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研究生:邱健豪
研究生(外文):Chiou, Jian-Hau
論文名稱:雙通道非侵入式近紅外光譜儀腦訊號量測系統實現
論文名稱(外文):Dual-channel Non-invasive Brain Signal Detection NIRS System implementation
指導教授:邱俊誠邱俊誠引用關係
指導教授(外文):Chiou, Jin-Chern
學位類別:碩士
校院名稱:國立交通大學
系所名稱:電控工程研究所
學門:工程學門
學類:電資工程學類
論文種類:學術論文
論文出版年:2013
畢業學年度:102
語文別:中文
論文頁數:67
中文關鍵詞:近紅外光腦訊號非侵入式
外文關鍵詞:NIRSBrain SignalNon-invasive
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本論文利用帶氧與去氧血紅素對於不同波長之近紅外光吸收率不同來換算出組織血流的反應。主旨在實現一套雙通道近紅外光譜儀量測腦部生理訊號的系統,開發出一套比坊間市售儀器更簡單的系統架構以及更小的體積與較低廉的價格的系統。本系統使用發光二極體光源與感光二極體感測器,對人體組織發射與接收光源,透過類比訊號處理電路,並利用可程式邏輯陣列(FPGA)當作控制核心,控制脈衝寬度調變光源,實現分光架構與自動光強度校正。設計互動式軟體介面,建立手部血流阻斷實驗,驗證系統與演算法可行性,並藉由閉氣實驗驗證腦部血氧變化量測的正確性。接著將本系統與市售儀器(Hitachi ETG-4000)量測相同任務來進行比較,可得知在非使用Hitachi系統特定實驗的情形下,本系統在多次疊加實驗結果皆優於Hitachi。最後進行相關文獻所使用之系統比較,比較結果可得知本系統有完整實驗進行系統可行性驗證,在光源使用與分光架構較為簡便。
This study aims a simpler near-infaraed spectroscopy (NIRS) system with smaller and lower cost than commercial instrument. To detect the hemodynamic response of oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb) in human tissue based on the different absorption of near-infrared light wavelengths, this system used cheap light emitted diodes (LEDs) photodiodes (PDs) as the light source and detector, respectively. For peripheral Interface control, FPGA was utilized to control the pulse width modulation (PWM) for LEDs to generate various density of light source. The light distributor for red and infrared light and the automatic power calibration in this system were implemented by analog signal processing circuits and controlled by the FPGA. This study designed an interactive brain computer interface (BCI) with the arterial occlusion experiments to test the feasibility, and then verified the system and its algorithm with breath-hold experiments. In the experiment results, the proposed system has better hemodynamic response then ETG-4000, an extremely expensive NIRS system designed by Hitachi Medical Corporation. Finally, compared with other related NIRS systems, the light source and light distributor architecture of the proposed system is more easily and simply to implement, and this study has proved the feasibility of series of experiments.
摘要 …………………………… .……………………………………………………………………………I
ABSTRACT ….……………………………………………………………………………………………….II
致謝 ……………………….IV
目錄 V
表目錄 VIII
圖目錄 IX
第一章 緒論 1
1.1 近紅外光譜儀應用與現狀 1
1.2 相關論文研究與探討 3
1.3 論文架構 5
第二章 實驗原理與架構 6
2.1 實驗原理 6
2.1.1 帶氧血紅素與去氧血紅素與人體關係 6
2.1.2 近紅外光波長與帶氧及去氧血紅素之關係探討 7
2.1.3 近紅外光譜儀穿透路徑預測 8
2.1.4 Modified Beer-Lambert Law 9
2.2 系統架構 12
2.2.1 系統架構介紹 12
2.2.2 探頭設計 13
2.2.3 光感應元件的選擇 16
第三章 訊號處理與各級介紹 17
3.1 訊號處理架構介紹 17
3.2 類比訊號處理 17
3.2.1 分光電路設計 17
3.2.2 各級濾波電路設計 18
3.3 數位訊號處理 21
3.3.1 利用FPGA設計控制電路 21
3.3.2 Nios II 控制模組設計 21
第四章 軟體介面設計與實現 24
4.1 軟體介面設計 24
4.2 自動光強度校正機制設計 29
4.2.1 發光二極體與溫度關係 29
4.2.2 假體量測LED陣列衰減程度 30
4.2.3 自動光強度校正設計 31
第五章 實驗設計與結果比較 33
5.1 系統與演算法確立實驗 33
5.1.1 手部血流阻斷實驗設計 33
5.1.2 手部實驗結果 35
5.2 腦部血氧濃度量測驗證實驗 37
5.2.1 腦部憋氣實驗設計 37
5.2.2 腦部憋氣實驗結果 38
5.3 腦部活動實驗 41
5.3.1 心算實驗設計 41
5.3.2 心算實驗結果 42
5.4 與ETG-4000實驗比較 48
5.5 雙通道實驗 53
5.6 論文比較 54
第六章 結論 56
6.1 結論 56
6.2 未來展望 56
參考文獻 ………………………………………………………………………...………………….58
附錄 ………………………………………………………………………………………………………………………60

[1] Jöbsis, “Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters”, Science, 198, pp. 1264-1267, December 1977
[2]Rossmax, “http://www.rossmax.com/index.php?option=com_zoo&;task=item&;item_id=64&;Itemid=454&;lang=tw”
[3]Hitachi special, “www.innervision.co.jp” , 2013
[4]劉修權, “利用近紅外光譜做侵入式之生理訊號量測”, 國立交通大學, 碩士論文 , 2006
[5]林立堂, “利用近紅外光譜做侵入式之生理訊號量測”, 國立交通大學, 碩士論文 , 2005
[6] Gu¨ nther Bauernfeind, Robert Leeb, Selina Christin Wriessnegger, Gert Pfurtscheller, “Development, set-up and first results for a one-channel
near-infrared spectroscopy system”, Biomedizinische Technik, 53, pp. 36–43, February 2008
[7] Soraghan Christopher, Matthews Fiachra, Markham, Pearlmutter Barak, “A 12-channel, real-time near-infrared spectroscopy instrument for brain-computer interface applications”, 30th Annual International Conference of the IEEE, pp. 5648 – 5651, Vancouver, BC, August 2008
[8] Alhemsi, “Time-resolved near-infrared spectroscopic imaging systems”, Electronics Communications and Photonics Conference, pp. 1 – 6, Riyadh, April 2013
[9] Roy, Sherrington, “On the Regulation of the Blood-supply of the Brain”, Journal of Physiology, 11, pp. 1-2, January 1890
[10Hueber, Franceschini, Zhang, “Non-invasive and quantitative near-infrared
haemoglobin spectrometry in the piglet brain duringhypoxic stress, using a frequency-domainmultidistance instrument”, physics in medcine and biology, 46, 41-62
[11] David Boas, “http://www.scholarpedia.org/article/Near_infrared_imaging”, 2009
[12] Yuich Fukui, “Monte Carlo prediction of near-infrared light propagationin realistic adult and neonatal head models”, Applied Optics, 42, pp. 2881-2887, June 2003
[13] Peter Rolfe, “IN VIVO NEAR-INFRARED SPECTROSCOPY”, Annual Review of Biomedical Engineering, 2, pp. 715-754, August 2000
[14] Rammohan Maikala, “Modified Beer’s Law – historical perspectives and relevance in near-infraredmonitoring of optical properties of human tissue”, International Journal of Industrial Ergonomics, 40, pp. 125–134, 2010
[15]Burr-Brown Products from Texas Instruments, “OPT101 Datasheet”, JANUARY 1994
[16] Hamamatsu Corporation, “C5460-01 Datasheet”, September 2007
[17] Lighting Research Center, “http://www.lrc.rpi.edu/programs/NLPIP/lightingAnswers/led/heat.asp”, 2003
[18] Sergio Fantini, “Muscle studies”, Department of Biomedical Engineering Tufts University
[19] Alexandre Lima, Jan Bakker, “Near-infrared spectroscopy for monitoring
peripheral tissue perfusion in critically ill patients”, Rev Bras Ter Intensiva, 23, pp. 341-351, 2011

[20] Jaakko Virtanena, Tommi Noponenc, Risto Ilmoniemia, “Properties of end-expiratory breath hold responses measured with near-infrared spectroscopy”, Biomedical Optics Symposium, San Francisco, California, USA, January 2011
[21] Bradley MacIntosh, Martyn Klassen, Ravi Menona, “Transient hemodynamics during a breath hold challenge in a two part functional imaging study with simultaneous near-infrared spectroscopy in adult humans”, NeuroImage, 20, pp. 1246-1252, 2003
[22] Takafumi Nagaoka, Kaoru Sakatani, Takayuki Awano, Noriaki Yokose,Tatsuya Hoshino, Yoshihiro Murata, Yoichi Katayama,Akihiro Ishikawa, Hideo Eda, “a New Rehabilitation System Based on a Brain-Computer Interface Using Near-Infrared Spectroscopy”, Oxygen Transport to Tissue XXXI Advances in Experimental Medicine and Biology, 662, pp. 497-503, 2010
[23] Etienne Lareau, Frederic Lesage, Philippe Pouliot, Dang Nguyen, Jerome Le Lan, Mohamad Sawana, “Multichannel wearable system dedicated for simultaneous electroencephalography/near-infrared spectroscopy real-time data acquisitions”, Journal of Biomedical Optics, 19, September 2011

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