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研究生:謝明倩
研究生(外文):Ming-Chien Hsieh
論文名稱:影響腹部動態斷層動脈相擷取時機相關因子之探討
論文名稱(外文):The Correlation between Abdominal Dynamic Imaging Scan Time and Participant Physiological Factors
指導教授:黃文濤黃文濤引用關係
指導教授(外文):Wen-Tao Huang
學位類別:碩士
校院名稱:元培科技大學
系所名稱:醫學影像暨放射技術研究所
學門:醫藥衛生學門
學類:醫學技術及檢驗學類
論文種類:學術論文
畢業學年度:101
語文別:中文
論文頁數:63
中文關鍵詞:腹部電腦斷層掃描動脈相延遲掃描時間平均動脈壓血壓差
外文關鍵詞:Abdominal computed tomographyArterial phaseDelayed scan time (DST)Mean arterial pressure (MAP)Pulse pressure (PP)
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目的:探討腹部動態電腦斷層掃描動脈相取像延遲掃描時間與受檢者生理因子的相關性。
材料與方法:經人體試驗委員會同意進行受檢者回溯性研究,受檢者包含79名 (男性42名,女性37名,平均年齡59.1歲)。以SmartPrep監測CT閥值下以團注式注射顯影劑,接著進行32-slices MDCT動脈相掃描,經測得動脈相延遲掃描時間與受檢者生理因子進行統計分析,統計方法包括獨立t檢定、Pearson相關係數分析、單因子與多因子變異數分析。
結果: 動脈像延遲掃描時間與各生理變數間的Pearson相關係數檢定得:身高、體重、體表面積、淨體重、理想體重、心輸出量、全血體積有中度相關。單因子變異數分析延遲掃描時間與各種生理因子,發現年齡、性別、身高、體重、體表面積、理想體重、心輸出量、全血體積、收縮壓、舒張壓均具顯著性(p<0.05)。另外,延遲掃描時間與分組年齡(Age)、分組平均動脈壓(MAP)與分組血壓差(PP)進行多因子變異數分析:延遲掃描時間分別與MAP、Age×MAP、Age×PP、MAP×PP、Age×MAP×PP(交互作用)均具顯著性(p<0.05)。透過逐步迴歸非標準化β值來分析,顯示動脈影像延遲掃描時間與年齡、淨體重有顯著相關,年齡每增加一歲,秒數就增加0.093秒;體重每增加一公斤,秒數就增加0.363秒。
結論:本研究發現延遲掃描時間與受檢者身高、體重等有關的生理因子具相關性,延遲掃描時間亦與受檢者年齡、平均動脈壓與血壓差有統計顯著意義,可作為動脈相取像延遲掃描時間的參考。

Purpose: To evaluate the correlation between the delayed scan time (DST) for image acquisition of arterial phases during abdominal dynamic CT and participant physiological factors.
Materials and Methods: The institutional review board approved a retrospective study comprising 79 participants (42 males, 37 females; average age 59.1). The SmartPrep method was used to monitor the CT threshold under the bolus injection of contrast medium, and a 32-slice multi-detector computed tomography (MDCT) arterial phase scan was subsequently used to measure the DST. Statistical analyses of the DST data and the physiological characteristics of the participants were performed. The statistical methods comprised an independent t test, Pearson correlation, and one-way analysis of variance.
Results: The DST and Pearson correlation coefficients of various physiological variables indicated a moderate correlation between DST and height, total body weight (TBW), body surface area (BSA), lean body mass (LBM), ideal body weight (IBW), cardiac output (CO), and blood volume (BV). The one-way ANOVA analyses of the DST and various physiological factors indicated that age, sex, height, TBW, BSA, IBW, CO, BV, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were statistically significant (P < .05). In addition, the multi-factor ANOVA analyses of the DST and age, mean arterial pressure (MAP), and pulse pressure (PP) groups suggested that the correlation between DST and MAP, age × MAP (interaction), age × PP (interaction), MAP × PP (interaction), and age × MAP × PP (interaction) were statistically significant (P < .05). By stepwise regression and evaluating non-standardized β values, the DST would increase 0.093 sec when the age increased 1 year and the DST would also increase 0.363 sec when the LBW increased 1 kg.
Conclusion: The DST was correlated to height- and weight-related physiological factors; was statistically correlated to participant age, MAP, and PP; and can serve as a DST reference for arterial phase imaging.

第一章緒論
1
1.1 前言 1
1.2 研究背景 2
1.3 文獻回顧 4
1.3.1血液動力學 4
1.3.2顯影劑及注射速率的影響 8
1.3.3平均動脈壓 12
1.3.4 體重因子 13
1.4 研究目的 16
第二章動脈影像擷取方式之發展 17
2.1 盲目法 17
2.2 小量灌注顯影測試(test bolus) 19
2.3 全自動藥劑濃度監控(automatic bolus tracking) 23
第三章材料與方法 28
3.1儀器設備 28
3.2受檢者挑選 31
3.3進行研究之流程及方法 32
3.4統計方式 35
第四章統計結果 36
第五章討論 52
第六章結論 57

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