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研究生:游雅琇
研究生(外文):Ya-Hsiu Yu
論文名稱:2-胺基丙二醇改質醚型聚胺酯/多壁奈米碳管複合材料之製備、鑑定和生物相容性
論文名稱(外文):Synthesis , Characterization, and Biocompatibility of the Serinol-modified Polyurethane(Ether-typed)/Multi-walled Carbon Nanotube Composites
指導教授:王賢達王賢達引用關係
口試委員:陳建中黃豪銘
口試日期:2012-07-18
學位類別:碩士
校院名稱:國立臺北科技大學
系所名稱:有機高分子研究所
學門:工程學門
學類:化學工程學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:中文
論文頁數:111
中文關鍵詞:聚胺酯改質聚胺酯奈米碳管複合材料生物相容性
外文關鍵詞:PolyurethaneMulti-walled Carbon NanotubeBiocompatibility
相關次數:
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  • 下載下載:22
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本實驗以聚氧四亞基二醇(PTMO)和4,4’-二苯甲烷二異氰酸鹽(MDI)形成前驅物後,再以含保護基的2-胺基丙二醇(N-BOC-serinol)和1,4-丁二醇(1,4-butanediol)之混合溶液鏈延長合成改質PU,最後將其去活化接上氯醯化多壁奈米碳管形成改質聚胺基甲酸酯/多壁奈米碳管複合材料(MWNTs/PU)。

FTIR,NMR結果說明成功改質奈米碳管與改質PU的接枝。DSC與TGA結果顯示奈米碳管的添加,可提升材料的耐熱性。靜態接觸角測試數據顯示,奈米碳管添加量越高,MWNTs/PU親水性越佳。MWNTs/PU的表面電阻隨著奈米碳管添加量的增加降低。拉伸測試結果顯示,適量的加入奈米碳管可增強複合材之斷裂抗拉強度及楊氏模數,但斷裂延伸反而下降。

全血凝固動力試驗結果發現,相較於PU,全血在MWNTs/PU複材上較不易凝固,血液凝結測試也顯示加入適當量的MWNTs/PU的活化部份凝血質時間

(APTT)和凝血酶原時間(PT)是較長於PU,因此奈米碳管添加促成材料有較好的抗凝血特性。


Polytetramethylene oxide(PTMO) and 4,4’-diphenylmethane diisocyanide(MDI) with different molar ratios were used to synthesizing prepolymers. These products were chain-extended by N-BOC-serinol and 1,4-butanediol(BD) to form the modified polyurethane(PU). After the de-protection of BOC group of serinol, modified multi-walled carbon nanotubes (MWNTs) containing COCl groups were added to form chemically bonded composite (MWNTs/PU).

The chemical structures of intermediates and final products were confirmed by the FTIR and NMR methods. Decomposition temperature(5%wt loss) of MWNTs/PU was slightly higher than that of PU. Glass transition temperature and breaking tensile extension of MWNTs/PU were decreased upon increasing carbon nanotube loadings

in composites. Young’s modulus and surface electric resistivity were reduced by increasing carbon nanotubes content in MWNTs/PU.

Blood compatibility were tested with the whole blood clotting test and the blood coagulation methods. The results showed that the anticoagulation ability of MWNTs/PU was better than those of PU and the modified PU’s.


摘 要 i
ABSTRACT iii
目錄 vi
表目錄 ix
圖目錄 x
第一章 緒論 1
1.1前言 1
1.2研究動機 1
1.3研究方法 2
第二章 文獻回顧 3
2.1 聚胺酯 3
2.1.1 聚胺酯的結構與性質 3
2.1.2聚胺酯的合成 4
2.1.3聚胺酯的改質 5
2.2 奈米碳管 7
2.2.1奈米碳管的發現 7
2.2.2奈米碳管的改質 7
2.2.3奈米碳管官能基之鑑定(反滴定法) 8
2.3 改質奈米碳管/聚胺酯複合材料 9
第三章 實驗 15
3.1 實驗藥品 15
3.2 實驗器材 22
3.3實驗儀器及檢測方法 24
3.3.1核磁共振儀 (Nuclear Magnetic Resonance Spectroscopy,NMR) 24
3.3.2凝膠滲透層析儀(Gel Permeation Chromatogrphy,GPC) 25
3.3.3示差掃描熱分析儀( Diffterential Scanning Calorimetry,DSC) 26
3.3.4熱重損失分析儀(Thermogravimetric Analyzer,TGA) 27
3.3.5傅立葉轉換紅外線光譜儀(Fourier Transformation Infrared Spectrophotometer,FTIR) 28
3.3.6 接觸角測量儀(Contact -Angle Meter) 29
3.3.7粒徑分析儀(Quasielastic Light Scatteing) 30
3.3.8 超絕緣儀(Super Megohmmeter) 30
3.3.9 萬能材料試驗機 31
3.3.10反滴定法(Boehm’s method) 32
3.3.11全血凝固測試(The Whole Blood Clotting Test) 33
3.3.12血液凝固分析 33
3.3.13細胞毒性測試 35
3.4 奈米碳管的純化與改質 36
3.4.1奈米碳管的純化 36
3.4.2奈米碳管的酸化 36
3.4.3奈米碳管的氯醯化 36
3.5聚胺酯合成 38
3.5.1 實驗藥品前處理 38
3.5.2改質聚胺酯的合成 38
3.5.3改質聚胺酯/多壁奈米碳管複合材料製備 39
第四章 結果與討論 41
4.1 純化及改質奈米碳管鑑定 41
4.1.1 粒徑分析 41
4.1.2官能基之鑑定(反滴定法) 41
4.1.3 FTIR鑑定分析 42
4.2 改質聚胺酯/多壁奈米碳管複合材料鑑定 43
4.2.1 FTIR鑑定 43
4.2.2 1H NMR鑑定 46
4.2.3 GPC分析 50
4.2.4 DSC分析 51
4.2.5 TGA分析 52
4.2.6 靜態接觸角分析 53
4.2.7 機械性質拉伸測試 54
4.2.8 表面電阻測試 57
4.3 生物相容性測試 58
4.3.1 全血凝固動力試驗 58
4.3.2 血液凝固測試 60
4.3.3 細胞毒性測試 62
第五章 結論 63
參考文獻 64
附錄A 70
附錄B 73
附錄C 75
附錄D 78
附錄E 83
附錄F 87
附錄G 94
附錄H 101
附錄I 103
附錄J 106
附錄K 108


[1]S. Iijima, “Helical microtubules of graphitic carbon” Nature, Vol.354, 1991, p.p 56.

[2]C. Hepburn, “Polyurethane elastomers” Applied Science, Vol.402, 1982.

[3]M.V. Pandya, D.D. Seshande, D.G. Hundiwale, “Effect of diisocyanate structure on viscoelastic, thermal, mechanical and electrical properties of cast polyurethanes” J. Appl. Poly. Sci., Vol.32, 1986, p.p 4959.

[4]W.C. John, V. Bograt, A. lilaontkul, L.E. Lernerm S.L. Cooper, “Morphology and properties of short segment block copolymers” J. Macromol. Sci. Part B Phys., Vol.17, 1980, p.p 267.

[5]顏明雄、張昌榮,「聚氨基甲酸酯(PU)之組成構造對其成型薄膜及加工織物物性之影響」,化學技術,第十三卷,第三期,p.p 167-182.

[6]J.C. Smith, M.C. Davier, C.D. Melia, S.P. Denyer, M.R. Derrick, “Uptake of drugs by catheters: the influence of the drug molecule on sorption by polyurethane catheters” Biomaterials, Vol.17, 1996, p.p 1469-1472.

[7]K.A. Woodhouse, P. Klement, V. Chen, M.B. Gorbet, F.W. Keeley, R. Stahl, J.D. Fromstein, C.M. Bellingham, “Investigation of recombinant human elastin polypeptides as non-thrombogenic coatings” Biomaterials, Vol.25, 2004, p.p

4543-4553.

[8]M.T. Khorasani, S. Shorgashti, “Fabrication of microporous polyurethane by spray phase inversion method as small diameter vascular grafts material” J. Biomed. Mater. Res. Part B, Vol.77A, 2006, p.p 253-260.

[9]J. Rickerby, R. Prabhakar, A. Patel, J. Knowler, S. Brocchini, “A biomedical library of serinol-derived polyesters” J. Controlled Release, Vol.101, 2005, p.p 21-34.

[10]D. Park, W. Wu, Y. Wang, “A functionalizable reverse thermal gel based on a polyurethane/PEG block copolymer” Biomaterials, Vol.32, 2011, p.p 777-786.

[11]P.M. Ajayan, O. Stephen, C. Colleix, DTrauth, “Aligned carbon nanotube arrays formed by cutting a polymer resin-nanotube composite” Science, Vol.1994, p.p 1212.

[12]A. Oberun, M. Endo, “Filamentous growth of carbon through benzene decomposition” J. Cryst. Growth, Vol.32, 1976, p.p 335-349.

[13]S.C. Tsang, P.J.F. Harris, M.L.H. Green, “Thinning and opening of carbon nanotubes by oxidation using carbon dioxide”, Nature, Vol.362, 1993, p.p 520.

[14]P.M. Ajayan, T.W. Ebbesen, T. Ichinashi, S. Iijima, K.Tanigaki, H. Hiura, “Opening carbon nanotubes with oxygen and implications for filling” Nature, Vol.362, 1993, p.p 522.

[15]S.C. Tsang, T.W. Chen, P.J.F. Harrie, M.L.H .Green, “A simple chemical method of opening and filling carbon nanotubes” Nature, Vol.372, 1994, p.p 159.

[16]J. Liu, A.G. Rinzler, H. Dai, J.H. Hafner, R. Kelley Rradley, P.J. Boul, A. Lu, T. Iversonm, K. Shelimov, C.B. Huffman, F.R. Macias, Y.S. Shon, T.R. Lee, D.T. Cokbert, R.E. Smalley, “Fullerene pipes” Science, Vol.280, 1998, p.p 1253.

[17]C. Kahattha, P. Woointranont, T. Chodjarusawad, W. Pecharapa,“Study of acid-treated multiwall carbon nanotubes by electron microscopy and raman spectroscopy” Journal of the Microscopy Society of Thailand, Vol.24, 2010, p.p 133-135.

[18]Y. H. Li, S. Wang, Z. Luan, D. Ding, C. Xu, D. Wu, “Adsorption of cadmium(II) from aqueous solution by surface oxidized carbon nanotubes” Carbon, Vol.41, 2003, p.p 1057-1062.

[19]H.P. Boehm, “Surface oxides on carbon and their analysis: a critical assessment” Carbon, Vol.41, 2002, p.p 145-149.

[20]L.V. Karabanova, R.L.D. Whitby, A. Korobeinyk, O. Bondaruk, J.P. Salvage, A.W. Lloyd, S.V. Mikhalovsky,“Microstructure changes of polyurethane by inclusion of chemically modified carbon nanotubes at low filler content” Compos. Sci. Technol., Vol.72, 2012, p.p 865-872.

[21]J. Chen, A.M. Rao, S. Lyuksyutov, M.E. Itkis, M.A. Hamon, H. Hu, R.W. Cohn,


P.C. Eklund, D.T. Colbert, R.E. Smelley, R.C. Haddon, “Dissolution of full-length single-walled carbon nanotubes”J. Phys. Chem. B, Vol.105, 2001, p.p 2525.

[22]J.L. Bahr, J. Yang, D.V. Kosynkin, M.J. Bronikowski, R.E. Smalley, J.M.Tour, “Functionalization of carbon nanotubes by electrochemical reduction of aryl diazonium salts: A bucky paper electrode” J. Am. Chem. Soc., Vol.123, 2001, p.p 6536-6542.

[23]G. Wei, S. Saitoh, H. Saitoh, K. Fujiki, T. Yamauchi, N. Tsubokawa, “Grafting of polymers onto vapor grown carbon fiber surface by ligand-exchange reaction of ferrocene moieties of polymer with polycondensed aromatic rings of the wall-surface” Polymer, Vol.45, 2004, p.p 8723–8730.

[24]H. Deka, N. Karak, R.D. Kalita, A.K. Buragohain, “Biocompatible hyperbranched polyurethane/multi-walled carbon nanotube composites as shape memory materials” Carbon, Vol.48, 2010, p.p 2013–2022.

[25]M. Xu, T. Zhang, B. Gu, J. Wu, Q. Chen, “Synthesis and properties of novel polyurethane-urea/multi-walled carbon nanotube composites” Macromolecules, Vol. 39, 2006, p.p 3540-3545.

[26]J. Kwon, H. Kim, “Comparison of the properties of waterborne polyurethane/ multi-walled carbon nanotube and acid-treated multi-walled carbon nanotube composites prepared by in situ polymerization”, J. Polym. Sci. Part A: Polym.


Chem., Vol.43, 2005, p.p 3973–3985.

[27]C.H. Lee, J.Y. Liu, S.L. Chen, Y.Z. Wang, “Miscibility and properties of acid-treated multi-walled carbon nanotubes/polyurethane nanocomposites” Polym. J., Vol.39, 2007, p.p138–146.

[28]H. Xia, M. Song, “Preparation and characterization of polyurethane–carbon nanotube composites” Soft Mater., Vol. 1, 2005, p.p 386–394.

[29]H.C. Kuan, C.C.M. Ma, W.P. Chang, S.M. Yuen, H.H. Wu, T.M. Lee, “Synthesis, thermal, mechanical and rheological properties of multiwall carbon nanotube/waterborne polyurethane nanocomposite” Compos. Sci. Technol., Vol. 65, 2005, p.p 1703–1710.

[30]S. Mondal, J.L. Hu, “Thermal degradation study of functionalized MWNT reinforced segmented polyurethane membrane” J. Elastomers Plast., Vol. 38, 2006, p.p 261-271.

[31]M. Raja, A.M. Shanmugharaj, S.H. Ryu, "Influence of surface functionalized carbon nanotubes on the properties of polyurethane nanocomposites" Soft Materials, Vol.6, 2008, p.p 65–74.

[32]J. Meng, H. Kong, H.Y. Xu, L. Song, C.Y. Wang, S.S. Xie, “Improving the blood compatibility of polyurethane using carbon nanotubes as fillers and its implications to cardiovascular surgery” J Biomed Mater Res A, Vol. 74, 2005, p.p 208–214.

[33]J. Xiong, Z. Zheng, X. Qin, M. Lin, H. Li, X. Wang, “The thermal and mechanical properties of a polyurethane/multi-walled carbon nanotube composite” Carbon, Vol.44, 2006, p.p 2701-2707.

[34]S. Murugesan, T.J. Park, H. Yang, S. Mousa, R.J. Linhardt, “Blood compatible carbon nanotubes - nano-based neoproteoglycans” Langmuir, Vol. 22, 2006, p.p 3461-3463.

[35]陳睿瑾,化學改質奈米碳管/醚型聚胺酯複合材料合成鑑定及生物相容性,碩士學位,台北科技大學有機高分子所,台北市,2010。

[36]陳敏麗,燕翔,陳麗華,陳亭儒,簡淑慧,曾明月,吳秋燕,林梅香,何昭
中,蔡青青,張薰榕,黃人珍,趙莉芬,王瑜欣,李玉秀,姜如珊,張玉珠,范君瑜,袁光霞,王埩,最新實用內外科護理學,台北:永大書局股份有限公司,2005,第3-11頁。


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