跳到主要內容

臺灣博碩士論文加值系統

(3.229.142.104) 您好!臺灣時間:2021/07/27 04:10
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

我願授權國圖
: 
twitterline
研究生:蔡馨惠
研究生(外文):Shin-Hui Tsai
論文名稱:微奈米多孔陣列二氧化鈦薄膜之製程探討與應用研究
論文名稱(外文):Synthesis and applications of porous nano TiO2 array on titanium substrate
指導教授:楊永欽楊永欽引用關係
指導教授(外文):Yung-Chin Yang
口試委員:李志偉吳玉娟
口試委員(外文):Chih-Wei LiYu-Chuan Wu
口試日期:2012-06-13
學位類別:碩士
校院名稱:國立臺北科技大學
系所名稱:材料科學與工程研究所
學門:工程學門
學類:材料工程學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:中文
論文頁數:82
中文關鍵詞:中孔洞二氧化鈦氫氧基磷灰石
外文關鍵詞:MesoporousTiO2Hydroxyapatite
相關次數:
  • 被引用被引用:0
  • 點閱點閱:127
  • 評分評分:
  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:0
本研究中分成三個部份討論,第一部分為利用自組合成反應(Evaporation Induced Self Assembly)於鈦基板上合成中孔洞二氧化鈦薄膜,以三嵌段共聚塊界面活性劑產生之微胞作為模板,形成有機之自組裝體,以旋轉塗佈(spin-coating)於鈦基板上形成三維中孔洞結構之二氧化鈦薄膜;藉由有機界面活性劑(P123)與無機前趨物(TBOT)的含量改變對於孔洞形成的影響,熟化時間變化影響孔洞狀態和煆燒溫度作用下探討孔洞規則性。實驗結果顯示在熟化時間48小時,煆燒溫度250°C,對於中孔洞二氧化鈦長程序化之排列明顯提升;當P123/TBOT莫耳比為0.6,由SEM分析所形成二氧化鈦薄膜具有二維垂直通道之中孔洞形態,透過TEM觀察二氧化鈦薄膜橫截面明顯看到中孔洞之橫條紋;當莫耳比增加到0.9時(具有平行奈米通道之中孔洞二氧化鈦薄膜),TEM影像呈現為二維六方堆積排列中孔洞結構,透過電子繞射圖譜(Electron Diffraction patteren)證明莫耳比0.6和莫耳比0.9皆為多晶形態。
第二部分主要為體外試驗(in vitro)之分析,實驗結果顯示試片經由3天到28天之模擬體液浸泡,具有平行通道之二氧化鈦薄膜較佳氫氧基磷灰石骨生長之能力。第三部分利用水熱法於試片表面成長氫氧基磷灰石,實驗結果顯示於表面披覆二氧化鈦薄膜對於成長球狀六方晶氫氧基磷灰石有較佳成核能力。


In this study, we have three topics to discuss. First part is the preparation of mesoporous TiO2 was based on an evaporation induced self assembly (EISA) method using the Pluronic P123 as the structure-directing agent and the TBOT as the titanium source. Then,the three dimensional mesoporous titania thin film was prepared on the Ti substrate by the spin coating. A study amount on the basis of the interactions between inorganic-organic to form meso-structured composites.The reaction temperature is relatively order of mesostructure.The pore condition of mesoporous materials depend on the temperature changing of a micells. The result showns that aging time for 48 hrs and calcined at 250°C to synthesis the long range ordered mesoporous TiO2. By the SEM analysis, the ratio of P123/TBOT was 0.6 with two dimensional vertical channel shapes. And the TEM observation, it can clearly see the horizontal stripes by TiO2 thin film cross-section.When P123/TBOT was 0.9 (mesoporous TiO2 thin film with parallel channel), these results were confirmed by TEM, it reveals 2D-hexagonal arrangement mesoporous structure. And the electron diffraction patterns shows that the molar ratio of 0.6 and 0.9 are polycrystal.
Second part is in vitro bioactivity appraisement. The results shown that apatite was formed on the coating surface after immersion in simulated body fluid for 3 days to 28 days which indicates that the mesoporous film has the potential to chemical bonding with bone tissue.
Third part major discusses three parameters (mesoporous TiO2 thin film with vertical channel, parallel channel and pure titanium) to grow hydroxyapatite by hydrothermal method. The result shows that parallel channel mesoporous TiO2 thin film has better nucleation potential to grow hexagonal hydroxyapatite.


摘 要 i
ABSTRACT ii
致 謝 iv
目 錄 v
表 目 錄 vii
圖 目 錄 viii
第一章 緒論 1
1.1 前言 1
1.2 研究動機與目的 2
第二章 理論基礎與文獻回顧 3
2.1生醫材料 3
2.1.1生醫骨科材料 3
2.1.2二氧化鈦之簡介 5
2.1.3氫氧基磷灰石之介紹 7
2.2鈦金屬氧化薄膜合成之方法 9
2.2.1 以自組合成法製備中孔洞薄膜 9
2.2.2以陽極氧化處理在鈦金屬表面生成奈米管 16
2.3中孔洞奈米通道薄膜於各領域之應用 17
2.3.1生醫應用之浸泡模擬體液成長氫氧基磷灰石 18
2.3.2 半導體蝕刻 20
第三章 實驗方法與步驟 22
3.1實驗步驟和方法 22
3.1.1製備中孔洞二氧化鈦薄膜 22
3.1.2浸泡模擬體液成長氫氧基磷灰石 24
3.1.3以水熱法於成長氫氧基磷灰石 26
3.2 材料性質分析 27
第四章 結果與討論 31
4.1 中孔洞薄膜浸泡模擬體液成長氫氧基磷灰石 31
4.1.1 合成中孔洞二氧化鈦薄膜結構與分析 31
4.1.2 不同P123與TBOT之莫耳比對中孔洞薄膜影響 32
4.1.3 不同熟化時間對中孔洞二氧化鈦薄膜之影響 40
4.1.4 不同煆燒溫度對中孔洞二氧化鈦薄膜之影響 47
4.1.5 中孔洞二氧化鈦薄膜成長於鈦基板之TEM影像 54
4.1.6 中孔洞二氧化鈦薄膜經不同天數模擬體液浸泡 56
4.2利用水熱法於成長氫氧基磷灰石 72
4.2.1利用水熱法於成長氫氧基磷灰石之XRD分析 72
4.2.2利用水熱法於成長氫氧基磷灰石之SEM分析 74
第五章 結論 77
參考文獻 78


[1]鄭信忠,陳長志,謝家倫,蔡明宏,歐耿良,李勝揚,施永勳,鈦基植體表面生成奈米多孔性二氧化鈦層之機制研究,中華牙誌,2007,第26期,26–32
[2]鄭信忠,詹宗瑾,李勝揚,林哲堂,歐耿良,經電化學處理之鈦金屬表面奈米多孔性氧化層之研究,中華牙誌,2006,第25期,96–102
[3]吳玉祥,黃建瑋,水熱法合成氫氧基磷灰石之鈣磷比研究,中華科技大學學報,2010,第45期,1–14
[4]張家豪,利用模擬體液製程誘導金屬纖維表面生成類骨磷灰石之研究,博士論文,逢甲大學紡織工程研究所,94
[5]Yuan-Yuan Zhang, Jie Tao, Ying-Chun Pang, Wei Wang, Tao Wang, “Electrochemical deposition of hydroxyapatite coatings on titanium”, Trans. Nonferrous Met. SOC. China , 2006, 16, 633–637
[6]Fuping Wang, Tadao Shimizu, Kaoru Igarashi, Liancheng Zhao, “Formation of hydroxyapatite on Ti–6Al–4V alloy bymicroarc oxidation and hydrothermal treatment”, Surface & Coatings Technology,2005, 199,220–224
[7]Xianwu Zeng, Yong X. Gan, Evan Clark, Lusheng Su, “Amphiphilic and photocatalytic behaviors of TiO2 nanotube arrays on Ti prepared via electrochemical oxidation”, Journal of Alloys and Compounds ,2011,509,221–227
[8]B. Yanga, M. Uchidab,H. M. Kimc, X. Zhanga, T. Kokubo, “ Preparation of bioactive titanium metal via anodic oxidation treatment” ,Biomaterials,2004,25,1003–1010
[9]F. Xiao, K. Tsuru, S. Hayakawa, A. Osaka,“In vitro apatite deposition on titania film derived from chemical treatment of Ti substrates with an oxysulfate solution containing hydrogen peroxide at low temperature”,Thin Solid Films,2003 271–276
[10]H.M.Kim, F. Miyaji, T. Kokubo, S. Nishuguchi, T. Nakamura,”Grade surface structure of bioactive titanium prepared by chemical treatment”,J Biomed Mater, 1999,45,100–101
[11]I. B. Leonor, F. Balas, M. Kawashita, R. L. Reis, T. Kokubo, T. Nakamura, “Biomimetic Apatite Formation on Different Polymeric Microspheres Modified with Calcium Silicate Solutions”, Key Engineering Materials ,2006,18, 279–282
[12]A. Sepahvandia, F. Moztarzadeha, M. Mozafaria , M. Ghaffaria, N. Raee, “Photoluminescence in the characterization and early detection of biomimetic bone-like apatite formation on the surface of alkaline-treated titanium implant:State of the art” ,Biointerfaces,2011, 86,390–396
[13]H.M. Kim, T. Himeno, M.Kawashita, T. Kokubo and T. Nakamura, “The mechanism of biomineralization of bone-like apatite on synthetic hydroxyapatite: an in vitro assessment”, J. R. Soc. Interface ,2004,1,17–22
[14]Zhen-jun Wu, Jian-Min Yuan, Wen-Sheng Li,Yan-Qun Ren, Zong-Zhang Chen,“Formation and in vitro induction ability of apatite nanobelt coating on silicon”, Trans. Nonferrous Met. Soc. China, 2010 ,20,1916−1920
[15]魏強,楊巍,楊賢金,崔振鋒,Ti6Al4V表面生物陶瓷塗層設計與生物活性研究,功能材料,2007,第5期38卷,806-808
[16]S. Pallu, J.C. Fricain, R. Bareille, C. Bourget, M. Dard, A. Sewing, “Cyclo-Dfkrg peptide modulates in vitro and in vivo behavior of human osteoprogenitor cells on titanium alloys”, Acta Biomaterialia ,2009, 5, 3581–3592
[17]楊崇煒,水熱法與高溫後處理對電漿熔射氫氧基磷灰石塗層微觀組織及結合強度之效應,博士論文,國立成功大學材料科學及工程學系,94
[18]王毅,利用自組合成反應法合成中孔洞二氧化鈦之研究,碩士論文,元智大學化學工程與材料科學學系,96
[19]Takayuki Ban, Yusuke Tanaka, Yutaka Ohya, “Fabrication of titania films by sol–gel method using transparent colloidal aqueous solutions of anatase nanocrystals”, Thin Solid Films ,2011,1-6
[20]S.S. Lin, “Effect of substrate temperature on the properties of TiO2 nanoceramic films”, Ceramics International,2012,38,2461–2466.
[21]Chun-Hsien Huang, Yen-Tung Yang, Ruey-An Doong, “Microwave-assisted hydrothermal synthesis of mesoporous anatase TiO2 via sol–gel process for dye-sensitized solar cells”,Microporous and Mesoporous Materials ,2011,142,473–480
[22]維基百科,二氧化鈦結晶構造,http://zh.wikipedia.org/wiki
[23]施威任,奈米級氫氧基磷灰石之合成及燒結,博士論文,國立成功大學材料科學及工程學系,95
[24]Ho-Jun Song, Kyung-Ha Shin, Min-Suk Kook, Hee-Kyun Oh, Yeong-Joon Park , “Effects of the electric conditions of AC-type microarc oxidation and hydrothermal treatment solution on the characteristics of hydroxyapatite formed on titanium”, Surface & Coatings Technology, 2010,204, 2273–2278
[25]Maria Regina Tavares Filgueiras, Tsuneharu Ogasawara, “Hydrothermal nucleation of hydroxyapatite on titanium surface”, Journal of the European Ceramic Society,2002 ,22, 505–510
[26]Chengfeng Li, Shuguang Liu, Guochang Li, Jiahai bai, Weiwei Wang, Qingyang Du, “Hydrothermal synthesis of large-sized hydroxyapatite whiskers regulated by glutamic acid in solutions with low supersaturation of precipitation”, Advanced Powder Technology,2011, 22 , 537–543
[27]K. Ozekia, H. Aoki, T. Masuzawa, “Influence of the hydrothermal temperature and pH on the crystallinity of a sputtered hydroxyapatite film”, Applied Surface Science, 2010,256 ,7027–7031
[28]D.M. Liu, T. Troczynski, W.J. Yseng, “Water-based sol–gel synthesis of hydroxyapatite: process development”, Biomaterials,2001, 22,1721–1730.
[29]Y. Masuda, K. Matubara, S. Sakka, ”Synthesis of hydroxyapatite from metal alkoxides through sol gel technique”, Journal of the Ceramic Society of Japan 1990,98 ,1266–1277
[30]C. Jeffrey Brinker,Yunfeng Lu, Alan Sellinger, and Hongyou Fan,” Evaporation-Induced Self-Assembly : Nanostructures Made Easy** ”, Adv. Mater,1999, 11,579-585
[31]F. Hoffmann, M. Cornelius, J_rgen Morell, and M. Fr_ba ,“Silica-Based Mesoporous Organic–Inorganic Hybrid Materials”, Angewandte Chemie, 2006, 45, 3216–3251
[32]趙志欣,中孔洞二氧化鈦薄膜的合成與分析及其藥物釋放研究,碩士論文,國立交通大學,材料科學與工程系所,97
[33]賴映竹,具垂直通道之中孔洞氧化矽薄膜製備於基板與其性質研究,臺灣大學,化學研究所,99
[34]C. J. Brinker, “Sol-gel science:the physics and chemistry of sol-gel processing” , Harcourt Brace Jovanovich, Boston,1990,3-57
[35]吳嘉文,中孔洞奈米材料之孔洞方向控制及其應用,工業材料,2009,274,129-137
[36]S. Besson, T. Gacoin, C. Jacquiod, C. Ricolleau, D. Babonneaud and J.P. Boilot, ”Structural study of 3D-hexagonal mesoporous spin-coated sol-gel films”, Materials Chemistry,2000,10, 1331-1336
[37]Jia-Hong Pan, X.S. Zhao, Wan-In Lee, “Block copolymer-templated synthesis of highly organized mesoporous TiO2-based films and their photoelectrochemical applications.”, Chemical Engineering Journal , 2011,170 , 363–380
[38]Jun Wana, Yanb, Junjie Ding, Meng Wang, Kongcheng Hua, “Self-organized highly ordered TiO2 nanotubes in organic aqueous system”,, Materials Characterization,2009, 60 ,1534–1540
[39]M. Iyoshi, K.Y. Kim, A. Hozumi, H. Sugimura, O. Takai,”Spin casted mesoporous silica coatings for medical applications”, Thin Solid Films,2001,615–620
[40]D. Liu, K. Savino, M. Z. Yates, “Coating of hydroxyapatite films on metal substrates by seeded hydrothermal deposition”, Surface & Coatings Technology , 2011,205,3975–3986
[41]Shunsuke Tanaka, Junji Kaihara, Norikazu Nishiyama, Yoshiaki Oku, Yasuyuki Egashira, and Korekazu Ueyama, “Incorporation of Organic Groups within the Channel Wall of Spin-On Mesostructured Silica Films by a Vapor Infiltration Technique”, Langmuir ,2004, 20, 3780–3784
[42]T. Kokubo, Ito S, Z. T.Huang, Hayashi T., Sakka S., Kitsugi T., and Yamamuro T., “Ca, P-rich Layer Formed on High-strength Bioactive Glass-ceramic A-W”, J. Biomed. Mater,1990,24, 331-343
[43]Tadashi Kokubo, ”Aaptite Formation on Surface of ceramics, Metals and Polymers in Body Environment”, Acta mater, 1998,46, 2519-2527
[44]楊永欽,殘留應力對電漿熔射氫氧基磷灰石塗層與鈦鋁釩合金基材間結合強度之影響研究,國立成功大學,博士論文,材料科學及工程學系,91
[45]鄭信民,林麗娟,X 光繞射應用簡介,工業材料雜誌,2011,181
[46]白木靖寬,吉田貞史,薄膜工程學,全華,2009,47-48
[47]Shi-An Gao, Ai-Ping Xian, Li-Hua Cao, Rong-Cai Xie, Jian-Ku Shang,“Influence of calcining temperature on photoresponse of TiO2 film under nitrogen and oxygen in room temperature” , Sensors and Actuators , 2008 ,134, 718–726
[48]Hamid Oveisi , Norihiro Suzuki , Yoshihiro Nemoto , Pavuluri Srinivasu , Ali Beitollahi ,Yusuke Yamauchi,“Critical effect of aging condition on mesostructural ordering in mesoporous titania thin film”, Thin Solid Films,2010, 518 ,6714–6719
[49]Hui-suk Yun, Kuni-chi Miyazawa, Itaru Honma, Haoshen Zhou, Makoto Kuwabara,“Synthesis of semicrystallized mesoporous TiO2 thin films using triblock copolymer templates”,Materials Science and Engineering,2003,23, 487–494
[50]Hirokatsu Miyata, and Kazuyuki Kuroda,“Formation of a Continuous Mesoporous Silica Film with Fully Aligned Mesochannels on a Glass Substrate”, Chem. Mater,2000,12,49-54
[51]Yongsheng Wang, Meer Saiful Hassan, Poernomo Gunawan, Raymond Lau, Xin Wang, Rong Xu, “Polyelectrolyte mediated formation of hydroxyapatite microspheres of controlled size and hierarchical structure.”, Journal of Colloid and Interface Science ,339 ,2009,69-77
[52]梁伯潤,高分子物理學第二版,中國紡織出版社,52–53
[53]Jessica M. Williams, Adebisi Adewunmi, Rachel M. Schek, Colleen L. Flanagan, Paul H. Krebsbach, Stephen E. Feinberg, Scott J. Hollister, Suman Das, “Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering.”, Biomaterials ,2005,26,4817–4827


連結至畢業學校之論文網頁點我開啟連結
註: 此連結為研究生畢業學校所提供,不一定有電子全文可供下載,若連結有誤,請點選上方之〝勘誤回報〞功能,我們會盡快修正,謝謝!
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top