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研究生:高寧㚬
研究生(外文):Ning-Chun Kao
論文名稱:山竹濃縮果汁對STZ誘發之第2型糖尿病大鼠其血糖恆定及肝臟粒線體功能性的調節
論文名稱(外文):Mangosteen mix juice controls blood glucose and modulateshepatic mitochondrial function in streptozotocin-induced type 2 diabetic rats
指導教授:謝榮鴻
口試委員:許瑞芬陳玉華
口試日期:2013-06-24
學位類別:碩士
校院名稱:臺北醫學大學
系所名稱:保健營養學研究所
學門:醫藥衛生學門
學類:營養學類
論文種類:學術論文
論文出版年:2013
畢業學年度:101
語文別:中文
論文頁數:87
中文關鍵詞:山竹;streptozotocin;粒線體;抗氧化;第2型糖尿病
外文關鍵詞:magosteen;Streptozotocin;liver;mitochondria;antioxidant;type 2 diabetes
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現今全球罹患糖尿病之人口高達三億多人,其中90~95%屬於第2型糖尿病,在我國糖尿病也已成為國人主要之慢性病之一,而高血糖所誘發之氧化壓力增加,會造成粒線體功能缺失。文獻指出,山竹果皮萃取物具有抗氧化、抗發炎之功效,但能否改善糖尿病粒線體功能缺失的情形仍然未知。本研究是以注射streptozotocin合併nicotinamide 誘發之第2型糖尿病大鼠模式,探討給予山竹濃縮果汁對於血糖及肝臟粒線體之影響。實驗大鼠分為對照組 (N) 與實驗組,實驗組又分為糖尿病 (C) 組及飼料添加山竹濃縮果汁低 (L: 0.5 mL/day) 、中 (M: 1.0 mL/day) 、高 (H: 2.0 mL/day) 劑量組,實驗為期八週後進行犧牲,取其血液及肝臟進行分析。研究結果發現,以山竹濃縮果汁飼養八週後可顯著降低第2型糖尿病大鼠禁食血糖,且可抑制葡萄糖耐受試驗180分鐘血糖曲線下面積之增加;增加catalase、glutathione reductase、glutathione peroxidase及SOD等抗氧化酵素活性,降低TBARS (Thiobarbituric acid reactive substances)濃度,並增加粒線體NCCR (nicotinamide adenine dinucleotide (NADH)-cytochrome c reductase)及SCCR (succinate-cytochrome c reductase)之酵素活性;總合以上結論,山竹濃縮果汁的補充對於第2型糖尿病大鼠可增加其體內之抗氧化能力,並改善粒線體功能缺失之情形,有助於糖尿病之血糖調控。
There are 347 million people with diabetes worldwide, whereas 90% comprises of Type 2 diabetes. Diabetes mellitus (DM) is one of the major chronic disease in Taiwan. Hyperglycemia induced oxidative stress causes mitochondrial dysfunction. Mangosteen (Garcinia mangostana) pericarp extract is rich in xanthone, and exhibits strong antioxidant, anti-inflammatory, and antitumor activities. However, its potential to ameliorate mitochondrial dysfunction in diabetes is unknown. Therefore, the purpose of this study was to investigate the effects of mangosteen mix juice on liver mitochondrial functions in type 2 diabetic rats. DM was induced in male Wistar rats by intraperitoneal injection of streptozotocin/nicotinamide. The experiment was divided in to five groups: (N) normal group (C) DM group (L) DM group + low dose mangosteen mix juice (0.5ml/day), (M) DM group + medium dose mangosteen mix juice (1ml/day) , (H) DM group + high dose mangosteen mix juice (2ml/day). After 8 weeks, rats were sacrificed and examined liver tissues for activity of superoxidase dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), catalase (CAT), and thiobiobarbitric acid reactive substances (TBARS). Liver mitochondria were analysed for nicotinamide adenine dinucleotide cytochrome c reductase (NCCR), succinate cytochrome c reductase (SCCR), respiratory control ratio (RCR), and mtDNA copy number. The results showed significantly lower plasma glucose in the M and H groups than in the group C. Mangosteen mix juice consumption prevented increased glucose (AUC 0-180 min) after intraperitoneal injection of in rats. The M, and H group had significantly increased CAT and SOD activities compared with respective activities in group C. The GR and GPx activity was significantly higher in L, M, and H groups showed than in group C. L, M, and H group had significantly lower hepatic TBARS than group C. NCCR and SCCR activities in L, M, and H groups were significantly higher than activity in group C. RCR and mtDNA copy number in L, M, and H groups were significantly higher than group C. In conclusion, mangosteen mix juice consumption increased hepatic antioxidant capacity, improved mitochondrial function, and controlled type 2 diabetes blood sugar homeostasis.
目錄
目錄................................................... i
表目錄................................................. iv
圖目錄................................................. vi
摘要................................................... vii
Abstract............................................... 8
第一章 前言............................................ 9
第二章 文獻回顧........................................ 11
第一節 糖尿病......................................... 11
一、流行病學......................................... 11
二、簡介............................................. 11
三、糖尿病分類....................................... 13
(一)第1型糖尿病 (type 1 diabetes)................... 13
(二)第2型糖尿病 (Type 2 diabetes)................... 13
(三)妊娠型糖尿病 (gestational diabetes, GDM)........ 14
四、Streptozotocin (STZ)............................. 14
(一)致病機轉........................................ 15
(二)以nicotinamide (NA)合併STZ誘發動物高血糖之機制與原
理.............................................. 16
第二節 粒線體......................................... 18
一、粒線體概述與功能................................. 18
二、粒線體之電子傳遞鏈與氧化磷酸化功能............... 19
三、粒線體功能評估................................... 20
四、粒線體與氧化壓力................................. 21
五、氧化壓力、糖尿病與粒線體之關聯性................. 22
六、粒線體與STZ...................................... 23
第三節 山竹........................................... 25
一、山竹簡介:....................................... 25
二、傳統醫療功效..................................... 26
三、活性成分......................................... 27
四、生理活性......................................... 28
(一)抗氧化功能...................................... 28
(二)抗腫瘤.......................................... 29
(三)抗發炎與抗過敏作用.............................. 30
五、安全性評估....................................... 31
第三章 研究目的........................................ 33
第四章 材料與方法...................................... 34
一、實驗設計......................................... 34
二、第2型糖尿病誘發.................................. 37
三、樣品採集及處理................................... 38
四、分析項目......................................... 38
(一)血液樣品分析.................................... 38
(二)肝臟樣品分析.................................... 42
(三)粒線體功能分析.................................. 46
(四)肝臟粒線體DNA................................... 48
第五章 統計分析........................................ 50
第六章 結果............................................ 51
一、體重及攝食量變化................................. 51
二、禁食血漿葡萄糖及脂質濃度變化..................... 51
三、腹腔注射葡萄糖耐受試驗180分鐘血糖曲線下面積...... 52
四、肝臟抗氧化酵素活性及脂質過氧化終產物濃度......... 52
五、肝臟粒線體呼吸傳遞鏈複合體酵素活性............... 53
六、肝臟粒線體呼吸控制率............................. 54
七、肝臟粒線體DNA套數................................ 54
第七章 討論............................................ 55
一、山竹濃縮果汁對攝食量及體重之影響................. 55
二、山竹濃縮果汁對血糖恆定之影響..................... 55
三、山竹濃縮果汁對肝臟抗氧化酵素活性之影響........... 57
四、山竹濃縮果汁對肝臟粒線體功能之影響............... 59
五、山竹濃縮果汁對糖尿病之影響....................... 60
第八章 結論............................................ 61
第九章 參考文獻........................................ 62
附錄................................................... 91
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行政院衛生署 食品藥物消費者知識服務網 (2011) 2005 - 2008 台灣國民營養健康狀況變遷調查結果 摘自
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