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研究生:劉芳芸
研究生(外文):Fang-Yun Liu
論文名稱:代謝症候群患者肌肉骨骼不適與生理性指標相關性探討-以台北某區域醫院為例
論文名稱(外文):The Investigation of the Relationship Between Musculoskeletal Disorders and Metabolic Syndrome –A Regional Hospital in Taipei
指導教授:林榮信
指導教授(外文):Rong-Shinn Lin
口試委員:黃士哲林榮志
口試委員(外文):Shi-Che HuangRong-Chih Lin
口試日期:2014-07-24
學位類別:碩士
校院名稱:國立宜蘭大學
系所名稱:生物資源學院碩士在職專班
學門:生命科學學門
學類:生物科技學類
論文種類:學術論文
論文出版年:2014
畢業學年度:102
語文別:中文
論文頁數:84
中文關鍵詞:代謝症候群肌肉骨骼不適胰島素阻抗
外文關鍵詞:Metabolic syndromeMusculoskeletal disordersInsulin resistance
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代謝症候群(metabolic syndrome)是造成糖尿病及心血管疾病的危險因子。這些危險因子包括腹部肥胖、血脂異常、血糖代謝異常、高血壓等。目前醫學研究胰島素阻抗是代謝症候群致病的機轉,而骨骼肌則是人體最主要的糖脂代謝庫。骨骼肌代謝功能異常,可能影響全身代謝及引發心血管疾病。本研究針對臨床上診斷有代謝症候群且肌肉骨骼不適之患者進行調查,研究代謝症患者生理指標與肌肉骨骼不適(musculoskeletal disorder)之間是否存在關聯性。結果顯示,代謝症候群患者之生理指標(總膽固醇、三酸甘油脂、高密度脂蛋白膽固醇、低密度脂蛋白膽固醇、血壓值、空腹血糖值、身高、體重、身體質量指數及腰圍)、過去病史(高血壓史、高血脂史、高血糖史)和運動習慣與患者肌肉骨骼不適之間有相關性存在。經邏輯斯迴歸分析結果顯示,三酸甘油脂、收縮壓、舒張壓、空腹血糖較高、高密度脂蛋白膽固醇較低、腰圍超過正常值對造成頸部不適有較高風險。空腹血糖值較高對造成手肘部及手腕部不適有較高風險。三酸甘油脂、舒張壓、空腹血糖較高、高密度脂蛋白膽固醇較低、腰圍超過正常值、運動習慣不足、年齡增加對造成下背部不適有較高風險。
空腹血糖較高、高密度脂蛋白膽固醇較低、腰圍超過正常值對造成膝部不適有較高風險。

Metabolic syndrome increases the risk of diabetes and cardiovascular disease. The associated risk factors of metabolic syndrome include central obesity, dyslipidemia, abnormal glucose metabolism, high blood pressure.
Insulin resistance is pathogenic mechanisms of metabolic syndrome. Skeletal muscle is the main tissue of metabolism glucose and lipid in human body. Skeletal muscle metabolic dysfunction may affect the whole body metabolism and cardiovascular disease. The study investigated the relationship between musculoskeletal disorders and metabolic syndrome. The results of survey showed that physiological indicators which included total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, blood pressure, fasting blood glucose, height, weight, body mass index, and larger size of waist circumference, and also the past history of hypertension, cholesterol and blood sugar and individual exercise habits were related to musculoskeletal disorders.
Logistic regression analysis showed that the patients with a higher level of triglycerides, systolic blood pressure, diastolic blood pressure, fasting glucose, and larger size of waist circumference, but a lower level of high-density lipoprotein cholesterol might result in a higher incidence of neck discomfort. A higher level of fasting blood glucose might result in a higher risk of elbow and wrist discomfort. A higher level of triglycerides, diastolic blood pressure, fasting glucose and larger size of waist circumference, but lower high-density lipoprotein cholesterol, and also insufficient exercise habits coupled with age increased might result in a higher risk of lower back discomfort. A higher level of fasting glucose and larger size of waist circumference, but lower level of high-density lipoprotein cholesterol might result in a higher risk of knee discomfort.

中文摘要.................................................I
英文摘要...............................................III
致謝....................................................IV
目錄.....................................................V
表目錄.................................................VII
圖目錄..................................................VI

第一章 緒論...............................................1
第一節 研究背景與動機...................................1
第二節 研究的重要性.....................................1
第三節 研究目的.........................................2
第二章 文獻回顧...........................................3
第一節 代謝症候群定義.............................. ....3
第二節 代謝症候群盛行率........................... .....9
第三節 代謝症候群與生理指標的關聯性................... 13
第四節 代謝症候群與肌肉骨骼不適的關聯性............... 14
第五節 文獻總結與研究方向.............................15


第三章 研究方法..........................................16
第一節 研究對象.......................................16
第二節 研究架構.......................................19
第三節 統計分析.......................................20
第四章 研究結果..........................................21
第一節 研究對象基本資料...............................21
第二節 代謝症患者肌肉骨骼不適與血液檢查項目關係.......27
第三節 代謝症患者肌肉骨骼不適與理學檢查項目關係.......38
第四節 代謝症與非代謝症患者肌肉骨骼不適與血液生化檢查項目關係.........................................59
第五節 代謝症與非代謝症患者肌肉骨骼不適與理學檢查項目關係............................................ 64
第六節 代謝症與非代謝症患者迴歸分析...................70
第五章 討論..............................................74
第一節 研究者基本資料................................74
第二節 肌肉骨骼不適與血液生化檢查項目相關性..........76
第三節 肌肉骨骼不適與理學檢查項目、病史、運動習慣相關性
..............................................77

第六章 結論..............................................79
參考文獻.................................................80

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