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論文名稱(外文):Measuring the Optical Properties of Superficial Turbid Sample Using the Steady State Frequency Domain Photon Migration System
指導教授(外文):Sheng-Hao Tseng
外文關鍵詞:Physiological ParametersAbsorption CoefficientReduced Scattering CoefficientOptical Properties
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In this thesis, we demonstrate the use of optical method, steady state frequency domain photon migration system (SSFDPM), to determine physiological parameters of biological tissues. It uses near-infrared light (from 600 to 1100 nm) coupled with mathematical photon transport models to accurately determine optical absorption (µa) and reduced scattering (µs′) properties of tissues. Absorption coefficient (µa) and reduced scattering coefficient (µs′) can be used to determine the chromophore concentrations, such as oxygenated hemoglobin, deoxygenated hemoglobin, water, and lipid, of biological tissues. Here, we employed the diffusing probe with the SSFDPM technique to quantify the optical properties of in-vivo skin. First, we characterize the stability of the amplitude and phase of the frequency domain photon migration system (FDPM) so that we can understand the limitations of our system. Second, we prepare four samples of different absorption to study the system linearity. Third, we use FDPM system to measure six liquid phantoms of various absorption and scattering properties. Finally, we combine the steady state (SS) and FDPM which is called SSFDPM to measure the liquid phantom, and quantify the chromophore concentrations of liquid phantoms. In addition, we carry out SSFDPM measurements on the in-vivo dorsal forearm and show the quantitative physiological concentration and compare with SS measurements. Our study reveals that the SSFDPM system provides a fast and noninvasive way for tissue composition quantification.
Abstract (in Chinese) I
Abstract (in English) II
Acknowledgements III
Table of Content IV
List of Tables VI
List of Figures VII
List of Symbols X
Chapter 1 Introduction 1
1.1 Motivation 1
1.2 Background 3
1.3 Objective of This Study 6
Chapter 2 Theoretical Background 8
2.1 Beer-Lambert Law 9
2.2 Radiative Transfer Equation 12
2.3 Diffusion Theory 16
2.4 Boundary Conditions 19
2.5 Two-Layered Diffusion Model 23
Chapter 3 Materials and Methods 27
3.1 Steady State Frequency Domain Photon Migration System 28
3.2 Characterizing the Stability of the Amplitude and Phase of the FDPM System 31
3.3 Modified Two-Layer Geometry 33
3.4 Liquid Phantom 34
3.5 Optical Property Determination 38
Chapter 4 Results and Discussion 41
4.1 Stability and Instrument Response of FDPM System 41
4.1.1 Stability of FDPM System 41
4.1.2 Instrument Response of FDPM System 48
4.2 Liquid Phantom Measurements by FDPM System 51
4.3 Liquid Phantom Measurements by SSFDPM System 56
4.4 Chromophore Fitting by SSFDPM System 60
4.5 Skin Measurements by SSFDPM System 62
Chapter 5 Conclusion and Future Work 68
5.1 Conclusion 68
5.2 Future Work 70
References 71
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