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研究生:翁興裕
研究生(外文):Hsing-Yu Weng
論文名稱:Denbinobin與zerumbone引發人類多型性神經膠原母細胞瘤凋亡之作用機轉
論文名稱(外文):Mechanism of denbinobin- and zerumbone-induced apoptosis in human glioblastoma multiforme cells
指導教授:邱文達邱文達引用關係
指導教授(外文):Wen-Ta Chiu
口試委員:施養性顧記華宋秉文施純明陳彥州
口試委員(外文):Yang-Hsin ShihJih-Hwa GuhBing-Wen SoongChuen-Ming ShihYen-Chou Chen
口試日期:2013-06-19
學位類別:博士
校院名稱:臺北醫學大學
系所名稱:臨床醫學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:2013
畢業學年度:101
語文別:英文
論文頁數:94
中文關鍵詞:denbinobinzerumbone多型性神經膠原母細胞瘤細胞凋亡IKKAktFOXO
外文關鍵詞:denbinobinzerumboneglioblatoma multiforme cellsIKKAktFOXO
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In recent years, some extract from plants was found to have anti-tumor effects, such as denbinobin from Shi-Hu, and zerumbone, from subtropical ginger Zingiber zerumbet Smith. Denbinobin, a phenanthraquinone derivative, and zerumbone, a sesquiterpene compound, were both shown to exert antitumor activities in several types of cancer cell lines. However, the precise mechanisms underlying cell death remain unclear. In this study, we investigated the apoptotic signaling cascade elicited by denbinobin and zerumbone in human glioblastoma multiforme (GBM) cells. Denbinobin and zerumbone concentration-dependently caused a decrease in the cell viability of GBM cells. A flow cytometric analysis of propidium iodide (PI)-stained cells demonstrated that denbinobin and zerumbone induced GBM cell apoptosis. Denbinobin and zerumbone evoked caspase-3 activation and degradation of poly (ADP-ribose) polymerase (PARP). N-benzyloxycarbonyl- Val-Ala-Asp- fluoromethylketone (zVAD-fmk), a broad-spectrum caspase inhibitor, prevented denbinobin- and zerumbone- induced cell death. In addition, denbinobin- and zerumbone- induced cell death were diminished by the transfection of wild-type (WT) Akt or IκB kinase (IKK) into GBM cells. Denbinobin and zerumbone reduced IKK phosphorylation in a time-dependent manner, and denbinobin- and zerumbone- dephosphorylated IKK were accompanied by a decrease in Akt phosphorylation. The phosphorylation status of forkhead in rhabdomyosarcoma (FKHR), a downstream signal molecule of Akt, was also diminished by the presence of denbinobin or zerumbone. Furthermore, transfection of GBM cells with WT IKKα markedly suppressed the decreases in Akt and FKHR phosphorylation caused by denbinobin or zerumbone. In contrast, transfection with WT IKKβ only slightly affected denbinobin’s or zerumbone’s action against IKK, Akt, and FKHR. These results suggest that IKKα inactivation, followed by Akt and FKHR dephosphorylation and caspase-3 activation, contributes to denbinobin- and zerumbone- induced GBM cell apoptosis.
致 謝 i
Abbreviation ii
Abstracts in Chinese 1
Abstracts in English 2
1.Introduction 4
2.Materials and Methods 22
3.Results
I.Denbinobin 26
II.Zerumbone 29
4.Discussion 34
5.Conclusion 45
6.Future Perspective 46
7.References 47
8.Tables and Figures 65
9.Appendix:
Published articles 94
Abdelwahab SI, Abdul AB, Alzubairi AS, Mohamed Elhassan M, Mohan S. In vitro ultramorphological assessment of apoptosis induced by zerumbone on (HeLa). J Biomed Biotechnol 2009:769568.

Abdelwahab SI, Abdul AB, Devi N, Taha MM, Al-zubairi AS, Mohan S, et al. Regression of cervical intraepithelial neoplasia by zerumbone in female Balb/c mice prenatally exposed to diethylstilboestrol: involvement of mitochondria regulated apoptosis. Exp Toxicol Pathol 2010; 62:461–9.

Aggarwal BB, Sethi G, Baladandayuthapani V, Krishnan S, Shishodia S. Targeting cell signaling pathways for drug discovery: an old lock needs a new key. J Cell Biochem 2007;102:580–92.

Aggarwal BB, Van Kuiken ME, Iyer LH, Harikumar KB, Sung B. Molecular targets of nutraceuticals derived from dietary spices: potential role in suppression of inflammation and tumorigenesis. Exp Biol Med (Maywood) 2009;234:825–49.

Arden KC. Multiple roles of FOXO transcription factors in mammalian cells point to multiple rolesvin cancer. Exp Gerontol 2006; 41:709–717.

Bolzani Vda S, Davies-Coleman M, Newman DJ, Singh SB, Gordon M, Cragg GM. A man for all natural products. J Nat Prod 2012;75:309–10.

Bonizzi G., Bebien M., Otero P.C., Johnson-Vroom K., et al. Activating of IKKa target genes depends on recognition of specific kB binding sites by RelB:p52 dimers. EMBO J. 2004; 23:4202-4210.

Boulares, A.H., Yakovlev, A.G., Ivanova, V., Stoica, B.A., Wang, G., Iyer, S. and Smulson, M. Role of poly (ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J Biol Chem 1999; 274(33):22932-22940.

Brunet, A., Bonni, A., Zigmond, M.J., Lin, M.Z., Juo, P., Hu, L.S., Anderson, M.J., Arden, K.C., Blenis, J. and Greenberg, M.E. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999; 96:857-868.

Buckner, J.C. Factors influencing survival in high-grade gliomas. Semin Oncol 2003; 30:10-14.

Butler MS, Newman DJ. Mother Nature’s gifts to diseases of man: the impact of natural products on anti-infective, anticholestemics and anticancer drug discovery. Prog Drug Res 2008; 65(1):3–44.

Cahill, C.M. and Rogers, J.T. Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase- dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1. J Biol Chem 2008;283: 25900-25912.

Calnan DR, Brunet A. The FoxO code. Oncogene 2008; 27:2276–88

Chang, H.C., Hung, W.C., Huang, M.S. and Hsu, H.K. Extract from the leaves of Toona sinensis roemor exerts potent antiproliferative effect on human lung cancer cells. Am J Chin Med 2002; 30:307-314.

Chen HY, Shiao MS, Huang YL, Shen CC, Lin YL, Kuo YH, et al. Antioxidant principles from Ephemerantha lonchophylla. J Nat Prod 1999;62:1225–7.

Chen TH, Pan SL, Guh JH, Chen CC, Huang YT, Pai HC, et al. Denbinobin induces apoptosis by apoptosis-inducing factor releasing and DNA damage in human colorectal cancer HCT-116 cells. Naunyn Schmiedebergs Arch Pharmacol 2008;378:447–57

Choi SH, Lee YJ, Seo WD, Lee HJ, Nam JW, Kim J, et al. Altered ross-linking of HSP27 by zerumbone as a novel strategy for overcoming HSP27-mediated radioresistance. Int J Radiat Oncol Biol Phys 2011; 79:1196–1205.

Cichy, S.B., Uddin, S., Danilkovich, A., Guo, S., Klippel, A. and Unterman, T.G. Protein kinase B/Akt mediates effects of insulin on hepatic insulin-like growth factor-binding protein-1 gene expression through a conserved insulin response sequence. J Biol Chem 1998; 273:6482-6487.

Cohen, G.M. Caspases: the executioners of apoptosis. Biochem J 1997; 326(Pt 1): 1-16.

Cong, L.N., Chen, H., Li, Y., Zhou, L., McGibbon, M.A., Taylor, S.I. and Quon, M.J. Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol 1997; 11:1881-1890.

Cragg GM, Grothaus PG, Newman DJ. Impact of natural products on developing new anti-cancer agents. Chem Rev 2009;109:3012–43.

Crowell, P.L. Prevention and therapy of cancer by dietary monoterpenes. J Nutr 1999; 129:775S-778S.

Dan, H.C., Cooper, M.J., Cogswell, P.C., Duncan, J.A., Ting, J.P. and Baldwin, A.S. Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev 2008; 22: 1490-1500.

Datta, S.R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y. and Greenberg, M.E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997; 91:231-241.

DeAngelis, L.M. Brain tumors. N Engl J Med 2001; 344:114-123.

Dejardin E. The alternative NF-kB pathway from biochemistry to biology: Pitfalls and promises for future drug development. Biochem. Pharmacol. 2006;72:1161-1179.

del Peso, L., Gonzalez-Garcia, M., Page, C., Herrera, R. and Nunez, G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 1997; 278, 687-689.

Deorukhkar A, Krishnan S, Sethi G, Aggarwal BB. Back to basics: how natural products can provide the basis for new therapeutics. Expert Opin Investig Drugs 2007; 16:1753–73

Dijkers, P.F., Birkenkamp, K.U., Lam, E.W., Thomas, N.S., Lammers, J.W., Koenderman, L. and Coffer, P.J. FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J Cell Biol 2006; 156: 531-542.

Dong XY, Chen C, Sun X, et al. FOXO1A is a candidate for the 13q14 tumor suppressor gene inhibiting androgen receptor signaling in prostate cancer. Cancer Res. 2006; 66:6998–7006.

Fu Y, Hsieh TC, Guo J, Kunicki J, Lee MY, Darzynkiewicz Z, Wu JM. Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells. Biochem Biophys Res Commun 2004; 322:263-270

Fujita, E., Jinbo, A., Matuzaki, H., Konishi, H., Kikkawa, U. and Momoi, T. Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9. Biochem Biophys Res Commun 1999; 264:550-555.

Furuyama, T., Nakazawa, T., Nakano, I. and Mori, N. Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J 2000; 349:629-634.

Gehrmann M, Schmidt M, Brase JC, Roos P, Hengstler JG. Prediction of paclitaxel resistance in breast cancer: is CYP1B1*3 a new factor of influence? Pharmacogenomics 2008; 9:969–74.

Ghosh, S. and Karin, M. Missing pieces in the NF-kappaB puzzle. Cell 2002; 109 Suppl, S81-96.

Gilmore, T.D. Introduction to NF- kappaB: players, pathways, perspectives. Oncogene 2006; 25:6680-6684.

Godefroy N, Lemaire C, Renaud F et al. p53 can promote mitochondria- and caspase-independent apoptosis. Cell Death Differ 2004; 11:785–787

Goswami, R., Kilkus, J., Dawson, S.A. and Dawson, G. Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli. J Neurosci Res 1999; 57(6):884-893.

Gullett NP, Ruhul Amin AR, Bayraktar S, Pezzuto JM, Shin DM, Khuri FR, et al. Cancer prevention with natural compounds. Semin Oncol 2010;37:258–81.

Gustin JA, Korgaonkar CK, Pincheira R, Li Q., Donner DB. Akt regulates basal and included processing of NF-kB2 (p100) to p52. J. Biol. Chem. 2006; 281:16473-16481.

Hacker, H. and Karin, M. Regulation and function of IKK and IKK-related kinases. Sci STKE 2006, re13.

Harvey AL. Natural products in drug discovery. Drug Discov Today 2008; 13:894–901.

Hayden, M.S. and Ghosh, S. Shared principles in NF-kappaB signaling. Cell 2008; 132: 344-362.

Hayden, M.S. and Ghosh, S. Signaling to NF-kappaB. Genes Dev 2004; 18:2195-2224.

Hoffmann, A., Natoli, G. and Ghosh, G. Transcriptional regulation via the NF-kappaB signaling module. Oncogene 2006; 25:6706-6716.

Hu J, Jin W, Yang PM. Reversal of resistance to adriamycin in human breast cancer cell line MCF-7/ADM by beta-elemene. Zhonghua Zhongliu Zazhi 2004; 26: 268-270

Hu, M.C. and Hung, M.C. Role of IkappaB kinase in tumorigenesis. Future Oncol 2005; 1:67-78.

Hu, M.C., Lee, D.F., Xia, W., Golfman, L.S., Ou-Yang, F., Yang, J.Y., Zou, Y., Bao, S., Hanada, N., Saso, H., Kobayashi, R. and Hung, M.C. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 2004; 117:225-237.

Huang YC, Guh JH, Teng CM. Denbinobin-mediated anticancer effect in human K562 leukemia cells: role in tubulin polymerization and Bcr-Abl activity. J Biomed Sci 2005; 12:113–121

Ichikawa H, Nakamura Y, Kashiwada Y, Aggarwal BB. Anticancer drugs designed by mother nature: ancient drugs but modern targets. Curr Pharm Des 2007;13:3400–16.

Jung, F., Haendeler, J., Goebel, C., Zeiher, A.M. and Dimmeler, S. Growth factor-induced phosphoinositide 3-OH kinase/Akt phosphorylation in smooth muscle cells: induction of cell proliferation and inhibition of cell death. Cardiovasc Res 2000; 48(1):148-157.

Karin, M. Nuclear factor-kappaB in cancer development and progression. Nature 2006; 441:431-436.

Kelekar, A., Chang, B.S., Harlan, J.E., Fesik, S.W. and Thompson, C.B. Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL. Mol Cell Biol 1997; 17:7040-7046.

Kelekar, A. and Thompson, C.B. Bcl-2-family proteins: the role of the BH3 domain in apoptosis. Trends Cell Biol 1998; 8:324-330.

Kesari S. Understanding glioblastoma tumor biology: the potential to improve current diagnosis and treatments. Semin Oncol 2011; 38 Suppl 4:S2-10.

Khosla C, Keasling JD. Metabolic engineering for drug discovery and development. Nat Rev Drug Discov 2003;2:1019–25.

Kim, M., Miyamoto, S., Yasui, Y., Oyama, T., Murakami, A. and Tanaka, T. Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice. Int J Cancer 2009;124(2):264-271.

Kirana, C., McIntosh, G.H., Record, I.R. and Jones, G.P. Antitumor activity of extract of Zingiber aromaticum and its bioactive sesquiterpenoid zerumbone. Nutr Cancer 2003; 45:218-225.

Kitayama, T., Okamoto, T., Hill, R.K., Kawai, Y., Takahashi, S., Yonemori, S., Yamamoto, Y., Ohe, K., Uemura, S. and Sawada, S. Chemistry of Zerumbone. 1. Simplified Isolation, Conjugate Addition Reactions, and a Unique Ring Contracting Transannular Reaction of Its Dibromide. J Org Chem 1999; 64:2667-2672.

Kovacs A, Vasas A, Hohmann J. Natural phenanthrenes and their biological activity. Phytochemistry 2008; 69:1084–110.

Krohn K, Loock U, Paavilainen K, Hausen B, Schmalle HW, Kiesele H. Synthesis and electrochemistry of annoquinone-A, cypripedin methyl ether, denbinobin and related 1,4-phenanthrenequinones. ARKIVOC 2001;973–1003.

Kuo CT, Hsu MJ, Chen BC, Chen CC, Teng CM, Pan SL, et al. Denbinobin induces apoptosis in human lung adenocarcinoma cells via Akt inactivation, Bad activation, and mitochondrial dysfunction. Toxicol Lett 2008;177:48–58

Kuo CT, Chen BC, Yu CC, Weng CM, Hsu MJ, Chen CC, Cheng MC, Teng CM, Pan SL, et al. Apoptosis signal-regulating kinase 1 mediates denbinobin- induced apoptosis in human lung adenocarcinoma cells. J Biomed Sci 2009; 177:48–58


Lee YH, Park JD, Baek NI, Kim SI, Ahn BZ. In vitro and in vivo antitumoral phenanthrenes from the aerial parts of Dendrobium nobile. Planta Med 1995;61:178–80

Lee, H.Y., Youn, S.W., Kim, J.Y., Park, K.W., Hwang, C.I., Park, W.Y., Oh, B.H., Park, Y.B., Walsh, K., Seo, J.S. and Kim, H.S. FOXO3a turns the tumor necrosis factor receptor signaling towards apoptosis through reciprocal regulation of c-Jun N-terminal kinase and NF-kappaB. Arterioscler Thromb Vasc Biol 2008; 28:112-120.

Liang J, Slingerland JM. Multiple roles of the PI3K/PKB (Akt) pathwayin cell cycle progression. Cell Cycle 2003; 2:339–45.

Liang CH, Liu LF, Shiu LY, Huang YS, Chang LC, Kuo KW. Action of solamargine on TNFs and cisplatin-resistant human lung cancer cells. Biochem Biophys Res Commun 2004; 322:751-758

Lin, L., Hron, J.D. and Peng, S.L. Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a. Immunity 2004; 21:203-213.

Lin TH, Chang SJ, Chen CC, Wang JP, Tsao LT. Two phenanthraquinones from Dendrobium moniliforme. J Nat Prod 2001;64:1084–6.

Luo, H.R., Hattori, H., Hossain, M.A., Hester, L., Huang, Y., Lee-Kwon, W., Donowitz, M., Nagata, E., Snyder, S.H. Akt as a mediator of cell death. Proc. Natl. Acad. Sci. U.S.A. 2003; 100: 11712–11717

Madrid, L.V., Wang, C.Y., Guttridge, D.C., Schottelius, A.J., Baldwin, A.S., Jr. and Mayo, M.W. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Mol Cell Biol 2000; 20:1626-1638.

Maimone TJ, Baran PS. Modern synthetic efforts toward biologically active terpenes. Nat Chem Biol 2007; 3:396–407

Mathieu, A.L., Gonin, S., Leverrier, Y., Blanquier, B., Thomas, J., Dantin, C., Martin, G., Baverel, G. and Marvel, J. Activation of the phosphatidylinositol 3-kinase/Akt pathway protects against interleukin-3 starvation but not DNA damage-induced apoptosis. J Biol Chem 2001; 276(14): 10935-10942.

Melinda M, Mortenson JMG, Michael G. Schlieman, Richard J. Bold. AKT: a novel target in pancreatic cancer therapy. Cancer Therapy. 2004;2:12.

Mukherji S, van Oudenaarden A. Synthetic biology: understanding biological design from synthetic circuits. Nat Rev Genet 2009; 10:859–71.

Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001; 410:50–6.

Murakami, A., Takahashi, M., Jiwajinda, S., Koshimizu, K. and Ohigashi, H. Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol -13-acetate- induced Epstein-Barr virus activation. Biosci Biotechnol Biochem 1999; 63:1811-1812.

Murakami, A., Takahashi, D., Kinoshita, T., Koshimizu, K., Kim, H.W., Yoshihiro, A., Nakamura, Y., Jiwajinda, S., Terao, J. and Ohigashi, H. Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite. Carcinogenesis 2002; 23:795-802.

Murakami, A., Tanaka, T., Lee, J.Y., Surh, Y.J., Kim, H.W., Kawabata, K., Nakamura, Y., Jiwajinda, S. and Ohigashi, H. Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice. Int J Cancer 2004; 110:481-490.

Myatt SS, Lam EW. The emerging roles of forkhead box (Fox) proteins in cancer. Nat Rev Cancer. 2007; 7:847–859.

Nagata, S. Apoptosis by death factor. Cell 1997; 88:355-365.

Nakae, J., Park, B.C. and Accili, D. Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin- sensitive pathway. J Biol Chem 1999; 274, 15982-15985.

Nakae, J., Barr, V. and Accili, D. Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR. EMBO J 2000; 19:989-996.

Newman D, Cragg G. Natural products in medicinal chemistry. Bioorg Med Chem 2009; 17:2120.

Newman DJ, Cragg GM. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod 2012; 75:311–35.

Nicholson KM, Anderson NG: The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 2002, 14(5):381–395.

Oh WK, Kantoff PW, Weinberg V, Jones G, Rini BI, Derynck MK, Bok R, Smith MR, Bubley GJ, Rosen RT, DiPaola RS, Small EJ. Prospective, multicenter, randomized phase II trial of the herbal supplement, PC-SPES, and diethylstilbestrol in patients with androgen-independent prostate cancer. J Clin
Oncol 2004; 22:3705-3712

Osaki M, Oshimura M, Ito H. PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis 2004; 9:667–76.

Ozes, O.N., Mayo, L.D., Gustin, J.A., Pfeffer, S.R., Pfeffer, L.M. and Donner, D.B. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 1999; 401:82-85.

Ozols RF. Paclitaxel (Taxol)/carboplatin combination chemotherapy in the treatment of advanced ovarian cancer. Semin Oncol 2000; 27: 3-7

Pastorino, J.G., Tafani, M. and Farber, J.L. Tumor necrosis factor induces phosphorylation and translocation of BAD through a phosphatidylinositide- 3-OH kinase-dependent pathway. J Biol Chem 1999; 274: 19411-19416.

Perkins, N.D. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol 2007; 8:49-62.

Philchenkov A. Caspases: potential targets for regulating cell death. J Cell Mol Med 2004; 8:432–444

Reed, J.C. and Kroemer, G. The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/ CD95- and ceramide-induced apoptosis. J Exp Med 1997; 186: 25-37.

Rudolf E, Rudolf K, Cervinka M. Selenium activates p53 and p38 pathways and induces caspase-independent cell death in cervical cancer cells. Cell Biol Toxicol 2008; 24:123–141

Sakinah SA, Handayani ST, Hawariah LP. Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio. Cancer Cell Int 2007; 7:4.

Salminen, A. and Kaarniranta, K. Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling. Cell Signal 2010; 22(4):573-577.

Sanchez-Duffhues G, Calzado MA, de Vinuesa AG, Caballero FJ, Ech-Chahad A, Appendino G, et al. Denbinobin, a naturally occurring 1 ,4- phenanthrenequinone, inhibits HIV-1 replication through an NF-kappaB- dependent pathway. Biochem Pharmacol 2008

Sayaka Mori-Iwamoto YK, Shomei Ryozawa, Kumiko Taba, Masanori Fujimoto, Kiwamu Okita, Kazuyuki Nakamura, et al. A proteomic rofiling of gemcitabine resistance in pancreatic cancer cell lines. Mol Med Rep 2008; 1:6

Scheidereit C. IkB kinase complexes: gateway to NF-kB activation and transcription. Oncogene 2006; 25:6685-6705

Shanmugam MK, Kannaiyan R, Sethi G. Targeting cell signaling and apoptotic
pathways by dietary agents: role in the prevention and treatment of cancer. Nutr Cancer 2011; 63:161–73.

Shanmugam MK, Nguyen AH, Kumar AP, Tan BK, Sethi G. Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids potential role in prevention and therapy of cancer. Cancer Lett 2012; 320:158–70.

Smith L, Watson MB, O’Kane SL, Drew PJ, Lind MJ, Cawkwell L. The analysis of doxorubicin resistance in human breast cancer cells using antibody microarrays. Mol Cancer Ther 2006; 5:2115–20.

Stambolsky P, Weisz L, Shats I et al. Regulation of AIF expression by p53. Cell Death Differ 2006; 13:2140–9

Strauss G, Westhoff MA, Fischer-Posovszky P et al. 4- hydroperoxy- cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ 2007; 15:342–343

Stupp, R., Mason, W.P., van den Bent, M.J., Weller, M., Fisher, B., Taphoorn, M.J., Belanger, K., Brandes, A.A., Marosi, C., Bogdahn, U., Curschmann, J., Janzer, R.C., Ludwin, S.K., Gorlia, T., Allgeier, A., Lacombe, D., Cairncross, J.G., Eisenhauer, E. and Mirimanoff, R.O. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352, 987-996.

Sung B, Jhurani S, Ahn KS, Mastuo Y, Yi T, Guha S, et al. Zerumbone downregulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells. Cancer Res 2008; 68:8938–44

Susin SA, Zamzami N, Castedo M, Daugas E, Wang HG, Geley S, Fassy F, Reed JC, Kroemer G: The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. J Exp Med 1997; 186(1):25–37.

Taha MM, Abdul AB, Abdullah R, Ibrahim TA, Abdelwahab SI, Mohan S. Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene- promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet). Chem Biol Interact 2010; 186:295–305.

Takada, Y., Murakami, A. and Aggarwal, B.B. Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and down regulation of invasion. Oncogene 2005; 24(46): 6957-6969.

Tanaka, H., Fujita, N. and Tsuruo, T. 3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling. J Biol Chem 2005; 280:40965-40973.

Thornberry NA, Lazebnik Y. Caspases: enemies within. Science 1998; 281:1312–1316

Tsai AC, Pan SL, Lai CY, Wang CY, Chen CC, Shen CC, Teng CM. The inhibition of angiogenesis and tumor growth by denbinobin is associated with the blocking of insulin-like growth factor-1 receptor signaling. J Nutr Biochem. 2011: 22, 625-633.

Tsujimoto, Y. and Shimizu, S. Bcl-2 family: life-or-death switch. FEBS Lett 2000; 466:6-10.

Tsujimoto, Y. Bcl-2 family of proteins: life-or-death switch in mitochondria. Biosci Rep 2002; 22:47-58.

Vallabhapurapu S., Karin M. Regulation and function of NF-kB transcription factors in the immune system. Annu. Rev. Immunol. 2009; 27: 693-733.

Vanhaesebroeck B, Alessi DR. The PI3K-PDK1 connection: more than just a road to PKB. Biochem J 2000; 346:561–76.

Vivanco I, Sawyers CL. Phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2:489–501.

West KA, Castillo SS, Dennis PA. Activation of the PI3K/Akt pathway and chemotherapeutic resistance. Drug Resist Updat 2002; 5:234–48.

Wendel HG, De Stanchina E, Fridman JS, Malina A, Ray S, Kogan S,
et al. Survival signalling by Akt and eIF4E in oncogenesis and cancer
therapy. Nature 2004; 428:332–7.

Yadav VR, Prasad S, Sung B, Kannappan R, Aggarwal BB. Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. Toxins (Basel) 2010; 2:2428–66.

Yang CR, Guh JH, Teng CM, Chen CC, Chen PH. Combined treatment with Denbinobin and Fas ligand has a synergistic cytotoxic effect in human pancreatic adenocarcinoma BxPC-3 cells. Br J Pharmacol 2009; 157: 1175–1185

Yang JY, Zong CS, Xia W, et al. ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2- mediated degradation. Nature Cell Biol. 2008; 10:138–148.

Yang JY, Hung MC. A new fork for clinical application: targeting forkhead transcription factors in cancer. Clin Cancer Res. 2009; 15:752–757.

Yang KC, Uen YH, Suk FM et al. Molecular mechanisms of denbinobin-induced anti-tumorigenesis effect in colon cancer cells. World J Gastroenterol 2005; 11:3040–3045

Yodkeeree S, Sung B, Limtrakul P, Aggarwal BB. Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: evidence for an essential role of reactive oxygen species. Cancer Res 2009; 69:6581–9.
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