臺灣博碩士論文加值系統

生醫硫酸鈣在植入人體內與骨組織接觸時可能具有骨誘導性。但是，由於過快的吸收速度，會在骨填補處再次產生骨缺陷現象，反而不利於骨組織生長。磷酸鈣所含之鈣磷成分與人體骨骼比例相似，但需經過相當長的時間才能完全被吸收，所以導引骨生長速度極為緩慢。本實驗探討硫酸鈣與磷酸鈣以不同比例混和，並以水合法製成複合材料，利用SEM、EDS、XRD對材料進行分析，建立化學轉化反應動力學方程式。實驗中可推測水份添加量與其轉化率及機械強度之關係。轉化速率再經程式推導後而可得知穩定二水硫酸鈣相之轉化速率係與受硬化後之材料孔隙率大小影響。本研究並針對材料衰減實驗的結果，將所得到之轉化趨勢線，歸納出材料轉化率反應之參考因素。同時討出在變化不同比例含量下，人體生醫植入硫酸鈣材料之物理、機械性質及生物相容性之變化。

Using implementable calcium sulfate in human body may promote bone regeneration, however, it was absorbed rather quickly and resulting a deficiency in the surrounding area. On the other hand, calcium phosphate contains similar compositions that are found in human bones, conversely, due to its low dissolution rate, calcium phosphate take a longer time to achieve a completely hardening in clinical. It seems that neither calcium sulfate nor calcium phosphate alone would be an ideal bone filling material by themselves. In this study, the properties of composite materials by mixing hydrated Calcium Sulfate and Calcium Phosphate in different weight ratio were investigated. The physical properties, mechanical properties, degradation rate and bio-compatibility were analyzed by using SEM, EDS, and XRD. A novel chemical kinetic formula to describe the dissolution rate against temperature is then established. The results show that the calcium sulfate and calcium phosphate composites had best physical and mechanical properties when the percentage of calcium sulfate are contained between 70 ~ 90 weight%. The addition of calcium phosphate is clearly showing its strengthen effects on calcium sulfate. The calcium phosphate concentration promotes the cell activity is shown in this study as well.

誌 謝 iii
摘 要 iv
Abstract v
目 錄 vi
表 目 錄 ix
圖 目 錄 x
略字解 xiv
第一章　緒 論 1
一、背景 1
二、動機與目的 3
第二章　總 論 5
第一節 骨組織與損傷修復機制 5
一、骨組織 5
二、骨組織細胞 6
三、骨組織生長機制 9
四、具骨引導性之磷酸鈣系材料於骨修復的過程 11
第二節 生醫材料 12
一、生醫材料種類 12
二、生醫材料與體內組織反應 14
三、生醫植入材料分類 16
四、生醫陶瓷分類 20
（一）惰性及近惰性生醫陶瓷 20
（二）表面活性生醫陶瓷 21
（三）可吸收性生醫陶瓷 25
（四）複合生醫陶瓷材料 26
（五）半水硫酸鈣的製造與水合 27
（六）三鈣磷酸鹽(TCP) 30
（七）二氧化鈦 32
第三節 模擬人工體液與反應動力學 35
一、模擬人工體液 35
二、反應動力學 37
第四節 實驗材料選用與整理 41
第三章　材料與方法 42
第一節 實驗藥品 42
第二節 實驗儀器 42
第三節 實驗方法與流程 43
一、實驗方法 43
二、實驗試片之製備 45
三、試片分析與檢測 45
（一）物理性質測定 45
（二）機械性質檢測 47
（三）衰減實驗及反應動力學 51
第四章　結果與討論 52
第一節 實驗試片 52
第二節 物理性質 68
第三節 機械性質 73
第四節 衰減實驗與反應動力學 78
一、不同組別試片的衰減率變化 78
二、反應動力學 83
三、純硫酸鈣在各個溫度下的衰減率與活化能 93
第五章　結　論 103
參考文獻 104
附錄 114
發表著作 123

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