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研究生:鄭渝丹
研究生(外文):Yu-Dan Cheng
論文名稱:米糠對高脂血症倉鼠降低膽固醇作用之探討
論文名稱(外文):Studies on the cholesterol reducing effect of rice bran in hyperlipidemia hamsters
指導教授:黃卓治黃卓治引用關係
指導教授(外文):Tzou-Chi Huang
學位類別:碩士
校院名稱:國立屏東科技大學
系所名稱:食品科學系所
學門:農業科學學門
學類:食品科學類
論文種類:學術論文
論文出版年:2013
畢業學年度:101
語文別:中文
論文頁數:76
中文關鍵詞:米糠高脂血症動脈粥樣硬化
外文關鍵詞:Rice branhyperlipidemiaatherosclerosis
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米糠為稻穀在磨製成精白米時所產生的副產品。根據文獻指出,米糠中含有各種營養物質和抗氧化劑,可以有效地防止心血管疾病。本實驗目的為探討以米糠餵食高脂血症倉鼠其降低膽固醇之作用。在本研究中,以基礎飼料添加0.2%的膽固醇和米糠(分別為2.5%,7.5%及12.5%)餵食倉鼠8週。56天後,米糠組與高膽固醇飲食組相比血清總膽固醇顯著下降,但相比於正常組則是增加。在米糠組中血清高密度脂蛋白膽固醇顯著增加,而在高膽固醇飲食組則降低。在米糠組中血清總膽固醇濃度顯著減少13.18%、8.26%和11.50%與高膽固醇飲食相比。在米糠組中血清三酸甘油酯濃度顯著減少37.68%、9.21%和24.85%與高膽固醇飲食相比。米糠組中主動脈粥樣硬化的形成顯著減少相較於高膽固醇飲組。這些結果顯示米糠的攝取量和降低膽固醇的吸收及預防主動脈粥樣硬化的產生具有相關性。
Rice bran is a by-product from paddy during milling to a polished rice. According to the literature, rice bran contain various nutrients and antioxidants that could be effective in preventing cardiovascular disease. The purpose of this study is to investigate of rice bran on the cholesterol reduction effect, the hyperlipidemia hamsters animal model will be used with rice brans. In this study, the hamsters were fed basal diets plus 0.2% added cholesterol and rice bran (2.5%, 7.5% and12.5%, respectively) for 8 weeks. After 56 days, the serum cholesterol was higher in hamsters fed the high-cholesterol diet than the normal group but significantly decreased in rice bran group. Serum high-density lipoprotein cholesterol was lowered in the high-cholesterol diet group but it was significantly increased in hamsters compared with the rice bran group. The serum total cholesterol concentration was significantly lower in all the rice bran group (13.18%, 8.26% and 11.50%), compared to high-cholesterol diet group. The serum triglyceride concentration was significantly lower in all the rice bran group (37.68%, 9.21% and 24.8%), compared to high-cholesterol diet group. Aortic atherosclerosis formation was significantly reduced by rice bran diets compared to the high-cholesterol diets group. These results suggested that the rice bran intake is related with decreased cholesterol absorption and prevent aortic atherosclerosis production.
目 錄
中文摘要..………………………………………………………………...Ⅰ
英文摘要………………………………………………………………….Ⅲ
誌謝 ……………………………………………………………………...Ⅴ
目錄……………………………………………………………………....Ⅵ
圖目錄…………………………………………………………………....XI
表目錄…………………………………………………………………....XIII
第1章 前言……………………………………………………………...1
第2章 文獻回顧………………………………………………………...3
2.1米糠之介紹 ………………………………………………………...3
2.1.1米糠簡介 ……………………………………………………..3
2.1.2 米糠之品種…………………………………………………...3
2.1.3 米糠之活性成分……………………………………………...3
2.2高脂血症定義及分類 ……………………………………………...10
2.3血漿脂質之介紹 …………………………………………………...10
2.3.1 膽固醇 ……………………………………………………...10
2.3.2 三酸甘油酯 ……………………………………………… …13
2.4脂蛋白之介紹…………………………………………………… …13
2.4.1乳糜微粒………………………………………………………13
2.4.2極低密度脂蛋白………………………………………………13
2.4.3低密度脂蛋白 ..……………………………………………..14
2.4.4高密度脂蛋白 ………………………………………………14
2.5高脂血症引起相關之疾病……………………………………… …15
2.5.1非酒精性脂肪肝………………………………………………15
2.5.2動脈粥樣硬化 ……………………………………………......17
第3章 材料與方法 …………………………………………………...19
3.1實驗架構 ………………………………………………………….. 19
3.2實驗材料 …………………………………………………………...20
3.2.1 米糠 ……………………………………………………….....20
3.2.2 設備與儀器 ……………………………………………….....20
3.2.3 試劑與藥品 ………………………………………………….20
3.3實驗方法 ……………………………………………………….....21
3.3.1 一般成分分析 ……………………………………………….21
3.3.1.1 水分 …………………………………………………..21
3.3.1.2 灰分 …………………………………………………21
3.3.1.3粗脂肪 ……………………………………………….. 22
3.3.1.4粗蛋白 ……………………………………………….. 22
3.3.1.5粗纖維 ……………………………………………….. 23
3.3.1.6總膳食纖維 …………………………………………... 24
3.3.1.7非氮抽出物 ……………………………………………25
3.3.2 高脂血症動物試驗……………………………………………25
3.3.2.1試驗設計………..………………………………………25
3.3.2.2實驗動物之飼養 ………………………………………25
3.3.2.3.實驗動物飼糧之配製…………………………………. 25
3.3.2.4實驗動物之血脂分析項目……………………………..28
3.3.2.5實驗動物之犧牲 ………………………………………28
3.4檢測分析方法………………………………………………………..28
3.4.1臨床觀察和血液及臟器樣本採集…………………………….28
3.4.2血脂質測定方法…………………………………………….....29
3.4.2.1血清總膽固醇測定( serum total cholesterol;TC)……...29
3.4.2.2血清三酸甘油酯測定(serum total triglyceride;TG).......29
3.4.2.3血清高密度脂蛋白膽固醇(HDL-C)測定…………….. 29
3.4.2.4血清低密度脂蛋白膽固醇(LDL-C)測定…………….. 29
3.4.2.5動脈粥樣硬化指數(Atherogenic Index ; AI) ………… 30
3.4.3肝臟脂質分析方法 …………………………………………..30
3.4.3.1肝臟總膽固醇含量測定……………………………….30
3.4.3.2肝臟三酸甘油酯含量測定…………………………… 31
3.4.4病理組織切片………………………………………………... 31
3.5統計分析 …………………………………………………………..31
第4章 結果與討論 ……………………………………………………32
4.1一般成分分析………………………………………………………32
4.2飼養期間倉鼠外觀、毛色、狀態、體重及攝食量之變化情況…32
4.3米糠對於倉鼠血脂之影響…………………………………………39
4.3.1倉鼠餵食米糠8週之血清總膽固醇(TC)變化……………... 39
4.3.2倉鼠餵食米糠8週之血清三酸甘油酯(TG)變化…………...39
4.3.3倉鼠餵食米糠8週之血清高密度脂蛋白膽固醇(HDL-C)變
化………………………………………………………………44
4.3.4倉鼠餵食米糠8週之血清低密度脂蛋白膽固醇(LDL-C)變化
…………………………………………………………………44
4.3.5倉鼠餵食米糠8週之動脈粥樣硬化指數 ………………….44
4.3.6倉鼠餵食米糠8週肝臟脂質之變化 ……………………….44
4.3.7倉鼠餵食米糠8週後肝臟肉眼觀察之變化 ……………….51
4.4病理學………………………………………………………………53
4.4.1肝臟病理切片之觀察……………………………………….. 53
4.4.2主動脈病理切片之觀察…………………………………….. 58
第5章 結論 …………………………………………………………... 63
第6章 參考文獻 ………………………………………………………65
作者簡介…………………………………………………………………76

















圖目錄
圖1、生育酚與生育三烯酚的化學結構………………………………….7
圖2、生育三烯酚抑制膽固醇的作用機制……………………………… 8
圖3、γ-谷維素三個主要成分的化學結構……………………………... 9
圖4、膽固醇生合成由乙酰輔酶A開始分成四個階段………………..12
圖5、胰島素對肝臟極低密度脂蛋白與載脂蛋白B合成和分泌調控之作
用………………………………………………………………….16
圖6、高密度脂蛋白和低密度脂蛋白在動脈粥樣硬化病變之聯合氧化作
用 ………………………………………………………………...18
圖 7、實驗飼糧對倉鼠每週體重之影響……………………………….36
圖 8、實驗飼糧對倉鼠攝食量之影響………………………………….38
圖 9、實驗飼糧對倉鼠血清總膽固醇(TC)之影響…………………41
圖10、實驗飼糧對倉鼠血清三酸甘油酯(TG)之影響…………………43
圖11、實驗飼糧對倉鼠血清高密度脂蛋白膽固醇(HDL-C)之影響….46
圖12、實驗飼糧對倉鼠血清低密度脂蛋白膽固醇(LDL-C)之影…….48
圖13、各組肝臟病變之觀察…………………………………………...52
圖14、各組肝臟H&E染色的組織病理學(200X)……………………54
圖15、各組肝臟H&E染色的組織病理學(400X)……………………56
圖16、各組主動脈H&E染色的組織病理學(40X)…………………..59
圖17、各組主動脈H&E染色的組織病理學(100X)………………….61


















表目錄
表1、不同水稻品種之米糠總維生素E、總生育酚、總生育三烯酚及
γ-谷維素之含量…………………………………………………6
表2、各組飼料配方組成……………………………………………….27
表3、米糠一般成分分析……………………………………………….33
表4、實驗飼糧對倉鼠體重、肝臟重量及攝食量之影響…………….34
表5、實驗飼糧對倉鼠每週體重之影響……………………………….35
表6、實驗飼糧對倉鼠攝食量之影響………………………………… 37
表7、實驗飼糧對倉鼠血清總膽固醇(TC)之影響…………………40
表8、實驗飼糧對倉鼠血清三酸甘油酯(TG)之影響………………….42
表9、實驗飼糧對倉鼠血清高密度脂蛋白膽固醇(HDL-C)之影響…..45
表10、實驗飼糧對倉鼠血清低密度脂蛋白膽固醇(LDL-C)之影響…47
表11、實驗飼糧對倉鼠動脈粥樣硬化指數之影響…………………...49
表12、實驗飼糧對倉鼠肝臟脂質之影響……………………………...50

第6章參考文獻
丁孝全、王明茂、王銀波、朱耀昕、李文輝、李蒼郎、李廣武、宋 勳、吳邦雄、林子清、林明仁、林美瑄、林富雄、林 欉、范明仁、洪梅珠、侯福分、盛中德、許志聖、許東暉、連 深、郭益全、郭鴻裕、陳一心、候寶川、馮丁樹、黃山內、黃伯恩、張採泉、張萬來、張義璋、張學琨、黃添財、曾東海、曾勝雄、劉大江、鄭清煥、鄭榮瑞、蔡清榮、鄧耀宗、盧 訓、盧福明、謝順景、蕭介宗、顏福成、簡錦忠、龔憲曉。1999。台灣稻作發展史。第一版。中華農藝學會豐年社。701頁。

中華民國國家標準。1986。飼料水分之檢驗方法,CNS總號2770-3類號N4024-3。

中華民國國家標準。1986。飼料粗脂肪之檢驗方法,CNS總號2770-4類號N4024-4。

中華民國國家標準。1986。飼料粗蛋白之檢驗方法,CNS總號2770-5類號N4024-5。

中華民國國家標準。1986。飼料粗纖維之檢驗方法,CNS總號2770-8類號N4024-8。

中華民國國家標準。1986。飼料灰分之檢驗方法,CNS總號2770-9類號N4024-9。

王明升、李碧珍、洪昭竹、許桂森、葉力森、余玉林、林宗德、翁仲男、陳保基、廖欽峰、余俊強、林宗毅、秦咸靜、張維正、蔡倉吾、宋永義、周京玉、梁善居、黃英豪、蘇怡欣。1997。實驗動物管理與使用指南。第三版。中華實驗動物學會。64-75頁
余俊強、余玉林、李碧珍、林宗德、周京玉、洪昭竹、陳幸浩、黃英豪、許桂森、陳美玲、梁善居、張維正、蔡清恩。2005。實驗動物技術人員訓練教材。第一版。中華實驗動物學會。195-201頁。

邱運全、吳志文。2005。水稻新品種-高雄145號(晶鑽)。 Research Bulletin of Kdares 16:1-14.

徐成金、吳志忠、盧義發、蕭慧美、魏明敏、張菡馨、黃惠煐、楊新玲、吳淑惠、林錦華、呂孟純、陳宣穎、吳素珍、趙碧玉。2009。營養學。第二版。華格那企業。4-22頁。

姚惠源。2004。稻米深加工。第一版。化學工業出版社。18頁

陳淑芳、簡相堂。2005。調節血脂或血糖類保健食品之現況與趨勢。第一版。食品工業月刊社。9-11頁。














Aggarwal B.B., Sundaram C., Prasad S. and Kannappan R. 2010. Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases. Biochemical Pharmacology. 80: 1613-1631.

Ahn K.S., Sethi G., Krishnan K. and Aggarwal B.B. 2007.Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. Journal of Biological Chemistry. 282: 809-820.

Angulo P. 2002. Nonalcoholic fatty liver disease. New England Journal of Medicine. 346: 1221-1231.

Auerbach B.J., Bisgaier C.L., Wolle J. and Saxena U. 1996. Oxidation of low density lipoproteins greatly enhances their association with lipoprotein lipase anchored to endothelial cell matrix. Journal of Biological Chemistry. 271: 1329-1335.

AOAC International. 2003. Total Dietary Fiber in Foods, Enzymatic- Gravimetric Method. In. “Official Methods of Analysis of AOAC International” 17th ed. 985.29. William Horwitz ed., Gaithersburg, MD U.S.A..

Awad A.B., Williams H. and Fink C.S. 2003. Effect of phytosterols on cholesterol metabolism and MAP kinase in MDA-MB-231 human breast cancer cells. Journal of Nutritional Biochemistry.14: 111-119.



Bowry V.W., Stanley K.K. and Stocker R. 1992. High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors. Proceedings of the National Academy of Sciences of the United States of America.89: 10316-10320.

Bucolo G. and David H. 1973. Quantitative determination of serum triglycerides by use of enzymes. Clinical Chemistry.19: 476-482.

Chen Z.Y., Ma K.Y., Liang Y.T., Cheng P. and Zuo Y.Y. 2011.Role and classification of cholesterol-lowering functional foods. Journal of Functional Foods. 3: 61-69.

Chen M.H. and Bergman C.J. 2005. A rapid procedure for analysingrice bran tocopherol, tocotrienol and γ-oryzanol contents. Journal of Food Composition and Analysis. 18: 319-331.

Correll C.C., Ng L. and Edwards P.A. 1994.Identification of farnesol as the non-sterol derivative of mevalonic acid required for the accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Journal of Biological Chemistry.269: 17390-17393.

Cockerill G.W., Rye K.A., Gamble J.R., Vadas M.A. and Barter P. J. 1995. High density lipoproteins inhibit cytokine-induced expression of endothelial cell adhesion molecules. Arteriosclerosis, Thrombosis, and Vascular Biology. 1995: 1987-1994.

Deepa P.R. and Varalakshimi P. 2005. Atheroprotective effect of exogenous heparin-derivative treatment on the aortic disturbances and lipoprotein oxidation in hypercholesterolemic diet fed rats. Clinica Chimica Acta. 355: 119-130.
Evans H.M. and Bishop K.S. 1922. On the existence of a hitherto unrecognized dietary factor essential for reproduction. Science. 56: 650.

Fielding C.J. and Fielding P.E. 1995. Molecular physiology of reverse cholesterol transport. Journal of Lipid Research. 36: 211-228.

Fluiter K., Vietsch H., Biessen E.A., Kostner G.M., Berkel T.J.V. and Sattler W. 1996. Increased selective uptake in vivo and in vitro of oxidized cholesteryl esters from high-density lipoprotein by rat liver parenchymal cells. Biochemical Journal. 319: 471-476.

Folch J., Lees M. and Sloane-Stanley G.H. 1957. A simple method for the isolation and purification of total lipids from animal tissures. Journal of Biological Chemistry. 226: 497-509.

Francis G.A. 2000. High density lipoproteins oxidation: in vitro susceptibility and potential in vivo consequences. Biochimica et Biophysica Acta.1483: 217-235.

Fukushima M., Fujii S., Yoshimura Y., Endo T. and Nakano M. 1999. Effect of rice bran on intraintestinal fermentation and cholesterol metabolism in cecectomized rats. Nutrition Research. 19: 235¬-245.

Goldstein J.L. and Brown M.S. 1990. Regulation of the mevalonate pathway.
Nature.343: 425-430.

Guo J., Bei W., Hua Y., Tang C., He W., Liu X., Huang L., Cao Y., Hu X., Zhong X. and Cao L. 2011. A new TCM formula FTZ lowers serum cholesterol by regulating HMG-CoA reductase and CYP7A1 in hyperlipidemic rats. Journal of Ethnopharmacology. 135: 299-307.
Gysin R., Azzi A. and Visarius T. 2002. Gamma-tocopherol inhibits human cancer cell cycle progression and cell proliferation by down-regulation of cyclins. Federation of American Societies for Experimental Biology Journal. 16: 1952-1954.

Ha T.Y., Han S., Kim S.R., Kim I.H., Lee H.Y. and Kim H.K. 2005. Bioactive components in rice bran oil improve lipid profiles in rats fed a high-cholesterol diet. Nutrition Research. 25: 597-606.

Harnafi H., Caid H.S., Bouanani N.H., Aziz M. and Amrani S. 2008. Hypolipemic activity of polyphenol-rich extracts from Ocimum basilicum in triton WR-1339-induced hyperlipidemic mice. Food Chemistry. 108: 205-212.

Huang S.H. and Ng L.T. 2011. Quantification of tocopherols, tocotrienols, and γ-oryzanol contents and their distribution in some commercial rice varieties in Taiwan. Journal of Agricultural and Food Chemistry. 59: 11150-11159.

Kato A., Yamaoka M., Tanaka A., Komiyama K. and Umezawa I.1985. Physiological effect of tocotrienol. Japan Oil Chemists’ Society .34: 375-376.

Kennedy G. and Burlingame B. 2003. Analysis of food composition data on rice from a plant genetic resources perspective. Food Chemistry. 80: 589-596.

Kleiner D.E., Brunt E.M., Natta M.V., Behling C., Contos M.J., Oscar W., Cummings O.W., Ferrell L.D., Liu Y.C., Torbenson M.S., Unalp-Arida A., Yeh M., McCullough A.J. and Sanyal A.J. 2005. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 41: 1313-1321.
Levine D.M., Parker T.S., Donnelly T.M. and Walsh A. 1993.In vivo protection against endotoxin by plasma high density lipoprotein. Proceedings of the National Academy of Sciences of the United States of America.90: 12040-12044.

Lopes M.F., Stone P., Ellis S. and Collwell J.A. 1977. Cholesterol determination in high density lipoprotein separated by three different methods. Clinical Chemistry.23: 882-887.

Mahley R.W.1985. Atherogenic lipoproteins and coronary artery disease: concepts derived from recent advances in cellular and molecular biology. Circulation.72: 943-948.

Maier J.A., Barenghi L., Pagani F., Bradamante S., Comi P. and Ragnotti G. 1994. The protective role of high-density lipoprotein on oxidized-low-density -lipoprotein-induced U937/endothelial cell interactions. European Journal of Biochemistry. 221: 34-41.

Marchesini G., Marzocchi R., Agostini F. and Bugianesi E. 2005.Nonalcoholic fatty liver disease and the metabolic syndrome. Current Opinion in Lipidology.16: 421-427.

Mceligot A. J., Yang S. and Meyskens F.L.J. 2005. Redox regulation by intrinsic species and extrinsic nutrients in normal and cancer cells. Annual Review of Nutrition. 25: 261-295.

Miyazawa T., Nakagawa K. and Sookwong P. 2011. Health benefits of vitamin E in grains, cereals and green vegetables. Trends in Food Science and Technology. 22: 1-4.

Morita T., Oh-Hashi A., Takei K., Ikai K., Kasaoka M. and Kiriyama S. 1997.
Cholesterol-lowering effects of soybean, potato and rice proteins depend on
their low methionine contents in rats fed a cholesterol-free purified diet. Journal of Nutrition. 127: 470-477.

Nikolic D., Katsiki N., Montalto G., Isenovic E.R., Mikhailidis D.P. and Rizzo M. 2013. Lipoprotein subfractions in metabolic syndrome and obesity: clinical significance and therapeutic approaches. Nutrients.5: 928-948.

Newaz M.A and Nawal N.N. 1999. Effect of gamma-tocotrienol on blood pressure, lipid peroxidation and total antioxidant status in spontaneously hypertensive rats(SHR). Clinical and experimental hypertension. 21: 1297-1313.

Parrado J., Miramontes E., Jover M., Márquez J.C., Mejias M. and Collantes de Terán L. 2003. Prevention of brain protein and lipid oxidation elicited by a water soluble oryzanol enzymatic extract derived from rice bran. European Journal of Nutrition. 42: 307-314.

Qureshi A.A., Burger W.C., Peterson D.M. and Elson C.E.1986. The structure of an inhibitor of cholesterol biosynthesis isolated from barley. Journal of Biological Chemistry. 261:10544-10550.

Qureshi A.A., Mo H., Packer L. and Peterson D.M. 2000. Isolation and identification of novel tocotrienols from rice bran with hypocholesterolemic, antioxidant and antitumor properties. Journal of Agricultural and Food Chemistry.48: 3130-3140.

Reagan-Shaw S., Nihal M. and Ahmad N. 2007. Dose translation from animal to human studies revisited. The Journal of the Federation of American Societies for Experimental Biology. 22: 659–661.

Revilla E., Maria C.S., Miramontes E., Bautista J., García-Martínez A., Cremades O., Cert R. and Parrado J. 2009. Nutraceutical composition, antioxidant activity and hypocholesterolemic effect of a water-soluble enzymatic extract from rice bran. Food Research International. 42: 387-393.

Rizzo M., Kotur-Stevuljevic J., Berneis K., Spinas G., Rini G.B., Jelic-Ivanovic Z., Spasojevic-Kalimanovska V. and Vekic J. 2009. Atherogenic dyslipidemia and oxidative stress: A new look. Translational Research. 153: 217-223.

Ross R. and Harker L.1976. Hyperlipidemia and atherosclerosis. Science. 193: 1094-1100.

Sen C.K., Khanna S. and Roy S. 2006. Tocotrienols: Vitamin E Beyond Tocopherols. Life Sciences. 78: 2088–2098.

Sharma R.D. and Rukmini C.1986. Rice Bran Oil and Hypocholesterolemia in Rats. Lipids. 21: 715-717.

Steinberg D., Parthasarathy S., Carew T.E., Khoo J.C. and Witztum J.L. 1989. Beyond cholesterol: modification of low-density lipoprotein that increases its atherogenicity. New England Journal of Medicine. 320: 915-924.

Tessari P., Coracina A., Cosma A. and Tiengo A. 2009. Hepatic lipid metabolism and non-alcoholic fatty liver disease. Nutrition, Metabolism and Cardiovascular Diseases.19: 291-302.
Theriault A., Chao J.T, Wang Q., Gapor A. and Adeli K. 1999. Tocotrienol: A review of its therapeutic potential. Clinical Biochemistry. 32: 309-319.

Tsuji H., Kimoto M. and Natori Y. 2001. Allergens in major crops. Nutrition Research. 21: 925-934.

Vance D.E. and Bosch H.V.D. 2000.Cholesterol in the year 2000. Biochimica et Biophysica Acta. 1529: 1-8.

Vinik A.I. 2005. The metabolic basis of atherogenic dyslipidemia. Clinical Cornerstone.7:27-35.

Weng-Yew W., Selvaduray K.R., Ming C.H. and Nesaretnam K. 2009. Suppression of tumor growth by palm tocotrienols via the attenuation of angiogenesis. Nutrition and Cancer.61: 367-373.

Wilson T.A., Nicolosi R.J., Woolfrey B. and Kritchevsky D. 2007. Rice bran oil and oryzanol reduce plasma lipid and lipoprotein cholesterol concentrations and aortic cholesterol ester accumulation to a greater extent
than ferulic acid in hypercholesterolemic hamsters. Journal of Nutritional Biochemistry. 18: 105-112.

Xu Z., Hua N. and Godber J.S. 2001. Antioxidant activity of tocopherols, tocotrienols, and γ-oryzanol components from rice bran against cholesterol oxidation accelerated by 2,2’-azobis (2-methylpropionamidine) dihydrochloride. Journal of Agricultural and Food Chemistry.49: 2077-2081.

Yu S.G., Nehus Z.T., Badger T.M., and Fang N. 2007. Quantification of vitamin E and gamma-oryzanol components in rice germ and bran. Journal of Agricultural and Food Chemistry 55: 7308-7313.
Zhang Z., Wang H., Jiao R., Peng C., Wong Y.M., Yeung V.S.Y., Huang Y and Chen Z.Y. 2009.Choosing hamsters but not rats as a model for studying plasma cholesterol-lowering activity of functional foods. Molecular Nutrition and Food Research.53: 921-930.

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