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研究生:黃靖雄
研究生(外文):Jing-Syong Huang
論文名稱:生物安全實驗室空調系統之性能分析與現場量測
論文名稱(外文):Performance analysis and field measurement of HVAC system for a biosafety laboratory
指導教授:王輔仁王輔仁引用關係
指導教授(外文):Fu-Jen Wang
學位類別:碩士
校院名稱:國立勤益科技大學
系所名稱:冷凍空調系
學門:工程學門
學類:其他工程學類
論文種類:學術論文
論文出版年:2013
畢業學年度:101
語文別:中文
論文頁數:126
中文關鍵詞:生物安全實驗室氣流模擬計算流體力學負壓環境現場量測
外文關鍵詞:biosafety level laboratoryair distributioncomputational fluid dynamicsnegative-pressured environmentfield measurement
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高危險性傳染疾病的猖獗,伴隨而來的是國家生產力與競爭力的衰退,而傳染疾病的研究與治療,皆須仰賴於負壓空間的保護。目前對於負壓實驗室的供風口與排風口配置,國內外規範並無確切的設計標準,因此,本研究針對教學醫院之結核桿菌生物安全第三等級(BSL-3)實驗室進行相關研究的探討分析,使用計算流體力學(CFD)模擬三種供風模式下,主實驗室濃度衰減之情況,並以局部平均空氣年齡將衰減結果進行量化,比較不同供風型式的影響。結果發現使用L型供風口配置,不僅於潛在危險區可獲得較佳的汙染移除效率,於其他區域也可獲得較佳的汙染移除能力。此外,在現場量測的部分,可發現穿牆設備的氣密性往往不佳,應於檢測時加強,門縫的洩漏則是無可避免的,而氣密門與生物安全操作櫃(BSC)的啟閉是影響壓力變化的重要因素,人員應避免兩者同時動作。另外,在安全性的模擬強調了壓力維持設備的重要性,且在主實驗室氣密性良好的情況下,可使用較少的風量差即可達到設計壓差值,進而達到節能之效果。透過本研究之分析,期望可為BSL-3實驗室在未來建置設計及安全管理及能源節約方面能提供重要參考。
The spread of high-risk contagious diseases will degrade the productivity and competitiveness of country. It is vital to provide negative-pressurized environment for infectious control and disease research in the biosafety level (BSL) laboratory. However, there is no official guideline of the layout arrangement for air distribution system in the negative-pressured environment. In this study, numerical simulation of a full-scale has been carried out at a BSL-3 laboratory in a district hospital to determine the better layout for contamination control. Computational fluid dynamics (CFD) simulation with three supply air arrangement alternatives were also conducted to investigate the airflow distribution as well as the concentration decay and age of air of the BSL-3 laboratory. The results from computer simulation revealed that the L-type arrangement for supply air diffusers will achieve better ventilation efficiency. Different arrangement of air distribution could be assessed extensively not only by airflow simulation but also by field measurement to achieve the infectious control purpose. Furthermore, the leakage of door and poor air tightness were discovered during field measurement period. The air tightness of doors and operation of biological safety cabinet (BSC) will influence the pressurization of BSL-3 laboratory dramatically. Numerical simulation were also conducted to evaluate the quantitative analysis of pressurization and air tightness in the BSL-3 laboratory. The results revealed the importance of pressurization and less supply air volume could be achieved under better air tightness condition. It was also expected that CFD aided simulation could identify strategies for best practice at design stage as well as reduce running cost at full operation.

摘要 I
誌謝 III
目錄 IV
圖目錄 VI
表目錄 IX
第一章 緒論 1
1.1 研究動機與目的 1
1.2 文獻回顧 2
第二章 生物安全實驗室系統 14
2.1生物安全實驗室設計 14
2.2生物安全操作櫃之分類 28
2.3 評估指標 35
第三章 生物安全實驗室現場量測 38
3.1生物安全實驗室系統描述 38
3.2量測方法 42
3.3量測儀器 55
第四章 生物安全實驗室數值模擬 62
4.1 供風口配置模擬 62
4.2 現況安全性模擬 70
第五章 結果與討論 75
5.1 供風口配置模擬結果 75
5.2現況量測結果分析 89
5.3 現況安全性模擬結果 110
第六章 結論與建議 119
6.1 結論 119
6.2 建議 120
參考文獻 121

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