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研究生:李嘉宜
研究生(外文):Jia-Yi Li
論文名稱:跑步運動對theta波之影響及其應用
論文名稱(外文):Effects of Running Exercise on Theta Rhythm and Its Applications
指導教授:郭博昭郭博昭引用關係楊靜修楊靜修引用關係
指導教授(外文):Terry B J KuoCheryl C H Yang
學位類別:博士
校院名稱:國立陽明大學
系所名稱:腦科學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:2012
畢業學年度:100
語文別:中文
論文頁數:104
中文關鍵詞:theta波腦波身體活動力滾輪運動跑步機運動
外文關鍵詞:theta rhythmEEGphysical activitywheel runningtreadmill running
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本論文建立一個新的實驗模式可同步記錄運動中的腦波圖 (electroencephalogram, EEG)、肌電圖 (electromyogram, EMG)、心電圖 (electrocardiogram, ECG) 及三軸向加速度等訊號,藉此探討運動對區別睡醒的腦波、心跳及活動力之影響。儘管已有許多文獻廣泛探討過運動對於生理功能之影響,但運動對心理功能之影響尚未清楚。已知theta 波與學習、記憶、運動及感覺運動整合有關,但是針對老化、速度及不同運動模式之影響及差異目前仍不清楚。為了探討運動對生理及心理功能之綜合影響,本論文以運動引發大鼠theta波為主軸,其目的分成四部分:(1) 運動是否可依照EEG反應而分期;(2) 運動速度與海馬迴theta波之關係;(3)是否能透過生理訊號測量區分動物進行強迫性運動與自主性運動;(4) 探討老化鼠是否有較低的theta波基礎值及其運動引起之theta波是否較弱。所有實驗使用8或60週齡之Wistar-Kyoto公鼠進行跑步機或滾輪運動並記錄訊號。第一部分結果,跑步機運動可以根據海馬迴theta頻率及振幅分成兩期,分別是初始期及維持期,兩期有不同生理反應。第二部分結果,發現只在滾輪運動初始期,運動速度才會與theta波頻率成正相關。第三部分結果,發現滾輪運動及跑步機運動的起跑過程各訊號變化都不一樣,且在相同速度及運動心跳下,兩種運動模式的心跳變化量與9.5到12 Hz的theta波活性存在顯著正相關。第四部分結果,發現運動造成腦波中theta 功率的顯著增加,但會降低delta功率,且與年輕大鼠相比,中年大鼠有較低的theta功率基礎值及對運動的反應較弱。藉由本論文所建立自由活動大鼠之運動模式,可提供許多運動產生之theta波研究的相關資訊,並藉此了解動物運動狀態下的身心理狀態。
This study establised a novel experimental model that records electroencephalogram (EEG), electromyogram (EMG), electrocardiogram (ECG), and 3-dimensional acceleration simultaneously to explore the effects of exercise on EEG, heart rate, and physical activity after distinghlishing sleep/wake status. While the effect of exercise on physical functions has been extensively explored, the effect of exercise on mental functions is still unclear. The theta rhythm is related to learning, memory, movement, and sensorimotor integration, and there is a great deal of study on locomotion induced theta. However, there is still contradictory on the effects of running speed, aging, and exercise model. To explore the integrative effects of exercise on mental and physical functions, this study investigated locomotion induced-theta (LIT) principally and the specific aims are therefore fourfold: (1) to determine whether a treadmill exercise can be classified into different stages according to the EEG response, (2) to explore the relationship between movement speed and hippocampal theta rhythm, (3) to determine whether forced exercise can be discriminated form voluntary exercise by physiological signals, and (4) to determine whether aging causes a lower baseline level and/or show a lower response to exercise. The experiments were carried out on 8 or 60 weeks old male Wistar-Kyoto rats which performed treadmill or wheel running with physiological signals recording. The results indicated, firstly, treadmill running can be classified into two stages, namely initiation and maintenance, according to the frequency and amplitude of the hippocampal theta waves. Secondly, running speed is positively correlated with the theta frequency only at the preparation and initiation of wheel running. Thirdly, the changes of all signals as the inital running are different in wheel and treadmill running. Under the same speed and exercise heart rate, the heart rate change is positively correlated with the theta power of 9.5 to 12 Hz in both two exercise models. Finally, treadmill exercise promptly elevated EEG theta power but suppressed delta power. As compared to young rat, middle-aged rats had a lower baseline theta power and a lower response to treadmill exercise. Because of establishing the experimental model for recording freely moving rat, this study can provide more information on LIT and the physical-psychological status of animal during exercise.
目錄 i
誌謝 v
中文摘要 vi
英文摘要 vii
第壹章 前言 1
第貳章 文獻探討 3
第一節、運動對大腦之影響 3
第二節、Theta波 4
一、海馬迴theta波 4
二、Theta波產生的相關腦區 4
三、Theta波的分類與頻率範圍 5
第二節、運動與theta波 6
一、運動產生的theta波 6
二、感覺動作整合模式 6
三、運動過程中theta波、心理狀態及運動分期 6
四、速度對運動引起之theta波之影響 7
第三節、自主性運動與強迫性運動之差異 8
第四節、老化對theta波之影響:運動之介入 8
第五節、緣起:運動過程中電生理訊號記錄之困難及方法之建立 9
第六節、以動物模式來研究運動議題的重要性 10
第参章 研究問題與目的 11
第肆章 重要性 13
第伍章 研究方法 15
第一節、實驗動物 15
第二節、EEG、EMG及ECG電極植入手術 15
第三節、動物運動模式 16
第四節、實驗流程及設計 16
一、定速跑步機運動初始期及維持期時海馬迴theta波之變化 16
二、自主性滾輪運動過程中海馬迴theta波之變化及與運動速度之關係 17
三、比較自主性滾輪運動與強迫性定速跑步機運動 17
四、老化對定速跑步機運動引起的theta波活性之影響 18
第五節、資料收集 18
一、有線系統資料收集 18
二、無線系統資料收集 19
第六節、資料分析 19
一、EEG及EMG訊號分析 19
二、Theta 波分析 20
三、睡眠分期 20
四、ECG訊號分析 20
五、ECG訊號頻域分析 21
六、頻譜分析判讀 21
七、身體活動力分析 22
八、滾輪速度分析 22
第七節、電極位置確定 22
第八節、統計分析 22
第陸章 結果 24
第一節、定速跑步機運動初始期及維持期時海馬迴theta波之變化 24
一、運動初期 24
二、運動維持期 25
第二節、自主性滾輪運動過程中海馬迴theta波之變化及與運動速度之關係 27
一、自主性滾輪運動準備-初始期 27
二、不考量運動時間的先後順序下 28
第三節、比較自主性滾輪運動與強迫性定速跑步機運動 30
一、相同身體活動力 31
二、相同運動速度 31
三、相同心跳速率 33
第四節、老化對定速跑步機運動引起的theta波活性之影響 35
一、清醒基礎值 35
二、運動過程中 35
三、中老年大鼠有較少與運動相關之theta波功率改變 36
第柒章 綜合討論 37
第一節、定速跑步機運動初始期及維持期時海馬迴theta波之變化 37
第二節、自主性滾輪運動過程中海馬迴theta波之變化及與運動速度之關係 41
第三節、比較自主性滾輪運動與強迫性定速跑步機運動 44
第四節、老化對定速跑步機運動引起的theta波活性之影響 49
第五節、總結 53
第六節、本論文的應用價值 54
第七節、未來展望 54
第八節、本論文的限制 55
第捌章 近期研究工作及規劃 56
參考文獻 57
附圖 72
論文相關著作 104


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