跳到主要內容

臺灣博碩士論文加值系統

(44.220.62.183) 您好!臺灣時間:2024/02/29 06:11
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

: 
twitterline
研究生:陳靖雅
研究生(外文):Ching-Ya Chen
論文名稱:以MEGA-PRESS頻譜編輯技術偵測人體大腦內之 γ-氨基丁酸、乳酸與纈氨酸
論文名稱(外文):The Detection of GABA, Lactate and Valine in Human Brain using MEGA-PRESS Spectral Editing Technique.
指導教授:柯正雯
指導教授(外文):Cheng-Wen Ko
學位類別:碩士
校院名稱:國立中山大學
系所名稱:資訊工程學系研究所
學門:工程學門
學類:電資工程學類
論文種類:學術論文
論文出版年:2014
畢業學年度:102
語文別:中文
論文頁數:68
中文關鍵詞:VeSPA磁共振頻譜MEGA-PRESS耦合系統頻譜編輯
外文關鍵詞:MEGA-PRESSVeSPAMRScoupled spin systemsspectrum editing
相關次數:
  • 被引用被引用:0
  • 點閱點閱:551
  • 評分評分:
  • 下載下載:9
  • 收藏至我的研究室書目清單書目收藏:0
GABA (γ-aminobutyric acid) 是一種胺基酸神經傳遞物質,在中樞神經系統中扮演非常重要的角色。GABA的濃度變化被認為與一些神經系統疾病有關聯,例如:癲癇(Epilepsy)、阿茲海默症(Alzheimer''s disease)。磁共振頻譜是一個能夠量測體內代謝物濃度的工具,最常使用的脈衝序列為PRESS (Point-RESolved Spectroscopy sequence)。然而,GABA的訊號容易被其他代謝物的訊號遮蔽,PRESS脈衝序列在臨床上的實驗中無法提供足夠高的解析度,為了能夠得到GABA的訊號,近年來,漸漸使用MEGA-PRESS脈衝序列來取代PRESS脈衝序列在GABA的偵測實驗上。

MEGA-PRESS頻譜編輯技術主要是於原本的PRESS脈衝序列增加兩個選擇性180度射頻脈衝,藉由兩個選擇性射頻脈衝來調配具有J-耦合特性之代謝物的訊號,透過頻譜相減消除不具有J-耦合特性或是沒有被編輯到的代謝物訊號,觀察出具有J-耦合特性之代謝物的頻譜變化。我們的結果顯示,在一般常用的3T磁場下,此方法能有效取得具有J-耦合特性之代謝物的訊號,如:GABA、Lactate與Valine 。

關鍵字:磁共振頻譜、頻譜編輯、耦合系統、MEGA-PRESS、VeSPA
GABA (γ-aminobutyric acid) is one of amino acid neurotransmitter which plays an important role in the central nervous system (CNS). A change in GABA concentration is considered to be associated with some neurological disorders, such as: Epilepsy, Alzheimer''s disease. Magnetic resonance spectroscopy is a tool that enables measurement of metabolic concentrations in vivo. One of the most commonly employed pulse sequences is PRESS (Point-RESolved Spectroscopy sequence). However, the signal of GABA is easily obstructed by signals of other metabolites. PRESS does not provide sufficiently high resolution in the clinical experiments. In recent years, in order to obtain signal from GABA, MEGA-PRESS has become popular in the detection of GABA.

MEGA-PRESS spectral editing technique is based on the original PRESS sequence along with two frequency-selective 〖180〗^° pulses to blend the signal of J-coupled metabolites. These edited J-coupled resonances can be enhanced by spectral subtraction removing non J-coupled resonances. Our results show that under conventional 3T magnetic field, MEGA-PRESS can be applied to detect signals of J-coupled metabolites, such as GABA, Lactate and Valine.

Key words: MRS, spectrum editing, coupled spin systems, MEGA-PRESS, VeSPA
致謝 i
摘要 ii
Abstract iii
目錄 iv
圖目錄 vi
表目錄 vii
第一章 簡介 1
1.1 背景 1
1.2 文獻回顧 1
1.3 研究動機 6
1.4 組織架構 6
第二章 原理 7
2.1 磁共振頻譜 7
2.2 人體大腦中常見具有J-耦合特性的代謝物 9
2.3 化學位移 15
2.4 J-耦合 17
2.5 MEGA-PRESS頻譜編輯 19
第三章 實驗方法設計與步驟 25
3.1 VeSPA 25
3.2 模擬與實驗的數值設計 32
3.2.1 VeSPA模擬參數設定 23
3.2.2 假體配方與正常人類大腦掃描參數設定 36
第四章 結果 40
4.1 VeSPA模擬分析結果 40
4.2 假體實驗分析結果 44
4.3 正常人類大腦分析結果 47
第五章 討論與結論 49
5.1 討論 49
5.2 結論 50
參考文獻 56
[1]F. G. Woermann, M. A. McLean, P. A. Bartlett, G. J. Parker, G. J. Barker, and J. S. Duncan, "Short echo time single‐voxel 1H magnetic resonance spectroscopy in magnetic resonance imaging–negative temporal lobe epilepsy: Different biochemical profile compared with hippocampal sclerosis," Annals of neurology, vol. 45, pp. 369-376, 1999.
[2]R. A. Moats, T. Ernst, T. K. Shonk, and B. D. Ross, "Abnormal cerebral metabolite concentrations in patients with probable Alzheimer disease," Magnetic resonance in medicine, vol. 32, pp. 110-115, 1994.
[3]V. Govindaraju, K. Young, and A. A. Maudsley, "Proton NMR chemical shifts and coupling constants for brain metabolites," NMR in Biomedicine, vol. 13, pp. 129-153, 2000.
[4]D. Lau, N. Klein, and B. Cunha, "Brain abscess mimicking brain tumor," Heart &; lung: the journal of critical care, vol. 18, pp. 634-637, 1989.
[5]P. H. Lai, J. T. Ho, W. L. Chen, S. S. Hsu, J. S. Wang, H. B. Pan, et al., "Brain abscess and necrotic brain tumor: discrimination with proton MR spectroscopy and diffusion-weighted imaging," American Journal of Neuroradiology, vol. 23, pp. 1369-1377, 2002.
[6]C. Rémy, S. Grand, E. S. Laï, V. Belle, D. Hoffmann, F. Berger, et al., "1H MRS of human brain abscesses in vivo and in vitro," Magnetic resonance in medicine, vol. 34, pp. 508-514, 1995.
[7]P. H. Lai, K. T. Li, S. S. Hsu, C. C. Hsiao, C. W. Yip, S. Ding, et al., "Pyogenic brain abscess: findings from in vivo 1.5-T and 11.7-T in vitro proton MR spectroscopy," American journal of neuroradiology, vol. 26, pp. 279-288, 2005.
[8] R. A. De Graaf, In vivo NMR spectroscopy: principles and techniques: John Wiley &; Sons, 2008.
[9]M. Mescher, H. Merkle, J. Kirsch, M. Garwood, and R. Gruetter, "Simultaneous in vivo spectral editing and water suppression," NMR in Biomedicine, vol. 11, pp. 266-272, 1998.
[10]R. A. Edden and P. B. Barker, "Spatial effects in the detection of γ‐aminobutyric acid: Improved sensitivity at high fields using inner volume saturation," Magnetic Resonance in Medicine, vol. 58, pp. 1276-1282, 2007.
[11]P. Bhattacharyya, M. Phillips, L. Stone, and M. Lowe, "In-vivo MRS measurement of gray-matter and white-matter GABA concentration in sensorimotor cortex using a motion-controlled MEGA-PRESS Sequence," Magnetic resonance imaging, vol. 29, p. 374, 2011.
[12]P. G. Mullins, D. J. McGonigle, R. L. O''Gorman, N. A. Puts, R. Vidyasagar, C. J. Evans, et al., "Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA," Neuroimage, vol. 86, pp. 43-52, 2014.
[13]B. Corporation, "波譜儀基本原理與實驗使用手冊."
[14]B. J. Soher, P. Semanchuk, K. Young, and D. Todd, "Vespa–Simulation User Manual and Reference."
[15]B. J. Soher, P. Semanchuk, K. Young, D. Todd, and J. Matson, "Vespa–RFPulse User Manual and Reference."
[16]B. J. Soher, P. Semanchuk, K. Young, and D. Todd, "Vespa–Priorset User Manual and Reference."
[17]B. J. Soher, P. Semanchuk, K. Young, and D. Todd, "Vespa–Analysis User Manual and Reference."
[18]S. Provencher, "LcModel and LcMgui user’s manual," Available at LCModel homepage http://s-provencher. com/pages/lcmodel. shtml. Manual updated July, vol. 18, 2011.
[19]O. Voevodskaya, "The reliability of GABA measurements in the human brain using MRS at 3T," 2012.
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top