臺灣博碩士論文加值系統

磷酸鈣/硫酸鈣複合骨水泥具有優良的生物相容性，磷酸鈣提供了適當的機械強度及骨傳導性，而硫酸鈣彌補了磷酸鈣降解速率慢的缺點，在體內溶解速率快，溶解的同時釋出鈣離子，鈣離子的釋出使得材料具有誘骨性，兩者皆各自具有不錯的生物相容性，因此磷酸鈣和硫酸鈣混合後，利用硫酸鈣快速被吸收當作製造骨基質原料及產生孔洞效果的特性，有利於新生骨長入。
本實驗主要探討JK1和JK2不同粉液比之下對骨水泥性質的影響和藉由提高粉液比來改善注射性質，結果顯示即便在嚴刻條件下(30cm細長管)的注射系統仍然能夠無殘留的射出，並維持其良好的不崩解性質。而且提高液粉比也可大幅增加孔隙率和溶解速率以利於骨細胞較易生長與貼附。

Calcium phosphate/calcium sulfate composite bone cement has excellent biocompatibility. Calcium phosphate has adequate mechanical properties and good osteoconductivity. Calcium sulfate is a kind of materials that has fast resorption in human body, and it will cover the drawback of poor degradation of calcium phosphate. When calcium sulfate dissolved, the calcium ion was released that makes the composite osteoinductive, in addition, calcium phosphate and calcium sulfate both have excellent biocompatibility. The resorbed calcium sulfate can be used as materials of bone matrix. Upon degrading it also generates porosities which makes the newly formed bone integrates into the implant along with the pore and contacts directly with crystals of calcium phosphate.
The aim of this study is to investigate the liquid-powder ratio effect on properties of calcium phosphate bone cement.
Results show that both JK1 and JK2 were able to improve the injectability of the paste by increasing liquid/powder ratio. This formula(with specific liquid/powder ratio) can be injected completely even through 30 cm tubes and maintained its shape without disintegration. Furthermore, increasing the liquid-powder ratio could increases porosity and degradation rates, which may help cell grow and attach more easily.

總目錄
中文摘要 I
Abstract II
誌謝 III
總目錄 IV
表目錄 VII
圖目錄 IX
第一章 總序論 1
1-1 生醫材料的定義 1
1-2 生醫材料的分類 2
1-2-1依材料化學組成分類 2
1-3依活性分類 10
1-4生醫材料的發展 12
1-5 理想生醫材料的要求 17
1-6 生醫陶瓷種類 19
1-7 人體骨骼的簡介 22
1-8 骨取代物的簡介 32
1-8-1 生物學上骨取代物的要求 32
1-8-2 骨取代物的來源與種類 32
1-9 骨水泥的注射性 34
1-9-1 骨水泥可注射性評测方法 34
1-9-2 改善磷酸鈣骨水泥可注射性的方法 35
第二章 文獻回顧 38
2-1 硫酸鈣發展歷史 38
2-2 骨水泥添加物文獻參考 40
2-2-1添加金屬離子 40
2-2-2 添加高分子製造造孔隙 41
2-3 研究目的 42
第三章 實驗原理及步驟 43
3-1 崩解性質的測試 43
3-2 抗壓試片製作與強度測試 44
3-3 工作與硬化時間測量 45
3-4 pH值的量測 45
3-5 X-Ray diffraction（XRD）分析 47
3-6 Scanning Electron Microscopy（SEM）表面觀察 48
3-7 孔隙度（Porosity）、重量損失測試 49
第四章 結果與討論 51
4-1 骨水泥性質測試 51
4-2 工作時間和硬化時間 51
4-3 骨水泥的崩解性質測試 53
4-4 骨水泥抗壓強度 63
4-5 骨水泥的孔隙度 64
4-6 骨水泥的重量損失 65
4-7 pH值分析 66
第五章 結論 76
參考文獻 77

Arise, R. O., Davies, F. F. ＆ Malomo, S. O. 2008 Independent and
interactive effect of Mg2t and Co2t on some kinetic parameters of ratkidney alkaline phosphatase. Sci. Res. Ess. 3, 488–494.

Becker TA, Kipke DR. Flowproperties of liquid calcium alginate
polymer injected through medical m icrocatheters for endovascular
embolization. J BiomedM ater Res, 2002, 61 (4) : 5332540.

Breed AL., Experimental production of vascular hypotension, and bonemarrow and fat embolism with methylmethacrylate cement. Traumatichypertension of bone. Clin Orthop, 1974; 102: 227-44.

Byong-Taek Lee, Do Van Quang, Min-Ho Youn, Ho-Yeon SongFabof biphasic calcium phosphates/polycaprolactone composites by meltinfiltration process. Journal of materials science. Materials in medicine.06/2008; 19(5):2223-9.

Clemson Advisory Board for Biomaterials “Definition of the word
biomaterial, Thc 6th Annnal Intermalionel Biomaterial Symposium, April 20-24, 1974.

de Groot K. Medical applications of calcium phosphate bioceramics. The centennial memorial issue of the ceramic society of Japan1991;99:943-953.

el Briak H, Durand D, Nurit J , et al. Study of a hydraulic dicalcium pho sphate dihydrateöcalcium oxide2based cement for dental applications. J BiomedMater Res, 2002, 63 (4) : 4472453.

Fernaâ ndez* E, Gil FJ, Ginebra MP, Driessens FCM, Planell JA.
Calcium phosphate bone cements for clinical applications, Journal of
Materials Science: Materials in Medicine 10 (1999) 169±183.

Ginebra M P, Rilliard A , Fernandez E, et al. M echanical and rheological imp rovement of a calcium pho sphate cement by the addition of a po- lymeric drug. J BiomedM ater Res, 2001, 57 (1) :1132118.
Hulbert SF, Hench LL, Forbers D, Bowman LS. History of bioceramics. Ceram Internat. 1982;8:131-140.

Hulbert SF, Hench LL, Forbers D, Bowman LS. History of bioceramics. Ceram Internat. 1982;8:131-140.

Hench LL, Bioceramics: from concept to clinic. J Am Ceram Soc1991;74:1487-1510.

Joon B. Park and Ruderic S. Lakes “BIOMATERIALS An Introduction
2nd ed. Plenum Press, New York, P.2-3, 1992.

Jonck LM, Grobbelaar CJ. The biological compatibility of glass
ionomer cement in joint replacement. Clin. Mater. , 1989; 4: 85-107

Junfeng Jia, Huanjun Zhou, Jie Wei, Xin Jiang, Hong Hua, Fangping
Chen, Shicheng Wei, Jung-Woog Shin and Changsheng Liu
Development of magnesium calcium phosphate biocement for bone regeneration J. R. Soc. Interface 2010 7, 1171-1180 first
published online 24 February 2010 doi: 10.1098/rsif.2009.0559.

Khairoun I, M agneD, Gauth ier O , et al. In vitro characterization
and in v ivo p roperties of a carbonated apatite bone cement. J
BiomedM ater Res, 2002, 60 (4) : 6332642.

Kokubo T. Recent progress in glass-based materials for biomedical applications. The Centennial Memorial Issue of The Ceramic Society of
Japan 99: 965-973, 1991.

Khairoun I, Bo ltongM G, D riessens FC, et al. Effect of calcium
carbonate on clinical comp liance of apatitic calcium pho sphate bone
cement. J BiomedM ater Res, 1997, 38 (4) : 3562360.

L eroux L , Hatim Z, F recheM , et al. Effects of various adjuvants
( lactic acid, glycero l, and ch ito san ) on the injectability of a
calcium pho sphate cement. Bone, 1999, 25 (2) : 31S234S.

Lewry A.J. and J. Williamsoon, The setting of gypsum plaster partIII
the effect of additives and impurities.J of materials science. Vol 29,
p6085~6090, 1994.

Lee RW , Volz RG, Sheridan D. The role of fixation and bone
quality on the mechanical stability of tibial knee components. Clin
O rthop Rel Res, 1991, 273: 1772183.

Lim TH, Brebach GT, Renner SM , et al. Biomechanical evaluation of an injectable calcium pho sphate cement for vertebroplasty. Spine,
2002, 27 (12) : 129721302.

Miyamo to Y, Ishikawa K, TakechiM , et al. Non2decay type fast2
setting calcium phosphate cement: setting behaviour in calf serum
and its tissue response. Biomaterials, 1996, 17 (14) : 142921435.

Marchi, J., Dantas, A. C. S., Greil, P., Bressiani, J. C., Bressiani, A. H.
A. ＆ Muller, F. A. 2007 Influence of Mg-substitution on the
physicochemical properties of calcium phosphate powders. Mater.
Res. Bull. 42,1040–1050. (doi:10.1016/j.materresbull.2006.09.015)

Myerson A.S. Handbook of Industrial Crystallization Butterworth
Heinemann Series, Chemical Engineering. USA, 1993.

Moore W.R, Graves S.E, Bain G.I. Synthetic Bone Graft Substitutes.
ANZ J. Surg 71: 354-361,2001.

Nilsson M., Ferna´ndez E. Sarda S. Lidgren 1L., Planell J.A.
Characterization of a novel calcium phosphate/sulphate bone cement. J
Biomed Mater Res 61: 600–607, 2002.

Nilsson M., Wielanek L., J.S. Wang, K. E. Tanner, L. Lidgren.
Factors Influencing the Compressive Strength of an Injectable Calcium Sulfate-Hydroxyapatite Cement. Journal of Materials Science: Materials
in Medicine 14: 399-404, 2003.

Park JB. Biomaterials science and engineering. Plenum Press, New York
and London, 1985.

Hulbert SF, Hench LL, Forbers D, Bowman LS. History of bioceramics.
Ceram Internat. 1982;8:131-140.

Park JB. Biomaterials science and engineering. Plenum Press, New York and London, 1985.

Park JB. Biomaterials science and engineering. Plenum Press, New
York and London, 1985.

Park JB, Bronzino JD. Biomaterials principles and applications. CRC
Press, New York, 2003.

Park JB, Lakes RS. Biomaterials: an introduction. Plenum Press, 2nd ed.,
New York, 1992.

Park JB. Biomaterials science and engineering. Plenum Press, New York
and London, 1985.

Penel G, L eroy N , V an L anduyt P, et al. Raman m icro spectrometry
studies of brush ite cement: in v ivo evo lution in a sheep model. Bone,
1999, 25 (2) : 81S284S.

Park JB, Bronzino JD. Biomaterials principles and applications. CRC
Press, New York, 2003.

Ratner BD, Hoffman AS, Schoen FJ, Lemons JE. Biomaterials science.
Academic Press, California, 1996;222-223.

Rude, R. K. ＆ Gruber, H. E. 2004 Magnesium deficiency and
osteoporosis: animal and human observations. J. Nutr.Biochem. 15,
710–716. (doi:10.1016/j.jnutbio.2004.08.001).

Rosa P. Félix Lanao, Sander C.G. Leeuwenburgh, Joop G.C. Wolke,
John A. Jansen Bone response to fast-degrading, injectable calcium
phosphate cements containing PLGA microparticles Biomaterials xxx
(2011) 1e9 4 August 2011.

R.P. Felix Lanao, S.C.G. Leeuwenburgh, J.G.C. Wolke, J.A. Jansen
In vitro degradation rate of apatitic calcium phosphate cement with
Incorporated PLGA microspheres Acta Biomaterialia 7 (2011)
3459–3468 6 June 2011.

Rude, R. K. ＆ Gruber, H. E. 2004 Magnesium deficiency andosteoporosis: animal and human observations. J. Nutr. Biochem. 15, 710–716. (doi:10.1016/j.jnutbio.2004.08.001).

Soballe K. Hydroxyapatite ceramic coating for bone implant fixation.
ACTA Orthopaed Scandin Supplem 1993;64:1-58.

Sheeny K. Lan Levengood , Samantha J. Polak , Matthew B. Wheeler
, Aaron J. Maki , Sherrie G. Clark ,Russell D. Jamison, Amy J. Wagoner
Johnson , Multiscale osteointegration as a new paradigm for the design of
calcium phosphate scaffolds for bone regeneration Biomaterials
313552–3563 Available online 11 February 2010.

Soballe K. Hydroxyapatite ceramic coating for bone implant fixation.ACTA Orthopaed Scandin Supplem 1993;64:1-58.

Silver FH. Biomaterials, medical devices, and tissue engineering: anintegrated approach. Chapman ＆ Hall, New York, 1994.

Staiger, M. P., Pietak, A. M., Huadmai, J. ＆ Dias, G. 2006 Magnesiumand its alloys as orthopedic biomaterials: a review. Biomaterials 27,1728–1734. (doi:10.1016/j.biomaterials.2005.10.003)

Sarda S, Fernandez E, Nilsson M , et al. Kinetic study of citric acidinfluence on calcium pho sphate bone cements as water2 reducing agent. J BiomedM ater Res, 2002, 61 (4) : 6532659.

Van Landuyt P, Peter B, Beluze L , et al. Reinforcement of
osteo synthesis screw swith brushite cement. Bone, 1999, 25 (2) :
95S298S.

Verlaan JJ, Oner FC, Slootweg PJ, Verbout AJ, Dhert WJ Histologic
Changes after vertebroplasty. J Bone Joint Surg [Am] 86(A):1230-1238,2004.
Zreiqat, H., Howlett, C. R., Zannettino, A., Evans, P., Schulze-Tanzil,
G., Knabe, C. ＆ Shakibaei, M. 2002 Mechanisms of magnesium-stimulated adhesion of osteoblastic cell to commonly
used orthopaedic implants. J. Biomed. Mater. Res. 62, 175–184.
(doi:10.1002/jbm.10270).