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研究生(外文):Tien, Che-Chia
論文名稱(外文):Urinary cotinine as a biomarker to explore the reliability and validity with questionnaire
指導教授(外文):Lai, Ching-Huang
口試委員(外文):Lai, Ching-HuangKao, Sen-YeongChien, Wu-Chien
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方法:以隨機抽樣方式選取國軍新訓單位某梯次的其中兩個連隊共計280員作為研究對象,研究設計採縱貫性研究,於新訓人員入伍第二天、休假前一天(入伍一周後)、休假三天後與休假六天後(結訓前一天)等四個時間點實施問卷調查並採集其50 mL尿液檢體,尿液檢體使用酵素免疫分析法檢測Cotinine濃度,問卷資料則使用SPSS 20.0版統計軟體進行分析。
Background: Questionnaire is often used as the research tool of smoking prevalence. However, the reliability and validity of the questionnaire could be influenced by the recall problem of participants, misclassification, and the situation when answering the question. By detecting the urine nicotine metabolites, the problems can be ruled out and the smoking condition of participants can be reflected precisely.
Objectives: To study the smoking behavior change of the recruits during initial entry training, and to test the reliability and validity with the questionnaire by detecting the urinary cotinine concentration.
Methods: We chose two companies 280 people as research subjects from initial entry training recruits through random sampling. Longitudinal study design was used while we collect questionnaire and 50 mL urine sample from the recruits at four timing periods. The second day of training, before the vacation, after three-day vacation and after six-day vacation. ELISA was used to analyze cotinine concentration of the collected urine sample, and the data from questionnaire was used SPSS 20.0 version for statistical analysis.
Results: According to the result of Cotinine concentration, the recruits smoke less during training and more during holidays. Besides, the reliability and validity with the questionnaire, the health investigation questionnaire and the three other daily exposure questionnaires are all good tools for smoking behavior measurement (AUC>0.95) except the daily exposure questionnaire on the second day of initial entry training (AUC=0.903).
Conclusions: The smoking condition of recruits is more severe during holidays then during training. Besides, we should avoid doing the questionnaire at the beginning of the initial entry training due to the less reliability and validity of the questionnaire on the second day of the training.
第一章 緒論1
第二章 文獻探討5
第三章 研究材料與方法16
第四章 結果27
第五章 討論65
第六章 結論與建議74
第七章 參考文獻76

Allem, J. P., Ayers, J. W., Irvin, V. L., Hofstetter, C. R., & Hovell, M. F. (2012). South Korean military service promotes smoking: a quasi-experimental design. Yonsei Med J, 53(2), 433-438.
Aurrekoetxea, J. J., Murcia, M., Rebagliato, M., Lopez, M. J., Castilla, A. M., Santa-Marina, L., . . . Ballester, F. (2013). Determinants of self-reported smoking and misclassification during pregnancy, and analysis of optimal cut-off points for urinary cotinine: a cross-sectional study. BMJ Open, 3(1).
Benowitz, N. L. (1996). Cotinine as a biomarker of environmental tobacco smoke exposure. Epidemiol Rev, 18(2), 188-204.
Benowitz, N. L. (1999). Biomarkers of environmental tobacco smoke exposure. Environ Health Perspect, 107 Suppl 2, 349-355.
Benowitz, N. L., Hukkanen, J., & Jacob, P., 3rd. (2009). Nicotine chemistry, metabolism, kinetics and biomarkers. Handb Exp Pharmacol(192), 29-60.
Benowitz, N. L., Jacob, P., 3rd, Ahijevych, K., Jarvis, M. J., Hall, S., LeHouezec, J., . . . Velicer, W. (2002). Biochemical verification of tobacco use and cessation. Nicotine Tob Res, 4(2), 149-159.
Benowitz, N. L., Perez-Stable, E. J., Fong, I., Modin, G., Herrera, B., & Jacob, P., 3rd. (1999). Ethnic differences in N-glucuronidation of nicotine and cotinine. J Pharmacol Exp Ther, 291(3), 1196-1203.
Bray, R. M., Hourani, L. L., Rae, K. L., Dever, J. A., Brown, J. M., Vincus, A. A., . . . Vandermaas-Peeler, R. (2003). 2002 Department of Defense Survey of Health Related Behaviors Among Military Personnel. Assistant Secretary of Defense (Health Affairs) under Cooperative Agreement.
Centers for Disease Control and Prevention, U. S. (2008). Smoking-attributable mortality, years of potential life lost, and productivity losses--United States, 2000-2004. MMWR Morb Mortal Wkly Rep, 57(45), 1226-1228.
Chu, N. F., Wu, D. M., Shen, M. H., & Lin, Y. S. (2006). Prevalence of adverse behaviors among young military conscripts in Taiwan. Mil Med, 171(4), 301-305.
Cronan, T. A., Conway, T. L., & Kaszas, S. L. (1991). Starting to smoke in the Navy: when, where and why. Soc Sci Med, 33(12), 1349-1353.
Davis, R. A., Stiles, M. F., deBethizy, J. D., & Reynolds, J. H. (1991). Dietary nicotine: a source of urinary cotinine. Food Chem Toxicol, 29(12), 821-827.
Dempsey, D., Jacob, P., 3rd, & Benowitz, N. L. (2000). Nicotine metabolism and elimination kinetics in newborns. Clin Pharmacol Ther, 67(5), 458-465.
Department of Health and Human Services, U. S. (2004). The Health Consequences of Smoking: A Report of the Surgeon General.
Di Nicola, M., Occhiolini, L., Di Mascio, R., Vellante, P., Colagrande, V., & Ballone, E. (2006). Smoking habits in a sample of young Italian soldiers. Mil Med, 171(1), 69-73.
Gilbert, D. D. (1993). Chemical analyses as validators in smoking cessation programs. J Behav Med, 16(3), 295-308.
Haufroid, V., & Lison, D. (1998). Urinary cotinine as a tobacco-smoke exposure index: a minireview. Int Arch Occup Environ Health, 71(3), 162-168.
Hecht, S. S. (2003). Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat Rev Cancer, 3(10), 733-744.
Hosmer, D. W., & Lemeshow, S. (2005). Applied Logistic Regression, Second Edition: Wiley Online Library.
Hsieh, T. H., Chang, K. J., Lee, W. K., & Ku, Y. C. (2010). Factors Associated with Depressive Symptoms among Soldiers. Taiwanese Journal of Psychiatry, 24, 51-60.
Hukkanen, J., Jacob, P., 3rd, & Benowitz, N. L. (2005). Metabolism and disposition kinetics of nicotine. Pharmacol Rev, 57(1), 79-115.
Jaakkola, M. S., & Jaakkola, J. J. (1997). Assessment of exposure to environmental tobacco smoke. Eur Respir J, 10(10), 2384-2397.
Jhun, H. J., Seo, H. G., Lee, D. H., Sung, M. W., Kang, Y. D., Syn, H. C., & Jun, J. K. (2010). Self-reported smoking and urinary cotinine levels among pregnant women in Korea and factors associated with smoking during pregnancy. J Korean Med Sci, 25(5), 752-757.
Llewellyn, D. J., Lang, I. A., Langa, K. M., Naughton, F., & Matthews, F. E. (2009). Exposure to secondhand smoke and cognitive impairment in non-smokers: national cross sectional study with cotinine measurement. BMJ, 338, b462.
Murray, R. P., Connett, J. E., Lauger, G. G., & Voelker, H. T. (1993). Error in smoking measures: effects of intervention on relations of cotinine and carbon monoxide to self-reported smoking. The Lung Health Study Research Group. Am J Public Health, 83(9), 1251-1257.
Ockene, I. S., & Miller, N. H. (1997). Cigarette smoking, cardiovascular disease, and stroke: a statement for healthcare professionals from the American Heart Association. American Heart Association Task Force on Risk Reduction. Circulation, 96(9), 3243-3247.
Park, S. W., & Kim, J. Y. (2009). Validity of self-reported smoking using urinary cotinine among vocational high school students. J Prev Med Public Health, 42(4), 223-230.
Perkins, N. J., & Schisterman, E. F. (2006). The Inconsistency of "Optimal" Cut-points Using Two ROC Based Criteria. Am J Epidemiol, 163(7), 670-675.
Pickett, K. E., Rathouz, P. J., Kasza, K., Wakschlag, L. S., & Wright, R. (2005). Self-reported smoking, cotinine levels, and patterns of smoking in pregnancy. Paediatr Perinat Epidemiol, 19(5), 368-376.
Pokorski, T. L., Chen, W. W., & Bertholf, R. L. (1994). Use of urine cotinine to validate smoking self-reports in U.S. Navy recruits. Addict Behav, 19(4), 451-454.
Schei, E., & Sogaard, J. (1994). The impact of military service on young men's smoking behavior. Prev Med, 23(2), 242-248.
Shipton, D., Tappin, D. M., Vadiveloo, T., Crossley, J. A., Aitken, D. A., & Chalmers, J. (2009). Reliability of self reported smoking status by pregnant women for estimating smoking prevalence: a retrospective, cross sectional study. BMJ, 339, b4347.
Swamy, G. K., Reddick, K. L., Brouwer, R. J., Pollak, K. I., & Myers, E. R. (2011). Smoking prevalence in early pregnancy: comparison of self-report and anonymous urine cotinine testing. J Matern Fetal Neonatal Med, 24(1), 86-90.
Thompson, S. G., Stone, R., Nanchahal, K., & Wald, N. J. (1990). Relation of urinary cotinine concentrations to cigarette smoking and to exposure to other people's smoke. Thorax, 45(5), 356-361.
Tsutsumi, A., Kagawa, J., Yamano, Y., Nakadate, T., & Shimizu, S. (2002). Relation between cotinine in the urine and indices based on self-declared smoking habits. Environ Health Prev Med, 6(4), 240-247.
Williams, R. A., Hagerty, B. M., Yousha, S. M., Hoyle, K. S., & Oe, H. (2002). Factors associated with depression in navy recruits. J Clin Psychol, 58(4), 323-337.
World Health Organization, W. H. O. (2013). Tobacco, from http://www.who.int/mediacentre/factsheets/fs339/en/
Zhang, J., Fang, S. C., Mittleman, M. A., Christiani, D. C., & Cavallari, J. M. (2013). Second hand tobacco smoke exposure and heart rate variability and inflammation among non-smoking construction workers: a repeated measures study. Environ Health, 12(1), 83.
Zielinska-Danch, W., Wardas, W., Sobczak, A., & Szoltysek-Boldys, I. (2007). Estimation of urinary cotinine cut-off points distinguishing non-smokers, passive and active smokers. Biomarkers, 12(5), 484-496.

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