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研究生:何惠玲
研究生(外文):Ho Hui Ling
論文名稱:台灣中部某醫院病人服用Fluvastatin後LDL改善之回溯性分析
論文名稱(外文):Effect of Fluvastatin on LDL Improvement for Patients in a Hospital in Central Taiwan
指導教授:顏裕鴻顏裕鴻引用關係
指導教授(外文):Yen Yue Horng
口試委員:顏裕鴻吳建一魏早辰
口試委員(外文):Yen Yue HorngWu Jane YiiWei Tsao Chen
口試日期:2014-07-28
學位類別:碩士
校院名稱:大葉大學
系所名稱:生物科技碩士在職學位學程
學門:生命科學學門
學類:生物科技學類
論文種類:學術論文
論文出版年:2014
畢業學年度:102
語文別:中文
論文頁數:34
中文關鍵詞:Fluvastatin高血脂Statins高膽固醇血症LDL
外文關鍵詞:Fluvastatinhigh cholesterolStatinshigh cholesterolLDL
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根據國民健康局九十一年台灣地區高血糖、高血脂、高血壓盛行率調查顯示,十五歲以上國人高血糖、高膽固醇、高三酸甘油酯、高血壓之盛行率分別為7.5%、10.9%、15.6%及21.4%。許多醫學研究報告已明確指出高血脂除會導致心臟疾病外,也與腦血管疾病、高血壓、糖尿病等慢性疾病息息相關。本研究目的為分析血脂異常病人服用Statins的療效與未服藥的差異性。
以回溯性方式收集2008年1月至2013年1月,台灣中部某地區醫院心臟內科門診看診90位病人服用Fluvastatin後3-6個月的LDL血液檢查報告。使用SPSS18.0軟體,以t-test分析P值是否有顯著差異性。
研究結果顯示,血脂異常病人服用Fluvastatin能使LDL下降,降幅達統計學上顯著差異。以期能預防心血管疾病以及減少相關死亡率。

According to the National Health Council, 2002 Taiwan high blood sugar, high cholesterol, hypertension prevalence survey, people aged 15 and above high blood sugar, high cholesterol, high triglyceride levels, prevalence of hypertension, respectively, 7.5%, 10.9 %, 15.6% and 21.4%. Many medical studies have clearly pointed out that in addition to high cholesterol can lead to heart disease, but also with cerebrovascular disease, hypertension, diabetes and other chronic diseases are closely related. The purpose of this study was to analyze the lipid abnormalities in patients taking Statins medication efficacy and not differences.
Collected retrospectively from January 2008 to January 2013, in central Taiwan in an area hospital cardiology clinic to see the doctor 90 patients taking Fluvastatin LDL blood test report 3-6 months. Using SPSS18.0 software to t-test to analyze whether there are significant differences between the P value.
The results showed that patients taking Fluvastatin dyslipidemia LDL can drop, a drop of statistically significant differences. With a view to the prevention of cardiovascular disease and reduce the associated mortality.

封面內頁
簽名頁
中文摘要............................................................................................iii
英文摘要............................................................................................iv
誌謝.....................................................................................................v
目錄....................................................................................................vi
圖目錄..............................................................................................viii
表目錄................................................................................................ix

1. 前言..............................................................................................1
2. 文獻探討......................................................................................2
2.1 冠狀動脈疾病....................................................................2
2.2 降血脂藥物的簡介............................................................4
2.2.1 何謂Statins...........................................................4
2.2.2 Statins類降血脂藥物所引發的肌肉毒性...........5
2.3 Statins類藥物所導致的肌肉毒性....................................8
2.4 Statins與fibrate合併療法相關的肌肉毒性....................9
2.5 Statins類之肌肉毒性的監測及處理方法.......................11
2.6 Fluvastatin說明與簡介....................................................12
2.7 台灣現行降膽固醇藥物給付...........................................18
2.8 行政院衛生署統計101年十大主要死因.......................20
3. 材料與研究方法.........................................................................22
3.1材料................... ................................................. ................22
3.2 研究方法...........................................................................22
3.2.1 生化儀器檢驗......................................................22
3.2.2 LDL-C計算公式.................................................22
3.3 評估及統計方法...............................................................24
4. 結果與討論.................................................................................25
4.1 兩組最後治療結果...........................................................25
4.2 性別...................................................................................25
4.3 服藥時間長短...................................................................25
4.4 Statins治療高脂血症可以預防腦中風...........................27
5. 結論.............................................................................................31
參考文獻............................................................................................32


參考文獻

1.Alycia Y. Lin, Pharm.D北醫藥劑部用藥安全電子報2001.06.23第五期 http://web2.tmu.edu.tw/
2.丁予安, 何橈通, 祝年豐, 高血脂防治手冊 - 國人血脂異常診療及預防指引. 台北: 遠流出版公司, 1997.
3.行政院衛生署國民健康局. 台灣地區高血壓、高血糖、高血脂盛行率調查報告. 台北市, 2003.
4.莊淑慧,慈劑藥訊第五十七期2007.07.15
5.衛生福利部中央健康保險署http://www.nhi.gov.tw/
6.衛生福利部中央健康保險署http://www.nhi.gov.tw/Lescol 仿單
7.Alper SY B, Metin K,M. llker Y, Ienan S, Fatih B, and I Haltki I, 2003.Humana Press Inc. vol. 22, no. 2, 151-15.1, November
8.Anouk Van Der Grafi , Melchior C Niermani , Jean C Firth2 , Karen H Wolmarans2 , A David Marais2 & Eric De Groo ,2006.TActa Paediatrica,95:1461-1466
9.Charles R H, Terry A J, Atlanta, G, 2008.American College of CardiologyVol. 51, No. 25.
10.David P, Sreenivasa R KS, Paul W,Sabina A,Jennifer E Ho, David D W, David A D, DPharm,P B,Christopher P C, Marc S S, MPH,EB, John J P K, James A de L, Michael A B, Terje R P, Matti J T, Naveed S, Kausik K R, 2011. JAMA.;305(24):2556-2564
11.Delanty N, Vaughan CJ,1997. Vascular effects of statins in stroke. Stoke. 28: 2315-20
12.Eric B, Gilles H, Sylvie Dejager, C Y, and Bernard B´,2005. Cardiovasc Drugs and Therapy (19): 403-414
13.Eric B, Marie-P V, Sylvie D, and Jonathan I, 2005.Am J Cardiol;96:1142–1148
14.Evan A S, Christie M B, Eberhard W, Per A S, Andrey S, Zerrin Y, Claudia S, andClaudio R Gimpelewicz, , 2008.Am JCardiol;101:490 – 496
15.Evans, Marc; Rees, Alan. 2002. The myotoxicity of statins. Curr Opin Lipidol,;13 ,415
16.H Holdaasa, B Fellstro¨mb, E Colec,G Nybergd, AG Olssone, TR Pedersenf,S Madseng, C Gr¨ onhagen-Riskah, H –HNeumayeri, B Maesj, P Ambu¨ hlk, A Hartmanna,B Stafflerl, AG Jardinem 2005.American Journal of Transplantation; 5: 2929–2936
17.Hallvard H, Bengt F, Alan G J, Ingar H, Gudrun N, Per F, Carola G-R,Soren M, Hans-HN, Edward C, Bart M, Patrice A, Anders G O, 2003. Anders Hartmann,Dag O Solbu, Terje R Pedersen, on, Lancet; 361: 2024–31
18.http://health.osa.ncku.edu.tw/files/16-1067-7394.php
19.http://health.osa.ncku.edu.tw/files/16-1067-7394.php
20.http://www.kmhk.kmu.edu.tw/medhome/1/6/92-3.2.htm
21.Jarett D B, Alan D, Xuan C, Daniel B G, BS,Hongyan Ning, Avis T S, Philip G, Linda V H, Russell P T, and Donald M Lloyd-Jones, 2012.N Engl J Med;366:321-9.
22.Michiro I, Atsushi N, Tetsuya K, Suguru Y,Masayuki F, Masao M and Kaoru S, 2006.The Japanese Society of Internal Medicine (45):51-55
23.Patrick W J C S, ,Pim de F,Carlos M,Norbert K,Jacques P,Matthias V,Angelo B,Marcelo C.Bertolami, ,Graham J,Bradley S,Bernhard M, 2002.JAMA, June 26,Vol 287, No. 24
24.Sinzinger, H, Wolfram, R. Peskar, Bernhard A. 2002.Muscular Side Effects of Statins. Journal of Cardiovascular Pharmacology.;40,163
25.Sposito, A C.and Chapman, M J 2002. Statin Therapy in Acute Coronary Syndromes: Mechanistic Insight Into Clinical Benefit. Arteriosclerosis, Thrombosis & Vascular Biology.;22,1524
26.Straus, S E Majumdar, S R McAlister, F A 2002. New Evidence for Stroke Prevention: Scientific Review. JAMA.;288,1388
27.Teixeira, A B, ATavares, AB Ribeiro, MT Zanella, O Kohlmann Jr and MC. 2011.BatistaDivision of Nephrology, Hypertension and Cardiovascular Metabology Center, Kidney and HypertensionHospital, Federal University of Sa˜o Paulo, Sa˜o Paulo, Brazil J Hum Hypertens (25): 492 ~ 499
28.Tsochiang Ma, Mu-Hsin Chang, Liyun Tien, Yi-Sheng Liou and Gwo-Ping Jong, 2012.Drugs Aging; 29 (1): 45-51

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