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研究生:曾俞螢
研究生(外文):Tseng, Yuying
論文名稱:維生素C幾丁聚醣微膠囊的研究
論文名稱(外文):The Study Of Vitamin C Chitosan Microcapsules
指導教授:官常慶官常慶引用關係
指導教授(外文):Kwan, Changchin
口試委員:黃克峰蔡琦
口試委員(外文):Huang, KehfengTsai, Chi
口試日期:2012-07-04
學位類別:碩士
校院名稱:靜宜大學
系所名稱:應用化學系
學門:自然科學學門
學類:化學學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:中文
論文頁數:70
中文關鍵詞:微膠囊幾丁聚醣維生素C磷酸鎂鹽
外文關鍵詞:MicrocapsuleChitosanVitamin C
相關次數:
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  • 下載下載:227
  • 收藏至我的研究室書目清單書目收藏:1
本研究設計是利用幾丁聚醣來製備微膠囊,幾丁聚醣具有良好的生物相容性及生物降解性,被廣泛應用在藥物載體上。將溶幾丁聚醣的醋酸溶液利用氫氧化鉀中和,因幾丁聚醣的溶解度降低,使幾丁聚醣的微膠囊產生。幾丁聚醣微膠囊以不同濃度〈0.5、1.0、1.5、2.0wt%〉的幾丁聚醣來製備。
維生素C磷酸鎂鹽能阻止酪胺酸脢的活化作用,並抑制黑色素生成,普遍用於美白抗老化產品。由於維生素C磷酸鎂鹽本身為水溶性且易氧化不安定,因此本研究利用幾丁聚醣微膠囊作為載體,並針對影響微膠囊的粒徑和包覆率作探討。
本研究結果顯示維生素C磷酸鎂鹽在較高濃度的幾丁聚醣微膠囊,其平均粒徑較大,幾丁聚醣濃度升高至1.5wt%時,維生素C磷酸鎂鹽包覆量會增加至52%,這是由於幾丁聚醣濃度越高,包覆溶液黏度相對升高,所以維生素C磷酸鎂鹽不易流失出去。
In the study is attempted to prepare microcapsule by using chitosan.Chitosan is a class of biodegradable and biocompatible are, widely used in drug carrier. Dissolved chitosan Acetic acid solution, Potassium hydroxide, due to the solubility of chitosan reduce Microcapsulation is prepared by emulsification method at different concentrations of Chitosan.
Magnesium ascorbyl phosphate is commonly used in the productions of whitening and anti-aging materials. It can prevent from the activation of tyrosine and reduce the oxidized melain. Magnesium ascorbyl phosphate, a hydrophilic derivative of ascorbic acid, is not stable in the air. In the study, Magnesium ascorbyl phosphate was encapsulated in microcapsule of chitosan the effects of particle size.
The results showed that Magnesium ascorbyl phosphate at Chitosan microcapsule of higher concentration has large average particle size. Chitosan concentration to 1.5wt%, Magnesium ascorbyl phosphate coating will be increased to 52%. It caused by viscosity of encapsulation solution that relative higher concentration chitosan was increased, so Magnesium ascorbyl phosphate will not be lost.

中文摘要 I
英文摘要 II
壹 緒論
1-1前言 01
貳、相關原理與文獻參考
2-1生物高分子
2-1-1微膠囊 03
2-1-2高分子囊材 07
2-1-3幾丁質與幾丁聚醣 09
2-1-4幾丁質與幾丁聚醣的溶解性質 12
2-2界面活性劑
2-2-1定義及分類 17
2-2-2微胞的形成 20
2-2-3乳化 23
2-2-4乳化包覆藥物 25
2-2-5乳化劑之HLB值 26
2-2-6乳液的安定性 28
2-3經皮輸藥系統介紹
2-3-1皮膚 32
2-3-2經皮膚吸收 35
2-3-3美白成份維生素C 39
2-4流變學 41
參、實驗
3-1藥品 46
3-2儀器 47
3-3微膠囊的製備 48
3-4幾丁聚醣溶液流變性的測定 49
3-5微膠囊粒徑大小的測定 49
3-6維生素C磷酸鎂鹽檢量線製作 50
3-7維生素C磷酸鎂鹽的包覆測量 52
肆、結果與討論
4-1幾丁聚醣流變學的性質 53
4-2幾丁聚醣濃度對微膠囊粒徑的影響 56
4-3幾丁聚醣濃度對微膠囊包覆量的影響 58
4-4顯微鏡觀察微膠囊外觀 60
伍、結論 62
參考文獻 63
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