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研究生:杜承霖
研究生(外文):Cheng-LinTu
論文名稱:白蛋白對含雙鏈陽離子型界面活性劑之陰陽離子液胞物化特性的影響
論文名稱(外文):The Effects of Albumin on the Physicochemical Properties of Catanionic Vesicles Containing Double-Chained Cationic Surfactant
指導教授:張鑑祥張鑑祥引用關係
指導教授(外文):Chien-Hsiang Chang
學位類別:碩士
校院名稱:國立成功大學
系所名稱:化學工程學系碩博士班
學門:工程學門
學類:化學工程學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:中文
論文頁數:248
中文關鍵詞:陰陽離子液胞雙鏈陽離子型界面活性劑離子對雙親分子液胞雙層膜
外文關鍵詞:catanionic vesicledouble-chained cationic sufactantion pair amphiphilevesicular bilayer
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本研究分別將陽離子型界面活性劑hexadecyltrimethylammonium bromide(HTMAB)及dodecyltrimethylammonium bromide(DTMAB)與陰離子型界面活性劑sodium dodecylsulfate(SDS)於水相中混合,以製備出離子對雙親分子(ion pair amphiphile, IPA)HTMA-DS及DTMA-DS。然後分別以HTMA-DS及DTMA-DS為主材料,添加不同莫耳分率的雙碳氫鏈二甲基溴化銨(dialkyldimethylammonium bromide, DXDAB),並透過適當的製程製備出帶正電的陰陽離子液胞。當DXDAB莫耳分率(XDXDAB)為0.5時,HTMA-DS/DHDAB及DTMA-DS/DHDAB所形成之液胞具較佳的物理穩定性。由於DHDAB的碳鏈長度介於DODAB及DTDAB之間,因此推測液胞的物理穩定性不僅與IPA和DXDAB之間的凡得瓦爾作用有關,也和液胞組成分子碳鏈間的對稱性有關。
在添加白蛋白的液胞系統中,白蛋白在液胞上的吸附會降低液胞的界面電位,且在高濃度白蛋白存在下,會使液胞的電性反轉。由紅外光譜分析發現,白蛋白的疏水基團插入液胞雙層膜與IPA和DXDAB之間的交互作用有關,而IPA與DHDAB之間明顯的交互作用,使得白蛋白的疏水基團不易插入HTMA-DS/DHDAB及DTMA-DS/DHDAB所形成之液胞雙層膜中。在液胞的電性出現反轉之前,白蛋白的吸附使液胞界面電位降低,以及白蛋白的疏水基團插入液胞雙層膜中,皆會降低液胞的物理穩定性。在電性反轉之後,更多的白蛋白吸附在液胞上反而能提升液胞的物理穩定性。本研究也嘗試藉由添加膽固醇來提升液胞的物理穩定性,發現膽固醇具有提升液胞的界面電位,以及調整液胞雙層膜中分子碳氫鏈排列的特性,而得以使液胞的物理穩定性提升。膽固醇的添加也能避免白蛋白造成之液胞聚集及融合,因而提升液胞的物理穩定性。

In this study, the ion pair amphiphiles (IPAs), hexadecyltrimethylammonium-dodecylsulfate (HTMA-DS) and dodecyltrimethylammonium-dodecylsulfate (DTMA-DS), were prepared by mixing aqueous solutions of the cationic surfactants, hexadecyltrimethylammonium bromide (HTMAB) and dodecyltrimethylammonium bromide (DTMAB), respectively, with the anionic surfactant, sodium dodecylsulfate (SDS). HTMA-DS and DTMA-DS were then used as the main materials, respectively, with the addition of various molar fractions of dialkyldimethylammonium bromide (DXDAB) to form positively charged catanionic vesicles by an appropriate process. When the molar fraction of DXDAB (XDXDAB) was 0.5, the vesicles composed of HTMA-DS/DHDAB and DTMA-DS/DHDAB possessed better physical stability. Since the alkyl chain length of DHDAB is between those of DODAB and DTDAB, it is proposed that the vesicle physical stability was related to not only the van der Waals interaction between IPA and DXDAB, but also the symmetry of the hydrocarbon chains of the vesicle-forming materials.
For the vesicle systems with the addition of bovine serum albumin (BSA), the adsorption of BSA on the vesicles could decrease the zeta potential of the vesicles, and charge reversal of the vesicles was observed at high BSA concentrations. From the IR spectrum analysis, one could find that the insertion of the hydrophobic groups of BSA into the vesicular bilayers was related to the interaction between IPA and DXDAB. The strong interaction between IPA and DHDAB caused the difficulty for the hydrophobic groups of BSA to insert into the vesicular bilayers composed of HTMA-DS/DHDAB and DTMA-DS/DHDAB. Without the charge reversal of the vesicles, the reduced zeta potential of the vesicles due to the BSA adsorption and the insertion of the BSA hydrophobic groups into the vesicular bilayers would lower the physical stability of the vesicles. Nevertheless, with the charge reversal of the vesicles, more BSA adsorbing onto the vesicles could enhance the physical stability of the vesicles. The addition of cholesterol was also tried in this study to improve the vesicle physical stability, and it was found that cholesterol could increase the zeta potential of the vesicles and adjust the packing characteristic of the molecular hydrocarbon chains in the vesicular bilayers, resulting in enhanced physical stability of the vesicles. The addition of cholesterol could also prevent the vesicles from BSA-induced aggregation and fusion and thus increase the vesicle physical stability.

摘要 I
Abstract III
誌謝 V
總目錄 VI
表目錄 IX
圖目錄 XIII
符號說明 XXV
第一章 緒論 1
1-1 前言 1
1-2 研究動機與目的 3
1-3 文獻回顧 4
1-3-1 離子對雙親分子 4
1-3-2 帶電液胞 5
1-3-3 膽固醇效應 7
1-3-4 液胞相轉移行為及測定 10
1-3-5 液胞雙層膜中分子碳氫鏈的排列 13
1-3-6 液胞與白蛋白的交互作用 15
1-3-7 鹽類效應 20
第二章 實驗 32
2-1 藥品 32
2-2 實驗儀器及裝置 33
2-2-1 超音波震盪分散裝置 33
2-2-2 雷射光散射法粒徑及界面電位分析儀 33
2-2-3 傅利葉轉換紅外光譜儀 36
2-2-4 穿透式電子顯微鏡 37
2-2 實驗方法 38
2-3-1 IPA的製備 38
2-3-2 帶正電陰陽離子液胞的製備 39
2-3-3 液胞粒徑分布及界面電位的量測 39
2-3-4 動態光散射法偵測液胞相轉移行為 40
2-3-5 穿透式紅外光譜的分析 40
2-3-6 穿透式電子顯微鏡的分析 41
第三章 結果與討論 51
3-1 帶正電陰陽離子液胞 51
3-1-1 雙碳鏈陽離子型界面活性劑所形成的液胞 51
3-1-2 以IPA為主材料所形成的帶正電陰陽離子液胞 56
3-2 膽固醇效應 73
3-2-1 粒徑 73
3-2-2 界面電位 75
3-2-3 物理穩定性 78
3-2-4 液胞雙層膜的相轉移行為 81
3-2-5 雙層膜中分子碳氫鏈的排列 84
3-3 緩衝溶液的效應 85
3-4 液胞與白蛋白的交互作用 92
3-4-1 粒徑 92
3-4-2 界面電位 94
3-4-3 物理穩定性 95
3-4-4 雙層膜中分子碳氫鏈的排列 96
3-4-5 膽固醇效應 99
3-4-6 緩衝溶液的影響 102
3-4-7 TEM影像 105
第四章 結論 223
參考文獻 225
自述 248

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