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研究生:施明谷
研究生(外文):Shih Ming Ku
論文名稱:8週補充共軛亞麻油酸對於年輕健康人體胰島素敏感性之影響
論文名稱(外文):The effect of eight weeks oral CLA supplementation on glucose homeostasis and inulin action in health humans
指導教授:程一雄程一雄引用關係
指導教授(外文):Cheng I Shiung
口試委員:呂香珠林鵬翔
口試委員(外文):Leu Hsiang ChuLin Peng Hsiang
口試日期:2014-06-30
學位類別:碩士
校院名稱:國立臺中教育大學
系所名稱:體育學系碩士班
學門:教育學門
學類:專業科目教育學類
論文種類:學術論文
論文出版年:2014
畢業學年度:102
語文別:中文
論文頁數:61
中文關鍵詞:共軛亞麻油酸口服葡萄糖耐受度測驗胰島素敏感性
外文關鍵詞:Conjugated Linoleic Acid, CLAOral Glucose Tolerance Test, OGTTinsulin sensitivity
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共軛亞麻油酸(Conjugated Linoleic Acid, CLA) 是一群含18個碳分子,具共軛雙烯鍵的脂肪酸。先前動物研究顯示一段時間的CLA補充可以提高脂肪酸的氧化及減少體內脂肪堆積,但是,也有研究顯示CLA長期補充有可能影響葡萄糖利用。然而,少有人體研究對於短期CLA補充是否可改變年輕健康人體胰島素作用,進而影響全身葡萄糖利用。因此,本研究探討八週口服CLA補充是否會影響有運動習慣者全身葡萄糖利用。招募12名男性受試者(年齡 21.58 ± 0.53歲)給予8週CLA(4.0 g/day)補充。補充CLA前,及補充4週與8週後,受試者分別接受口服葡萄糖耐受度測驗(Oral Glucose Tolerance Test, OGTT)。實驗當天,受試者將進行3小時的OGTT。受試者在實驗當天到達實驗室時給予75公克葡萄糖水搭配500毫升純水飲用後開始計時3小時,3小時內每30分鐘採血一次,蒐集後做血液生化值的分析。研究結果顯示補充CLA至第4週後,受試者身體組成並未改變,OGTT 血糖濃度明顯升高,以ISI指數測得之全身胰島素敏感性也顯著變差,且至第8週仍未見改善。本研究顯示補充8週CLA無法改變年輕健康人體身體組成,同時可能無法提升葡萄糖的利用率,對人體全身胰島素敏感性亦可能沒有正面的效果。

關鍵詞:共軛亞麻油酸、口服葡萄糖耐受度測驗(Oral Glucose Tolerance Test, OGTT)、胰島素敏感性

Conjugated linoleic acid (CLA) is a compound that contains eighteen carbons and unsaturated fatty acids with two double bonds. CLA has been shown to enhance the fatty acid oxidation and reduce the body fat in animal studies. However, there were adverse effects on glucose uptake were found in obese human studies. Little study was found regarding to whether short term CLA administration is expected to influence glucose homeostasis and reducing insulin action in health humans. Therefore, the present study was to examined that effect of eight weeks oral CLA supplementation on whole body glucose and insulin response in health human study. Twelve male subjects (21.58 ± 0.53 yrs) completed eight weeks CLA supplementation (4.0 g per day). Before (baseline) and at the 4th week and the 8th week after CLA supplementation, all subject accepted OGTT test (oral glucose tolerance test, OGTT) and calculated AUC of glucose and insulin. Simultaneously, ISI (insulin sensitivity index) was calculated for represented the insulin action. No significant change in body composition was found in the present study. However, the AUC in glucose and insulin level after OGTT test were higher compared to baseline. In addition, ISI value was decreased significantly from 4th week to 8th week CLA supplementation compared to baseline. The results in this study implied that there was no change in body composition after eight weeks CLA supplementation. In addition, the CLA supplementation influenced glucose homeostasis and reduced insulin action in health humans.
Keywords: CLA, OGTT, insulin sensitivity

目 次
國科會授權書
國家圖書館授權書
謝誌
中文摘要 I
英文摘要 II
目 次 III
表 次 V
圖 次 V
附 錄 V
第一章 緒論 1
第一節 研究背景 1
第二節 研究問題 3
第三節 研究目的 4
第四節 研究假設 5
第五節 研究範圍與限制 5
第六節 名詞操作型定義 5
第二章 文獻探討 7
第一節 共軛亞麻油酸 7
第二節 胰島素敏感性 19
第三節 本章總結 25

第三章 研究方法與步驟 26
第一節 研究對象 26
第二節 實驗設計與流程 26
第三節 資料處理與統計分析 30
第四章 結果 31
第一節 研究對象基本資料 31
第二節 血液生化值反應 32
第五章 討論與結論 37
第一節 主要發現 37
第二節 身體組成 37
第三節 血液生化值 38
第四節 結論 39

參考文獻 40
中文部份 40
英文部分 41


表 次
表2-1 食物中共軛亞麻油酸的含量 8
表4-1 受試者基本資料 31

圖 次
圖2-1 共軛亞麻油酸結構 7
圖2-2 胰島素降血糖機轉路徑圖 24
圖3-1 實驗流程圖 27
圖3-2口服葡萄糖耐受度測驗流程圖 28
圖4-1第零週、第四週、第八週血液葡萄糖濃度之變化圖 32
圖4-2第零週、第四週、第八週葡萄糖反應曲線下面積圖 33
圖4-3第零週、第四週、第八週胰島素濃度之變化圖 34
圖4-4第零週、第四週、第八週胰島素曲線下面積圖 35
圖4-5第零週、第四週、第八週胰島素敏感性指數圖 36

附 錄
附錄一 人體試驗委員會審查意見表 54
附錄二 受測者同意書 55
附錄三 口服葡萄糖耐受度測驗步驟 56
附錄四 總實驗原始數據 57


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