臺灣博碩士論文加值系統

本篇論文主要探討銠催化骨牌式的氫甲醯化/雙環化反應應用在含氮(或氧)雜環的骨架和生物鹼的合成上。分別以肉桂衍生物42a、 42b、71、81與苯乙烯衍生物84進行骨牌式二次環合反應，建立三環tetrahydrofuranoindoline 45a、pyrrolidinoindoline 45b、pyrrolidinobenzofuran 72、tetrahydrofuranobenzofuran 82與piperidinoindoline 85。並將此方法應用於抗阿茲海默症的植物鹼physovenine 56之合成上。

The thesis describes the investigation of hetero-nucleophile mediated Rh-catalyzed domino hydroformylation double cyclizations, which have been developed for the construction of tricyclic skeletons tetrahydrofuranoindoline 45a、pyrrolidinoindoline 45b、pyrrolidinobenzofuran 72、tetrahydrofuranobenzofuran 82 and piperidinoindoline 85, and synthetic study on physovenine.

第一章 毒扁豆次鹼及其同系物之合成研究 1
1.1氫甲醯化反應 (Hydroformylation) 1
1.2 利用氫甲醯化反應進行骨牌式反應 7
1.3 毒扁豆次鹼之合成研究 12
1.3.1 研究動機 12
1.3.2 毒扁豆次鹼 physovenine之合成探討 14
1.4 Pyrrolidinodihydrobenzofuran骨架之合成研究 19
1.4.1 研究動機 19
1.4.2 Pyrrolidinodihydrobenzofuran骨架之合成探討 20
1.5 Tetrahydrofuranobenzofuran骨架之合成研究 24
1.5.1 研究動機 24
1.5.2 Tetrahydrofuranobenzofuran骨架之合成探討 25
1.6 Pentahydropyridoindoline骨架的合成研究 28
1.7 Hexahydrooxepinoindoline骨架的合成研究 37
1.8 結論 40
實驗部分 41
參考文獻 62
圖譜資料 66

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