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研究生:張維瀚
研究生(外文):Wei-HanChang
論文名稱:添加劑對於陰陽離子雙層膜之相轉移行為的探討
論文名稱(外文):Calorimetric Study of the Additive Effects on the Gel to Liquid-Crystalline Phase Transition Behavior of Catanionic Bilayer Membrane
指導教授:楊毓民楊毓民引用關係
指導教授(外文):Yu-Min Yang
學位類別:碩士
校院名稱:國立成功大學
系所名稱:化學工程學系碩博士班
學門:工程學門
學類:化學工程學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:中文
論文頁數:126
中文關鍵詞:陰陽離子界面活性劑相轉移行為相轉移溫度相轉移焓膽固醇維他命E維他命E醋酸酯
外文關鍵詞:ion pair amphiphilecatanionic surfactantbilayer membranephase transition temperatureenthalpy change
相關次數:
  • 被引用被引用:4
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  • 下載下載:9
  • 收藏至我的研究室書目清單書目收藏:0
本研究透過四種不同陰陽離子界面活性劑(IPA),分別為對稱型與不對稱型,總碳鏈數為24與28的系統。利用DSC來研究四種IPA的相轉移行為(凝膠態到液晶態的構型改變),本實驗進一步添加三種不同的添加劑分別為膽固醇、維他命E與維他命E醋酸酯對於IPA雙層膜的熱力學性質影響,包括相轉移溫度與焓值改變。
實驗中的結果可以發現到,IPA的相轉移溫度隨著總碳數增加而上升,另外可以發現到對稱型系統會比不對稱型系統的相轉移溫度來的高。另外可以發現到相轉移溫度幾乎不會隨著添加劑增加而改變,但可以發現到焓值改變均隨著添加劑增加而下降,甚至添加到超過一定量時,會使系統相轉移行為消失。另外影響到焓值改變的程度依序為:維他命E、維他命E醋酸酯最後則是膽固醇。
Four ion pair amphiphiles(IPAs) of different hydrocarbon chain lengths with symmetric and asymmetric hydrocarbon chains were prepared from cationic and anionic surfactants by the precipitation in this work. By using differential scanning calorimetry(DSC), the thermotropic transition behavior from gel to liquid-crystalline state was measured for bilayer membranes of these lipid-like catanionic surfactants. Moreover, the effects of additives(cholesterol, vitamin E, and vitamin E acetate) in catanionic bilayer membranes on phase transition temperature, enthalpy change and entropy change were determined.
The experimental results showed that the phase transition temperature is higher for catanionic surfactants with higher total carbon number in the hydrocarbon chains. And for the catanionic surfactants with the same total carbon number in the hydrocarbon chains, the phase transition temperature is higher for the symmetric one than that with asymmetric one. No consistent trend in enthalpy changes, however, was exhibited by the different catanionic surfactants. With the addition of cholesterol, vitamin E, and vitamin E acetate in the bilayer membrane of catanionic surfactants, the phase transition temperatures were found to be unaffected. On the other hand, the enthalpy and entropy changes decreased with the increase of these three additives.

摘要 I
Abstract II
致謝 IV
目錄 V
表目錄 IX
圖目錄 XII
符號說明 XV
第一章 緒論 1
1-1 前言 1
1-2 研究動機與目的 10
第二章 文獻回顧 11
2-1 陰陽離子對雙親分子 11
2-2 陰陽離子液胞的形成 13
2-3 膽固醇對液胞穩定性的影響 17
2-4 相轉移溫度與液胞形成之關係 19
2-5 固醇類對相轉移行為的影響 21
2-6 維他命E對於相轉移行為的影響 27
2-7 鹽類與帶電界劑對於雙鏈界面活性劑相轉移行為的影響 33
2-8 磷脂質的結構、相轉移行為與測定 36
第三章 實驗 41
3-1 實驗藥品 42
3-2 實驗儀器與裝置 47
3-2-1 均質機 47
3-2-1 元素分析儀 49
3-2-2 差式掃描式熱卡計 51
3-3 實驗方法 54
3-3-1 陰陽離子界面活性劑(IPA)的製備 54
3-3-2 陰陽離子界面活性劑分散液的製備 56
第四章 結果與討論 58
4-1 陰陽離子界面活性劑的製備和鑑定 58
4-1-1 陰陽離子界面活性劑的製備流程 60
4-1-2 陰陽離子界面活性劑元素分析鑑定 61
4-2 陰陽離子界面活性劑的相轉移行為 65
4-2-1 陰陽離子界面活性劑 65
4-2-2 對稱/不對稱陰陽離子界面活性劑 71
4-3 膽固醇對於陰陽離子界面活性劑相轉移行為的影響 72
4-3-1 總碳數為24之系統 72
4-3-2 總碳數為28之系統 75
4-3-3 膽固醇對於IPA雙層膜相轉移影響之機制 79
4-4 維他命E醋酸酯對於陰陽離子界面活性劑相轉移行為的影響 80
4-4-1 總碳數為24之系統 80
4-4-2 總碳數為28之系統 83
4-5 維他命E對於陰陽離子界面活性劑相轉移行為的影響 87
4-5-1 總碳數為24之系統 87
4-5-2 總碳數為28之系統 90
4-5-3 三種添加劑對於相轉移行為的影響與比較 94
4-6 陰陽離子界面活性劑對於陰陽離子界面活性劑相轉移行為的影響 99
第五章 結論與未來展望 103
5-1 結論 103
5-1-1 陰陽離子界面活性劑的鑑定 103
5-1-2 陰陽離子界面活性劑的相轉移行為 103
5-1-3 膽固醇對於陰陽離子界面活性劑相轉移行為的影響 104
5-1-4 維他命E系列對於陰陽離子界面活性劑相轉移行為的影響 104
5-1-5 組成對於陰陽離子界面活性劑相轉移行為的影響 105
5-2 建議 105
參考文獻 106
自述 126
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