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研究生:陳恩湛
論文名稱:具結構補強設計之撓性神經探針開發
論文名稱(外文):Development of Flexible Neural Microprobe with Improved Structural Design
指導教授:方維倫
學位類別:碩士
校院名稱:國立清華大學
系所名稱:動力機械工程學系
學門:工程學門
學類:機械工程學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:中文
論文頁數:87
中文關鍵詞:神經探針聚對二甲苯電鍍鎳
相關次數:
  • 被引用被引用:0
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  • 下載下載:12
  • 收藏至我的研究室書目清單書目收藏:0
本研究製作出具有結構補強設計的撓性神經探針,並可用於記錄生物體神經電訊號。傳統金屬線以及玻璃探針多為單電極的設計,無法同時記錄多個神經細胞的訊號。微機電技術所開發的矽基材與高分子基材神經探針雖然可以製作高密度的電極陣列,但矽基材探針因其脆性在操作不當的情形下易斷裂,且容易誘發發炎反應造成生物體組織的傷害。高分子探針與生物體的協調性較好可減少發炎反應,但容易在穿刺過程中產生挫曲。
本研究提出以高分子材料聚對二甲苯為基材,並結合電鍍鎳製程製做一具有結構補強的撓性神經探針,使探針兼具撓性與足夠剛性。經由實驗證實,本研究製作的神經探針可順利穿刺軟膠並偵測到老鼠大腦的神經電訊號。

目錄
第 1 章 序論 1
1-1 前言 1
1-2 文獻回顧 2
1-2.1 神經系統與神經細胞 2
1-2.2 神經電訊號的產生與傳遞 3
1-2.3 神經探針的發展 4
1-2.4 神經探針的結構補強 10
1-2.5 神經探針的應用 12
1-3 研究動機與目標 14
第 2 章 元件設計 26
2-1 神經探針基本架構 26
2-2 設計概念 28
2-3 元件設計 29
2-3.1 材料選擇 29
2-3.2 探針設計 30
第 3 章 製程與結果 40
3-1 製程規劃 40
3-2 製程步驟 41
3-3 製程結果 42
3-4 問題改善 43
3-4.1 陽極金屬溶解法之問題 43
3-4.2 氧電漿蝕刻聚對二甲苯之問題 44
第 4 章 量測與結果 53
4-1 穿刺測試 53
4-2 神經探針電極介面阻抗量測 54
4-3 神經電訊號量測 55
4-4 生物相容性測試 56
第 5 章 結論與未來工作 67
5-1 結論 67
5-2 未來工作 68
5-2.1 改善探針翹曲 68
5-2.2 改善電性連接方式 70
第 6 章 參考文獻 78


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