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研究生:黃俊傑
研究生(外文):Chun-Chieh Huang
論文名稱:以B-mode超音波影像序列和近似熵評估頸動脈彈性之研究
論文名稱(外文):Assessment of Carotid Artery Distensibility Using Approximate Entropy and B-mode Ultrasound Image Series
指導教授:劉偉名劉偉名引用關係
指導教授(外文):Wei-Min Liu
口試委員:許巍嚴林維暘劉偉名劉安邦
口試委員(外文):Wei-Yen HsuWei-Yang LinWei-Min LiuAn-Bang Liu
口試日期:2014-07-29
學位類別:碩士
校院名稱:國立中正大學
系所名稱:資訊工程研究所
學門:工程學門
學類:電資工程學類
論文種類:學術論文
論文出版年:2014
畢業學年度:102
語文別:中文
論文頁數:66
中文關鍵詞:頸動脈動脈硬化彈性超音波影像近似熵
外文關鍵詞:Carotid arteryArteriosclerosisDistensibilityUltrasound imagingApproximate entropy
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  • 下載下載:21
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世界衛生組織指出心血管疾病為目前全球頭號死因,且造成死亡的人數逐年攀升。而動脈硬化是導致許多心血管疾病的重要原因,臨床上越來越頻繁地使用動脈硬化程度做為心血管疾病的診斷指標。而頸動脈為提供大腦血液的主要通道,又是動脈硬化的好發部位,是臨床上預防中風的重點檢測部位。
頸動脈僅距離皮膚表面1~2公分,可透過超音波影像搭配操作者的經驗和技術檢查其管壁病變狀況。過去學者在發展局部性的評估動脈硬化上,大多僅考慮血管收縮和舒張時管腔截面積與血壓的瞬時變化,而這類方法因評估動脈硬化所使用的物理變化量會受諸多因素所影響,所以存在著根本性的問題而備受質疑。我們的目標是發展一套可供使用者方便取得血管長時間幾何資訊的影像處理工具,並以近似熵計算截面積在時間序列上的變化量,作為評估動脈彈性的指標。
實驗結果顯示,在擷取頸動脈連續影像截面積時,具有相當好的可靠性和一致性。在利用近似熵評估頸動脈彈性中,取樣頻率和資料量是必須固定的,而量測位置不影響估計結果。短時間的運動會造成動脈的彈性上升,其他學者使用主動脈脈波速度(APWV)時也發現了類似的現象。在量測可重複性實驗中,顯示有相當好的可重複性。在各項實驗中,我們與常用的統計測度 - 變異數相比較,結果顯示近似熵是更好且可靠的動脈彈性評估方法。

World Health Organization showed that cardiovascular disease is the main cause of death around the world, and the number of death is increasing every year. Atherosclerosis is an important factor that causes cardiovascular disease, and more and more clinical practices uses arterial stiffness to diagnose cardiovascular disease. The carotid artery is the main channel of blood supply to the brain, and also the predilection sites of atherosclerosis. Therefore it is an important diagnostic site to prevent stroke.
Carotid artery is only 1 to 2 cm below the skin surface, and the lesions on arterial wall can be assessed by ultrasound imaging plus the experience and skill of the operator. In the past the researchers only considered the instantaneous changes of lumen cross-section area and blood pressure between the systolic and diastolic period, which is fundamentally problematic and controversial because these changes are impressionable by many factors. Our objective is to develop an image processing tool that allows users to easily obtain the long term information of the arterial geometry, and quantify the temporal variation by approximate entropy in order to correlate with arterial distensibility.
Our experimental results show that the extracting cross-sectional area from carotid artery image series is reliable and consistent. The imaging rates and data length must be fixed when assessing arterial distensibility by approximate entropy. The site of imaging does not change the estimation results. The estimated arterial distensibility increased after short-term exercise. Other people showed the same phenomenon by using aortic pulse wave velocity (APWV). We also found such assessment is reproducible according to our repeated experiments. In all the experiments we compared approximate entropy with the common statistical measure, variance, and found approximate entropy is a better and convincing indicator for carotid atherosclerosis.
第一章 緒論 1
1.1 研究背景 1
1.2 研究動機與目的 2
1.3 本文貢獻 3
1.4 論文大綱 3
第二章 相關文獻探討 5
2.1 動脈硬化評估指標 5
2.2 指標特性和限制 8
2.3 文獻回顧總結 9
第三章 實驗與分析方法 11
3.1 系統架構 11
3.2 從頸動脈動態影像中擷取管腔截面積 12
3.2.1 初始化 12
3.2.1.1 ROI設置 12
3.2.1.2 種子點設置 13
3.2.2 前處理 14
3.2.2.1 去除雜訊 14
3.2.2.2 增強對比 16
3.2.3 影像分割 17
3.2.4 頸動脈區域的位移校準 20
3.2.5 計算分割區域 22
3.3 頸動脈彈性分析 23
第四章 實驗結果 25
4.1 實驗平台與環境 25
4.2 動脈彈性評估方法的可靠性 26
4.2.1 頸動脈區域校準的ROI設置 26
4.2.1.1 頸動脈區域設置 27
4.2.1.2 搜索區域設置 30
4.2.2 初始輪廓種子點設置 32
4.2.3 實驗方法的可靠性總結 35
4.3 影像分割的準確性 35
4.4 評估動脈彈性 37
4.4.1 取樣頻率 37
4.4.2 資料量 39
4.4.3 量測位置 41
4.4.4 短時間運動 43
4.4.5 量測可重複性 47
第五章 結論與未來展望 49
參考文獻 51
PUBLICATION LIST 55


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