兒童之預期壽命及預期損失壽命。
方法
選取1998至2009間的全民健康保險資料進行分析,選出7192位年齡小於18歲之自閉症兒童,利用13年的追蹤資料進行存活分析。使用Cox多變量比例風險模式控制性別、診斷年齡、癲癇、智能障礙等干擾因子,探討對自閉症患者存活風險之影響。利用存活函數外推80年估計預期壽命,並與性別、年齡相配對之參考族群做比較估計預期損失壽命。
結果
相較於0到5歲間診斷之病童,6到11歲間診斷之病童之調整後死亡危險增加2.46倍 (95% 信賴區間, 1.11-5.46),12到17歲間診斷之病童之調整後死亡危險升高至7.56倍 (95% 信賴區間, 3.63-15.74)。癲癇會顯著顯著增加自閉症死亡危險(調整後風險比, 3.12; 95% 信賴區間, 1.84-5.28),性別與智能障礙則無此相關性。男性患者預期壽命為30.7(±12.2)歲,女性患者預期壽命則為43.2 (±17.3)歲。在學齡前診斷的自閉症兒童與其性別年齡配對的一般兒童有相同的預期壽命。藉著世代效應的檢查證實了這個推論。最常見的死因為癲癇與非疾病死亡。
結論
自閉症的診斷年齡及是否併有癲癇是影響死亡風險的決定因子。早期診斷幫助自閉症獲得較好的存活。

Background
The prevalence of autism spectrum disorder is increasing worldwide, however, the mortality information is limited. We performed survival analysis, explored the determinants of survival and estimated the life expectancy and expected years of life lost for children with autism.
Method
Using the National Health Insurance data between 1998 and 2009, we identified a cohort of 7192 individuals with newly diagnosed autism younger than 18 years of age and performed survival analysis with 13 years of follow-up. Multivariable Cox proportional-hazards model were constructed to assess the effect of sex, age at diagnosis, epilepsy and intellectual disability on survival,. Life expectancy was estimated by the 80-year extrapolation of the survival function with the information of an age- and sex-matched reference population.
Result
The adjusted hazard ratio of mortality of 6-11 years of age at diagnosis was 2.46 (95% CI, 1.11-5.46) and that of 12-17 years of age at diagnosis was 7.56 (95% CI, 3.63-15.74) as compared with that of 0-5 years of age at diagnosis. Epilepsy significantly increased the risk of mortality (adjusted hazard ratio, 3.12; 95% CI, 1.84-5.28) while female sex and intellectual disability did not. The average life expectancy of male was 30.7(±12.2) years and that of female was 43.2 (±17.3) years. Children with autism diagnosed during 0-5 years old had no significant difference in life expectancy as compared with the age- and sex- matched reference population. Examination for cohort effect corroborates the inference. Epilepsy and external causes were the most common causes of death.
Conclusion
Age at diagnosis and epilepsy were predictors of mortality of autism. The earlier the children received the ASD diagnosis, the better they would survive.

Contents
摘要 I
Abstract III
誌謝 V
Contents VI
List of abbreviations VIII
Introduction 1
Epidemiological studies in autism spectrum disorder 1
Specific aims of this study 1
Subjects and Methods 2
Study population 2
Data source 2
Statistical Analysis 4
Validation 6
Results 6
Baseline characteristics of subjects with autism 6
Cause of death, death age, K-M survival 7
Life expectancy in ASD and validation of extrapolation method 7
Discussion 8
Main findings 8
Epilepsy 10
Mental retardation and gender difference 11
Limitation of this study 12
List of Tables 14
Table 1: Baseline characteristics of subjects with autism stratified by gender 14
Table 2: Adjusted hazard ratios (HR) and 95% CI (confidence intervals) for mortality in a multivariable Cox regression model 14
Table 3: Estimates of mean survival time in 13 years of follow-up, extrapolated based on the first 6-year follow-up estimates of Monte Carlo method compared with estimates of Kaplan-Meier analysis at 13 years 15
List of Figures 16
Figure 1: Distribution of age of diagnosis 16
Figure 2: Comparison of lifetime survival curves between male and female and their sex- and age- matched reference population. 16
References 19

1.Fombonne E. Epidemiological surveys of autism and other pervasive developmental disorders: an update. Journal of autism and developmental disorders 2003;33:365-82.
2.Yeargin-Allsopp M. Prevalence of Autism in a US Metropolitan Area. JAMA: The Journal of the American Medical Association 2003;289:49-55.
3.Fombonne E. The prevalence of autism. JAMA : the journal of the American Medical Association 2003;289:87-9.
4.Baird G, Simonoff E, Pickles A, et al. Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). The Lancet 2006;368:210-5.
5.Prevalence of autism spectrum disorders--Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008. MMWR Surveill Summ 2012;61:1-19.
6.Volkmar FR, Pauls D. Autism. The Lancet 2003;362:1133-41.
7.Levy SE, Mandell DS, Schultz RT. Autism. Lancet 2009;374:1627-38.
8.Mefford HC, Batshaw ML, Hoffman EP. Genomics, intellectual disability, and autism. The New England journal of medicine 2012;366:733-43.
9.Pickett JA, Paculdo DR, Shavelle RM, Strauss DJ. 1998-2002 Update on Causes of death in autism. Journal of autism and developmental disorders 2006;36:287-8.
10.Mouridsen SE, Bronnum-Hansen H, Rich B, Isager T. Mortality and causes of death in autism spectrum disorders: an update. Autism : the international journal of research and practice 2008;12:403-14.
11.Gillberg C, Billstedt E, Sundh V, Gillberg IC. Mortality in autism: a prospective longitudinal community-based study. Journal of autism and developmental disorders 2010;40:352-7.
12.Woolfenden S, Sarkozy V, Ridley G, Coory M, Williams K. A systematic review of two outcomes in autism spectrum disorder - epilepsy and mortality. Developmental medicine and child neurology 2012;54:306-12.
13.Warren Z, McPheeters ML, Sathe N, Foss-Feig JH, Glasser A, Veenstra-Vanderweele J. A systematic review of early intensive intervention for autism spectrum disorders. Pediatrics 2011;127:e1303-11.
14.http://www.nhi.gov.tw
15.Hwang JS, Wang JD. Monte Carlo estimation of extrapolation of quality-adjusted survival for follow-up studies. Statistics in medicine 1999;18:1627-40.
16.Fang CT, Chang YY, Hsu HM, et al. Life expectancy of patients with newly-diagnosed HIV infection in the era of highly active antiretroviral therapy. QJM : monthly journal of the Association of Physicians 2007;100:97-105.
17.Johnson CP, Myers SM. Identification and evaluation of children with autism spectrum disorders. Pediatrics 2007;120:1183-215.
18.Honda H, Shimizu Y, Nitto Y, et al. Extraction and Refinement Strategy for detection of autism in 18-month-olds: a guarantee of higher sensitivity and specificity in the process of mass screening. Journal of child psychology and psychiatry, and allied disciplines 2009;50:972-81.
19.Tuchman R, Rapin I. Epilepsy in autism. The Lancet Neurology 2002;1:352-8.
20.Shavelle RM, Strauss DJ, Pickett J. Causes of death in autism. Journal of autism and developmental disorders 2001;31:569-76.
21.Amiet C, Gourfinkel-An I, Bouzamondo A, et al. Epilepsy in autism is associated with intellectual disability and gender: evidence from a meta-analysis. Biological psychiatry 2008;64:577-82.

連結至畢業學校之論文網頁點我開啟連結
註: 此連結為研究生畢業學校所提供,不一定有電子全文可供下載,若連結有誤,請點選上方之〝勘誤回報〞功能,我們會盡快修正,謝謝!
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top