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研究生:陳信文
研究生(外文):Hsin-Wen Chen
論文名稱:硫酸鈣與磷酸鈣複合之研究
論文名稱(外文):Study of Calcium Sulfate and Calcium Phosphate Composites
指導教授:薛文景
指導教授(外文):Wen-Ching Say
口試委員:陳適範陳建仲林峰輝
口試委員(外文):Fitness Fan ChenJian-Jung ChenFeng-Huei Lin
口試日期:2012-06-19
學位類別:碩士
校院名稱:國立臺北科技大學
系所名稱:材料科學與工程研究所
學門:工程學門
學類:材料工程學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:中文
論文頁數:69
中文關鍵詞:硫酸鈣二水磷酸鈣磷酸三鈣氫氧基磷灰石
外文關鍵詞:Calcium sulfateDihydrate calcium phosphateTricalcium phosphateHydroxyapatite
相關次數:
  • 被引用被引用:1
  • 點閱點閱:232
  • 評分評分:
  • 下載下載:20
  • 收藏至我的研究室書目清單書目收藏:0
人體骨骼主要的成分為鈣與磷,所以我們所使用的骨替代材為硫酸鈣及磷酸鈣,此兩種材料都具有良好的生物相容性。此種骨替代材的特性為植入人體骨缺損處後,鈣離子(Ca2+)會被人體所吸收且誘導新骨由此處形成,良好的骨替代材必須在人體內使骨誘導性及骨吸收性達成一種動態平衡。
而本實驗以硫酸鈣(CSD)為主,分別添加入二水磷酸鈣(DCPD)、磷酸三鈣(TCP)、氫氧基磷灰石(HA)以形成複合骨替代材。由於硫酸鈣具有良好的機械強度,置於人體內可以代替骨骼的支撐能力,所以用硫酸鈣做為我們試片的主要成分;為了讓鍵結力較強的硫酸鈣較慢被人體所吸收,所以我們添加了鍵結力較弱的磷酸鈣使其先被人體所吸收,使得孔洞產生及釋放出鈣離子,以達到骨誘導性的功能。
本實驗的重點著重於不同磷酸鈣之骨替代材的機械強度、孔隙率、降解速率的變化,且由SEM圖及XRD繞射解釋含有不同磷酸鈣之變化情形,接著做生物相容性(In Vitro試驗)實驗,如此才能選出優良的骨替代材。


The main ingredients of the human skeleton of calcium and phosphorus, so we use bone substitute materials for calcium sulfate and calcium phosphate, both materials have good biocompatibility. Such bone substitute material characteristics for the implantation of human bone defect, calcium ion (Ca 2 + )will be absorbed by the body and induce new bone formation by here, a good bone substitute material in the human body to bone induction and bone resorption to achieve a dynamic equilibrium.
In this experiment, the calcium sulfate (CSD) were added into the dihydrate calcium phosphate (DCPD), tricalcium phosphate (TCP), hydroxyapatite (HAP) to form a composite bone substitute material. Because CSD has a good mechanical strength, placed in the human body can replace bone support, so the main ingredient for our specimens with CSD; strong bonding force calcium sulfate was absorbed slowly by the body. Therefore, we add a weak bonding calcium phosphate to first by the human body absorption, making holes in the generation and release of calcium ions, in order to achieve the function of bone induction.
The experiment focuses on the different calcium phosphate bone substitute material mechanical strength, porosity, degradation rate changes, and explain the change of situation with different calcium phosphate by the SEM and XRD, and then do the biocompatibility (In Vitro test) experiment, in order to select a good bone substitute material.


摘要 i
ABSTRACT ii
誌謝 iv
目錄 v
表目錄 vii
圖目錄 viii
第一章 緒論 1
1.1 前言 1
1.2 研究背景 2
1.3 研究動機與目的 3
第二章 理論基礎與文獻回顧 4
2.1 生醫材料簡介 4
2.2 生醫植入材料分類 6
2.3 生醫陶瓷分類 8
2.3.1 惰性、近惰性生醫陶瓷 8
2.3.2 表面活性生醫陶瓷 8
2.3.3 可吸收性生醫陶瓷 9
2.4 半水硫酸鈣的製造與水合 10
2.5 三鈣磷酸鹽(TCP) 12
2.6 二水磷酸氫鈣(DCPD) 13
2.7 氫氧基磷灰石(HA) 13
2.8 模擬人工體液 15
2.9 沖提 (Eluted) 17
第三章 實驗方法 18
3.1 實驗藥品 18
3.2 實驗儀器 19
3.3 實驗流程圖 20
3.4實驗試片製備 20
3.5試片的檢測與分析 23
3.5.1體密度與孔隙率檢測 23
3.5.2機械性質檢測 25
3.5.3 掃描電子顯微鏡分析 26
3.5.4 EDS元素分析 26
3.5.5 XRD分析 27
3.6 降解實驗 28
3.7 生物相容性 30
3.7.1 LDH細胞毒性測試 30
3.7.2 WST-1細胞增生測試 31
第四章 結果與討論 33
4.1 SEM顯微分析 33
4.2 物理性質分析 40
4.3 材料機械性質 46
4.4 XRD繞射分析 48
4.5 降解試驗 52
4.5.1 試片降解試驗 52
4.5.2 顆粒大小降解試驗 56
4.5.3 孔隙率與降解率共同分析 57
4.6 生物相容性 58
4.6.1 細胞毒性LDH測試 58
4.6.2細胞增生 WST-1 測試 61
第五章 結論 65
參考文獻 66




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