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研究生:康孝先
研究生(外文):Kang, Hsiaohsien
論文名稱:以小動物正子斷層造影探討因噪音性聽損
論文名稱(外文):Investigating The Effects Of Noise-Induced Hearing Loss On Serotonin Transporters In Rat Brain Using 4-[18F]-ADAM/Small Animal PET
指導教授:馬國興馬國興引用關係
指導教授(外文):Ma, Kuohsing
口試委員:劉江川李立仁王智弘鄭澄意馬國興
口試委員(外文):Liu, JiangchuanLee, LijenWang, ChihhungCheng, ChengyiMa, Kuohsing
口試日期:2012-07-23
學位類別:博士
校院名稱:國防醫學院
系所名稱:醫學科學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:中文
論文頁數:41
中文關鍵詞:血清素轉運體噪音性聽損正子斷層造影
外文關鍵詞:SERTNoise Induced Hearing LossPET18F-ADAM
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目前的研究顯示,血清素轉運體是用來評估血清素神經元狀態的一個重要指標。血清素轉運體最主要的功能就是調節突觸間血清素的濃度。而最近的研究更指出,血清素轉運體在中樞的聽覺路徑中也有表現並且可能在聽覺形成的過程中扮演了一個相當重要的角色。然而目前關於噪音對腦部血清素系統可能造成的作用仍所知甚少。在本實驗中我們利用了4-[18F]-ADAM (一種對血清素轉運體具有高度專一性的造影藥物)以及小型動物專用的正子斷層造影技術,來探討經由噪音引起的聽力損害模式下,大鼠腦中血清素轉運體變化的情形。本實驗我們使用雄性SD大鼠暴露在8 kHz,118dB強度的噪音中3.5小時,之後在不同的時間點分別進行聽覺腦幹反應測試及正子斷層造影。正子斷層造影影像處理後之 4-[18F]-ADAM 專一性攝取率分別於七個不同的腦區圈選計算。另外在暴露噪音後第30天將動物犧牲取腦及耳蝸分別進行免疫組織化學染色及毛細胞染色。我們的研究結果清楚的顯示在暴露噪音之後,大鼠的聽力閾值有顯著升高的情形,另外耳蝸外毛細胞也有明顯的減少。在正子斷層造影實驗中,我們發現在噪音暴露隔天,聽損組大鼠各腦區的血清素轉運體之專一性攝取率與控制組相比明顯的降低了35%–56%。這樣的減少情形在噪音暴露後第8天及第15天依然持續著,在第29天時各腦區的專一性攝取率與控制組相比仍有約26%–48%的減少。另外在免疫化學組織染色的實驗結果中,血清素轉運體在各腦區減少的情形與趨勢也與正子斷層造影的結果類似。以上這些實驗結果顯示因噪音引起的聽力損失會導致大鼠各個腦區中的血清素轉運體產生降低的情形,而這樣的血清素轉運體變化的狀態,可以利用4-[18F]-ADAM以及活體正子斷層造影技術來進行偵測。
The serotonin transporter (SERT) is an important marker of the status of serotonergic neurons. The main function of SERT is to regulate the serotonin concentration in the synapse. Recent studies have shown that SERT is expressed in the central auditory pathway and may play a role in the auditory process. However, little is known about the effects of noise on the cerebral serotonin system. In this study, we explored the status of brain SERT in a rat model of noise-induced hearing loss using 4-[18F]-ADAM (a SERT imaging agent) and small animal positron emission tomography (PET) imaging. Male Sprague Dawley rats were exposed to an 8 kHz noise at 118 dB sound pressure level for 3.5 h. An auditory brainstem response test and 4-[18F]-ADAM/small animal PET were performed at different time points after noise exposure. The specific uptake ratios (SURs) for 4-[18F]-ADAM were calculated from the PET imaging data in seven brain regions. Immunohistochemistry and surface preparation of the cochleae were performed 30 days after noise exposure. Our data clearly show that the hearing and cochlear outer hair cells of the rats were lost after noise exposure. In the PET study, the SURs of SERT were markedly reduced by 35%–56% in various brain regions one day after noise exposure. The decrement remained on days 8 and 15 and was approximately 26%–48% on day 29. The distribution and intensity of SERT immunostaining in the brain paralleled the PET imaging data. These results suggest that noise-induced hearing loss involves a reduction in SERT expression in various regions of the rat brain and that changes in SERT are detectable by 4-[18F]-ADAM/small animal PET in vivo.
正文目錄----------------------------------------------------------------------------------Ⅰ
表目錄-------------------------------------------------------------------------------------Ⅲ
圖目錄-------------------------------------------------------------------------------------Ⅵ
中文摘要----------------------------------------------------------------------------------V
英文摘要---------------------------------------------------------------------------------VII
第一章、緒言----------------------------------------------------------------------------1
第二章、目的----------------------------------------------------------------------------4
第三章、材料與方法-------------------------------------------------------------------5
第一節、動物模式---------------------------------------------------------------------5
第二節、噪音暴露與聽力閾值------------------------------------------------------5
第三節、耳蝸毛細胞染色------------------------------------------------------------6
第四節、放射藥物製備---------------------------------------------------------------7
第五節、影像資料擷取與分析------------------------------------------------------7
第六節、免疫組織化學染色法及組織切片之光學定量-----------------------8
第七節、統計分析--------------------------------------------------------------------10
第四章、結果---------------------------------------------------------------------------11
第一節、噪音暴露對聽力閾值及耳蝸毛細胞存活情形之影響----------------11
第二節、正子斷層造影影像及4-[18F]-ADAM之專一性攝取率-----------11
第三節、免疫組織化學染色及組織切片光學定量結果-----------------------12
第五章、討論----------------------------------------------------------------------------22
第六章、結論----------------------------------------------------------------------------30
第七章、參考文獻----------------------------------------------------------------------31

Abi-Hachem, R.N., Zine, A., Van De Water, T.R., 2010. The injured cochlea as a target for inflammatory processes, initiation of cell death pathways and application of related otoprotectives strategies. Recent Pat CNS Drug Discov 5, 147-163.
Acton, P.D., Choi, S.R., Hou, C., Plössl, K., Kung, H.F., 2001. Quantification of serotonin transporters in nonhuman primates using [123I]ADAM and SPECT. J Nucl Med 42, 1556-1562.
Andersson, G., McKenna, L., 1998. Tinnitus masking and depression. Audiology 37, 174-182.
Ask, H., Krog, N.H., Tambs, K., 2010. Impact of hearing impairment on spousal mental health: the Nord-Trondelag Health Study. Eur J Public Health 20, 271-275.
Belli, S., Belli, H., Bahcebasi, T., Ozcetin, A., Alpay, E., Ertem, U., 2008. Assessment of psychopathological aspects and psychiatric comorbidities in patients affected by tinnitus. Eur Arch Otorhinolaryngol 265, 279-285.
Bengel, D., Johren, O., Andrews, A.M., Heils, A., Mossner, R., Sanvitto, G.L., Saavedra, J.M., Lesch, K.P., Murphy, D.L., 1997. Cellular localization and expression of the serotonin transporter in mouse brain. Brain Res 778, 338-345.
Bernabei, V., Morini, V., Moretti, F., Marchiori, A., Ferrari, B., Dalmonte, E., De Ronchi, D., Rita Atti, A., 2011. Vision and hearing impairments are associated with depressive-anxiety syndrome in Italian elderly. Aging Ment Health 15, 467-474.
Bonny, C., Borsello, T., Zine, A., 2005. Targeting the JNK pathway as a therapeutic protective strategy for nervous system diseases. Rev Neurosci 16, 57-67.
Booij, J., de Win, M.M., 2006. Brain kinetics of the new selective serotonin transporter tracer [123I]ADAM in healthy young adults. Nucl Med Biol 33, 185-191.
Brust, P., Hinz, R., Kuwabara, H., Hesse, S., Zessin, J., Pawelke, B., Stephan, H., Bergmann, R., Steinbach, J., Sabri, O., 2003. In vivo measurement of the serotonin transporter with (S)-([18F]fluoromethyl)-(+)-McN5652. Neuropsychopharmacology 28, 2010-2019.
Chen, Y.A., Huang, W.S., Lin, Y.S., Cheng, C.Y., Liu, R.S., Wang, S.J., Li, I.H., Huang, S.Y., Shiue, C.Y., Chen, C.Y., Ma, K.H., 2012. Characterization of 4-[18F]-ADAM as an imaging agent for SERT in non-human primate brain using PET: a dynamic study. Nucl Med Biol 39, 279-285.
Cheng, A.G., Cunningham, L.L., Rubel, E.W., 2005. Mechanisms of hair cell death and protection. Curr Opin Otolaryngol Head Neck Surg 13, 343-348.
Chew, H.S., Yeak, S., 2010. Quality of life in patients with untreated age-related
hearing loss. J Laryngol Otol 124, 835-841.
Chou, Y.H., Wang, S.J., Lin, C.L., Mao, W.C., Lee, S.M., Liao, M.H., 2010. Decreased brain serotonin transporter binding in the euthymic state of bipolar I but not bipolar II disorder: a SPECT study. Bipolar Disord 12, 312-318.
Clark, M.S., McDevitt, R.A., Hoplight, B.J., Neumaier, J.F., 2007. Chronic low dose ovine corticotropin releasing factor or urocortin II into the rostral dorsal raphe alters exploratory behavior and serotonergic gene expression in specific subregions of the dorsal raphe. Neuroscience 146, 1888-1905.
Cransac, H., Cottet-Emard, J.M., Hellström, S., Peyrin, L., 1998. Specific sound-induced noradrenergic and serotonergic activation in central auditory structures. Hear Res 118, 151-156.
Cruz, O.L., Kasse, C.A., Sanchez, M., Barbosa, F., Barros, F.A., 2004. Serotonin reuptake inhibitors in auditory processing disorders in elderly patients: preliminary results. Laryngoscope 114, 1656-1659.
Dunn, A.J., Berridge, C.W., 1990. Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses? Brain Res Brain Res Rev 15, 71-100.
Frisina, R.D., 2009. Age-related hearing loss: ear and brain mechanisms. Ann N Y Acad Sci 1170, 708-717.
Galiñanes, G.L., Taravini, I.R., Murer, M.G., 2009. Dopamine-dependent periadolescent maturation of corticostriatal functional connectivity in mouse. J Neurosci 29, 2496-2509.
Ginovart, N., Wilson, A.A., Meyer, J.H., Hussey, D., Houle, S., 2003. [11C]-DASB, a tool for in vivo measurement of SSRI-induced occupancy of the serotonin transporter: PET characterization and evaluation in cats. Synapse 47, 123-133.
Glavaski-Joksimovic, A., Virag, T., Chang, Q.A., West, N.C., Mangatu, T.A., McGrogan, M.P., Dugich-Djordjevic, M., Bohn, M.C., 2009. Reversal of dopaminergic degeneration in a parkinsonian rat following micrografting of human bone marrow-derived neural progenitors. Cell Transplant 18, 801-814.
Graham, C.E., Basappa, J., Turcan, S., Vetter, D.E., 2011. The cochlear CRF signaling systems and their mechanisms of action in modulating cochlear sensitivity and protection against trauma. Mol Neurobiol 44, 383-406.
Hartvig, P., Bergström, M., Antoni, G., Långström, B., 2002. Positron emission tomography and brain monoamine neurotransmission - entries for study of drug interactions. Curr Pharm Des 8, 1417-1434.
Hsu, J.W., Wang, S.J., Lin, C.L., Hsieh, W.C., Lirng, J.F., Shen, Y.C., Liao, M.H., Chou, Y.H., 2011. Short term vs. long term test-retest reproducibility of 123I-ADAM for the binding of serotonin transporters in the human brain. Psychiatry Res 194, 224-229.
Hu, B.H., Zheng, X.Y., McFadden, S.L., Kopke, R.D., Henderson, D., 1997. R-phenylisopropyladenosine attenuates noise-induced hearing loss in the chinchilla. Hear Res 113, 198-206.
Huang, Q., Tang, J., 2010. Age-related hearing loss or presbycusis. Eur Arch Otorhinolaryngol 267, 1179-1191.
Huang, Y.Y., Huang, W.S., Chu, T.C., Shiue, C.Y., 2009. An improved synthesis of 4-[18F]-ADAM, a potent serotonin transporter imaging agent. Appl Radiat Isot 67, 1063-1067.
Hwang, L.C., Chang, C.J., Liu, H.H., Kao, H.C., Lee, S.Y., Jan, M.L., Chen, C.C., 2007. Imaging the availability of serotonin transporter in rat brain with 123I-ADAM and small-animal SPECT. Nucl Med Commun 28, 615-621.
Ichise, M., Vines, D.C., Gura, T., Anderson, G.M., Suomi, S.J., Higley, J.D., Innis, R.B., 2006. Effects of early life stress on [11C]DASB positron emission tomography imaging of serotonin transporters in adolescent peer- and mother-reared rhesus monkeys. J Neurosci 26, 4638-4643.
Jarkas, N., McConathy, J., Votaw, J.R., Voll, R.J., Malveaux, E., Camp, V.M., Williams, L., Goodman, R.R., Kilts, C.D., Goodman, M.M., 2005. Synthesis and characterization of EADAM: a selective radioligand for mapping the brain serotonin transporters by positron emission tomography. Nucl Med Biol 32, 75-86.
Joyce, J.N., Woolsey, C., Ryoo, H., Borwege, S., Hagner, D., 2004. Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor. BMC Biol 2, 22.
Kalin NH 1990. Behavioral and endocrine studies of corticotropinreleasing hormone in primates. In Corticotropin-Releasing Factor: Basic and Clinical Studies of a Neuropeptide, pp 275–289. Eds EB De Souza & CB Nemeroff. Boca Raton, FL: CRC Press, Inc.
Kish, S.J., Furukawa, Y., Chang, L.J., Tong, J., Ginovart, N., Wilson, A., Houle, S., Meyer, J.H., 2005. Regional distribution of serotonin transporter protein in postmortem human brain: is the cerebellum a SERT-free brain region? Nucl Med Biol 32, 123-128.
Koob, G.F., Heinrichs, S.C., Pich, E.M., Menzaghi, F., Baldwin, H., Miczek, K., Britton, K.T., 1993. The role of corticotropin-releasing factor in behavioural responses to stress. Ciba Found Symp 172, 277-289; discussion 290-275.
Kotak, V.C., Fujisawa, S., Lee, F.A., Karthikeyan, O., Aoki, C., Sanes, D.H., 2005. Hearing loss raises excitability in the auditory cortex. J Neurosci 25, 3908-3918.
Kotak, V.C., Takesian, A.E., Sanes, D.H., 2008. Hearing loss prevents the maturation of GABAergic transmission in the auditory cortex. Cereb Cortex 18, 2098-2108.
Kvam, M.H., Loeb, M., Tambs, K., 2007. Mental health in deaf adults: symptoms of anxiety and depression among hearing and deaf individuals. J Deaf Stud Deaf Educ 12, 1-7.
Lebrand, C., Gaspar, P., Nicolas, D., Hornung, J.P., 2006. Transitory uptake of serotonin in the developing sensory pathways of the common marmoset. J Comp Neurol 499, 677-689.
Li-Korotky, H.S., 2012. Age-Related Hearing Loss: Quality of Care for Quality of Life. Gerontologist.
Li, I.H., Huang, W.S., Shiue, C.Y., Huang, Y.Y., Liu, R.S., Chyueh, S.C., Hu, S.H., Liao, M.H., Shen, L.H., Liu, J.C., Ma, K.H., 2010. Study on the neuroprotective effect of fluoxetine against MDMA-induced neurotoxicity on the serotonin transporter in rat brain using micro-PET. Neuroimage 49, 1259-1270.
Linthorst, A.C., Flachskamm, C., Hopkins, S.J., Hoadley, M.E., Labeur, M.S., Holsboer, F., Reul, J.M., 1997. Long-term intracerebroventricular infusion of corticotropin-releasing hormone alters neuroendocrine, neurochemical, autonomic, behavioral, and cytokine responses to a systemic inflammatory challenge. J Neurosci 17, 4448-4460.
Ma, K.H., Huang, W.S., Kuo, Y.Y., Peng, C.J., Liou, N.H., Liu, R.S., Hwang, J.J., Liu, J.C., Chen, H.J., Shiue, C.Y., 2009. Validation of 4-[18F]-ADAM as a SERT imaging agent using micro-PET and autoradiography. Neuroimage 45, 687-693.
Madruga, C., Xavier, L.L., Achaval, M., Sanvitto, G.L., Lucion, A.B., 2006. Early handling, but not maternal separation, decreases emotional responses in two paradigms of fear without changes in mesolimbic dopamine. Behav Brain Res 166, 241-246.
Marcusson, J., Ross, S., 1990. Binding of some antidepressants to the 5-hydroxytryptamine transporter in brain and platelets. Psychopharmacology 102, 145-155.
Mausset-Bonnefont, A.L., de Sèze, R., Privat, A., 2003. Immunohistochemistry as a tool for topographical semi-quantification of neurotransmitters in the brain. Brain Res Brain Res Protoc 10, 148-155.
Murphy, D.L., Fox, M.A., Timpano, K.R., Moya, P.R., Ren-Patterson, R., Andrews, A.M., Holmes, A., Lesch, K.-P., Wendland, J.R., 2008. How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Neuropharmacology 55, 932-960.
Nielsen, K., Brask, D., Knudsen, G.M., Aznar, S., 2006. Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin. Synapse 59, 270-276.
Noristani, H.N., Olabarria, M., Verkhratsky, A., Rodríguez, J.J., 2010. Serotonin fibre sprouting and increase in serotonin transporter immunoreactivity in the CA1 area of hippocampus in a triple transgenic mouse model of Alzheimer's disease. Eur J Neurosci 32, 71-79.
Ohinata, Y., Miller, J.M., Schacht, J., 2003. Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea. Brain Res 966, 265-273.
Owens, M.J., Nemeroff, C.B., 1991. Physiology and pharmacology of corticotropin-releasing factor. Pharmacol Rev 43, 425-473.
Papesh, M.A., Hurley, L.M., 2012. Plasticity of serotonergic innervation of the inferior colliculus in mice following acoustic trauma. Hear Res 283, 89-97.
Paxinos, G., Watson, C., 2007. The Rat Brain in Stereotaxic Coordinates, 6th ed. .
Peng, C.J., Huang, Y.Y., Huang, W.S., Shiue, C.Y., 2008. An automated synthesis of N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) for imaging serotonin transporters. Appl Radiat Isot 66, 625-631.
Rao, D., Basura, G.J., Roche, J., Daniels, S., Mancilla, J.G., Manis, P.B., 2010. Hearing loss alters serotonergic modulation of intrinsic excitability in auditory cortex. J Neurophysiol 104, 2693-2703.
Rasul, A., El-Nour, H., Blakely, R.D., Lonne-Rahm, S.B., Forsberg, J., Johansson, B., Theodorsson, E., Nordlind, K., 2011. Effect of chronic mild stress on serotonergic markers in the skin and brain of the NC/Nga atopic-like mouse strain. Arch Dermatol Res 303, 625-633.
Ravindran, R., Rathinasamy, S.D., Samson, J., Senthilvelan, M., 2005. Noise-stress-induced brain neurotransmitter changes and the effect of Ocimum sanctum (Linn) treatment in albino rats. J Pharmacol Sci 98, 354-360.
Remine, M.D., Brown, P.M., 2010. Comparison of the prevalence of mental health problems in deaf and hearing children and adolescents in Australia. Aust N Z J Psychiatry 44, 351-357.
Shiue, G.G., Choi, S.R., Fang, P., Hou, C., Acton, P.D., Cardi, C., Saffer, J.R., Greenberg, J.H., Karp, J.S., Kung, H.F., Shiue, C.Y., 2003a. N,N-dimethyl-2-(2-amino-4-18F-fluorophenylthio)-benzylamine (4-18F-ADAM): an improved PET radioligand for serotonin transporters. J Nucl Med 44, 1890-1897.
Shiue, G.G., Fang, P., Shiue, C.Y., 2003b. Synthesis of N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine as a serotonin transporter imaging agent. Appl Radiat Isot 58, 183-191.
Shoji, F., Miller, A.L., Mitchell, A., Yamasoba, T., Altschuler, R.A., Miller, J.M., 2000. Differential protective effects of neurotrophins in the attenuation of noise-induced hair cell loss. Hear Res 146, 134-142.
Sinanović O., Brkić F., Salihović N., Junuzović L., Mrkonjić Z., 2004. [Anxiety and depression in deaf and hard-of-hearing adults]. Med Arh 58, 87-90.
Sur, C., Betz, H., Schloss, P., 1996. Immunocytochemical detection of the serotonin transporter in rat brain. Neuroscience 73, 217-231.
Tadros, S.F., D'Souza, M., Zettel, M.L., Zhu, X., Lynch-Erhardt, M., Frisina, R.D., 2007. Serotonin 2B receptor: upregulated with age and hearing loss in mouse auditory system. Neurobiol Aging 28, 1112-1123.
Takeuchi, Y., Sawada, T., Blunt, S., Jenner, P., Marsden, C.D., 1991. Effects of 6-hydroxydopamine lesions of the nigrostriatal pathway on striatal serotonin innervation in adult rats. Brain Res 562, 301-305.
Tornabene, S.V., Sato, K., Pham, L., Billings, P., Keithley, E.M., 2006. Immune cell recruitment following acoustic trauma. Hear Res 222, 115-124.
Vicente-Torres, M.A., Dávila, D., Bartolomé, M.V., Carricondo, F., Gil-Loyzaga, P., 2003. Biochemical evidence for the presence of serotonin transporters in the rat cochlea. Hear Res 182, 43-47.
Wang, J., Van De Water, T.R., Bonny, C., de Ribaupierre, F., Puel, J.L., Zine, A., 2003. A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. J Neurosci 23, 8596-8607.
Wu, W.L., Wang, C.H., Huang, E.Y., Chen, C.C., 2009. Asic3-/- female mice with hearing deficit affects social development of pups. PLoS One 4, e6508.
Wutzler, A., Winter, C., Kitzrow, W., Uhl, I., Wolf, R.J., Heinz, A., Juckel, G., 2008. Loudness dependence of auditory evoked potentials as indicator of central serotonergic neurotransmission: simultaneous electrophysiological recordings and in vivo microdialysis in the rat primary auditory cortex. Neuropsychopharmacology 33, 3176-3181.
Xu, H., Kotak, V.C., Sanes, D.H., 2007. Conductive hearing loss disrupts synaptic and spike adaptation in developing auditory cortex. J Neurosci 27, 9417-9426.
Yang, B.H., Wang, S.J., Chou, Y.H., Su, T.P., Chen, S.P., Lee, J.S., Chen, J.C., 2008. Evaluation of reference tissue model and tissue ratio method for 5-HTT using [123I] ADAM tracer. Comput Methods Programs Biomed 92, 294-298.
Zessin, J., Deuther-Conrad, W., Kretzschmar, M., Wüst, F., Pawelke, B., Brust, P., Steinbach, J., Bergmann, R., 2006. [11C]SMe-ADAM, an imaging agent for the brain serotonin transporter: synthesis, pharmacological characterization and microPET studies in rats. Nucl Med Biol 33, 53-63.
Zhou, F.C., Chiang, Y.H., Wang, Y., 1996. Constructing a new nigrostriatal pathway in the Parkinsonian model with bridged neural transplantation in substantia nigra. J Neurosci 16, 6965-6974.
Zhou, F.C., Lesch, K.P., Murphy, D.L., 2002. Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative. Brain Res 942, 109-119.
Zhou, F.C., Tao-Cheng, J.H., Segu, L., Patel, T., Wang, Y., 1998. Serotonin transporters are located on the axons beyond the synaptic junctions: anatomical and functional evidence. Brain Res 805, 241-254.

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