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研究生:葉家碩
研究生(外文):Chia-Shuo Yeh
論文名稱:次氯酸鈉沖洗液於診間環境下其儲放方式與濃度變化的關係
論文名稱(外文):The relationship between ways of storage in clinics and concentration change of sodium hypochlorite irrigating solutions
指導教授:涂明君涂明君引用關係
指導教授(外文):Ming-Gene Tu
學位類別:碩士
校院名稱:中國醫藥大學
系所名稱:牙醫學系碩士班
學門:醫藥衛生學門
學類:牙醫學類
論文種類:學術論文
論文出版年:2013
畢業學年度:101
語文別:中文
論文頁數:53
中文關鍵詞:次氯酸鈉沖洗液
外文關鍵詞:sodium hypochloriteirrigating solutions
相關次數:
  • 被引用被引用:6
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  • 下載下載:86
  • 收藏至我的研究室書目清單書目收藏:0
次氯酸鈉於現代根管治療學當中是最重要的沖洗溶液,除了極佳的殺菌消毒功用之外,亦有不錯的溶解組織之功效;然而次氯酸鈉是一個強氧化劑,本身性質極度不穩定,其效能主要取決於溶液當中「有效氯」的濃度。所謂的有效氯(Available chlorine)乃是指次氯酸鈉水溶液中所有具有氧化的次氯酸與次氯酸根離子之總和。有效氯的濃度會隨著時間、光線照射、加熱、接觸空氣、有機物消耗、金屬或金屬離子的影響,而產生降解。因此在診間盛放的次氯酸鈉溶液有可能因周遭環境的影響導致濃度發生改變,進而影響根管治療時沖洗的效能。
本研究旨在模擬現有牙科臨床環境與一般盛放次氯酸鈉的方式,依不同變因的改變,使用硫代硫酸鈉與碘化鉀來進行碘滴定法,以觀察分裝後次氯酸鈉沖洗液之濃度變化。
實驗結果顯示,四週過後,接受光線照射並且與空氣接觸的次氯酸鈉有效氯濃度衰退最多(-62.63%),其次是與空氣接觸但無光線影響的組別(-53.46%),再者為受光線影響但限制與空氣接觸的組別(-23.26%),不受光線空氣干擾的次氯酸鈉其有效氯僅衰退-4.65%,經檢驗確實有顯著差異。
是以,次氯酸鈉的有效氯濃度會因為時間而產生衰減,並且光線照射與空氣接觸都將會加快次氯酸鈉濃度衰減的速率。因此,建議於診間使用時應盛放於褐色瓶中防止光線照射,並且應蓋上避免長時間與空氣接觸。


Sodium hypochlorite is the most important irrigant in modern endodontology because of its well-known antimicrobial effect and tissue-dissolving activity. However, sodium hypochlorite is an unstable chemicals for being a strong oxidizers . The activity of sodium hypochlorite depends on the concentration of available chlorine. The available chlorine is the sum of the concentrations of HOCl and OCl- in sodium hypochlorite solution. Its concentration would be changed by time, light, heat, air, organic, metals and metallic ions. Therefore, the sodium hypochlorite stored in the clinic could be interfered by the surroundings. Its change in concentration may affect the efficacy of irrigation during root canal treatment.
This study is to simulate the ways of storing the sodium hypochlorite on the table in dental clinics, to observe the change in concentration in different situations by using iodometric titration.
The result revealed : 4 weeks later, G1 group ( exposed to light without coverage ) showed greatest regression in concentration of available chlorine (-62.63%), followed by G3 group ( stored in darkness without coverage ) -53.46%, G2 group (exposed to light with coverage ) -23.26%, and G4 group ( stored in darkness with coverage ) -4.55%. The analysis showed significant difference( p<0.05 ) between G1 v.s. G4, G3 v.s. G4 and G2 v.s. G4.
Thus, the concentration of sodium hypochlorite would be regressed as time goes by. Exposing to light and contacting with air would speed the rate of degradation of available chlorine in sodium hypochlorite. For this reason, we recommend the sodium hypochlorite should be kept in brown bottle to prevent the effect of light. Besides, proper coverage would enhance the stability of sodium hypochlorite.


目錄
I. 中文摘要 1
II. 英文摘要 2
III. 序言或誌謝辭 4
IV. 目錄 5
V. 圖表目錄 7
VI. 正文 8
VII. 圖表 41
VIII.參考文獻 45
IX.附錄 47
第一章 前言 8
第一節研究背景 8
一、口腔內微生物與根管感染 8
二、理想的根管沖洗液 9
三、次氯酸鈉的介紹 11
四、次氯酸鈉的組織溶解能力 13
五、次氯酸鈉的殺菌能力 16
六、次氯酸鈉沖洗液濃度的選擇 18
七、影響次氯酸鈉殺菌效能之因素 20
八、如何量測次氯酸鈉的濃度 21
第二節 研究目的 24
第二章 研究方法 26
第一節 研究材料 26
一、實驗材料 26
二、實驗藥品試劑 26
三、實驗器材儀器 26
第二節 研究設計 27
一、實驗架構設計與使用原理 27
二、實驗方程式計算公式 29
三、實驗流程 30
四、實驗分組 32
第三節 統計方法 33
第三章 研究結果 34
第四章 討論 35
第一節 實驗設計討論 35
一、標定硫代硫酸鈉標準溶液的討論 35
二、標定次氯酸鈉有效氯濃度的討論 35
第二節 實驗結果討論 37
第五章 結論與建議 40
第一節結論 40
第二節建議 40


圖表目錄
頁次
表一、實驗結果。 41
表二、統計檢定分析。 42
圖一、相對於第 0 週不同環境
下次氯酸鈉有效氯濃度的衰減狀況。 43
圖二、不同環境下次氯酸鈉有效氯隨時間衰
減的情況。 44
圖三、不同環境下次氯酸鈉有效氯衰退速率
之比較。 44

附錄
一、硫代硫酸鈉標準溶液之標定數據。 47
二、次氯酸鈉有效氯之標定數據。 48


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