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研究生:吳建勝
研究生(外文):Chien-Sheng Wu
論文名稱:皿培式牛樟芝子實體對小鼠發炎性腸病及腸癌惡病質減緩作用
論文名稱(外文):Ameliorating Effects of Petri Dish Cultured Antrodia cinnamomea Fruiting Body Toward Colon Cancer Cachexia and Inflammatory Bowel Disease in Murine
指導教授:龔瑞林龔瑞林引用關係
指導教授(外文):Zwe-Ling Kong
學位類別:碩士
校院名稱:國立臺灣海洋大學
系所名稱:食品科學系
學門:農業科學學門
學類:食品科學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:中文
論文頁數:121
中文關鍵詞:發炎性腸病發炎性腸癌牛樟芝
外文關鍵詞:Colorectal cancerinflammatory bowel diseaseAntrodia cinnamomea
相關次數:
  • 被引用被引用:1
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發炎性腸病是一種重複發生的慢性腸道發炎疾病。研究指出發炎性腸炎會顯著增加大腸癌的風險,目前已知發炎性腸炎與生活習慣以及飲食有密切的關係。研究指出牛樟芝具有抗氧化、抗發炎以及保肝功效。但牛樟芝對於發炎性腸炎的抗發炎功效尚未明朗。首先本研究利用皿培式牛樟芝子實體利用水萃 (ACP) 與乙醇萃取 (ACE) 的產物,針對 LPS 誘導產生發炎反應的巨噬細胞 RAW264.7 觀察抑制NO、TNF-、IL-6 以及 PGE2 的作用,IL-6 與 iNOS 的 mRNA 的表現也有因 ACP 與 ACE 而降低表現。動物實驗以發炎性腸炎的模式, C57BL/6 小鼠給予含硫酸葡聚醣鈉 (3% DSS) 的飲用水誘導十四天,在後七天管餵牛樟芝粉末,DSS 造成粘膜水腫和血便促使腸道縮短並增加腸重量與長度的比值以及增加發炎反應。牛樟芝能夠減緩發炎性腸炎藉由抑制發炎激素的產生。大腸癌模式中,腹腔注射致癌劑 azoxymethane (AOM) ,再以 2% DSS重複誘導腸道發炎,結果顯示牛樟芝具有防止腫瘤的生成。綜合上述結果牛樟芝可以減緩 DSS 誘導的傷害並且在發炎性腸炎與腸癌中可能具有治療的功用。
Inflammatory bowel diseases (IBD) are associated with chronic relapsing inflammation of the intestinal tract. IBD are at increased risk of developing CRC since it is now known that 90–95% of the cause is attributable to lifestyle and diet. Many studies have confirmed that Antrodia cinnamomea have antioxidant and anti-inflammatory and protect liver property. But, anti-inflammatory effects of AC in IBD have not been investigated. First,we use petri dish cultured AC fruiting body water extract (ACP) and ethanol extract (ACE) was assessed via inhibitory effect of nitric oxide (NO) and tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in lipopolysaccharide (LPS) induced RAW 264.7 macrophage cells.The mRNA expression levels of interleukin-6 (IL-6) and inducible NO synthase (iNOS) were reduced by the addition of ACP and ACE in a dose-dependent manner. Second , we used dextran sulfate sodium (DSS) (3% W/V) in drinking water fourteen days to induce male C57BL/6 mice colitis, and oral AC powder to mice for last seven days. DSS produced shrinkage of colon length and increased the relative colon weight/length ratio and inducing inflammatory response. AC attenuated the severity of DSS-induced IBD,reducing pro-inflammatory cytokine. In the colitis-associated colorectal cancer (CRC) model, mice were treated with 3 cycle DSS (2% W/V) for colitis and intraperitoneal injection of azoxymethane (10 mg/kg AOM), AC could be in prevent of CRC in the AOM-DSS model. The result shows that AC mitigated the injurious effects of DSS and inhibited pro-inflammatory cytokine and reduced tumor number. These results suggest that AC could possibly have improve injurious effects of DSS and that it may have therapeutic value in the setting of IBD and CAC.
目錄
謝誌 I
中文摘要 III
英文摘要 IV
名詞縮寫 V
目錄 VI
圖表目錄 XI
壹、序論 1
貳、文獻回顧 3
一、大腸直腸癌 (Colorectal cancer) 3
(一)分佈與症狀 3
(二)成因與因子 4
二、發炎性腸炎與大腸直腸癌的關係 5
三、發炎性腸炎 (Inflammatory bowel disease) 6
(一)潰瘍性腸炎 (Ulcerative colitis) 6
(二)克隆氏症 (Crohn's disease) 6
四、發炎性腸癌與發炎反應 7
(一)發炎反應 (Inflammatory response) 7
(二)活性氧 (Reactive Oxygen Species;ROS) 傷害 8
(三)環氧合酶 (Cyclooxygenase;COX) 9
(四)一氧化氮合成酶 (Nitric oxide synthase;NOS) 10
(五)NF-B 11
(六)細胞激素 11
(一)TNF- 11
(二)IL-6 12
(三)IL-1 13
五、惡病質 13
(一)成因 13
(二)急性期反應 15
六、牛樟芝 15
(一)牛樟芝 15
(二)命名由來 16
(三)牛樟芝分類 17
(四)生理活性 17
1.抗氧化活性 17
2.抗病毒活性 19
3.抑制腫瘤 19
4.護肝活性 21
5.降血脂 22
6.增強免疫活性 23
参、實驗設計 25
(一)Inflammatory bowel disease model 27
(二)Colitis-associated colon cancer model 28
肆、材料方法 29
一、實驗材料 29
(一)細胞株 29
(二)樣品 29
(三)藥品 29
1.細胞培養 29
2.細胞存活率測定 30
3.胞內活性氧分析 30
4.吞噬球呼吸爆 30
5.反轉錄酶鏈反應分析(RT-PCR) 30
6.動物 31
7.飼料來源 31
8.冷凍切片染色 31
9.血液細胞激素測定 32
10.急性蛋白 32
11.脾臟細胞分離 32
12.脾臟細胞增殖反應 32
(四)儀器設備 32
二、實驗方法 34
(一)樣品製備 34
(二)抗發炎分析 34
1.RAW264.7培養 34
2.細胞存活率測定 35
3.RT-PCR分析 iNOS 和 IL-6 36
3.細胞激素測定 39
4. 吞噬球呼吸爆 (Respiratory burst) NBT還原分析 40
5.細胞內活性氧分析 41
6.前列腺素E2測定 42
(三)、牛樟芝減緩動物發炎性腸病及腸癌實驗 42
1. 實驗動物之飼養 42
2. 動物實驗組別設定 43
3. 取得老鼠下腔大動脈血及其他臟器 43
4. 疾病指數的評分 44
5. 小鼠脾臟細胞之取得 44
6. 小鼠腸組織之處理 44
7. 血清之脂質過氧化影響 45
8. C 反應蛋白測定 45
9. 淋巴球增生數量測定 (MTT Assay) 46
10. 一氧化氮測定 46
(四)、統計方法 46
伍、結果與討論 47
陸、結論 58
柒、參考文獻 60
捌、圖表 74
玖、附錄 104


行政院衛生署。台灣死因統計分析。101年。
呂美津。2007。台灣特有牛樟芝及番荔枝科乙醯生合物。高雄醫學大學天然藥物研究所博士論文。高雄。台灣。
沈立言。2000。牛樟芝菌絲體發酵萃取液對肝臟生理機能之影響。89年度保健食品研究開發計畫心得發表會。p.191-198。
陳秀雯,陳清農,黃仕政,許勝傑,曹虹萍,洪鳴遠,傅麒玲,陳勁初。2002。牛樟芝菌絲體之免疫調節功能評估。中華民國食品科學技術學會第三十二次學員大會手冊。p.326。
陳欣怡。2002。牛樟芝發酵過濾液對大白鼠肝臟生理機能之影響。中國醫藥學院營養研究所碩士論文。台中。台灣。
陳維熊、魏承生。2008。中西醫會診-大腸癌(二版)。書泉出版社。台北,台灣。
黃宗人譯、藤田伸原著。2000。認識大腸癌(初版)。長年出版社。高雄,台灣。
楊燿銘。2009。牛樟芝讓生命更豐富(初版)。巨煒出版。台北,台灣。
楊燿銘。2010。生技時代的皿培式牛樟芝(初版)。巨煒出版。台北,台灣。
葉怡真。2002。樟芝對血管內皮細胞之影響及保心血管疾病之機制探討。中國醫藥學院營養研究所碩士論文。台中。台灣。
劉千瑈。2006。樟芝對樹突狀細胞之免疫調控作用與對巨噬細胞之抗發炎反應。國立陽明大學熱帶醫學研究所碩士論文。台北。台灣。
劉翠玲。2002。樟芝對倉鼠體內脂質代謝與抗氧化狀態之影響。輔仁大學食品營養學系碩士論文。台北,台灣。
鄭清榮譯、馬克、波恰品原著、。2005。大腸癌診療室(初版)。原水文化出版。台北,台灣。
賴宏亮,呂美津,陳武元,莊秀琪。2002。樟芝免疫調節活性之研究。台灣保健食品學會。第二屆第二次年會大會議程及壁報論文摘要。p.49。
嚴貴榮。2002。樟芝對STZ誘發高血糖鼠血糖調節與抗氧化之影響。
輔仁大學食品營養學系碩士論文。台北,台灣。
Acharyya S, Ladner KJ, Nelsen LL, Damrauer J, Reiser PJ, Swoap S, Guttridge DC. 2004. Cancer cachexia is regulated by selective targeting of skeletal muscle gene products. The Journal of Clinical Investigation 114:370-378.
Adelizzi RA. 1999. COX-1 and COX-2 in health and disease. The Journal of the American Osteopathic Association 99:S7-12.
Alexandrakis MG, Passam FH, Boula A, Christophoridou A, Aloizos G, Roussou P, Kyriakou DS. 2003. Relationship between circulating serum soluble interleukin-6 receptor and the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in multiple myeloma. Ann Hematol 82:19-23.
Asting AG, Caren H, Andersson M, Lonnroth C, Lagerstedt K, Lundholm K. 2011. COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status. BMC Cancer 11:238.
Baldwin AS, Jr. 2001. Series introduction: the transcription factor NF-kappaB and human disease. The Journal of Clinical Investigation 107:3-6.
Bamba S, Andoh A, Ban H, Imaeda H, Aomatsu T, Kobori A, Mochizuki Y, Shioya M, Nishimura T, Inatomi O, Sasaki M, Saitoh Y, Tsujikawa T, Araki Y, Fujiyama Y. 2012. The severity of dextran sodium sulfate-induced colitis can differ between dextran sodium sulfate preparations of the same molecular weight range. Digestive Diseases and Sciences 57:327-334.
Barber MD, Fearon KC, Ross JA. 1999. Relationship of serum levels of interleukin-6, soluble interleukin-6 receptor and tumour necrosis factor receptors to the acute-phase protein response in advanced pancreatic cancer. Clin Sci (Lond) 96:83-87.
Barton BE. 2005. Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes. Expert Opin Ther Targets 9:737-752.
Becker C, Fantini MC, Wirtz S, Nikolaev A, Kiesslich R, Lehr HA, Galle PR, Neurath MF. 2005. In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy. Gut 54:950-954.
Bemelmans MH, van Tits LJ, Buurman WA. 1996. Tumor necrosis factor: function, release and clearance. Critical Reviews in Immunology 16:1-11.
Berkower I, Kawamura H, Matis LA, Berzofsky JA. 1985. T cell clones to two major T cell epitopes of myoglobin: effect of I-A/I-E restriction on epitope dominance. J Immunol 135:2628-2634.
Bruckdorfer R. 2005. The basics about nitric oxide. Molecular Aspects of Medicine 26:3-31.
Brynskov J, Foegh P, Pedersen G, Ellervik C, Kirkegaard T, Bingham A, Saermark T. 2002. Tumour necrosis factor alpha converting enzyme (TACE) activity in the colonic mucosa of patients with inflammatory bowel disease. Gut 51:37-43.
Busquets S, Deans C, Figueras M, Moore-Carrasco R, Lopez-Soriano FJ, Fearon KC, Argiles JM. 2007. Apoptosis is present in skeletal muscle of cachectic gastro-intestinal cancer patients. Clin Nutr 26:614-618.
Camacho-Barquero L, Villegas I, Sanchez-Calvo JM, Talero E, Sanchez-Fidalgo S, Motilva V, Alarcon de la Lastra C. 2007. Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis. International Immunopharmacology 7:333-342.
Cerretti DP, Kozlosky CJ, Mosley B, Nelson N, Van Ness K, Greenstreet TA, March CJ, Kronheim SR, Druck T, Cannizzaro LA, et al. 1992. Molecular cloning of the interleukin-1 beta converting enzyme. Science 256:97-100.
Chan YY, Chang CS, Chien LH, Wu TF. 2010. Apoptotic effects of a high performance liquid chromatography (HPLC) fraction of Antrodia camphorata mycelia are mediated by down-regulation of the expressions of four tumor-related genes in human non-small cell lung carcinoma A549 cell. J Ethnopharmacol 127:652-661.
Chandel NS, Trzyna WC, McClintock DS, Schumacker PT. 2000. Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin. Journal of Immunology 165:1013-1021.
Chang TT, Chou WN. 1995. Antrodia cinnamomea sp. nov. on Cinnamomum kanehirai in Taiwan. Mycological Research 99:756-758.
Chen CH, Yang SW, Shen YC. 1995. New steroid acids from Antrodia cinnamomea, a fungal parasite of Cinnamomum micranthum. Journal of Natural Products 58:1655-1661.
Cheng PC, Hsu CY, Chen CC, Lee KM. 2008. In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni. Toxicol Appl Pharmacol 227:291-298.
Chi YS, Cheon BS, Kim HP. 2001. Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells. Biochemical Pharmacology 61:1195-1203.
Cui X, Jin Y, Hofseth AB, Pena E, Habiger J, Chumanevich A, Poudyal D, Nagarkatti M, Nagarkatti PS, Singh UP, Hofseth LJ. 2010a. Resveratrol suppresses colitis and colon cancer associated with colitis. Cancer Prev Res (Phila) 3:549-559.
Cui YQ, Zhang LJ, Zhang T, Luo DZ, Jia YJ, Guo ZX, Zhang QB, Wang X, Wang XM. 2010b. Inhibitory effect of fucoidan on nitric oxide production in lipopolysaccharide-activated primary microglia. Clinical and Experimental Pharmacology & Physiology 37:422-428.
Deguchi Y, Andoh A, Inatomi O, Yagi Y, Bamba S, Araki Y, Hata K, Tsujikawa T, Fujiyama Y. 2007. Curcumin prevents the development of dextran sulfate Sodium (DSS)-induced experimental colitis. Digestive Diseases and Sciences 52:2993-2998.
Dogasaki C, Murakami H, Nishijima M, Ohno N, Yadomae T, Miyazaki T. 1994. Biological activity and structural characterization of alkaline-soluble polysaccharides from the kernels of Prunus mume Sieb. et Zacc. Biological & Pharmaceutical Bulletin 17:386-390.
Dove-Edwin I, Thomas HJ. 2001. Review article: the prevention of colorectal cancer. Alimentary Pharmacology & Therapeutics 15:323-336.
Dray X, Marteau P. 2007. [Crohn's disease and ulcerative colitis]. La Revue du Praticien 57:2305-2310.
Falconer JS, Fearon KC, Ross JA, Elton R, Wigmore SJ, Garden OJ, Carter DC. 1995. Acute-phase protein response and survival duration of patients with pancreatic cancer. Cancer 75:2077-2082.
Fan Y, Yu Y, Shi Y, Sun W, Xie M, Ge N, Mao R, Chang A, Xu G, Schneider MD, Zhang H, Fu S, Qin J, Yang J. 2010. Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation. The Journal of Biological Chemistry 285:5347-5360.
Fantini MC, Pallone F. 2008. Cytokines: from gut inflammation to colorectal cancer. Current Drug Targets 9:375-380.
Farrow B, Evers BM. 2002. Inflammation and the development of pancreatic cancer. Surgical Oncology 10:153-169.
Fernandez-Duenas V, Sanchez S, Planas E, Poveda R. 2008. Adjuvant effect of caffeine on acetylsalicylic acid anti-nociception: prostaglandin E2 synthesis determination in carrageenan-induced peripheral inflammation in rat. European Journal of Pain 12:157-163.
Figueras M, Busquets S, Carbo N, Almendro V, Argiles JM, Lopez-Soriano FJ. 2005. Cancer cachexia results in an increase in TNF-alpha receptor gene expression in both skeletal muscle and adipose tissue. Int J Oncol 27:855-860.
Gao JJ, Zuvanich EG, Xue Q, Horn DL, Silverstein R, Morrison DC. 1999. Cutting edge: bacterial DNA and LPS act in synergy in inducing nitric oxide production in RAW 264.7 macrophages. J Immunol 163:4095-4099.
Ghosh S, May MJ, Kopp EB. 1998. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annual Review of Immunology 16:225-260.
Gilfillan AM, Tkaczyk C. 2006. Integrated signalling pathways for mast-cell activation. Nature reviews Immunology 6:218-230.
Gloire G, Legrand-Poels S, Piette J. 2006. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochemical Pharmacology 72:1493-1505.
Gupta RB, Harpaz N, Itzkowitz S, Hossain S, Matula S, Kornbluth A, Bodian C, Ullman T. 2007. Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study. Gastroenterology 133:1099-1105; quiz 1340-1091.
Hanauer SB, Sandborn W. 2001. Management of Crohn's disease in adults. Am J Gastroenterol 96:635-643.
Hendrickson BA, Gokhale R, Cho JH. 2002. Clinical aspects and pathophysiology of inflammatory bowel disease. Clinical Microbiology Reviews 15:79-94.
Henriksen M, Moum B. 2007. [Colorectal cancer in inflammatory bowel disease]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 127:2696-2699.
Hseu YC, Chang WC, Hseu YT, Lee CY, Yech YJ, Chen PC, Chen JY, Yang HL. 2002. Protection of oxidative damage by aqueous extract from Antrodia camphorata mycelia in normal human erythrocytes. Life Sci 71:469-482.
Hseu YC, Chen SC, Yech YJ, Wang L, Yang HL. 2008. Antioxidant activity of Antrodia camphorata on free radical-induced endothelial cell damage. J Ethnopharmacol 118:237-245.
Hseu YC, Wu FY, Wu JJ, Chen JY, Chang WH, Lu FJ, Lai YC, Yang HL. 2005. Anti-inflammatory potential of Antrodia Camphorata through inhibition of iNOS, COX-2 and cytokines via the NF-kB pathway. International Immunopharmacology 5:1914-1925.
Hseu YC, Yang HL, Lai YC, Lin JG, Chen GW, Chang YH. 2004. Induction of apoptosis by Antrodia camphorata in human premyelocytic leukemia HL-60 cells. Nutr Cancer 48:189-197.
Hsiao G, Shen MY, Lin KH, Lan MH, Wu LY, Chou DS, Lin CH, Su CH, Sheu JR. 2003. Antioxidative and hepatoprotective effects of Antrodia camphorata extract. J Agric Food Chem 51:3302-3308.
Hsieh YC, Rao YK, Wu CC, Huang CY, Geethangili M, Hsu SL, Tzeng YM. 2010. Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and Bax-triggered mitochondrial pathway. Chem Res Toxicol 23:1256-1267.
Huang CH, Chang YY, Liu CW, Kang WY, Lin YL, Chang HC, Chen YC. 2010. Fruiting body of Niuchangchih (Antrodia camphorata) protects livers against chronic alcohol consumption damage. J Agric Food Chem 58:3859-3866.
Itzkowitz SH, Yio X. 2004. Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. American journal of physiology Gastrointestinal and Liver Physiology 287:G7-17.
Jatoi A. 2008. Weight loss in patients with advanced cancer: effects, causes, and potential management. Curr Opin Support Palliat Care 2:45-48.
Jin Y, Mailloux CM, Gowan K, Riccardi SL, LaBerge G, Bennett DC, Fain PR, Spritz RA. 2007. NALP1 in vitiligo-associated multiple autoimmune disease. The New England Journal of Medicine 356:1216-1225.
Katayama K, Wada K, Nakajima A, Mizuguchi H, Hayakawa T, Nakagawa S, Kadowaki T, Nagai R, Kamisaki Y, Blumberg RS, Mayumi T. 2003. A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model. Gastroenterology 124:1315-1324.
Khan N, Afaq F, Mukhtar H. 2008. Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxidants & Redox Signaling 10:475-510.
Kinzler KW, Vogelstein B. 1996. Lessons from hereditary colorectal cancer. Cell 87:159-170.
Knowles RG. 1996. Nitric oxide synthases. Biochemical Society Transactions 24:875-878.
Knowles RG, Moncada S. 1994. Nitric oxide synthases in mammals. The Biochemical Journal 298 ( Pt 2):249-258.
Kornbluth A, Sachar DB. 2004. Ulcerative colitis practice guidelines in adults (update): American College of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol 99:1371-1385.
Kwon HS, Oh SM, Kim JK. 2008. Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium-induced colitis. Clinical and Experimental Immunology 151:165-173.
Lakshminarayanan V, Drab-Weiss EA, Roebuck KA. 1998. H2O2 and tumor necrosis factor-alpha induce differential binding of the redox-responsive transcription factors AP-1 and NF-kappaB to the interleukin-8 promoter in endothelial and epithelial cells. The Journal of Biological Chemistry 273:32670-32678.
Lee IH, Huang RL, Chen CT, Chen HC, Hsu WC, Lu MK. 2002a. Antrodia camphorata polysaccharides exhibit anti-hepatitis B virus effects. FEMS Microbiol Lett 209:63-67.
Lee IH, Huang RL, Chen CT, Chen HC, Hsu WC, Lu MK. 2002b. Antrodia camphorata polysaccharides exhibit anti-hepatitis B virus effects. FEMS Microbiology Letters 209:63-67.
Leighton JA, Shen B, Baron TH, Adler DG, Davila R, Egan JV, Faigel DO, Gan SI, Hirota WK, Lichtenstein D, Qureshi WA, Rajan E, Zuckerman MJ, VanGuilder T, Fanelli RD. 2006. ASGE guideline: endoscopy in the diagnosis and treatment of inflammatory bowel disease. Gastrointestinal Endoscopy 63:558-565.
Locksley RM, Killeen N, Lenardo MJ. 2001. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104:487-501.
Lu MC, Du YC, Chuu JJ, Hwang SL, Hsieh PC, Hung CS, Chang FR, Wu YC. 2009a. Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A. Arch Toxicol 83:121-129.
Lu MC, Du YC, Chuu JJ, Hwang SL, Hsieh PC, Hung CS, Chang FR, Wu YC. 2009b. Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A. Archives of Toxicology 83:121-129.
MacDonald N, Alexander HR, Bruera E. 1995. Cachexia-anorexia-asthenia. J Pain Symptom Manage 10:151-155.
Maeda S, Hikiba Y, Sakamoto K, Nakagawa H, Hirata Y, Hayakawa Y, Yanai A, Ogura K, Karin M, Omata M. 2009. Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression. Hepatology 50:1851-1860.
Martin F, Santolaria F, Batista N, Milena A, Gonzalez-Reimers E, Brito MJ, Oramas J. 1999. Cytokine levels (IL-6 and IFN-gamma), acute phase response and nutritional status as prognostic factors in lung cancer. Cytokine 11:80-86.
Martin P, Leibovich SJ. 2005. Inflammatory cells during wound repair: the good, the bad and the ugly. Trends in Cell Biology 15:599-607.
Martinon F, Burns K, Tschopp J. 2002. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Molecular cell 10:417-426.
Matsukawa A, Hogaboam CM, Lukacs NW, Kunkel SL. 2000. Chemokines and innate immunity. Reviews in Immunogenetics 2:339-358.
Melgar S, Karlsson A, Michaelsson E. 2005. Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation. American journal of physiology Gastrointestinal and Liver Physiology 288:G1328-1338.
Mercier S, Breuille D, Mosoni L, Obled C, Patureau Mirand P. 2002. Chronic inflammation alters protein metabolism in several organs of adult rats. The Journal of Nutrition 132:1921-1928.
Nigrovic PA, Lee DM. 2005. Mast cells in inflammatory arthritis. Arthritis Research & Therapy 7:1-11.
Nixon DW. 1996. Cancer, cancer cachexia, and diet: lessons from clinical research. Nutrition 12:S52-56.
Ota S, Bamba H, Kato A, Kawamoto C, Yoshida Y, Fujiwara K. 2002. Review article: COX-2, prostanoids and colon cancer. Aliment Pharmacol Ther 16 Suppl 2:102-106.
Ouaissi M, Maggiori L, Alves A, Giger U, Sielezneff I, Valleur P, Sastre B, Panis Y. 2011. Colorectal cancer complicating inflammatory bowel disease: a comparative study of Crohn's disease vs ulcerative colitis in 34 patients. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 13:684-688.
Oyama T, Yasui Y, Sugie S, Koketsu M, Watanabe K, Tanaka T. 2009. Dietary tricin suppresses inflammation-related colon carcinogenesis in male Crj: CD-1 mice. Cancer Prev Res (Phila) 2:1031-1038.
Ozin Y, Kilic MZ, Nadir I, Cakal B, Disibeyaz S, Arhan M, Dagli U, Tunc B, Ulker A, Sahin B. 2009. Clinical features of ulcerative colitis and Crohn's disease in Turkey. Journal of gastrointestinal and liver diseases : JGLD 18:157-162.
Palamaras I, El-Jabbour J, Pietropaolo N, Thomson P, Mann S, Robles W, Stevens HP. 2008. Metastatic Crohn's disease: a review. Journal of the European Academy of Dermatology and Venereology : JEADV 22:1033-1043.
Park JB. 2003. Phagocytosis induces superoxide formation and apoptosis in macrophages. Experimental & Molecular Medicine 35:325-335.
Park SW, Kim HS, Choi MS, Jeong WJ, Heo DS, Kim KH, Sung MW. 2011. The effects of the stromal cell-derived cyclooxygenase-2 metabolite prostaglandin E2 on the proliferation of colon cancer cells. J Pharmacol Exp Ther 336:516-523.
Pozza A, Scarpa M, Ruffolo C, Polese L, Erroi F, Bridda A, Norberto L, Frego M. 2011. Colonic carcinogenesis in IBD: molecular events. Ann Ital Chir 82:19-28.
Ramos EJ, Suzuki S, Marks D, Inui A, Asakawa A, Meguid MM. 2004. Cancer anorexia-cachexia syndrome: cytokines and neuropeptides. Curr Opin Clin Nutr Metab Care 7:427-434.
Rankin JA. 2004. Biological mediators of acute inflammation. AACN clinical issues 15:3-17.
Rao CV, Indranie C, Simi B, Manning PT, Connor JR, Reddy BS. 2002. Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor. Cancer Research 62:165-170.
Requena P, Gonzalez R, Lopez-Posadas R, Abadia-Molina A, Suarez MD, Zarzuelo A, de Medina FS, Martinez-Augustin O. 2010. The intestinal antiinflammatory agent glycomacropeptide has immunomodulatory actions on rat splenocytes. Biochemical Pharmacology 79:1797-1804.
Ridker PM, Silvertown JD. 2008. Inflammation, C-reactive protein, and atherothrombosis. Journal of Periodontology 79:1544-1551.
Roessner A, Kuester D, Malfertheiner P, Schneider-Stock R. 2008a. Oxidative stress in ulcerative colitis-associated carcinogenesis. Pathology, Research and Practice 204:511-524.
Roessner A, Kuester D, Malfertheiner P, Schneider-Stock R. 2008b. Oxidative stress in ulcerative colitis-associated carcinogenesis. Pathology, Research and Practice 204:511-524.
Rogez-Kreuz C, Maneglier B, Martin M, Dereuddre-Bosquet N, Martal J, Dormont D, Clayette P. 2005. Involvement of IL-6 in the anti-human immunodeficiency virus activity of IFN-tau in human macrophages. International Immunology 17:1047-1057.
Ruby AJ, Kuttan G, Babu KD, Rajasekharan KN, Kuttan R. 1995. Anti-tumour and antioxidant activity of natural curcuminoids. Cancer Letters 94:79-83.
Sano H, Kawahito Y, Wilder RL, Hashiramoto A, Mukai S, Asai K, Kimura S, Kato H, Kondo M, Hla T. 1995. Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res 55:3785-3789.
Sawa T, Ohshima H. 2006. Nitrative DNA damage in inflammation and its possible role in carcinogenesis. Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 14:91-100.
Schottelius AJ, Dinter H. 2006. Cytokines, NF-kB, microenvironment, intestinal inflammation and cancer. Cancer Treatment and Research 130:67-87.
Sharma RA, Steward WP, Gescher AJ. 2007. Pharmacokinetics and pharmacodynamics of curcumin. Advances in Experimental Medicine and Biology 595:453-470.
Sheth K, Duffy A, Nolan B, Banner B, Bankey P. 2000. Activated neutrophils induce nitric oxide production in Kupffer cells. Shock 14:380-384; discussion 384-385.
Shirakami Y, Shimizu M, Tsurumi H, Hara Y, Tanaka T, Moriwaki H. 2008. EGCG and Polyphenon E attenuate inflammation-related mouse colon carcinogenesis induced by AOM plus DDS. Molecular Medicine reports 1:355-361.
Singh S, Aggarwal BB. 1995. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]. The Journal of Biological Chemistry 270:24995-25000.
Song TY, Yen GC. 2002. Antioxidant properties of Antrodia camphorata in submerged culture. J Agric Food Chem 50:3322-3327.
Song TY, Yen GC. 2003. Protective effects of fermented filtrate from Antrodia camphorata in submerged culture against CCl4-induced hepatic toxicity in rats. J Agric Food Chem 51:1571-1577.
Sugimoto K, Hanai H, Tozawa K, Aoshi T, Uchijima M, Nagata T, Koide Y. 2002. Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice. Gastroenterology 123:1912-1922.
Suntres ZE, Shek PN. 1996. Treatment of LPS-induced tissue injury: role of liposomal antioxidants. Shock 6 Suppl 1:S57-64.
Swardfager W, Lanctot K, Rothenburg L, Wong A, Cappell J, Herrmann N. 2010. A meta-analysis of cytokines in Alzheimer's disease. Biological Psychiatry 68:930-941.
Tackey E, Lipsky PE, Illei GG. 2004. Rationale for interleukin-6 blockade in systemic lupus erythematosus. Lupus 13:339-343.
Talero E, Sanchez-Fidalgo S, Villegas I, de la Lastra CA, Illanes M, Motilva V. 2011. Role of different inflammatory and tumor biomarkers in the development of ulcerative colitis-associated carcinogenesis. Inflamm Bowel Dis 17:696-710.
Tenzaki T, Ishiguro T. 1989. [Response of human lymphocytes to phytohemagglutinin (PHA) as measured by fluorescence polarization technique--differences between malignant conditions and benign or healthy conditions]. Nihon Gan Chiryo Gakkai shi 24:817-825.
Tisdale MJ. 2001. Loss of skeletal muscle in cancer: biochemical mechanisms. Frontiers in Bioscience : a journal and virtual library 6:D164-174.
Tisdale MJ. 2003a. The 'cancer cachectic factor'. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 11:73-78.
Tisdale MJ. 2003b. Pathogenesis of cancer cachexia. The Journal of Supportive Oncology 1:159-168.
Tisdale MJ. 2005. The ubiquitin-proteasome pathway as a therapeutic target for muscle wasting. J Support Oncol 3:209-217.
Tumminello FM, Badalamenti G, Incorvaia L, Fulfaro F, D'Amico C, Leto G. 2009. Serum interleukin-6 in patients with metastatic bone disease: correlation with cystatin C. Medical Oncology 26:10-15.
Valdes Mas M, Pons Minano JA, Carballo Alvarez F. 2007. [Intraabdominal abscesses in Crohn's disease]. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 99:673-674.
Venkataranganna MV, Rafiq M, Gopumadhavan S, Peer G, Babu UV, Mitra SK. 2007. NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene- induced colitis through down-regulation of NFkappa-B and iNOS. World Journal of Gastroenterology : WJG 13:1103-1107.
Vermeire S, Van Assche G, Rutgeerts P. 2004. C-reactive protein as a marker for inflammatory bowel disease. Inflammatory Bowel Diseases 10:661-665.
Vidal-Vanaclocha F, Fantuzzi G, Mendoza L, Fuentes AM, Anasagasti MJ, Martin J, Carrascal T, Walsh P, Reznikov LL, Kim SH, Novick D, Rubinstein M, Dinarello CA. 2000. IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1. Proceedings of the National Academy of Sciences of the United States of America 97:734-739.
Walsh NC, Crotti TN, Goldring SR, Gravallese EM. 2005. Rheumatic diseases: the effects of inflammation on bone. Immunological Reviews 208:228-251.
Watchorn TM, Waddell I, Dowidar N, Ross JA. 2001. Proteolysis-inducing factor regulates hepatic gene expression via the transcription factors NF-(kappa)B and STAT3. Faseb J 15:562-564.
Wilborn J, DeWitt DL, Peters-Golden M. 1995. Expression and role of cyclooxygenase isoforms in alveolar and peritoneal macrophages. The American Journal of Physiology 268:L294-301.
Wissing D, Mouritzen H, Jaattela M. 1998. TNF-induced mitochondrial changes and activation of apoptotic proteases are inhibited by A20. Free Radical Biology & Medicine 25:57-65.
Wu MT, Tzang BS, Chang YY, Chiu CH, Kang WY, Huang CH, Chen YC. 2011. Effects of Antrodia camphorata on alcohol clearance and antifibrosis in livers of rats continuously fed alcohol. J Agric Food Chem 59:4248-4254.
Yamada H, Arai T, Endo N, Yamashita K, Fukuda K, Sasada M, Uchiyama T. 2006. LPS-induced ROS generation and changes in glutathione level and their relation to the maturation of human monocyte-derived dendritic cells. Life Sciences 78:926-933.
Yamamoto-Furusho JK. 2007. Genetic factors associated with the development of inflammatory bowel disease. World Journal of Gastroenterology : WJG 13:5594-5597.
Yan B, Wang H, Rabbani ZN, Zhao Y, Li W, Yuan Y, Li F, Dewhirst MW, Li CY. 2006. Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation. Cancer Research 66:11565-11570.
Yeh CT, Rao YK, Yao CJ, Yeh CF, Li CH, Chuang SE, Luong JH, Lai GM, Tzeng YM. 2009. Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells. Cancer Lett 285:73-79.
Zaidman BZ, Yassin M, Mahajna J, Wasser SP. 2005. Medicinal mushroom modulators of molecular targets as cancer therapeutics. Appl Microbiol Biotechnol 67:453-468.



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