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研究生(外文):Ci-Ting Hong
論文名稱(外文):The Intraocular Pressure-Lowing Activity of Semen Cassia in DBA/2J Mice Glaucoma Model
指導教授(外文):Fu-an Chen
外文關鍵詞:Semen CassiaGlaucomaDBA/2J mice
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結論︰由本實驗發現口服低、中、高劑量的決明子萃取物其降眼壓效果(五週後)與增強房水液中抗氧化的能力,與點眼用藥brimonidine和口服用藥acetazolamide 相比較,並無明顯差異。此外服用決明子萃取物的小鼠,其肝臟、腎臟與眼睛的病理組織切片並無明顯異常;且外觀與生長狀況亦稱良好。以上結果推論決明子確有治療青盲上的理論基礎,在臨床上應可用來治療與預防人類的青光眼。
Glaucoma is mainly cause of blindness in the world. Visual loss in glaucoma typically involves retinal ganglion cell death and optic nerve atrophy subsequent to a pathologic elevation of intraocular pressure(IOP). The Semen Cassia (Jue Ming Zi) were used to cure glaucoma in ancient China. In this study, we evaluate the potential of Cassia tora in the treatment of glaucoma.
Young (mean ages:3 months) inherited glaucoma mice (BDA/2J; n=26) and health mice (C57BL/6J; n=10) were enrolled in this study. To
evaluate the potential of Semen Cassia the treatment of glaucoma,, all animals were divided into six groups. There were one shame group, two groups of control(topical brimonidine instillation and oral acetazolamide), and three groups treated by semen cassiae extract (low, middle and high doses). The anti-glaucoma effect of Semen Cassia was access by LDH and IOP. The side effect was investigated, too.
In result 1: LDH level was significantly lower than the baseline with the treatment of brimonide, middle and high doses of Semen Cassia. In result 2: the IOP was also lower than the pre-treatment level with the treatment of two lowering IOP drugs and any doses of Semen Cassia. In result 3: abnormal weight gain occurred after approximately five weeks with taking oral acetazolamide. In result 4: we found renal tubular focal atrophy and mild hepatocyte aptosis combined with inflammatory cells in the oral acetazolamide group. Besides, corneal opacity was found in topical brimonide instillation group, and the results of pathology showed subepithelial deposits and cystic degeneration within stromal layer.
The ability to lower IOP and the activity of antioxidants in the middle and high doses of Jue Min Zi were equal to the groups of brimonide and acetazolamide used. The Semen Cassia is a relatively safe Chinese herbal medicine because no side effect was observed such as body weight loss, pathologic change. Perhaps, combination of the extracts of Semen Cassia with other anti-glaucoma drugs in treating the development and progression of glaucoma in the future could be expected.
中文摘要…………………………………………………………… Ⅰ
英文摘要…………………………………………………………… Ⅲ
誌謝………………………………………………………………… Ⅴ
目錄………………………………………………………………… Ⅵ
表目錄……………………………………………………………… Ⅶ
圖目錄……………………………………………………………… Ⅷ
第一章 前言……………………………………………………… 1
第二章 文獻回顧………………………………………………… 5
第三章 材料與方法……………………………………………… 9
第四章 結果……………………………………………………… 19
第五章 討論……………………………………………………… 26
第六章 結論……………………………………………………… 71
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