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研究生:潘惟綺
研究生(外文):Wei-Chi Pan
論文名稱:開發分析染髮劑中含有醫療或劇毒成分之水相HPLC方法
論文名稱(外文):Development and analysis in hair dye containing medical or toxic components of the aqueous phase HPLC method
指導教授:華國媛華國媛引用關係
指導教授(外文):Kuo-Yuan Hwa
口試委員:董崇民張淑美
口試委員(外文):Trong-Ming DonSui-Mei Chang
口試日期:2012-07-29
學位類別:碩士
校院名稱:國立臺北科技大學
系所名稱:有機高分子研究所
學門:工程學門
學類:化學工程學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:中文
論文頁數:56
中文關鍵詞:染髮劑致癌高效液相層析法毒性
外文關鍵詞:Hair DyeCarcinogenicHPLCToxicity
相關次數:
  • 被引用被引用:0
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  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:1
市面上最廣泛使用的染髮劑為永久性染髮劑,而永久性染髮劑裡的主要成分屬於芳香胺類,最常見的為對苯二胺(p-Phenylenediamine, PPD)則是國際上所公認的致癌物質。本研究的主要目的為建立一便利性、有效性及環境友善之水相高效液相層析法(HPLC)以分析染髮劑成份,以單管移動相方法可同時定量及定性分析多成分永久性染髮劑 : m-aminophenol、resorcinol、2-methylresorcinl及sodium picramate,相較於以往利用梯度溶離方法,此方法更便利,分析時間短且使用溶劑少;而且樣品響應值與濃度呈良好線性關係,R2最佳可達1.000。將此分析方法應用於數種市售永久性染髮劑,結果顯示其成份含量符合台灣食品與藥物管理局之規範值。本研究開發的分析方法可提供消費者檢驗染髮劑以自行確認其安全性。

The most widely used hair dye in the market is permanent hair dye which contains various aromatic amines as its main ingredients. The most common one is p-phenylenediamine (PPD) which is internationally recognized as a carcinogen. The purpose of this study is to establish a convenient, effective and environmentally-friendly analytical method based on a high-performance liquid chromatography (HPLC) with a single-tube aqueous mobile phase for the analysis of multi-components in the permanent hair dye both qualitatively and quantitatively, including m-aminophenol, resorcinol, 2-methylresorcinl and sodium picramate. Compared to the conventional gradient-elution method, the method developed herein is more convenient with shorter analytical time and less solvents. In addition, the response changes with the concentration in a perfect linear relationship with the R2 value up to 1.000. When applied to the analysis of several commercially available permanent hair dyes, the concentrations of the ingredients were in accordance with the specifications of the Taiwan Food and Drug.

中文摘要 i
英文摘要 ii
誌謝 iii
目錄 iv
表目錄 vi
圖目錄 vii
第一章 緒論 1
第二章 文獻研究 4
2.1 染髮劑的種類 4
2.1.1 暫時性染髮劑 4
2.1.2 漸進式染髮劑 5
2.1.3 半永久性染髮劑 5
2.1.4 永久性染髮劑 6
2.2 染髮劑對人體的健康危害 11
2.2.1 膀胱癌 11
2.2.2 淋巴癌 11
2.2.3 白血病 12
2.2.4 對皮膚的影響 12
2.3 各國對於染髮劑之成分規範 13
2.3.1 各國對於染髮劑之成分限量 13
2.4 染髮劑成分檢驗方法文獻彙整 19
第三章 實驗材料及方法 25
3.1 材料與試劑 25
3.2 器材與儀器 26
3.3 實驗方法 27
第四章 結果與討論 30
4.1 標準品層析圖之滯留時間 30
4.2 標準品各成分之層析圖與檢量線 32
4.3 市售染髮劑之檢測 38
4.3.1 市售染髮劑編號A之結果 38
4.3.2 市售染髮劑編號B之結果 39
4.3.3 市售染髮劑編號C之結果 41
第五章 結論與建議 43

參考文獻 44
附錄 47
A MSDS物質安全資料表 47
B市售樣品各成分含量結果計算 53
C名詞解釋 54



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