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研究生:何建宜
研究生(外文):Chen-Yi Ho
論文名稱:電針及針灸對於大鼠截斷正中神經再生的影響
論文名稱(外文):The effects of electroacupuncture and acupuncture on the rat transected median nerve regeneration
指導教授:陳悅生
指導教授(外文):Yueh-Sheng Chen
學位類別:博士
校院名稱:中國醫藥大學
系所名稱:中醫學系博士班
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:2014
畢業學年度:102
語文別:中文
論文頁數:89
中文關鍵詞:神經再生針灸電針正中神經
外文關鍵詞:Nerve regenerationAcupunctureElectroacupunctureMedian nerve
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背景:針灸和電針治療有關可幫助後肢受損神經神經再生已經證實,但對於前肢正中神經的影響尚不清楚。
方法:本研究應用矽膠管,來接合每隻大鼠的截斷正中神經。從形態學,電生理和電生理功能的角度,使用針灸及電針來治療截斷的正中神經,並對其對於正中神經再生的影響進行了評估。
結果:形態上,與對照組相比發現接受針灸和電針治療組有較大面積的總神經面積及血管數量。電生理上,接受電針組相對於對照組有顯著較大幅度的面積和誘發的肌肉動作電位。在功能上,針灸和電針治療促進受傷爪子的能力增強,恢復其握力,並造成一個新的雙邊平衡。
結論:我們的研究結果提供了針灸和電針促進正中神經神經再生方面的多項角度的療效評估。事實上,針灸和電針可以對於神經再生過程產生積極的影響。這個平台,有利於進一步研究使用針灸和電針替代療法治療神經損傷,提供患者的臨床應用。

Background: Acupuncture and electroacupuncture treatments of damaged nerve may aid nerve regeneration related to hindlimb function, but the effects on forelimb-related median nerve was not known.
Methods: A gap was made in rat median nerve by suturing the stumpsinto silicone rubber tubes and the influences of acupuncture and electro- acupuncture treatments on nerve regeneration were evaluated from morphological, electrophysiological and functional angles.
Results: Morphologically, the groups receiving acupuncture and electroacupuncture treatments had larger total nerve area and blood vessel number compared with the controls. Electrophysiologically, the group receiving electroacupuncture had significantly larger amplitude and larger area of the evoked muscle action potentials compared with the controls. Functionally, the acupuncture and electroacupuncture treatment enhanced the injured paw to regain the grasping power, and a faster efficiency to a new bilateral balance.
Conclusion: Our findings provided multi-approach evidence of the efficacy for acupuncture and electroacupuncture treatments to the regeneration of median nerve.Indeed, the acupuncture and electroacupuncture appeared to have a detrimental effect on the regeneration processes. The platform is beneficial to further study of the clinical application of acupuncture and electroacupuncture alternative treatments on nerve-injured patients.

目錄
第一章 前言 1
1.1背景資料 1
1.2神經再生的簡介 1
1.3 矽膠管內神經再生之細胞學變化 2
1.4神經再生長度的標準化評估 10
1.5周邊神經損傷修復的運用 12
第二章 文獻探討 14
2.1 神經再生促進的研究方向 14
2.2 相關針灸及電場對於神經再生文獻之回顧 16
2.3 神經系統在傳統醫學中的定位 21
2.4神經損傷的中醫觀點與相關之中醫病證 22
2.5正中神經與針灸穴位應用的探討 25
2.5.1針灸穴位的探討 25
2.6 實驗研究的動機及目的 26
第三章 材料與方法 28
3.1材料 28
3.2 方法 31
3.2.1實驗動物分組 31
3.2.2 手術過程 31
3.2.3電針刺激過程 33
3.2.4動物針灸穴位的選取 33
3.2.5動物飼養環境 34
3.3資料收集及分析方法 34
3.3.1觀察正中神經成功的結果 34
3.3.2觀察實驗大鼠外表之變化 35
3.3.3再生神經組織切片評估 35
3.3.4再生神經組織學定性分析 36
3.3.5再生神經組織學定量分析 36
3.3.6電生理檢測分析 38
3.3.7大鼠正中神經功能評估抓握取觀察實驗 39
第四章 結果 42
4.1 正中神經成功率結果分析 42
4.1.1矽膠管外觀觀察 42
4.1.2各組神經再生成功率 43
4.1.3各組神經再生成功率統計分析 44
4.2外在觀測與評估結果 44
4.2.1大鼠外觀變化基本資料 44
4.2.2存活情況 44
4.2.3行動方面 44
4.2.4毛色方面 44
4.2.5電針刺激 44
4.2.6傷口方面 45
4.3再生神經組織學定性分析結果 45
4.3.1正常大鼠正中神經切面之描述 45
4.3.2矽膠管內白色再生管狀物切面之觀察 46
4.4再生神經組織學定量分析結果 49
4.4.1再生神經的全部面積(Total Area) 51
4.4.2再生神經內膜面積(Endo. Area) 51
4.4.3神經軸突數目(Axon number) 52
4.4.4神經軸突平均面積(Mean axon area) 53
4.4.5神經軸突密度(axon density) 54
4.4.6神經軸突面積百分比 55
4.4.7再生血管之數目(B.V. number) 56
4.4.8再生血管總面積(B.V. area) 57
4.5電生理檢測分析結果 58
4.5.1電生理檢測 58
4.5.2潛伏期Latency 1 (L1) 59
4.5.3潛伏期Latency 2 (L2) 60
4.5.4波期(Duration) 61
4.5.5振幅(Amplit) 62
4.5.6面積(Area) 63
4.5.7神經傳導速度(MCV) 64
4.6 大鼠正中神經握取功能評估觀察實驗結果 65
4.6.1未受傷肢評估 65
4.6.2受傷肢評估 66
第五章 討論 68
5.1 本研究結果之探討 68
5.1.1矽膠管為導管作為神經傳導介質 68
5.1.2正中神經再生成功率的結果討論 68
5.1.3外在觀測與評估結果討論 70
5.1.4再生神經組織學定量分析結果討論 70
5.1.5電生理檢測分析結果結果討論 72
5.1.6大鼠正中神經握取功能評估觀察實驗結果討論 74
5.2未來研發方向 75
第六章 結論 76
文獻 79
謝辭 89

圖目錄
圖1.1 神經導管再生室模型中影響神經再生之正反兩股力量 7
圖1.2 周邊神經再生機轉假說 8
圖1.3 影響神經再生品質導管內的因素 9
圖1.4 神經間隙標準化圖 11
圖1.5 影響神經再生的原因 12
圖1.6 職業傷病上下肢比例圖13
圖2.1 本實驗室之前所做針對神經再生的研究結果14
圖3.1 功能電刺激器 30
圖3.2 氣體麻醉機 30
圖3.3 大鼠正中神經手術定位圖 32
圖3.4 大鼠手術矽膠管接合圖 32
圖3.5 大鼠手術過程圖 32
圖3.6 實驗進行流程圖 33
圖3.7 抓握器 41
圖3.8 抓握分析 41
圖4.1 截斷神經後五週取出矽膠管的外觀圖 43
圖4.2 神經再生成功圖 43
圖4.3 正常大鼠正中神經橫切面 45
圖4.4 各組在40倍下顯微鏡觀察 47
圖4.5 各組在100倍下顯微鏡觀察 48
圖4.6 各組在400倍下顯微鏡觀察 49
圖4.7 各組之神經再生面積比較長條圖 51
圖4.8 各組之神經內膜面積比較長條圖 52
圖4.9 各組之神經軸突數比較長條圖 53
圖4.10 各組之神經軸突平均面積比較長條圖 54
圖4.11 各組之神經軸突密度比較長條圖 55
圖4.12 各組之神經軸突面積百分比比較長條圖 56
圖4.13 各組之再生血管之數目比較長條圖 57
圖4.14 各組之再生血管總面積比較長條圖 58
圖4.15 電生理檢測波形代表意義 58
圖4.16 各組之潛伏期Latency 1比較長條圖 60
圖4.17 各組之潛伏期Latency 2比較長條圖 61
圖4.18 各組之波期比較長條圖 62
圖4.19 各組之振幅比較長條圖 63
圖4.20 各組之面積比較長條圖 64
圖4.21 各組之神經傳導速度比較長條圖 65
圖4.22 各組之大鼠未受傷肢抓握力比較長條圖 66
圖4.23 各組之大鼠未受傷肢抓握力比較長條圖 67

表目錄
表2.1 本實驗室電針及針灸相關研究 19
表3.1 實驗動物分組表 31
表4.1 各組顯微鏡不同倍數下之型態比較 46
表4.2 組織學定量分析結果 50
表4.3 組織學定量分析比較表 50
表4.4 各組與神經再生全部面積之結果與統計 51
表4.5 各組與神經再生神經內膜面積之結果與統計 52
表4.6 各組與神經神經軸突數之結果與統計 52
表4.7 各組與神經軸突平均面積之結果與統計 53
表4.8 各組與神經軸突密度之結果與統計 54
表4.9 各組與神經軸突面積百分比之結果與統計 55
表4.10 各組與再生血管之數目之結果與統計 56
表4.11 各組與再生血管總面積之結果與統計 57
表4.12 各組之電生理檢測分析結果 59
表4.13 各組與潛伏期Latency 1之結果與統計 59
表4.14 各組與潛伏期Latency 2之結果與統計 60
表4.15 各組與波期之結果與統計 61
表4.16 各組與振福之結果與統計 62
表4.17 各組與面積之結果與統計 63
表4.18 各組與神經傳導速度之結果與統計 64
表4.19 正中神經握取功能 65
表4.20 未受傷肢之結果與統計 66
表4.21 受傷肢握力之結果與統計 67

文獻
1.闕山璋. 骨科植入物-生醫材料及器材. Vol 1(13): 科儀新知; 1991.
2.Kreiger N, Kelsey JL, Harris C, Pastides H. Injuries to the upper extremity: patterns of occurrence. Clin Plast Surg. Jan 1981;8(1):13-19.
3.Nolte C, Schachner M, Martini R. Immunocytochemical localization of the neural cell adhesion molecules L1, N-CAM, and J1 in Pacinian corpuscles of the mouse during development, in the adult and during regeneration. J Neurocytol. Dec 1989;18(6):795-808.
4.楊萬同、廖維靖、劉玲俐. 中藥當歸對大鼠坐骨神經損傷後脊髓再生的形態研究. 湖北醫科大學學報. 1998;19(4):343-345.
5.Le Beau JM, Ellisman MH, Powell HC. Ultrastructural and morphometric analysis of long-term peripheral nerve regeneration through silicone tubes. J Neurocytol. Apr 1988;17(2):161-172.
6.Longo FM, Hayman EG, Davis GE, Ruoslahti E, Engvall E, Manthorpe M, Varon S. Neurite-promoting factors and extracellular matrix components accumulating in vivo within nerve regeneration chambers. Brain Res. Aug 20 1984;309(1):105-117.
7.Williams LR, Longo FM, Powell HC, Lundborg G, Varon S. Spatial-temporal progress of peripheral nerve regeneration within a silicone chamber: parameters for a bioassay. J Comp Neurol. Aug 20 1983;218(4):460-470.
8.Jenq CB, Coggeshall RE. The effects of an autologous transplant on patterns of regeneration in rat sciatic nerve. Brain Res. Jan 29 1986;364(1):45-56.
9.Rodriguez FJ, Gomez N, Perego G, Navarro X. Highly permeable polylactide-caprolactone nerve guides enhance peripheral nerve regeneration through long gaps. Biomaterials. Aug 1999;20(16):1489-1500.
10.Morris JH, Hudson AR, Weddell G. A study of degeneration and regeneration in the divided rat sciatic nerve based on electron microscopy. IV. Changes in fascicular microtopography, perineurium and endoneurial fibroblasts. Z Zellforsch Mikrosk Anat. 1972;124(2):165-203.
11.MH. FRLBJE. Nerve regeneration through artifical tubular implants. Prog Neurobiol. 1989;33(2):87-134.
12.Zhang M, Yannas IV. Peripheral nerve regeneration. Adv Biochem Eng Biotechnol. 2005;94:67-89.
13.Griffin JW, Hogan MV, Chhabra AB, Deal DN. Peripheral nerve repair and reconstruction. J Bone Joint Surg Am. Dec 4 2013;95(23):2144-2151.
14.Longo FM, Manthorpe M, Skaper SD, Lundborg G, Varon S. Neuronotrophic activities accumulate in vivo within silicone nerve regeneration chambers. Brain Res. Feb 14 1983;261(1):109-116.
15.Chamberlain LJ, Yannas IV, Hsu HP, Spector M. Connective tissue response to tubular implants for peripheral nerve regeneration: the role of myofibroblasts. J Comp Neurol. Feb 21 2000;417(4):415-430.
16.Yannas IV, Hill BJ. Selection of biomaterials for peripheral nerve regeneration using data from the nerve chamber model. Biomaterials. Apr 2004;25(9):1593-1600.
17.Xu X, Lao J, Zhao X. How to prevent injury to the palmar cutaneous branch of median nerve and ulnar nerve in a palmar incision in carpal tunnel release, a cadaveric study. Acta Neurochir (Wien). Sep 2013;155(9):1751-1755.
18.Rohilla R, Singla R, Magu NK, Singh R, Devgun A, Mukhopadhyay R, Gogna P. Combined radial and median nerve injury in diaphyseal fracture of humerus: a case report. Chin J Traumatol. Dec 1 2013;16(6):365-367.
19.Ai L, Oya H, Howard M, Xiong J. Functional MRI detection of hemodynamic response of repeated median nerve stimulation. Magn Reson Imaging. May 2013;31(4):550-554.
20.Tsai YJ, Huang CT, Lin SC, Yeh JH. Effects of regional and whole-body hypothermic treatment before and after median nerve injury on neuropathic pain and glial activation in rat cuneate nucleus. Anesthesiology. Feb 2012;116(2):415-431.
21.Yannas IV, Zhang M, Spilker MH. Standardized criterion to analyze and directly compare various materials and models for peripheral nerve regeneration. J Biomater Sci Polym Ed. 2007;18(8):943-966.
22.Chen CT, Lin JG, Lu TW, Tsai FJ, Huang CY, Yao CH, Chen YS. Earthworm extracts facilitate PC12 cell differentiation and promote axonal sprouting in peripheral nerve injury. Am J Chin Med. 2010;38(3):547-560.
23.Chen HT, Yao CH, Chao PD, Hou YC, Chiang HM, Hsieh CC, Ke CJ, Chen YS. Effect of serum metabolites of Pueraria lobata in rats on peripheral nerve regeneration: in vitro and in vivo studies. J Biomed Mater Res B Appl Biomater. Jan 2008;84(1):256-262.
24.Chen SH, Tsai YJ, Lin CT, Wang HY, Li SF, Lue JH. Changes in GABA and GABA(B) receptor expressions are involved in neuropathy in the rat cuneate nucleus following median nerve transection. Synapse. Jun 2012;66(6):561-572.
25.Chen SH, Tsai YJ, Wang HY, Lin CT, Li SF, Lue JH. Decreases of glycine receptor expression induced by median nerve injury in the rat cuneate nucleus contribute to NPY release and c-Fos expression. Life Sci. Feb 13 2012;90(7-8):278-288.
26.Chen YS, Chang JY, Cheng CY, Tsai FJ, Yao CH, Liu BS. An in vivo evaluation of a biodegradable genipin-cross-linked gelatin peripheral nerve guide conduit material. Biomaterials. Jun 2005;26(18):3911-3918.
27.Chen YS, Hsieh CL, Tsai CC, Chen TH, Cheng WC, Hu CL, Yao CH. Peripheral nerve regeneration using silicone rubber chambers filled with collagen, laminin and fibronectin. Biomaterials. Aug 2000;21(15):1541-1547.
28.Chen YS, Hsu SF, Chiu CW, Lin JG, Chen CT, Yao CH. Effect of low-power pulsed laser on peripheral nerve regeneration in rats. Microsurgery. 2005;25(1):83-89.
29.Chen YS, Hu CL, Hsieh CL, Lin JG, Tsai CC, Chen TH, Yao CH. Effects of percutaneous electrical stimulation on peripheral nerve regeneration using silicone rubber chambers. J Biomed Mater Res. Dec 15 2001;57(4):541-549.
30.Chen YS, Liu CJ, Cheng CY, Yao CH. Effect of bilobalide on peripheral nerve regeneration. Biomaterials. Feb 2004;25(3):509-514.
31.Chen YS, Wu CH, Yao CH, Chen CT. Ginsenoside Rb1 enhances peripheral nerve regeneration across wide gaps in silicone rubber chambers. Int J Artif Organs. Nov 2002;25(11):1103-1108.
32.Chen YS, Yao CH, Chen TH , Lin JG, Hsieh CL, Lin CC, Lao CJ, Tsai CC. Effect of acupuncture stimulation on peripheral nerve regeneration using silicone rubber chambers. Am J Chin Med. 2001;29(3-4):377-385.
33.Cheng CY, Yao CH, Liu BS, Liu CJ, Chen GW, Chen YS. The role of astragaloside in regeneration of the peripheral nerve system. J Biomed Mater Res A. Mar 1 2006;76(3):463-469.
34.Ho CY, Yao CH, Chen WC, Shen WC, Bau DT. Electroacupuncture and Acupuncture Promote the Rat''s Transected Median Nerve Regeneration. Evid Based Complement Alternat Med. 2013;2013:514610.
35.Lu MC, Ho CY, Hsu SF, Lee HC, Lin JH, Yao CH, Chen YS. Effects of electrical stimulation at different frequencies on regeneration of transected peripheral nerve. Neurorehabil Neural Repair. Jul-Aug 2008;22(4):367-373.
36.Lu MC, Hsiang SW, Lai TY, Yao CH, Lin LY, Chen YS. Influence of cross-linking degree of a biodegradable genipin-cross-linked gelatin guide on peripheral nerve regeneration. J Biomater Sci Polym Ed. 2007;18(7):843-863.
37.Lu MC, Huang YT, Lin JH, Yao CH, Lou CW, Tsai CC, Chen YS. Evaluation of a multi-layer microbraided polylactic acid fiber-reinforced conduit for peripheral nerve regeneration. J Mater Sci Mater Med. May 2009;20(5):1175-1180.
38.Lu MC, Tsai CC, Chen SC, Tsai FJ, Yao CH, Chen YS. Use of electrical stimulation at different current levels to promote recovery after peripheral nerve injury in rats. J Trauma. Nov 2009;67(5):1066-1072.
39.Lu MC, Yao CH, Wang SH, Lai YL, Tsai CC, Chen YS. Effect of Astragalus membranaceus in rats on peripheral nerve regeneration: in vitro and in vivo studies. J Trauma. Feb 2010;68(2):434-440.
40.Yao CH, Chang RL, Chang SL, Tsai CC, Tsai FJ, Chen YS. Electrical stimulation improves peripheral nerve regeneration in streptozotocin-induced diabetic rats. J Trauma Acute Care Surg. Jan 2012;72(1):199-205.
41.English AW, Schwartz G, Meador W, Sabatier MJ, Mulligan A. Electrical stimulation promotes peripheral axon regeneration by enhanced neuronal neurotrophin signaling. Dev Neurobiol. Feb 1 2007;67(2):158-172.
42.Geremia NM, Gordon T, Brushart TM, Al-Majed AA, Verge VM. Electrical stimulation promotes sensory neuron regeneration and growth-associated gene expression. Exp Neurol. Jun 2007;205(2):347-359.
43.Cordeiro PG, Seckel BR, Miller CD, Gross PT, Wise RE. Effect of a high-intensity static magnetic field on sciatic nerve regeneration in the rat. Plast Reconstr Surg. Feb 1989;83(2):301-308.
44.Lazar DA, Curra FP, Mohr B, McNutt LD, Kliot M, Mourad PD. Acceleration of recovery after injury to the peripheral nervous system using ultrasound and other therapeutic modalities. Neurosurg Clin N Am. Apr 2001;12(2):353-357.
45.Kolosova LI, Akoev GN, Avelev VD, Riabchikova OV, Babu KS. Effect of low-intensity millimeter wave electromagnetic radiation on regeneration of the sciatic nerve in rats. Bioelectromagnetics. 1996;17(1):44-47.
46.Brandt K, Evans GR, Ang KK, Gürlek A, Peden E, Savel T, Patrick C Jr. Postoperative irradiation: are there long-term effects on nerve regeneration? J Reconstr Microsurg. Aug 1999;15(6):421-425.
47.Anders JJ, Moges H, Wu X, Erbele ID, Alberico SL, Saidu EK, Smith JT, Pryor BA. In vitro and in vivo optimization of infrared laser treatment for injured peripheral nerves. Lasers Surg Med. Jan 2014;46(1):34-45.
48.Siemionow M, Bozkurt M, Zor F. Regeneration and repair of peripheral nerves with different biomaterials: review. Microsurgery. Oct 2010;30(7):574-588.
49.Wei YE, Ling Z. [Acupuncture promotes regeneration of the rat''s hypoglossal nerve]. Zhen Ci Yan Jiu. 1987;12(2):126-129, 193.
50.Li AH, Zhang JM, Xie YK. Human acupuncture points mapped in rats are associated with excitable muscle/skin-nerve complexes with enriched nerve endings. Brain Res. Jun 25 2004;1012(1-2):154-159.
51.Schroder S, Liepert J, Remppis A, Greten JH. Acupuncture treatment improves nerve conduction in peripheral neuropathy. Eur J Neurol. Mar 2007;14(3):276-281.
52.Khosrawi S, Moghtaderi A, Haghighat S. Acupuncture in treatment of carpal tunnel syndrome: A randomized controlled trial study. J Res Med Sci. Jan 2012;17(1):1-7.
53.Jaffe LF, Poo MM. Neurites grow faster towards the cathode than the anode in a steady field. J Exp Zool. Jul 1979;209(1):115-128.
54.Patel N, Poo MM. Orientation of neurite growth by extracellular electric fields. J Neurosci. Apr 1982;2(4):483-496.
55.Ito H, Bassett CA. Effect of weak, pulsing electromagnetic fields on neural regeneration in the rat. Clin Orthop Relat Res. Dec 1983(181):283-290.
56.Raji AR, Bowden RE. Effects of high-peak pulsed electromagnetic field on the degeneration and regeneration of the common peroneal nerve in rats. J Bone Joint Surg Br. Aug 1983;65(4):478-492.
57.Kerns JM, Pavkovic IM, Fakhouri AJ, Wickersham KL, Freeman JA. An experimental implant for applying a DC electrical field to peripheral nerve. J Neurosci Methods. Mar 1987;19(3):217-223.
58.Borgens RB. Electrically mediated regeneration and guidance of adult mammalian spinal axons into polymeric channels. Neuroscience. 1999;91(1):251-264.
59.McCaig CD, Rajnicek AM, Song B, Zhao M. Has electrical growth cone guidance found its potential? Trends Neurosci. Jul 2002;25(7):354-359.
60.Brushart TM, Hoffman PN, Royall RM, Murinson BB, Witzel C, Gordon T. Electrical stimulation promotes motoneuron regeneration without increasing its speed or conditioning the neuron. J Neurosci. Aug 1 2002;22(15):6631-6638.
61.Mendonca AC, Barbieri CH, Mazzer N. Directly applied low intensity direct electric current enhances peripheral nerve regeneration in rats. J Neurosci Methods. Oct 30 2003;129(2):183-190.
62.Cheng WL, Lin CC. The effects of different electrical stimulation protocols on nerve regeneration through silicone conduits. J Trauma. Jun 2004;56(6):1241-1246.
63.Alrashdan MS, Park JC, Sung MA, Yoo SB, Jahng JW, Lee TH, Kim SJ, Lee JH. Thirty minutes of low intensity electrical stimulation promotes nerve regeneration after sciatic nerve crush injury in a rat model. Acta Neurol Belg. Jun 2010;110(2):168-179.
64.Liu X, Wang J, Dai K. Research advance of treatment of peripheral nerve injury with neuromuscular electric stimulation. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. May 2010;24(5):622-627.
65.Wang ET, Zhao M. Regulation of tissue repair and regeneration by electric fields. Chin J Traumatol. Feb 2010;13(1):55-61.
66.Inoue M, Katsumi Y, Itoi M, Hojo T, Nakajima M, Ohashi S, Oi Y, Kitakoji H. Direct current electrical stimulation of acupuncture needles for peripheral nerve regeneration: an exploratory case series. Acupunct Med. Jun 2011;29(2):88-93.
67.Zhang X, Xin N, Tong L, Tong XJ. Electrical stimulation enhances peripheral nerve regeneration after crush injury in rats. Mol Med Rep. May 2013;7(5):1523-1527.
68.Yeh CC, Lin YC, Tsai FJ, Huang CY, Yao CH, Chen YS. Timing of applying electrical stimulation is an important factor deciding the success rate and maturity of regenerating rat sciatic nerves. Neurorehabil Neural Repair. Oct 2010;24(8):730-735.
69.Xia Q, Liu XW, Wang XL, Tao Y. Efficacy observation of carpal tunnel syndrome treated with electroacupuncture. Zhongguo Zhen Jiu. Aug 2013;33(8):700-702.
70.Wang L. Electrodiagnosis of carpal tunnel syndrome. Phys Med Rehabil Clin N Am. Feb 2013;24(1):67-77.
71.Gibby WA, Koerber HR, Horch KW. A quantitative evaluation of suture and tubulization nerve repair techniques. J Neurosurg. Apr 1983;58(4):574-579.
72.Sinis N, Schaller HE, Becker ST, Schlosshauer B, Doser M, Roesner H, Oberhoffner S, Müller HW, Haerle M. Long nerve gaps limit the regenerative potential of bioartificial nerve conduits filled with Schwann cells. Restor Neurol Neurosci. 2007;25(2):131-141.
73.Tos P, Ronchi G, Nicolino S, Audisio C, Raimondo S, Fornaro M, Battiston B, Graziani A, Perroteau I, Geuna S. Employment of the mouse median nerve model for the experimental assessment of peripheral nerve regeneration. J Neurosci Methods. Mar 30 2008;169(1):119-127.
74.Jung JM, Chung MS, Kim MB, Baek GH. Contribution of the proximal nerve stump in end-to-side nerve repair: in a rat model. Clin Orthop Surg. Jun 2009;1(2):90-95.
75.清‧張隱菴. 醫學大成[二] 黃帝內經靈樞集注. 上海科學技術出版社; 1992.
76.張燕華. 經絡—神經—內分泌—免疫網路。. Vol 13 (3): 華西醫學; 1998.
77.朱兵. 經絡的內涵與神經的聯繫. 中華醫史雜誌. 2004;34 (3):153-157.
78.任應秋、劉長林. 內經研究論叢. 湖北人民出版社. 1982.
79.陳太羲、姥芝瑞. 彩色集合觀解剖圖稿. 中華醫學院三一出版中心. 1994.
80.莊宏達. 內經新解. 台北: 志遠書局; 1993.
81.周一謀、蕭佐桃. 馬王堆醫書考注. 台北: 樂群出版社; 1989.
82.針灸治療學會. 中國針灸治療學. 台北: 文光出版社; 1973.
83.王麗慧、周國琪. 《內經》痿證與現代痿證之比較. 吉林中醫藥. 2005;25(1):5-7.
84.宋‧趙佶編. 聖濟總錄. 人民衛生出版社. 1982.
85.韓濟生. H.A.N.S.韓氏穴位暨神經刺激器. 北京: 使用手冊; 1999.
86.Kaplan EA. Percutaneous electrical nerve stimulation for treatment of low back pain. JAMA. Sep 8 1999;282(10):941-942.
87.潘隆森. 臨床十四經361腧穴. 台中: 昭人出版社; 1989.
88.王德深. 中國針灸穴位通鑒. 青島出版社; 1994
89.Mackinnon SE, Hudson AR, Hunter DA. Histologic assessment of nerve regeneration in the rat. Plast Reconstr Surg. Mar 1985;75(3):384-388.
90.Buti M, Verdu E, Labrador RO, Vilches JJ, Fores J, Navarro X. Influence of physical parameters of nerve chambers on peripheral nerve regeneration and reinnervation. Exp Neurol. Jan 1996;137(1):26-33.
91.An S, Zhang P, Peng J, Deng L, Wang Z, Wang Z, Wang Y, Yin X, Kou Y, Ha N, Jiang B. Motor function recovery during peripheral nerve multiple regeneration. J Tissue Eng Regen Med. Dec 10 2013.
92.de la Llave-Rincon AI, Fernandez-de-Las-Penas C, Perez-de-Heredia-Torres M, Martinez-Perez A, Valenza MC, Pareja JA. Bilateral deficits in fine motor control and pinch grip force are not associated with electrodiagnostic findings in women with carpal tunnel syndrome. Am J Phys Med Rehabil. Jun 2011;90(6):443-451.
93.Ghizoni MF, Bertelli JA, Grala CG, da Silva RM. The anabolic steroid nandrolone enhances motor and sensory functional recovery in rat median nerve repair with long interpositional nerve grafts. Neurorehabil Neural Repair. Mar-Apr 2013;27(3):269-276.
94.Yeh CC, Hsieh CH, Wang YC, Chung PK, Chen RJ. Commotio cordis as a rare cause of traumatic cardiac arrest in motorbike crashes: Report of a case. Surg Today. Apr 2010;40(4):369-372.
95.Bertelli JA, Mira JC. The grasping test: a simple behavioral method for objective quantitative assessment of peripheral nerve regeneration in the rat. J Neurosci Methods. May 1995;58(1-2):151-155.
96.Bertelli JA, Mira JC. Behavioral evaluating methods in the objective clinical assessment of motor function after experimental brachial plexus reconstruction in the rat. J Neurosci Methods. Mar 1993;46(3):203-208.
97.Lundborg G, Kanje M. Bioartificial nerve grafts. A prototype. Scand J Plast Reconstr Surg Hand Surg. Jun 1996;30(2):105-110.
98.Di Fabio R, Casali C, Pierelli F. Iatrogenic selective lesion of the median nerve at the elbow. Acta Neurol Belg. Mar 2010;110(1):97-99.
99.Rosen JM, Pham HN, Abraham G, Harold L, Hentz VR. Artificial nerve graft compared to autograft in a rat model. J Rehabil Res Dev. Winter 1989;26(1):1-14.
100.Kerns JM, Lucchinetti C. Electrical field effects on crushed nerve regeneration. Exp Neurol. Jul 1992;117(1):71-80.
101.McGinnis ME, Murphy DJ. The lack of an effect of applied d.c. electric fields on peripheral nerve regeneration in the guinea pig. Neuroscience. Nov 1992;51(1):231-244.
102.Chang YM, Chi WY, Lai TY, Chen YS, Tsai FJ, Tsai CH, Kuo WW, Cheng YC, Lin CC, Huang CY. Dilong: role in peripheral nerve regeneration. Evid Based Complement Alternat Med. 2011;2011:380809.
103.Jaminet P, Kohler D, Schäufele M, Rahmanian-Schwarz A, Lotter O, Fornaro M, Ronchi G, Geuna S, Rosenberger P, Schaller HE. Evaluating the role of Netrin-1 during the early phase of peripheral nerve regeneration using the mouse median nerve model. Restor Neurol Neurosci. 2013;31(3):337-345.
104.Muratori L, Ronchi G, Raimondo S, Giacobini-Robecchi MG, Fornaro M, Geuna S. Can regenerated nerve fibers return to normal size? A long-term post-traumatic study of the rat median nerve crush injury model. Microsurgery. Jul 2012;32(5):383-387.
105.Yao T, Andersson S, Thoren P. Long-lasting cardiovascular depression induced by acupuncture-like stimulation of the sciatic nerve in unanaesthetized spontaneously hypertensive rats. Brain Res. May 20 1982;240(1):77-85.
106.Lundborg G, Dahlin LB, Danielsen N, Nachemson AK. Tissue specificity in nerve regeneration. Scand J Plast Reconstr Surg. 1986;20(3):279-283.
107.Politis MJ, Zanakis MF, Albala BJ. Facilitated regeneration in the rat peripheral nervous system using applied electric fields. J Trauma. Sep 1988;28(9):1375-1381.
108.Barcroft H, Millen JL. The blood flow through muscle during sustained contraction. J Physiol. Nov 14 1939;97(1):17-31.
109.Matsumine H, Sasaki R, Takeuchi Y, Miyata M, Yamato M, Okano T, Sakurai H. Vascularized versus Nonvascularized Island Median Nerve Grafts in the Facial Nerve Regeneration and Functional Recovery of Rats for Facial Nerve Reconstruction Study. J Reconstr Microsurg. Feb 2014;30(2):127-136.
110.Kniffeki KD, Mense S, Schmidt RF. Muscle receptors with fine afferent fibers which may evoke circulatory reflexes. Circ Res. Jun 1981;48(6 Pt 2):I25-31.
111.Clemente FR, Barron KW. The influence of muscle contraction on the degree of microvascular perfusion in rat skeletal muscle following transcutaneous neuromuscular electrical stimulation. J Orthop Sports Phys Ther. Sep 1993;18(3):488-496.
112.Widick MH, Tanabe T, Fortune S, Zealear DL. Awake evoked electromyography recording from the chronically implanted rat. Laryngoscope. Apr 1994;104(4):420-425.
113.Inoue M, Hojo T, Yano T, Katsumi Y. The effects of electroacupuncture on peripheral nerve regeneration in rats. Acupunct Med. Jun 2003;21(1-2):9-17.
114.Rochester JR, Clarke KA. Gait analysis in the rat as a model for the study of peripheral vascular disease. Physiol Behav. Apr 1994;55(4):723-726.
115.Jaminet P, Schaufele M, Geuna S, Schaller HE, Rosenberger P, Kohler D. Scope and limitations of the median nerve mouse model in research on peripheral nerve regeneration. Handchir Mikrochir Plast Chir. Aug 2012;44(4):204-208.

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