跳到主要內容

臺灣博碩士論文加值系統

(3.235.60.144) 您好!臺灣時間:2021/07/27 00:14
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

我願授權國圖
: 
twitterline
研究生:巫佩容
研究生(外文):Pei-JungWu
論文名稱:探討人格特質在重鬱症與雙極症之分佈與家庭聚集性
論文名稱(外文):The profile and familiality of personality traits in mood disorder families
指導教授:陸汝斌陸汝斌引用關係
指導教授(外文):Ru-Band Lu
學位類別:碩士
校院名稱:國立成功大學
系所名稱:行為醫學研究所
學門:社會及行為科學學門
學類:心理學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:英文
論文頁數:23
中文關鍵詞:人格特質重鬱症雙極症家庭聚集性
外文關鍵詞:personality traitsmajor depressive disorderbipolar I/II disorderfamilial aggregation
相關次數:
  • 被引用被引用:0
  • 點閱點閱:211
  • 評分評分:
  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:1
研究背景
過去的家庭研究證實情感性疾患如重鬱症與雙極症具有家庭聚集性,並且曾有國外學者試圖從病患的人格特質來暸解重鬱症或雙極症的嚴重程度。國內目前對人格特質在重鬱症與雙極症之家庭聚集性的了解仍為貧乏。

研究目的
探討人格特質在家庭中的分佈與聚集的狀況,並且評估人格特質是否為預測重鬱症與雙極症的家庭聚集性之指標。

研究方法
為家庭研究設計。分別從台灣區域醫院與診所收取指標個案(包括重鬱症病患、第一型雙極症病患與第二型雙極症病患)及其家屬,並於社區樣本中收取一般控制組。病患的疾病診斷除了依據醫生的臨床診斷,還會對照國際診斷會談(CIDI),合併訪談內容做最佳的診斷。人格變項使用自填式中文艾森克人格問卷修訂簡短版與三向度人格量表的中文修訂版。人格特質在重鬱症與雙極症之家庭聚集性是以混合模式(mixed model),以及組內相關係數(ICC)進行評估。

研究結果
相較於一般控制組,患有情感性疾患的病患,在外向性量表得分較低,在神經質、逃避傷害以及追求新奇性等量表得分較高。未患病之家屬在四個人格特質的得分與一般控制組的差異性不大。第一型雙極症病患比重鬱症病患有較高的外向性、追求新奇性以及較低的神經質、逃避傷害(p〈0.01)。神經質量表分數可以區分第一型雙極症與第二型雙極症病患(p=0.02),第一型雙極症在神經質量表得分較低。外向性(ICC=0.184~0.239)及逃避傷害(ICC=0.355)人格特質在雙極症家庭呈中度家庭聚集性。

研究限制
人格特質的評量係採用橫斷研究法,並未以量化方式控制情緒症狀的嚴重度。

結論
不同人格特質的組合,可以區分患病與未患病個體,以及區辨情感性疾患的診斷,說明人格特質的評量可以更廣泛地應用於臨床實務工作。透過外向性與逃避傷害等人格特質聚集在雙極症家庭的發現,提供未來研究方向─探討雙極症合併行為問題之關連性。

關鍵字:人格特質、重鬱症、雙極症、家庭聚集性。

Objective: Personality traits have impacts on individuals’ response to stress and mood expression. The current study aimed to investigate the profile of personality traits in patients with bipolar disorders and major depressive disorder (MDD). Familial aggregation of personality traits in mood disorder families was also evaluated.

Methods: We recruited 260 clinical patients of MDD (92), bipolar disorder-I and II (BP-I=111, BP-II=57), 190 biological first-degree relatives, and 180 controls. Four personality traits were assessed using the Eysenck and Tridimensional Personality Questionnaires, including Extraversion (E), Neuroticism (N), Harm Avoidance (HA), and Novelty Seeking (NS). The magnitude of familiality of personality traits in mood disorder families was evaluated by mixed models and intra-class correlation coefficients (ICC).

Results: Patients with mood disorders had lower E, and higher N, HA and NS than controls. Unaffected relatives were not differed from controls in the four personality traits. BP-I had higher E, NS and lower N, HA than MDD patients (p〈0.01). The scale N further distinguished BP-I from BP-II (p=0.02) with lower N among BP-I patients. There exhibited moderate familiality in E (ICC=0.184~0.239) and HA (ICC=0.355) in bipolar disorder families.

Limitation: Personality traits were accessed cross-sectionally without quantitatively controlled severity of mood symptoms.

Conclusion: Different patterns of personality traits distinguish patients from unaffected individuals as well as separate diagnoses of mood disorders, indicating the usage of more comprehensive evaluation of personality traits in clinical settings. Familiality of extraversion and harm avoidance in bipolar disorder families provides insights for further investigating correlates of comorbid behavioral problems in bipolar disorders.

Key words: personality traits, major depressive disorder, bipolar I/II disorder, familial aggregation.

Publication: Wu, P.J., Chang, S.M., Lu, M.K., Chen, W.J., Yang, Y.K., Yeh, T.L., Liao, S.C., Lu, R.B., Kuo, P.H., 2012. The profile and familiality of personality traits in mood disorder families. J Affect Disord 138, 367-374.
Abstract in Mandarin ……………………………………………………………………………… I
Abstract ……………………………………………………………………………………………………………… II
Acknowledgement …………………………………………………………………………………………… III
Contents ……………………………………………………………………………………………………………… IV
List of Table ………………………………………………………………………………………………… V
1.Introduction ……………………………………………………………………………………………… 1
2.Methods …………………………………………………………………………………………………………… 4
2.1 Subjects ……………………………………………………………………………………………… 4
2.2 Assessments and Procedures ……………………………………………… 4
2.3 Statistical Analysis ……………………………………………………………… 6
3. Results ………………………………………………………………………………………………………… 7
3.1 Sample Characteristics and Profile of Personality Traits …………………………………………………………………………………………………………………… 7
3.2 Familial Aggregation of Personality Traits …… 8
4. Discussion ………………………………………………………………………………………………… 9
Role of Funding Resource ………………………………………………………………… 14
References ………………………………………………………………………………………………………… 15

Akaike, H., 1987. Factor-Analysis and Aic. Psychometrika 52, 317-332.

Akiskal, H.S., Kilzieh, N., Maser, J.D., Clayton, P.J., Schettler, P.J., Traci Shea, M., Endicott, J., Scheftner, W., Hirschfeld, R.M., Keller, M.B., 2006. The distinct temperament profiles of bipolar I, bipolar II and unipolar patients. J Affect Disord 92, 19-33.

Akiskal, H.S., Maser, J.D., Zeller, P.J., Endicott, J., Coryell, W., Keller, M., Warshaw, M., Clayton, P., Goodwin, F., 1995. Switching from 'unipolar' to bipolar II. An 11-year prospective study of clinical and temperamental predictors in 559 patients. Arch Gen Psychiatry 52, 114-123.

APA, 1994. Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association, Washington, DC.

Blazer, D.G., Kessler, R.C., Mcgonagle, K.A., Swartz, M.S., 1994. The Prevalence and Distribution of Major Depression in a National Community Sample - the National Comorbidity Survey. Am J Psychiat 151, 979-986.

Boyce, P., Parker, G., Barnett, B., Cooney, M., Smith, F., 1991. Personality as a vulnerability factor to depression. Br J Psychiatry 159, 106-114.

Celikel, F.C., Kose, S., Cumurcu, B.E., Erkorkmaz, U., Sayar, K., Borckardt, J.J., Cloninger, C.R., 2009. Cloninger's temperament and character dimensions of personality in patients with major depressive disorder. Compr Psychiatry 50, 556-561.

Chen, W.J., Chen, H.M., Chen, C.C., Yu, W.Y., Cheng, A.T., 2002. Cloninger's Tridimensional Personality Questionnaire: psychometric properties and construct validity in Taiwanese adults. Compr Psychiatry 43, 158-166.

Chen, Y.C., Lu, M.K., Young, Y.K., Liao, S.C., Chen, W.J., Lu, R.B., Kuo, P.H., Submitted. Parental psychopathology and poor family relationship predict risk of diagnosis and early onset of bipolar disorders.

Cloninger, C.R., 1987. A Systematic Method for Clinical Description and Classification of Personality Variants - a Proposal. Arch Gen Psychiat 44, 573-588.

Cloninger, C.R., Przybeck, T.R., Svrakic, D.M., 1991. The Tridimensional Personality Questionnaire: U.S. normative data. . Psychol Rep 69, 1047-1057.

Cloninger, C.R., Przybeck, T.R., Svrakic, D.M., Wetzel, R.D., 1994. The temperament and character inventory (TCI): A guide to its development and use. . Washington University Center for Psychobiology of Personality., St. Louis.

Conrad, R., Walz, F., Geiser, F., Imbierowicz, K., Liedtke, R., Wegener, I., 2009. Temperament and character personality profile in relation to suicidal ideation and suicide attempts in major depressed patients. Psychiatry Res 170, 212-217.

Corruble, E., Duret, C., Pelissolo, A., Falissard, B., Guelfi, J.D., 2002. Early and delayed personality changes associated with depression recovery? A one-year follow-up study. Psychiatry Res 109, 17-25.

Duggan, C., Sham, P., Lee, A., Minne, C., Murray, R., 1995. Neuroticism: a vulnerability marker for depression evidence from a family study. J Affect Disord 35, 139-143.

Duggan, C.F., Lee, A.S., Murray, R.M., 1990. Does personality predict long-term outcome in depression? Br J Psychiatry 157, 19-24.

Dunner, D.L., 2003. Clinical consequences of under-recognized bipolar spectrum disorder. Bipolar Disord 5, 456-463.

Eaves, L., Heath, A., Martin, N., Maes, H., Neale, M., Kendler, K., Kirk, K., Corey, L., 1999. Comparing the biological and cultural inheritance of personality and social attitudes in the Virginia 30,000 study of twins and their relatives. Twin Res 2, 62-80.

Eysenck, H.J., 1991. Dimensions of Personality - 16, 5 or 3 - Criteria for a Taxonomic Paradigm. Pers Indiv Differ 12, 773-790.

Eysenck, H.J., Eysenck, S.B., 1994. Manual of the Eysenck Personality Questionnaire: Comprising the EPQ-Revised (EPQ) and EPQ-R Short Scale. EDITS, San Diego, CA.

Eysenck, H.J., Eysenck, S.B.G., 1992. The Eysenck Personality Questionnaire-Revised. . Hodder & Stoughton., Sevenoaks, UK.

Eysenck, S.B.G., Eysenck, H.J., Barrett, P., 1985. A Revised Version of the Psychoticism Scale. Pers Indiv Differ 6, 21-29.

Farmer, A., Redman, K., Harris, T., Mahmood, A., Sadler, S., Pickering, A., McGuffin, P., 2002. Neuroticism, extraversion, life events and depression. The Cardiff Depression Study. Br J Psychiatry 181, 118-122.

Gerra, G., Bertacca, S., Zaimovic, A., Pirani, M., Branchi, B., Ferri, M., 2008. Relationship of personality traits and drug of choice by cocaine addicts and heroin addicts. Subst Use Misuse 43, 317-330.

Ghaemi, S.N., Boiman, E.E., Goodwin, F.K., 2000. Diagnosing bipolar disorder and the effect of antidepressants: a naturalistic study. J Clin Psychiatry 61, 804-808; quiz 809.

Ghaemi, S.N., Ko, J.Y., Goodwin, F.K., 2001. The bipolar spectrum and the antidepressant view of the world. J Psychiatr Pract 7, 287-297.

Gillespie, N.A., Cloninger, C.R., Heath, A.C., Martin, N.G., 2003. The genetic and environmental relationship between Cloninger's dimensions of temperament and character. Pers Indiv Differ 35, 1931-1946.

Gillespie, N.A., Zhu, G., Evans, D.M., Medland, S.E., Wright, M.J., Martin, N.G., 2008. A genome-wide scan for Eysenckian personality dimensions in adolescent twin sibships: psychoticism, extraversion, neuroticism, and lie. J Pers 76, 1415-1446.

Hettema, J.M., Neale, M.C., Myers, J.M., Prescott, C.A., Kendler, K.S., 2006. A population-based twin study of the relationship between neuroticism and internalizing disorders. Am J Psychiatry 163, 857-864.

Heym, N., Lawrence, C., 2008. The role of personality in blame attribution and perceived emotions for hypothetical incidences of victimisation. Int J Psychol 43, 586-586.

Janowsky, D.S., Morter, S., Hong, L., Howe, L., 1999. Myers Briggs Type Indicator and Tridimensional Personality Questionnaire differences between bipolar patients and unipolar depressed patients. Bipolar Disord 1, 98-108.

Joffee, R., Bagby, M., Levitt, A., Regan, J., Parker, J., 1993. The TPQ in major depression. Am J Psychiat, 959-960.

Jylha, P., Melartin, T., Isometsa, E., 2009. Relationships of neuroticism and extraversion with axis I and II comorbidity among patients with DSM-IV major depressive disorder. J Affect Disorders 114, 110-121.

Kamat, S.A., Rajagopalan, K., Pethick, N., Willey, V., Bullano, M., Hassan, M., 2008. Prevalence and humanistic impact of potential misdiagnosis of bipolar disorder among patients with major depressive disorder in a commercially insured population. J Manage Care Pharm 14, 632-642.

Kassem, L., Lopez, V., Hedeker, D., Steele, J., Zandi, P., McMahon, F.J., 2006. Familiality of polarity at illness onset in bipolar affective disorder. Am J Psychiatry 163, 1754-1759.

Katon, W., 2009. The impact of depression on workplace functioning and disability costs. Am J Manag Care 15, S322-327.

Katon, W.J., Lin, E., Russo, J., Unutzer, J., 2003. Increased medical costs of a population-based sample of depressed elderly patients. Arch Gen Psychiatry 60, 897-903.

Keller, M.C., Coventry, W.L., Heath, A.C., Martin, N.G., 2005. Widespread evidence for non-additive genetic variation in Cloninger's and Eysenck's personality dimensions using a twin plus sibling design. Behav Genet 35, 707-721.

Kendler, K.S., Neale, M.C., Sullivan, P., Corey, L.A., Gardner, C.O., Prescott, C.A., 1999. A population-based twin study in women of smoking initiation and nicotine dependence. Psychol Med 29, 299-308.

Kessler, R.C., Akiskal, H.S., Ames, M., Birnbaum, H., Greenberg, P., Hirschfeld, R.M.A., Jin, R., Merikangas, K.R., Simon, G.E., Wang, P.S., 2006. Prevalence and effects of mood disorders on work performance in a nationally representative sample of U.S. workers. Am J Psychiat 163, 1561-1568.

Kessler, R.C., Ustun, T.B., 2004. The World Mental Health (WMH) Survey Initiative Version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI). Int J Methods Psychiatr Res 13, 93-121.

Kuo, P.H., Yang, H.J., Soong, W.T., Chen, W.J., 2002. Substance use among adolescents in Taiwan: associated personality traits, incompetence, and behavioral/emotional problems. Drug Alcohol Depend 67, 27-39.

Lai, Y.C., Lu, M.K., Yang, Y.K., Lin, J.J., Tan, H.P., Chen, W.J., Lu, R.B., Kuo, P.H., 2010. Clinical features and familial aggregation of social relationships in major depressive and bipolar disorders in Southern Taiwan. Taiwan Journal of Public Health 29, 169-182.

Lake, R.I., Eaves, L.J., Maes, H.H., Heath, A.C., Martin, N.G., 2000. Further evidence aganist the environmental transmission of individiual differences in neuroticism from a collaborative study of 45,850 twins and relatives on two continents. Behav Genet. 30, 223-233.

MacKinnon, D.F., Zandi, P.P., Gershon, E., Nurnberger, J.I., Reich, T., DePaulo, J.R., 2003. Rapid switching of mood in families with multiple cases of bipolar disorder. Arch Gen Psychiat 60, 921-928.

McCrae, R.R., Costa, P.T., Jr., 1989. The structure of interpersonal traits: Wiggins's circumplex and the five-factor model. J Pers Soc Psychol 56, 586-595.

Merikangas, K.R., Akiskal, H.S., Angst, J., Greenberg, P.E., Hirschfeld, R.M.A., Petukhova, M., Kessler, R.C., 2007. Lifetime and 12-month prevalence of bipolar spectrum disorder in the national comorbidity survey replication. Arch Gen Psychiat 64, 543-552.

Miller, J.D., Lynam, D., 2001. Structural models of personality and their relation to antisocial behavior: A meta-analytic review. Criminology 39, 765-798.

Mulder, R.T., 2002. Personality pathology and treatment outcome in major depression: a review. Am J Psychiatry 159, 359-371.

Mulder, R.T., Joyce, P.R., 1994. Relationships of the Tridimensional Personality Questionnaire to mood and personality measures for depressed patients. Psychol Rep 75, 1315-1325.

Newbury-Birch, D., White, M., Kamali, F., 2000. Factors influencing alcohol and illicit drug use amongst medical students. Drug Alcohol Depen 59, 125-130.

Osher, Y., Cloninger, C.R., Belmaker, R.H., 1996. TPQ in euthymic manic-depressive patients. J Psychiat Res 30, 353-357.

Osher, Y., Lefkifker, E., Kotler, M., 1999. Low persistence in euthymic manic-depressive patients: a replication. J Affect Disorders 53, 87-90.

Ouimette, P.C., Klein, D.N., Pepper, C.M., 1996. Personality traits in the first degree relatives of outpatients with depressive disorders. J Affect Disord 39, 43-53.

Potash, J.B., Chiu, Y.F., MacKinnon, D.F., Miller, E.B., Simpson, S.G., McMahon, F.J., McInnis, M.G., DePaulo, J.R., Jr., 2003. Familial aggregation of psychotic symptoms in a replication set of 69 bipolar disorder pedigrees. Am J Med Genet B Neuropsychiatr Genet 116B, 90-97.

Potash, J.B., Kane, H.S., Chiu, Y.F., Simpson, S.G., MacKinnon, D.F., McInnis, M.G., McMahon, F.J., DePaulo, J.R., 2000. Attempted suicide and alcoholism in bipolar disorder: Clinical and familial relationships. Am J Psychiat 157, 2048-2050.

Quilty, L.C., Sellbom, M., Tackett, J.L., Bagby, R.M., 2009. Personality trait predictors of bipolar disorder symptoms. Psychiatry Res 169, 159-163.

Reddy, Y.C.J., Raman, R.P.B., Sheshadri, S.P., Girimaji, S.C., Srinath, S., Raghunandan, V.N.G.P., 2007. Is bipolar II disorder misdiagnosed as major depressive disorder in children? J Affect Disorders 98, 263-266.

Rosa, A.R., Reinares, M., Franco, C., Comes, M., Torrent, C., Sanchez-Moreno, J., Martinez-Aran, A., Salamero, M., Kapczinski, F., Vieta, E., 2009. Clinical predictors of functional outcome of bipolar patients in remission. Bipolar Disord 11, 401-409.

Sariusz-Skapska, M., Czabala, C., Dudek, D., Zieba, A., Rduch, S., 2003. [Personality traits in patients with unipolar and bipolar disorder]. Psychiatr Pol 37, 225-233.

Sato, T., Narita, T., Hirano, S., Kusunoki, K., Goto, M., Sakado, K., Uehara, T., 2001. Factor validity of the temperament and character inventory in patients with major depression. Compr Psychiatry 42, 337-341.

Shin, Y.C., Lim, S.W., Choi, S.W., Kim, S.W., Grant, J.E., 2009. Comparison of Temperament and Character Between Early- and Late-Onset Korean Male Pathological Gamblers. J Gambl Stud.

Smillie, L.D., Bhairo, Y., Gray, J., Gunasinghe, C., Elkin, A., McGuffin, P., Farmer, A., 2009. Personality and the bipolar spectrum: normative and classification data for the Eysenck Personality Questionnaire-Revised. Compr Psychiatry 50, 48-53.

Smith, D.J., Griffiths, E., Kelly, M., Hood, K., Craddock, N., Simpson, S.A., 2011. Unrecognised bipolar disorder in primary care patients with depression. Br J Psychiatry.

Smoller, J.W., Finn, C.T., 2003. Family, twin, and adoption studies of bipolar disorder. Am J Med Genet C Semin Med Genet 123C, 48-58.

Stein, M.B., Chartier, M.J., Lizak, M.V., Jang, K.L., 2001. Familial aggregation of anxiety-related quantitative traits in generalized social phobia: clues to understanding disorder heritability? Am J Med Genet 105, 79-83.

Strelau, J., 1987. Emotion as a Key Concept in Temperament Research. J Res Pers 21, 510-528.

Teh, L.K., Izzuddin, A.F., Fazleen Haslinda, M.H., Zakaria, Z.A., Salleh, M.Z., 2011. Tridimensional Personalities and Polymorphism of Dopamine D2 Receptor Among Heroin Addicts. Biol Res Nurs.

Tikkanen, R., Holi, M., Lindberg, N., Virkkunen, M., 2007. Tridimensional Personality Questionnaire data on alcoholic violent offenders: specific connections to severe impulsive cluster B personality disorders and violent criminality. BMC Psychiatry 7, 36.

Wittchen, H.U., Robins, L.N., Cottler, L.B., Sartorius, N., Burke, J.D., Regier, D., 1991. Cross-cultural feasibility, reliability and sources of variance of the Composite International Diagnostic Interview (CIDI). The Multicentre WHO/ADAMHA Field Trials. Br J Psychiatry 159, 645-653, 658.

Wray, N.R., Birley, A.J., Sullivan, P.F., Visscher, P.M., Martin, N.G., 2007. Genetic and phenotypic stability of measures of neuroticism over 22 years. Twin Res Hum Genet 10, 695-702.

Young, L.T., Bagby, R.M., Cooke, R.G., Parker, J.D., Levitt, A.J., Joffe, R.T., 1995. A comparison of Tridimensional Personality Questionnaire dimensions in bipolar disorder and unipolar depression. Psychiatry Res 58, 139-143.

連結至畢業學校之論文網頁點我開啟連結
註: 此連結為研究生畢業學校所提供,不一定有電子全文可供下載,若連結有誤,請點選上方之〝勘誤回報〞功能,我們會盡快修正,謝謝!
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top