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研究生:李昱翰
研究生(外文):Yu-HanLi
論文名稱:單粒徑噴霧造粒技術及其在栓塞微球製程之研究
論文名稱(外文):Monodispersed particle generation and its application in formation of Embolization microspheres by spraying processes
指導教授:王覺寬
指導教授(外文):Muh-Rong Wang
學位類別:碩士
校院名稱:國立成功大學
系所名稱:航空太空工程學系碩博士班
學門:工程學門
學類:機械工程學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:中文
論文頁數:86
中文關鍵詞:噴霧造粒單粒徑液滴栓塞微球壓力式霧化器
外文關鍵詞:Particle generationMonodispersed dropletEmbolization microspherePressure type atomizer
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本研究以實驗方法探討外部激擾法對單粒徑液滴產生之影響,以應用在微膠囊及栓塞劑微球之造粒需求。本研究以壓力式微管霧化器,利用注射幫浦將工作流體注入霧化器內,調整進料率至液束形成後,再由一波形產生器產生方波,經功率放大器後供給喇叭訊號,喇叭再將此外部激擾訊號傳達至霧化器,振動由噴口噴出之液體,以產生單粒徑液滴,工作流體包括甘油溶液、褐藻膠溶液與醫療用栓塞劑配方。先以甘油溶液做霧化器性能及基本參數研究,透過無因次參數分析,找出適用於本系統之經驗公式;接著以褐藻膠溶液進行造粒實驗,將受激擾後之褐藻膠液滴以氯化鈣溶液收集,形成微膠囊,分析造粒後之顆粒粒度與分佈;最後進行栓塞劑微球的造粒實驗。結果顯示工作流體之液滴在受到外部激擾後,皆可以形成單粒徑液滴,其粒徑皆隨激擾頻率遞增而下降,但有一單粒徑產生之工作區間,高於或低於這範圍則為多粒徑液滴產生區。黏度在16.43 cP到65.05 cP範圍內對於單粒徑液滴之趨勢線影響不顯著。無因次參數分析則是將實驗數據做進一步的整理,受激擾後的甘油液滴單粒徑尺度為噴口孔徑之2.0~3.5倍,液滴粒徑與孔徑比(dp/d0)隨史卓荷數(St)遞增而下降,且發現當在雷諾數(Re)8.57到35.96的範圍內,對於液滴實驗結果影響不顯著,液滴粒徑與孔徑比與徑長比(L/d0)呈線性關係,經過無因次參數迴歸分析,可得粒徑與史卓荷數及徑長比之經驗公式。褐藻膠液滴之實驗結果與甘油液滴相似,而實際收集之微膠囊顆粒因囊壁產生化學反應,有收縮的現象。栓塞劑微球造粒實驗結果顯示,本製程可成功製造單粒度之栓塞劑微球,其平均粒度約為噴口孔徑之3.06倍,因為栓塞劑為複合藥物配方,其黏度隨配方之混合比例及溫度變化,故造粒所得之粒度亦隨之變化。本研究發現藉由控制史卓荷數(St)、霧化器噴口之徑長比(L/d0)與工作流體之黏度可得到不同粒度單粒徑液滴,將來若能設計一收集艙體,使液滴在收集艙內直接固化,不僅可以製造出特定粒度之栓塞劑微球,亦可以提升產品之良率。

This research aims at the development of a monodispersed particle generation system for the production of micro-capsule and medical embolization microsphere. The apparatus is a pressure type micro-atomizer with external excitation by a speaker. The laminar fluid stream issued from the atomizer is disintegrated to monodispersed droplets under resonant frequency. The working fluids include the glycerine solution, sodium alginate solution and the medical embolization material. The performance of the monodispersed droplet generation system was first characterized by glycerine solutions. Sodium alginate solution was then used to form the micro-capsule. Finally, the generation of the medical embolization microsphere was performed. Results shows that the droplet mean diameter decreased with increasing excitation frequency. Furthermore, the droplet size increased as the feeding rate of the working fluid was increased. Hence the particle size can be reduced by increasing the excitation frequency and reducing the feeding rate. Result also shows that the effect of viscosity of the fluid on particle size is not significant for viscosity ranging from 16.43 cP to 65.05 cP was not. Dimensional analysis indicates that the ratio of droplet diameter and orifice diameter is a function of Strouhal number and orifice length to diameter ratio. It can be expressed by an empirical formula. It turn out that the particle diameter of the glycerine solution was 2.0~3.5 times of the orifice size. After dimensionless parameter analysis, an empirical formula was derived. In a test of sodium alginate solution with viscosity 61.58 cP, the droplet diameter was about 3 times of the orifice diameter. On the other hand, a test of medical embolization material with viscosity 66.12 cP, the particle size of the medical embolization microsphere was 3.06 times of the orifice diameter. It is concluded that particle size of the monodispersed sphere can be controlled by Strouhal number, the orifice length to diameter ratio and viscosity of the working fluids.

目錄 I
表目錄 IV
圖目錄 V
第一章 緒論 1
1-1 簡介 1
1-2 文獻回顧 3
1-2-1 液體碎化過程 3
1-2-2 連續式單液滴產生機制 4
1-2-3 工作流體與流變性 7
1-2-4 微膠囊之製備 8
1-2-4-1 微膠囊壁材芯材配方與硬化溶液 9
1-2-5 肝動脈腫瘤栓塞術 10
1-3 研究動機與目的 11
第二章 實驗設備與量測儀器 12
2-1 實驗設備 12
2-1-1 單粒徑液滴影像觀測與擷取 12
2-1-2 外部激擾裝置 12
2-1-3 液體供應裝置 13
2-1-4 栓塞劑藥物加熱裝置 13
2-1-5 壓力式微管霧化器 13
2-1-6 影像處理與粒徑分析 14
2-2 實驗儀器 14
2-2-1 黏度測試儀 14
2-2-2 電磁加熱攪拌器 15
2-2-3 電子天秤 15
2-2-4 粉末觀測儀器 15
第三章 實驗步驟與方法 16
3-1 實驗量測條件 16
3-2 微管流受外部激發之視流觀察 16
3-3 數據之取樣與分析 17
3-4 參數因次分析 17
3-4-1 白金漢π定理 17
3-4-2 無因次參數 18
第四章 結果與討論 20
4-1 單液滴甘油實驗 20
4-1-1 外部激擾頻率對單液滴形成之效應 20
4-1-2 外部激擾頻率對單粒徑甘油液滴平均粒徑之影響 22
4-1-3黏滯係數對單粒徑甘油液滴平均粒徑之影響 25
4-1-4 單液滴甘油實驗之無因參數次分析 26
4-1-4-1 史卓荷數對液滴粒徑與孔徑比之影響 26
4-1-4-2 雷諾數對液滴粒徑與孔徑比之影響 28
4-1-4-3 無因次曲線迴歸分析 28
4-2 單粒徑微膠囊造粒實驗 30
4-2-1 外部激擾頻率對微膠囊平均粒度之影響 30
4-2-2 單粒褐藻膠液滴無因次分析 32
4-2 栓塞劑微球造粒實驗 33
第五章 結論與未來工作 35
5-1 結論 35
5-2 未來工作 36
參考文獻 37
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