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研究生:陳湘玲
研究生(外文):Xiang-Ling Chen
論文名稱:洋車前子殼纖維介入對於心血管疾病風險相關之體位變化及血液生化值之探討
論文名稱(外文):Effect of psyllium husk fiber on risk factor of cardiovascular disease: anthropometric data and specific biomarkers
指導教授:翁玉青翁玉青引用關係
學位類別:碩士
校院名稱:中山醫學大學
系所名稱:營養學研究所
學門:醫藥衛生學門
學類:營養學類
論文種類:學術論文
論文出版年:2013
畢業學年度:101
語文別:中文
論文頁數:108
相關次數:
  • 被引用被引用:1
  • 點閱點閱:498
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  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:0
美國膳食協會指出膳食纖維不僅有助於維護健康、預防疾病,更可當作一種醫學營養治療。已有證據顯示補充水溶性膳食纖維可有效改善心血管疾病相關指標因子及體重控制;水溶成分越高其黏稠力也隨之增加,並能有效地降低血脂濃度。洋車前子殼所含的水溶性纖維高達70%。本研究主要之目的為探討補充洋車前子殼纖維後,對於心血管疾病相關之血液生化值及體位之影響。本研究為平行、隨機及單盲試驗;並採用洋車前子殼純化粉末作為介入品,研究為期12週;招募對象為過重或肥胖者(BMI≥24),兩組每日介入劑量皆為7公克。有效樣本洋車前子殼組17人,安慰劑組16人。結果發現:洋車前子殼纖維介入後之熱量攝取、體重、身體質量指數、腰圍周長均有顯著性減少(p <0.05);總膽固醇與低密度脂蛋白膽固醇濃度有顯著性降低(p <0.05),高密度脂蛋白膽固醇濃度也有顯著性增加(p <0.05)。 TC/HDL-C與LDL-C/HDL-C比值則同為顯著性下降(p <0.05)。研究結論為每日補充7公克洋車前子殼纖維有助於降低體重、腰圍及身體質量指數並改善體內血膽固醇濃度;積極減重及控制血脂濃度,可能有效降低罹患心血管疾病之風險。

The Academy of Nutrition and Dietetics had demonstrated the benefits of dietary fiber in health maintenance, disease prevention and as a component for medical nutrition. There are evidences showed that soluble fiber might reduce the risk factors predicting cardiovascular disease and beneficial in weight control. The greater the solubility of a dietary fiber will perform greater viscosity and show a good effect in lowering serum cholesterol. Psyllium husk contains about 70% soluble fiber. The purpose of this study is to observe the effect of psyllium husk on the risk factor of cardiovascular disease: the value of biomarkers and body weight. This is a parallel, single-blinded randomized controlled trial by adding high purity psyllium husk into the normal diet of the overweight people (BMI≥24) for twelve weeks. Seventeen subjects are categorized into psyllium group and 16 subjects into placebo group while 7 gram of psyllium or placebo was included in their daily diet. Intake of psyllium for 12 weeks resulted a significant decrease in calorie intake, body weight, BMI and waist length (P<0.05); a significant decline in the level of total serum cholesterol and low-density lipoprotein cholesterol. Moreover, the level of high-density lipoprotein cholesterol was elevated (P<0.05) and the ratio of TC/HDL-C and LDL-C/HDL-C showed significant decrease (P<0.05). In conclusion, intake of 7 gram of psyllium husk will reduce the body weight, waist length and BMI and it help in controlling the level of serum cholesterol. In addition, the loss of body weight and good control of lipid profile can help in reduce the risk of cardiovascular disease.

中文摘要 I
英文摘要 III
圖表目錄 VII

第一章 緒論 1
第一節 研究動機 1
第二節 研究目的 6
第三節 研究問題 7
第四節 名詞界定 8
第二章 文獻探討 9
第一節 心血管疾病之流行病學 9
第二節 心血管疾病之致病機轉(病理過程) 12
第三節 心血管疾病之危險因子及預防方法 14
第四節 膳食纖維介入後對於心血管疾病之成效 24
第三章 研究方法 30
第一節 研究設計與流程 30
第二節 研究對象 34
第三節 研究工具 37
第四節 資料分析統計 41
第四章 研究結果 44
第一節 受試者基本資料分析 44
第二節 洋車前子殼纖維介入後之飲食攝取改變與食慾變化成效 47
第三節 洋車前子殼纖維介入後之心血管疾病危險因子改善成效 51
第五章 研究討論 57
第一節 洋車前子殼纖維對飲食攝取及食慾變化之影響 58
第二節 洋車前子殼纖維對體位變化之影響 61
第三節 洋車前子殼纖維對特定血液生化值改善之成效 63
第四節 安慰劑介入後之體位、血液生化值、飲食攝取改變分析 73
第五節 研究限制 74
第六章 結論與建議 75

英文參考文獻 76
中文參考文獻 95
附件一 中山醫大附設醫院人體試驗委員會臨床試驗計畫許可書 96
附件二 受試者背景資料問卷 97
附件三 飲食紀錄問卷 98
附件四 食慾問卷 102
附件五 受試者同意書 103
附件六 使用洋車前子殼纖維之相關規定(TFDA) 108

表2-1、 99年及100年主要死因死亡人數 ..................... 11
表2-2、 101年主要死因死亡人數 ............................ 11
表2-3、 心血管疾病之致病機轉 .............................. 13
表2-4、 洋車前子殼纖維照片..................................28
表3-1、 試驗執行時程圖 ............................. ....... 32
表4-1、 受試者背景資料 .................................... 43
表4-2、 受試者試驗前之體位測量及血液生化值概況 ............ 44
表4-3、 試驗介入前之組間總熱量與營養素變化比較 ............ 45
表4-4、 試驗介入前後之食慾變化 .............. ........ ..... 47
表4-5、 試驗介入前後之飢餓程度比較 ............ ...... ..... 47
表4-6、 洋車前子殼纖維介入前後之總熱量與營養素變........... 48
表4-7、 安慰劑介入前後之總熱量與營養素變..... ............. 49
表4-8、 洋車前子殼纖維介入前後之體位變化 .................. 50
表4-9、 安慰劑介入前後之體位變化.................. ...... .. 51
表4-10、洋車前子殼纖維介入前後之血液生化值變化 ............52
表4-11、安慰劑介入前後之血液生化值變化 ....................53

圖一、 飢餓程度........................................... 54
圖二、 飢餓程度V.S.飽足程度 ..............................54
圖三、 洋車前子殼纖維介入後之體位與血液生化值之百分比變化..55
圖四、 安慰劑介入後之體位與血液生化值之百分比變化 .........55



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行政院衛生署1: 全球肥胖浪潮下的全民行動-全國健康減重1100噸. http://www.doh.gov.tw/CHT2006/DM/DM2_p01.aspx?class_no=486&now_fod_list_no=&level_no=&doc_no=84771 Accessed May 24, 2012
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