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研究生:陳合興
研究生(外文):Chen, Ho-Hsing
論文名稱:改變動態多葉式準直儀移動型態應用於臨床放射線治療:呼吸中移動腫瘤同步追蹤照射及全身放射線治療
論文名稱(外文):Modification of leaf sequences of dynamic multileaf collimator in radiotherapy: respiratory motion target tracking and total body irradiation
指導教授:莊克士莊克士引用關係
學位類別:博士
校院名稱:國立清華大學
系所名稱:生醫工程與環境科學系
學門:工程學門
學類:生醫工程學類
論文種類:學術論文
論文出版年:2013
畢業學年度:101
語文別:英文
論文頁數:107
中文關鍵詞:強度調控放射治療呼吸運動全身放射治療動態照野交界多葉式準值儀及時動態追蹤
外文關鍵詞:Dynamic multileaf collimatorLeaf sequencesrespiratory motionDynamic trackingTotal body irradiationDynamic field matching
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本研究使用編修直線加速器內建之多葉式準直儀(MultiLeaf Collimator)之葉片移動描述檔案(leaf sequences file),改變其放射線照野強度分布,進而應用在臨床放射治療以解決技術上的難題而達到準確的劑量給予。本研究中處理兩個問題:1. 呼吸運動造成放射治療劑量與預期劑量會不一致。針對此議題本研究提出使用動態式多葉準直儀技術(DMLC)做動態追蹤照射(dynamic tracking)之可行性研究,確認在良好的同步追蹤前提下可以達到正確的照射劑量。2. 在空間受限的小治療室中難以兼顧照射劑量均勻及準確降低肺部劑量之臨床需求。本研究使用編修之DMLC雙照野銜接方法施行正反面(AP/PA)照射,經使用假體做劑量驗證後顯示可符合臨床之需求。
we applied an aperture adaptive technique with a visual guiding system to tackle the problem of respiratory motion. A homemade computer program showing a cyclic respiratory pattern was projected onto the ceiling to visually help the patient adjust their respiration. Once the respiratory motion became regular, the leaf sequence could be synchronized with the target motion. An oscillator was employed to simulate the patient’s breathing pattern. Two simple fields and one IMRT field were measured to verify the accuracy. Preliminary results showed that after appropriate training, the amplitude and duration of a volunteer’s breathing could be well controlled by the visual guiding system. The high dose gradient at the edges of the radiation fields were successfully retained. The aperture adaptive technique with the visual guiding system can be an inexpensive and feasible alternative without compromising delivery efficiency in clinical practice.
this study was to develop a total body irradiation technique that does not require additional devices or sophisticated procedures to overcome the space limitation of a small treatment room by modifying the leaf sequences of intensity modulated fields.The technique treated the patient lying on the floor anteriorly and posteriorly. For each AP/PA treatment, two complementary fields with dynamic field edges were matched over an overlapped region defined by the marks on the body surface.The results confirmed that the technique is capable of delivering a uniform dose distribution to the midline of the body in a small treatment room while keeping the lung dose within the tolerance level.
Abstract I
誌謝 III
Table of Contents IV
List of Figures VII
List of Tables XII
Chapter 1. Introduction 1
Chapter 2. Dynamic multileaf collimator (DMLC) 5
2.1. MLC design and structure 5
2.2. Dynamic intensity modulated radiotherapy (IMRT) 8
2.2.1. The generation of DMLC 9
2.2.2. Leaf motion calculator (LMC) 11
2.2.3. Leaf sequences algorithm 13
2.2.4. Large IMRT field splitting 16
2.2.5. Dynalog file viewer (DFV) 19
Chapter 3. The management of respiratory motion 22
3.1. Dose delivery under free breathing 24
3.2. Dose delivery with breath hold 25
3.3. Treatments incorporate Gating technique 26
3.4. Active breathing control during radiation delivery 27
3.5. Dynamic tracking of target motion 27
Chapter 4. Total body irradiation (TBI) 32
4.1. Conventional TBI treatment 32
4.2. Beam delivery with gantry rotation 33
4.3. Beam delivery with couch Translation 36
4.4. Linac-base intensity modulated TBI 38
4.5. TBI delivery with Helical tomotherapy 41
Chapter 5. Correction of respiratory motion for IMRT using aperture adaptive technique and visual guidance 42
5.1. Introduction 42
5.2. Methods and Materials 45
5.2.1. Synchronization 45
5.2.2. Visual guidance of patient’s respiratory motion 46
5.2.3. Simulating respiratory motion 47
5.2.4. Simple field measurements 49
5.2.5. IMRT field measurements 49
5.2.6. Verifying effects of visual guiding system 50
5.3. Results 50
5.4. Discussion 56
Chapter 6. Total body irradiation with step translation and dynamic field-matching 60
6.1. Introduction 60
6.2. Materials and methods 63
6.2.1. Dynamic field-matching 64
6.2.2. Dynamic MLC field editing 66
6.2.3. Treatment setup 67
6.2.4. Beam intensity compensator 69
6.2.5. Optimal overlapping widths in the phantom 70
6.2.6. Dose profiles in the overlapped region at different depths 71
6.2.7. Total dose profile of the dynamic matching fields 72
6.2.8. Percentage depth dose in the buildup region 73
6.2.9. Rando phantom dosimetry 73
6.3. Results 74
6.3.1. Beam intensity compensator 74
6.3.2. Optimal overlap width of dynamic matching fields 75
6.3.3. Dose profiles in the overlapped region at depths 79
6.3.4. Total dose profiles of dynamic matching fields 80
6.3.5. Percentage depth dose in the buildup region 81
6.3.6. Rando phantom dosimetry 83
6.4. Discussion 88
Chapter 7. Conclusions and future works 94
References 97

Abraham, D., Colussi, V., Shina, D., Kinsella, T., & Sibata, C. (2000). TBI treatment planning using the ADAC pinnacle treatment planning system. Med Dosim, 25(4), 219-224.
Aruga, T., Itami, J., Aruga, M., Nakajima, K., Shibata, K., Nojo, T., . . . Ito, H. (2000). Target volume definition for upper abdominal irradiation using CT scans obtained during inhale and exhale phases. Int J Radiat Oncol Biol Phys, 48(2), 465-469.
Balter, J. M., Wright, J. N., Newell, L. J., Friemel, B., Dimmer, S., Cheng, Y., . . . Mate, T. P. (2005). Accuracy of a wireless localization system for radiotherapy. Int J Radiat Oncol Biol Phys, 61(3), 933-937. doi: 10.1016/j.ijrobp.2004.11.009
Breneman, J. C., Elson, H. R., Little, R., Lamba, M., Foster, A. E., & Aron, B. S. (1990). A technique for delivery of total body irradiation for bone marrow transplantation in adults and adolescents. Int J Radiat Oncol Biol Phys, 18(5), 1233-1236.
Chao, M., Penagaricano, J., Yan, Y., Moros, E. G., Corry, P., & Ratanatharathorn, V. (2012). Voxel-based dose reconstruction for total body irradiation with helical tomotherapy. Int J Radiat Oncol Biol Phys, 82(5), 1575-1583. doi: 10.1016/j.ijrobp.2011.01.021
Chen, Ho-Hsing, Wu, Jay, Chuang, Keh-Shih, & Kuo, Hsiang-Chi. (2007). Correction of respiratory motion for IMRT using aperture adaptive technique and visual guidance: A feasibility study. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 577(3), 734-740. doi: http://dx.doi.org/10.1016/j.nima.2007.04.122
Chen, Q. S., Weinhous, M. S., Deibel, F. C., Ciezki, J. P., & Macklis, R. M. (2001). Fluoroscopic study of tumor motion due to breathing: facilitating precise radiation therapy for lung cancer patients. Med Phys, 28(9), 1850-1856.
Chretien, M., Cote, C., Blais, R., Brouard, L., Roy-Lacroix, L., Larochelle, M., . . . Pouliot, J. (2000). A variable speed translating couch technique for total body irradiation. Med Phys, 27(5), 1127-1130.
Chui, C. S., Fontenla, D. P., Mullokandov, E., Kapulsky, A., Lo, Y. C., & Lo, C. J. (1997). Total body irradiation with an arc and a gravity-oriented compensator. Int J Radiat Oncol Biol Phys, 39(5), 1191-1195.
Chui, C. S., Yorke, E., & Hong, L. (2003). The effects of intra-fraction organ motion on the delivery of intensity-modulated field with a multileaf collimator. Med Phys, 30(7), 1736-1746.
Collins, B. T., Vahdat, S., Erickson, K., Collins, S. P., Suy, S., Yu, X., . . . Anderson, E. D. (2009). Radical cyberknife radiosurgery with tumor tracking: an effective treatment for inoperable small peripheral stage I non-small cell lung cancer. J Hematol Oncol, 2, 1. doi: 10.1186/1756-8722-2-1
D'Souza, W. D., & McAvoy, T. J. (2006). An analysis of the treatment couch and control system dynamics for respiration-induced motion compensation. Med Phys, 33(12), 4701-4709.
Duan, J., Shen, S., Fiveash, J. B., Popple, R. A., & Brezovich, I. A. (2006). Dosimetric and radiobiological impact of dose fractionation on respiratory motion induced IMRT delivery errors: a volumetric dose measurement study. Med Phys, 33(5), 1380-1387.
Duan, J., Shen, S., Spencer, S. A., Ahmed, R. S., Popple, R. A., Ye, S. J., & Brezovich, I. A. (2004). A dynamic supraclavicular field-matching technique for head-and-neck cancer patients treated with IMRT. Int J Radiat Oncol Biol Phys, 60(3), 959-972. doi: 10.1016/j.ijrobp.2004.06.213
Ford, E. C., Mageras, G. S., Yorke, E., & Ling, C. C. (2003). Respiration-correlated spiral CT: a method of measuring respiratory-induced anatomic motion for radiation treatment planning. Med Phys, 30(1), 88-97.
Giraud, Philippe, Yorke, Ellen, Ford, Eric C., Wagman, Raquel, Mageras, Gig S., Amols, Howard, . . . Rosenzweig, Kenneth E. (2006). Reduction of organ motion in lung tumors with respiratory gating. Lung Cancer, 51(1), 41-51.
Hara, R., Itami, J., Kondo, T., Aruga, T., Abe, Y., Ito, M., . . . Kobiki, T. (2002). Stereotactic single high dose irradiation of lung tumors under respiratory gating. Radiother Oncol, 63(2), 159-163.
Held, M., Kirby, N., Morin, O., & Pouliot, J. (2012). Dosimetric aspects of inverse-planned modulated-arc total-body irradiation. Med Phys, 39(8), 5263-5271. doi: 10.1118/1.4739250
Hong, L., Alektiar, K., Chui, C., LoSasso, T., Hunt, M., Spirou, S., . . . Leibel, S. (2002). IMRT of large fields: whole-abdomen irradiation. Int J Radiat Oncol Biol Phys, 54(1), 278-289.
Hoogeman, M., Prevost, J. B., Nuyttens, J., Poll, J., Levendag, P., & Heijmen, B. (2009). Clinical accuracy of the respiratory tumor tracking system of the cyberknife: assessment by analysis of log files. Int J Radiat Oncol Biol Phys, 74(1), 297-303. doi: 10.1016/j.ijrobp.2008.12.041
Hugo, G. D., Agazaryan, N., & Solberg, T. D. (2003). The effects of tumor motion on planning and delivery of respiratory-gated IMRT. Med Phys, 30(6), 1052-1066.
Hui, S. K., Das, R. K., Thomadsen, B., & Henderson, D. (2004). CT-based analysis of dose homogeneity in total body irradiation using lateral beam. J Appl Clin Med Phys, 5(4), 71-79.
Hussain, A., Dunscombe, P., Villarreal-Barajas, J. E., & Brown, D. (2012). Total body irradiation dose optimization based on radiological depth. J Appl Clin Med Phys, 13(3), 3767. doi: 10.1120/jacmp.v13i3.3767
Hussain, A., Villarreal-Barajas, J. E., Dunscombe, P., & Brown, D. W. (2011). Aperture modulated, translating bed total body irradiation. Med Phys, 38(2), 932-941.
J. Van Dyk, Chairman, & Galvin, J. M. (1986). THE PHYSICAL ASPECTS OF TOTAL AND HALF BODYPHOTON IRRADIATION. 335 E. 45 Street New York. NY 10017: American Association of Physicists in Medicine by the American institute of Physics.
Keall, P. J., Kini, V. R., Vedam, S. S., & Mohan, R. (2001). Motion adaptive x-ray therapy: a feasibility study. Phys Med Biol, 46(1), 1-10.
Keall, P. J., Mageras, G. S., Balter, J. M., Emery, R. S., Forster, K. M., Jiang, S. B., . . . Yorke, E. (2006). The management of respiratory motion in radiation oncology report of AAPM Task Group 76. Med Phys, 33(10), 3874-3900.
Keall, Paul J., Mageras, Gig S., Balter, James M., Emery, Richard S., Forster, Kenneth M., Jiang, Steve B., . . . Yorke, Ellen. (2006). The management of respiratory motion in radiation oncology report of AAPM Task Group 76. Medical Physics, 33(10), 3874-3900.
Khan, Faiz M, & Khan, FM. (2010). The physics of radiation therapy (Vol. 4): Lippincott Williams & Wilkins Philadelphia.
Kim, D. J., Murray, B. R., Halperin, R., & Roa, W. H. (2001). Held-breath self-gating technique for radiotherapy of non-small-cell lung cancer: a feasibility study. Int J Radiat Oncol Biol Phys, 49(1), 43-49.
Kirby, N., Held, M., Morin, O., Fogh, S., & Pouliot, J. (2012). Inverse-planned modulated-arc total-body irradiation. Med Phys, 39(5), 2761-2764. doi: 10.1118/1.4705366
Kubo, H. D., & Hill, B. C. (1996). Respiration gated radiotherapy treatment: a technical study. Phys Med Biol, 41(1), 83-91.
Lagerwaard, F. J., Van Sornsen de Koste, J. R., Nijssen-Visser, M. R., Schuchhard-Schipper, R. H., Oei, S. S., Munne, A., & Senan, S. (2001). Multiple "slow" CT scans for incorporating lung tumor mobility in radiotherapy planning. Int J Radiat Oncol Biol Phys, 51(4), 932-937.
Landberg, T, Chavaudra, J, & Dobbs, J. (1993). ICRU (International Commission of Radiation Units and Measurements) Report No. 50: Prescribing, Recording, and Reporting Photon Beam Therapy. International Commission of Radiation Units and Measurements, Washington, DC.
Lavallee, M. C., Aubin, S., Chretien, M., Larochelle, M., & Beaulieu, L. (2008). Attenuator design for organs at risk in total body irradiation using a translation technique. Med Phys, 35(5), 1663-1669.
Lavallee, M. C., Aubin, S., Larochelle, M., Vallieres, I., & Beaulieu, L. (2011). 3D heterogeneous dose distributions for total body irradiation patients. J Appl Clin Med Phys, 12(3), 3416.
Lavallee, M. C., Gingras, L., Chretien, M., Aubin, S., Cote, C., & Beaulieu, L. (2009). Commissioning and evaluation of an extended SSD photon model for PINNACLE3: an application to total body irradiation. Med Phys, 36(8), 3844-3855.
LoSasso, T., Chui, C. S., & Ling, C. C. (1998). Physical and dosimetric aspects of a multileaf collimation system used in the dynamic mode for implementing intensity modulated radiotherapy. Med Phys, 25(10), 1919-1927.
Lu, W., Parikh, P. J., El Naqa, I. M., Nystrom, M. M., Hubenschmidt, J. P., Wahab, S. H., . . . Low, D. A. (2005). Quantitation of the reconstruction quality of a four-dimensional computed tomography process for lung cancer patients. Med Phys, 32(4), 890-901.
Lujan, A. E., Larsen, E. W., Balter, J. M., & Ten Haken, R. K. (1999). A method for incorporating organ motion due to breathing into 3D dose calculations. Med Phys, 26(5), 715-720.
Mah, D., Hanley, J., Rosenzweig, K. E., Yorke, E., Braban, L., Ling, C. C., . . . Mageras, G. (2000). Technical aspects of the deep inspiration breath-hold technique in the treatment of thoracic cancer. Int J Radiat Oncol Biol Phys, 48(4), 1175-1185.
Malone, S., Crook, J. M., Kendal, W. S., & Szanto, J. (2000). Respiratory-induced prostate motion: quantification and characterization. Int J Radiat Oncol Biol Phys, 48(1), 105-109.
McMahon, R., Berbeco, R., Nishioka, S., Ishikawa, M., & Papiez, L. (2008). A real-time dynamic-MLC control algorithm for delivering IMRT to targets undergoing 2D rigid motion in the beam's eye view. Med Phys, 35(9), 3875-3888.
Miralbell, R., Rouzaud, M., Grob, E., Nouet, P., Bieri, S., Majno, S. B., . . . Precoma, J. C. (1994). Can a total body irradiation technique be fast and reproducible? Int J Radiat Oncol Biol Phys, 29(5), 1167-1173.
Molloy, J. A. (2010). Statistical analysis of dose heterogeneity in circulating blood: implications for sequential methods of total body irradiation. Med Phys, 37(11), 5568-5578.
Murphy, Martin J. (2004). Tracking moving organs in real time. Seminars in Radiation Oncology, 14(1), 91-100.
Negoro, Y., Nagata, Y., Aoki, T., Mizowaki, T., Araki, N., Takayama, K., . . . Hiraoka, M. (2001). The effectiveness of an immobilization device in conformal radiotherapy for lung tumor: reduction of respiratory tumor movement and evaluation of the daily setup accuracy. Int J Radiat Oncol Biol Phys, 50(4), 889-898.
Neicu, T., Shirato, H., Seppenwoolde, Y., & Jiang, S. B. (2003). Synchronized moving aperture radiation therapy (SMART): average tumour trajectory for lung patients. Phys Med Biol, 48(5), 587-598.
Onal, C., Sonmez, A., Arslan, G., Sonmez, S., Efe, E., & Oymak, E. (2012). Evaluation of Field-in-Field Technique for Total Body Irradiation. Int J Radiat Oncol Biol Phys, 83(5), 1641-1648. doi: 10.1016/j.ijrobp.2011.10.045
Onimaru, R., Shirato, H., Fujino, M., Suzuki, K., Yamazaki, K., Nishimura, M., . . . Miyasaka, K. (2005). The effect of tumor location and respiratory function on tumor movement estimated by real-time tracking radiotherapy (RTRT) system. Int J Radiat Oncol Biol Phys, 63(1), 164-169. doi: 10.1016/j.ijrobp.2005.01.025
Pan, T., Lee, T. Y., Rietzel, E., & Chen, G. T. (2004). 4D-CT imaging of a volume influenced by respiratory motion on multi-slice CT. Med Phys, 31(2), 333-340.
Papiez, L., McMahon, R., & Timmerman, R. (2007). 4D DMLC leaf sequencing to minimize organ at risk dose in moving anatomy. Med Phys, 34(12), 4952-4956.
Papiez, L., Rangaraj, D., & Keall, P. (2005). Real-time DMLC IMRT delivery for mobile and deforming targets. Med Phys, 32(9), 3037-3048.
Papieza, L. (2004). DMLC leaf-pair optimal control of IMRT delivery for a moving rigid target. Med Phys, 31(10), 2742-2754.
Pepin, E. W., Wu, H., Zhang, Y., & Lord, B. (2011). Correlation and prediction uncertainties in the cyberknife synchrony respiratory tracking system. Med Phys, 38(7), 4036-4044.
Popple, R. A., & Brezovich, I. A. (2011). Dynamic MLC leaf sequencing for integrated linear accelerator control systems. Med Phys, 38(11), 6039-6045. doi: 10.1118/1.3651628
Ramsey, C. R., Scaperoth, D., Arwood, D., & Oliver, A. L. (1999). Clinical efficacy of respiratory gated conformal radiation therapy. Med Dosim, 24(2), 115-119.
Remouchamps, V. M., Letts, N., Vicini, F. A., Sharpe, M. B., Kestin, L. L., Chen, P. Y., . . . Wong, J. W. (2003). Initial clinical experience with moderate deep-inspiration breath hold using an active breathing control device in the treatment of patients with left-sided breast cancer using external beam radiation therapy. Int J Radiat Oncol Biol Phys, 56(3), 704-715.
Remouchamps, V. M., Letts, N., Yan, D., Vicini, F. A., Moreau, M., Zielinski, J. A., . . . Wong, J. W. (2003). Three-dimensional evaluation of intra- and interfraction immobilization of lung and chest wall using active breathing control: a reproducibility study with breast cancer patients. Int J Radiat Oncol Biol Phys, 57(4), 968-978.
Remouchamps, V. M., Vicini, F. A., Sharpe, M. B., Kestin, L. L., Martinez, A. A., & Wong, J. W. (2003). Significant reductions in heart and lung doses using deep inspiration breath hold with active breathing control and intensity-modulated radiation therapy for patients treated with locoregional breast irradiation. Int J Radiat Oncol Biol Phys, 55(2), 392-406.
Rosenzweig, K. E., Hanley, J., Mah, D., Mageras, G., Hunt, M., Toner, S., . . . Leibel, S. A. (2000). The deep inspiration breath-hold technique in the treatment of inoperable non-small-cell lung cancer. Int J Radiat Oncol Biol Phys, 48(1), 81-87.
Schaeken, B., Lelie, S., Meijnders, P., Van den Weyngaert, D., Janssens, H., & Verellen, D. (2010). Alanine/EPR dosimetry applied to the verification of a total body irradiation protocol and treatment planning dose calculation using a humanoid phantom. Med Phys, 37(12), 6292-6299.
Schultheiss, T. E., Wong, J., Liu, A., Olivera, G., & Somlo, G. (2007). Image-guided total marrow and total lymphatic irradiation using helical tomotherapy. Int J Radiat Oncol Biol Phys, 67(4), 1259-1267. doi: 10.1016/j.ijrobp.2006.10.047
Schweikard, A., Glosser, G., Bodduluri, M., Murphy, M. J., & Adler, J. R. (2000). Robotic motion compensation for respiratory movement during radiosurgery. Comput Aided Surg, 5(4), 263-277. doi: 10.1002/1097-0150(2000)5:4<263::AID-IGS5>3.0.CO;2-2
Seiler, P. G., Blattmann, H., Kirsch, S., Muench, R. K., & Schilling, C. (2000). A novel tracking technique for the continuous precise measurement of tumour positions in conformal radiotherapy. Phys Med Biol, 45(9), N103-110.
Seppenwoolde, Y., Shirato, H., Kitamura, K., Shimizu, S., van Herk, M., Lebesque, J. V., & Miyasaka, K. (2002). Precise and real-time measurement of 3D tumor motion in lung due to breathing and heartbeat, measured during radiotherapy. Int J Radiat Oncol Biol Phys, 53(4), 822-834.
Sharma, M., Dos Santos, T., Papanikolopoulos, N. P., & Hui, S. K. (2011). Feasibility of intrafraction whole-body motion tracking for total marrow irradiation. J Biomed Opt, 16(5), 058002. doi: 10.1117/1.3575645
Sharp, G. C., Jiang, S. B., Shimizu, S., & Shirato, H. (2004). Prediction of respiratory tumour motion for real-time image-guided radiotherapy. Phys Med Biol, 49(3), 425-440.
Shimizu, S., Shirato, H., Kagei, K., Nishioka, T., Bo, X., Dosaka-Akita, H., . . . Miyasaka, K. (2000). Impact of respiratory movement on the computed tomographic images of small lung tumors in three-dimensional (3D) radiotherapy. Int J Radiat Oncol Biol Phys, 46(5), 1127-1133.
Shirato, H., Oita, M., Fujita, K., Watanabe, Y., & Miyasaka, K. (2004). Feasibility of synchronization of real-time tumor-tracking radiotherapy and intensity-modulated radiotherapy from viewpoint of excessive dose from fluoroscopy. Int J Radiat Oncol Biol Phys, 60(1), 335-341. doi: 10.1016/j.ijrobp.2004.04.028
Shirato, H., Shimizu, S., Kitamura, K., Nishioka, T., Kagei, K., Hashimoto, S., . . . Miyasaka, K. (2000). Four-dimensional treatment planning and fluoroscopic real-time tumor tracking radiotherapy for moving tumor. Int J Radiat Oncol Biol Phys, 48(2), 435-442.
Shirato, H., Shimizu, S., Kunieda, T., Kitamura, K., van Herk, M., Kagei, K., . . . Miyasaka, K. (2000). Physical aspects of a real-time tumor-tracking system for gated radiotherapy. Int J Radiat Oncol Biol Phys, 48(4), 1187-1195.
Siebers, J. V., Lauterbach, M., Keall, P. J., & Mohan, R. (2002). Incorporating multi-leaf collimator leaf sequencing into iterative IMRT optimization. Med Phys, 29(6), 952-959.
Spirou, S. V., & Chui, C. S. (1994). Generation of arbitrary intensity profiles by dynamic jaws or multileaf collimators. Med Phys, 21(7), 1031-1041.
Spirou, S. V., & Chui, C. S. (1996). Generation of arbitrary intensity profiles by combining the scanning beam with dynamic multileaf collimation. Med Phys, 23(1), 1-8.
Starkschall, G., Forster, K. M., Kitamura, K., Cardenas, A., Tucker, S. L., & Stevens, C. W. (2004). Correlation of gross tumor volume excursion with potential benefits of respiratory gating. Int J Radiat Oncol Biol Phys, 60(4), 1291-1297. doi: 10.1016/j.ijrobp.2004.07.707
Stein, A., & Forman, S. J. (2008). Allogeneic transplantation for ALL in adults. Bone Marrow Transplant, 41(5), 439-446. doi: 10.1038/bmt.2008.1
Ten Haken, R. K., Balter, J. M., Marsh, L. H., Robertson, J. M., & Lawrence, T. S. (1997). Potential benefits of eliminating planning target volume expansions for patient breathing in the treatment of liver tumors. Int J Radiat Oncol Biol Phys, 38(3), 613-617.
Trofimov, A., Rietzel, E., Lu, H. M., Martin, B., Jiang, S., Chen, G. T., & Bortfeld, T. (2005). Temporo-spatial IMRT optimization: concepts, implementation and initial results. Phys Med Biol, 50(12), 2779-2798. doi: 10.1088/0031-9155/50/12/004
Tsunashima, Yoshikazu, Sakae, Takeji, Shioyama, Yoshiyuki, Kagei, Kenji, Terunuma, Toshiyuki, Nohtomi, Akihiro, & Akine, Yasuyuki. (2004). Correlation between the respiratory waveform measured using a respiratory sensor and 3D tumor motion in gated radiotherapy. International Journal of Radiation Oncology*Biology*Physics, 60(3), 951-958.
Umek, B., Zwitter, M., & Habic, H. (1996). Total body irradiation with translation method. Radiother Oncol, 38(3), 253-255.
Underberg, R. W., Lagerwaard, F. J., Slotman, B. J., Cuijpers, J. P., & Senan, S. (2005). Use of maximum intensity projections (MIP) for target volume generation in 4DCT scans for lung cancer. Int J Radiat Oncol Biol Phys, 63(1), 253-260. doi: 10.1016/j.ijrobp.2005.05.045
Vedam, S., Docef, A., Fix, M., Murphy, M., & Keall, P. (2005). Dosimetric impact of geometric errors due to respiratory motion prediction on dynamic multileaf collimator-based four-dimensional radiation delivery. Med Phys, 32(6), 1607-1620.
Vedam, S. S., Keall, P. J., Docef, A., Todor, D. A., Kini, V. R., & Mohan, R. (2004). Predicting respiratory motion for four-dimensional radiotherapy. Med Phys, 31(8), 2274-2283.
Vedam, S. S., Keall, P. J., Kini, V. R., & Mohan, R. (2001). Determining parameters for respiration-gated radiotherapy. Med Phys, 28(10), 2139-2146.
Wambersie, A, & Landgerg, T. (1999). ICRU Report 62: Prescribing, Recording and Reporting Photon Beam Therapy. ICRU Publication, Bethesda (MD).
Wilkie, J. R., Tiryaki, H., Smith, B. D., Roeske, J. C., Radosevich, J. A., & Aydogan, B. (2008). Feasibility study for linac-based intensity modulated total marrow irradiation. Med Phys, 35(12), 5609-5618.
Wilson, E. M., Williams, F. J., Lyn, B. E., Wong, J. W., & Aird, E. G. (2003). Validation of active breathing control in patients with non-small-cell lung cancer to be treated with CHARTWEL. Int J Radiat Oncol Biol Phys, 57(3), 864-874.
Wong, J. W., Sharpe, M. B., Jaffray, D. A., Kini, V. R., Robertson, J. M., Stromberg, J. S., & Martinez, A. A. (1999). The use of active breathing control (ABC) to reduce margin for breathing motion. Int J Radiat Oncol Biol Phys, 44(4), 911-919.
Wu, Q., Arnfield, M., Tong, S., Wu, Y., & Mohan, R. (2000). Dynamic splitting of large intensity-modulated fields. Phys Med Biol, 45(7), 1731-1740.
Xia, P., & Verhey, L. J. (1998). Multileaf collimator leaf sequencing algorithm for intensity modulated beams with multiple static segments. Med Phys, 25(8), 1424-1434.
Xu, J., Papanikolaou, N., Shi, C., & Jiang, S. B. (2009). Synchronized moving aperture radiation therapy (SMART): superimposing tumor motion on IMRT MLC leaf sequences under realistic delivery conditions. Phys Med Biol, 54(16), 4993-5007. doi: 10.1088/0031-9155/54/16/010
Yao, R., Bernard, D., Turian, J., Abrams, R. A., Sensakovic, W., Fung, H. C., & Chu, J. C. (2012). A simplified technique for delivering total body irradiation (TBI) with improved dose homogeneity. Med Phys, 39(4), 2239-2248. doi: 10.1118/1.3697526
Yeginer, M., Roeske, J. C., Radosevich, J. A., & Aydogan, B. (2011). Linear accelerator-based intensity-modulated total marrow irradiation technique for treatment of hematologic malignancies: a dosimetric feasibility study. Int J Radiat Oncol Biol Phys, 79(4), 1256-1265. doi: 10.1016/j.ijrobp.2010.06.029
Zhang, T., Jeraj, R., Keller, H., Lu, W., Olivera, G. H., McNutt, T. R., . . . Paliwal, B. (2004). Treatment plan optimization incorporating respiratory motion. Med Phys, 31(6), 1576-1586.
Zhuang, A. H., Liu, A., Schultheiss, T. E., & Wong, J. Y. (2010). Dosimetric study and verification of total body irradiation using helical tomotherapy and its comparison to extended SSD technique. Med Dosim, 35(4), 243-249. doi: 10.1016/j.meddos.2009.07.001
Zygmanski, P., Kung, J. H., Jiang, S. B., & Chin, L. (2003). Dependence of fluence errors in dynamic IMRT on leaf-positional errors varying with time and leaf number. Med Phys, 30(10), 2736-2749.


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