(3.236.214.19) 您好!臺灣時間:2021/05/07 13:10
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果

詳目顯示:::

: 
twitterline
研究生:陳楷翔
研究生(外文):Chen,Kai-Siang
論文名稱:利用LED裝置量測異常組織之研究
論文名稱(外文):The study of Applying LED Device to Measure Abnormal Tissue
指導教授:洪正瑞洪正瑞引用關係
指導教授(外文):Horng, Jenq-Ruey
學位類別:碩士
校院名稱:南台科技大學
系所名稱:電機工程系
學門:工程學門
學類:電資工程學類
論文種類:學術論文
論文出版年:102
畢業學年度:101
語文別:中文
論文頁數:59
中文關鍵詞:異常組織、非侵入式、含異常組織、非侵入式、含氧血紅素、去氧血紅素、近紅外線、仿體
外文關鍵詞:abnormal tissue, non-invasive, oxy-hemoglobin, deoxy-hemoglobin, near-infrared, phantom
相關次數:
  • 被引用被引用:0
  • 點閱點閱:86
  • 評分評分:系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔
  • 下載下載:4
  • 收藏至我的研究室書目清單書目收藏:0
要發掘人體異常組織,有許多檢測方式,除了醫生事先透過目測及觸診等物理方式外,利用侵入式人體細胞組織切片、超音波、X光檢視、電腦斷層掃描或是核磁共振成像等,皆可以輔助醫方達成檢測目的;但由於部分檢測需花費一定的檢測金額,也消耗了許多時間,因此,本研究所針對部分弱點,設計一套檢測系統,不僅在操作使用方面簡易,也不需要耗費過多時間,同時本設計為非侵入性檢測,能屏除了一般人對其安全性上的顧慮。
本研究的設計原理,是利用異常組織與正常組織中,比較含氧血紅素與去氧血紅素裡,其對光的吸收能力;本研究藉由特定可見光以及近紅外線的吸收光譜特性下,使用特定的LED波長穿透人體組織,當照射皮下組織,含氧血紅素及去氧血紅素因其對光訊號吸收能力的不同,產生繞射與散射的現象,再將光感測器接收到的光訊號轉變成電訊號,以接收訊號的數據結果,藉此判斷皮下是否有異常組織。而目前為止,本研究儀器大約可以偵測到人體表皮下組織二到三公分的範圍。
本研究最後使用自製仿體,以模擬人體表皮下的正常及異常組織,利用實驗來調整其電路特性,如此並能使研究成效發揮至極。藉由檢測儀器,本研究希望根據檢測而出的數據,能當作事先預防治療的參考依據,透過數據發現異常,及時給予治療,以避免內部組織已有了問題,卻因為表皮層顯現無異狀而錯失治療良機。
There are several ways to examine an abnormal tissue. Besides physical methods like visual estimation or palpation, invasive human tissue biopsy, ultrasound, x-ray examination, Computed Tomography (CT), Magnetic Resonance Imaging (MRI), and others. There are also other ways to detect the unusual pattern. However, many of the inspection systems cost huge amount of money and requires lengthy times. Therefore, the goal of this study is to provide a convenient and cheaper method for testing tissue abnormalities. The objective is not only to shorten the duration of the examination and reduce the cost but also design a non-invasive examination that can alleviate the safety concerns during an invasive inspection.
The main theory of this research is the comparison of the light absorption between oxy-hemoglobin and deoxy-hemoglobin in normal and abnormal tissues. Taking the characteristics of visual light and near-infrared spectrum, the research uses specific LED wavelengths for penetration. While irradiating the subcutaneous tissue, diffraction and scattering happens due to the different absorbing ability of HbO2 and Hb. In the end, this research collects and turns the light signal into electrical signals and calculates its statistical results. Subsequently, this device developed in this study is able to examine up to a depth of 2 to 3 centimeters into the human subcutaneous tissue.
In the final stage, this research uses a self-made phantom to imitate the normal and abnormal tissue under the epidermis of the human skin. Adjusting the circuit pattern in examines to get better outcomes. By utilizing this examination system, the research purposes to use the statistics data for the foundation of pre-treatment before it is too late.
摘  要............................................................................................................................i
ABSTRACT…………………………………………………………………………..…ii
致  謝..........................................................................................................................iii
目  次..........................................................................................................................iv
表目錄.............................................................................................................................vii
圖目錄............................................................................................................................viii
第一章 緒論...................................................................................................................1
1.1 研究背景............................................................................................................1
1.2 研究動機與目的................................................................................................2
第二章 原理與相關文獻...............................................................................................3
2.1 光學原理............................................................................................................3
2.1.1 反射定律.....................................................................................................3
2.1.2 全反射定律.................................................................................................4
2.1.3 散射定律.....................................................................................................5
2.1.4 折射定律.....................................................................................................6
2.1.5 繞射定律.....................................................................................................7
2.1.6 光譜吸收.....................................................................................................8
2.1.7 比爾朗伯定律(Beer Lambert’s Law)…………………………………….9
2.1.8 光譜和可見光...........................................................................................10
2.2 人體組織介紹..................................................................................................11
2.2.1 組織...........................................................................................................11
2.2.2 脂肪組織...................................................................................................13
2.3 人體腫瘤介紹..................................................................................................14
2.4 含氧血紅素與去氧血紅素..............................................................................15
第三章 材料與方法.......................................................................................................17
3.1 硬體電路設計..................................................................................................17
3.1.1 單晶片dsPIC30F4011功能說明.............................................................17
3.1.2 燒錄裝置...................................................................................................20
3.1.3 光感測器 .................................................................................................20
3.1.4 暗電流.......................................................................................................21
3.1.5 輸出(IC)電流的直線性.............................................................................22
3.1.6 電源設計...................................................................................................26
3.1.7 LED裝置................................................................................................26
3.1.8 放大器原理...............................................................................................28
3.1.9 放大器設計...............................................................................................29
3.1.10 LCD模組介紹......................................................................................30
3.2 系統架構..........................................................................................................31
3.2.1 儀器量測方法...........................................................................................32
3.2.2 儀器量測方式設計...................................................................................33
3.3 dsp30F4011單晶片程式設計........................................................................34
3.3.1 Timer模組...............................................................................................35
3.3.2 A/D模組.................................................................................................35
3.4 仿體介紹..........................................................................................................38
3.4.1 利波貝20%介紹.......................................................................................39
3.4.2 仿體製作...................................................................................................40
3.5 儀器實體設計..................................................................................................42
第四章 實驗結果與討論...............................................................................................46
4.1 仿體量測..........................................................................................................46
4.2 仿體(水+洋菜粉)量測結果.............................................................................48
4.3仿體(水+Lipovenoes-20%)量測結果...............................................................52
第五章 結論...................................................................................................................57
5.1 結論..................................................................................................................57
5.2 未來展望..........................................................................................................57
參考文獻.........................................................................................................................58
1. 行政院衛生署100年國人死因統計表- http://www.doh.gov.tw/。
2. 耿繼業、何建娃,幾何光學,全華科技圖書股份有限公司,民90年。
3. 楊建人,光學原理,徐氏基金會,民71年。
4. 張阜權、孫榮山、唐偉國,光學,凡異出版社,民84年。
5. 鄭華生,分析化學,國立清華大學,2007
6. 方松傳、方偉平、王健行、洪培元、陳連輝、陳銘田、劉世琳,有機化學,高立圖書有限公司,民87年。
7. 朱家瑜,人體組織學,藝軒圖書出版社,民92年。
8. 胡明一,人體解剖學 Human anatomy,藝軒圖書出版社,民93年。
9. Huang, K. C., Chang, C. L., Chang, H. C., & Chang, C. H., “The image analysis of skin tissue irradiated with difference wavelengths of LED sources”, Instrumentation and Measurement Technology Conference(I2MTC), 2012, pp. 1246-1250.
10. 林志聰、吳建宗、黃正仁、梁文雄,組織學。藝軒圖書出版社,1993
11. 閔華慶,腫瘤,牛頓出版公司,1991
12. 余麗君、姜亞芳,病理生理學,五南圖書出版股份有限公司,民92年。
13. 郭碧照、林豫亭,『探討小兒加護病房病童之SpO2 與SaO2 的關係』中山醫學大學醫學研究所碩士論文,2003。
14. Head, Linda M., and R. M. Pierson. "Functional near infrared spectroscopy for Hb and HbO2 detection using remote sensing." Sensors Applications Symposium (SAS), IEEE, 2010. pp. 166 – 169.
15. 曾百由,dsPIC數位訊號控制器原理與應用,宏友圖書開發股份有限公司,民94年。
16. Microchip dsPIC30F4011 Data Sheet.
17. 許書務,光感測器界面專題製作,電子技術出版社,民83年。
18. KODENSHI ST-1MLB Data Sheet.
19. STMicroelectronics L7805CV Data sheet.
20. ANALOG DEVICES ADM660 Data sheet.
21. Ocean Optics-http://www.oceanoptics.com/Products/hr4000.asp
22. 盧明智、黃敏祥,OP Amp應用+實驗模擬(含filter、A/D、D/A、VCO、V/F、F/V) : OP Amp應用+實驗模擬,全華科技圖書股份有限公司,民84年。
23. STMicroelectronics TL084 Data Sheet.
24. ANALOG DEVICES AD620 Data Sheet.
25. Van Staveren, H. J., Moes, C. J., Van Marle, J., Prahl, S. A., and Van Gemert, M. J., “Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm”, Applied Optics, vol. 30(31), 1991, pp. 4507-4514.
26. 台灣費森尤斯卡比股份有限公司- http://www.fresenius-kabi.com/
27. Alacam, Burak, Rensselaer Polytech. Inst., Troy ; Yazici, Birsen ; Chance, B. ; Nioka, S. "Characterization of breast tumors with NIR methods using optical indices." Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE. IEEE, 2007. pp. 5186 - 5189
28. Zhao, Zhongyao, Zhang, Jun, Zhang, Jun Du, Juan Nioka, Shoko Chance, Britton . "Handheld tumor scanner for breast cancer detection. Biomedical Technology Showcase, 2006
連結至畢業學校之論文網頁點我開啟連結
註: 此連結為研究生畢業學校所提供,不一定有電子全文可供下載,若連結有誤,請點選上方之〝勘誤回報〞功能,我們會盡快修正,謝謝!
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
系統版面圖檔 系統版面圖檔