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研究生:林彥良
研究生(外文):Lin, Yang-Liang
論文名稱:醫療焚化爐飛灰對人類肺泡上皮癌細胞A549毒性之影響
論文名稱(外文):Characteristics and cytotoxicity of particulate matters (PMs) emitted from a medical solid waste incinerator towards A549 cell
指導教授:黃鈺軫
指導教授(外文):Huang, Yuh-Jeen
學位類別:碩士
校院名稱:國立清華大學
系所名稱:生醫工程與環境科學系
學門:工程學門
學類:生醫工程學類
論文種類:學術論文
論文出版年:2014
畢業學年度:102
語文別:英文
論文頁數:92
中文關鍵詞:醫療廢棄物多環芳香烴活性氧化物質細胞生存率
外文關鍵詞:Hospital solid waste (HSW)PAHsROScell viabilityA549
相關次數:
  • 被引用被引用:0
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  • 收藏至我的研究室書目清單書目收藏:1
隨著醫療技術的發展,大幅提高醫療品質和延長人類的壽命,但隨之而來的代價卻是產生許多醫療廢棄物。處理醫療廢棄物的方法有很多,傳統上常用焚化來處理醫療廢物。但是焚化後所產生的飛灰排放是另一個環境問題。
此研究主要針對醫療焚化爐飛灰的化學成分及其對肺癌上皮細胞(A549)的生物效應(細胞生存率,發炎因子釋放和活性氧化因子的生成)之間的相關性進行探索。依據空氣粒徑大小不同,將粒子分類為全粒子(TP;未進行粒徑分析粒子)、PM10-2.5(2.5-10微米)、PM2.5-1(2.5-1微米),以及PM1(粒徑<1微米)。探討(一)不同粒徑顆粒的物理化學特性如非水溶性元素成分、水溶性離子和多環芳香烴。 (二)飛灰萃取物(水溶性離子和多環芳香烴)對A549細胞的細胞毒性。(三)粒徑大小、成分和細胞毒性的關聯性。並利用二元分析和Student檢驗(t檢驗)研究化學成分和生物反應之間的關係。
結果顯示水溶性離子(陽離子+陰離子)的佔總成分80%左右。空氣粒徑較小的粒子,含有較多的多環芳烴。低分子量的多環芳香烴(環數2和3;分子量:128-178)比中(環數4;分子量:202-228)和高(HMW 5和6多環芳烴結構的環數;分子量:252-278)分子量多環芳烴含量還要高,尤其是Nap和PA。然而,非水溶性的重金屬和主族元素的含量在PM10-2.5和PM2.5-1比PM1高。在TP、PM10-2.5、PM2.5-1和PM1中,PM10-2.5誘導較多的ROS產生和IL-8的分泌,而PM1導致較高的細胞凋亡。在化學成分方面,多環芳香烴所造成的細胞死亡率比水溶性離子成分高,水溶性離子成分主要造成ROS產生和IL-8的分泌,故PM1所產生較高細胞死亡率可能來自於多環芳香烴。

With the development of medical technology, the quality for caring and prolonging human’s life is greatly improved, but the price is a lot of hospital wastes are produced. Incineration is a traditional method used in disposal of hospital waste. However, the emission of fly ashes is another environmental issue.
In this work, the correlations between chemical components of PM in various particle sizes with the biological effects (cell viability, cytokine release and reactive oxygen species (ROS) generate) generated from human lung carcinoma epithelial cell line A549 exposing to PM emitted from a hospital solid waste were studied. According to aerodynamic diameter, four categories of PM were classified namely, “Total Particle” (TP; without particle size classification), “PM10-2.5”(diameter 2.5–10 μm), “PM2.5-1”(diameter 1–2.5 μm), and “PM1 “(diameter <1μm). We investigate (i) the physicochemical characteristics of particles (PM) such as elements, size distribution, water-soluble ions, and PAHs. (ii) the cytotoxicity of particles (PM) and the extract from PM e.g. water-soluble ions (i-PM)and PAHs(p-PM) towards A549 cell. Bivariate analysis and Student’s test (t-test) were applied to study the relationship between the PM chemical composition and the biological responses.
The results show that water-soluble ions (cation + anion) were constituted about 80% in fractions. The smaller aerodynamic diameter of PM is observed, the higher PAHs content is found. Low molecular weight PAH (2 and 3 ring number of PAHs structure; MW: 128-178) was higher than the other medium (MMW; 4 ring number of PAHs structure; MW: 202-228) and high (HMW; 5 and 6 ring number of PAHs structure; MW: 252-278) molecular weight PAHs in each particles size, especially NaP and PA. In contrast, the content of heavy metal and major element in PM10-2.5 and PM2.5-1 are more than in PM1. Among TP, PM10-2.5, PM2.5-1 and PM1, PM10-2.5 induced more ROS and IL-8 secretion, and PM1 caused higher cell apoptosis. Compare the cytotoxicity of water-soluble inorganic ions and the organic PAHs, organic PAHs induced more significant cytotoxicity.

Contents
Abstract I
摘要 III
致謝 V
Contents VI
List of Tables VIII
List of Figures IX
Chapter 1 Introduction 11
1.1. Background 11
1.2. Objects of this study 13
Chapter 2 Literature review 15
2.1. Aerosol particles 15
2.1.1. Source 15
2.1.2. Composition characteristics 15
2.2. Toxicology of nanoparticles 28
2.2.1. Cytotoxicity assays 28
2.2.2. Physicochemical characteristic on biological response 37
Chapter3 Materials and methods 42
3.1. Experiment flow chart and materials 42
3.2. Particle size classification 45
3.3. Lung cell cultures 47
3.4. Cells treatment 48
3.4.1. Sample preparation for treatment 48
3.4.2. Procedure of treatment 48
3.5. Characteristics 49
3.5.1. Mass distribution 49
3.5.2. Ion chromatography 50
3.5.3. Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) 50
3.5.4. GC/MS 51
3.6. Health effects 51
3.6.1. ROS assay 52
3.6.2. Analysis of cytokine –ELISA assay 52
3.6.3. Analysis of cell survival-alamar blue assay 53
Chapter4 Results and Discussion 54
4.1. PM10-2.5, PM2.5-1 and PM1 concentrations in particulate matters 54
4.2. Chemical composition 55
4.2.1. Chemical composition of PM 55
4.2.2. Elements 57
4.2.3. Water-soluble Ions 60
4.2.4. PAHs 63
4.3. Biological response 67
4.3.1. Particle 67
4.3.2. Water-soluble ions (i-PM) 70
4.3.3. PAHs 72
Chapter5 Conclusion 76
Chapter6 Future work 78
Chapter7 Reference 79

1 Alessandria, L., Schiliro, T., Degan, R., Traversi, D., &; Gilli, G. Cytotoxic response in human lung epithelial cells and ion characteristics of urban-air particles from Torino, a northern Italian city Environmental Science and Pollution Research 2014, 21, 5554-5564
2 Alves, C. A. Characterisation of solvent extractable organic constituents in atmospheric particulate matter: an overview Anais Da Academia Brasileira De Ciencias 2008, 80, 21-82
3 Amato, I. Making the right stuff Science News 1989, 136, 108-110
4 Anjum, F., Shahid, M., Bukhari, S., &; Potgieter, J. H. Combined ultrasonic and bioleaching treatment of hospital waste incinerator bottom ash with simultaneous extraction of selected metals Environmental Technology 2014, 35, 262-270
5 Araujo, J. A., &; Nel, A. E. Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress Particle and Fibre Toxicology 2009, 6,
6 Arditsoglou, A., Petaloti, C., Terzi, E., Sofoniou, M., &; Samara, C. Size distribution of trace elements and polycyclic aromatic hydrocarbons in fly ashes generated in Greek lignite-fired power plants Science of the Total Environment 2004, 323, 153-167
7 Barrett, E. G., Henson, R. D., Seilkop, S. K., McDonald, J. D., &; Reed, M. D. Effects of hardwood smoke exposure on allergic airway inflammation in mice Inhalation Toxicology 2006, 18, 33-43
8 Berridge, M. J. Calcium signal transduction and cellular control mechanisms Biochimica Et Biophysica Acta-Molecular Cell Research 2004, 1742, 3-7
9 Billet, S., Abbas, I., Le Goff, J., Verdin, A., Andre, V., Lafargue, P. E., . . . Garcon, G. Genotoxic potential of Polycyclic Aromatic Hydrocarbons-coated onto airborne Particulate Matter (PM(2.5)) in human lung epithelial a549 cells Cancer Letters 2008, 270, 144-155
10 Billet, S., Garcon, G., Dagher, Z., Verdin, A., Ledoux, F., Cazier, F., . . . Shirali, P. Ambient particulate matter (PM2.5): physicochemical characterization and metabolic activation of the organic fraction in human lung epithelial cells (A549) Environ Res 2007, 105, 212-223
11 Bittner, J.D., &; Howard, J.B. In Particle Carbon: Formation During Combustion 1981,
12 Borm, P., Klaessig, F. C., Landry, T. D., Moudgil, B., Pauluhn, J., Thomas, K., . . . Wood, S. Research strategies for safety evaluation of nanomaterials, Part V: Role of dissolution in biological fate and effects of nanoscale particles Toxicological Sciences 2006, 90, 23-32
13 Bourgeois, B., &; Owens, J. W. The influence of Hurricanes Katrina and Rita on the inflammatory cytokine response and protein expression in A549 cells exposed to PM2.5 collected in the Baton Rouge-Port Allen industrial corridor of Southeastern Louisiana in 2005 Toxicology Mechanisms and Methods 2014, 24, 220-242
14 Brown, D. M., Donaldson, K., Borm, P. J., Schins, R. P., Dehnhardt, M., Gilmour, P., . . . Stone, V. Calcium and ROS-mediated activation of transcription factors and TNF-alpha cytokine gene expression in macrophages exposed to ultrafine particles American Journal of Physiology-Lung Cellular and Molecular Physiology 2004, 286, L344-L353
15 Byun, M. S., Jeon, K. I., Choi, J. W., Shim, J. Y., &; Jue, D. M. Dual effect of oxidative stress on NF-kappa B activation in HeLa cells Experimental and Molecular Medicine 2002, 34, 332-339
16 Callen, M. S., de la Cruz, M. T., Lopez, J. M., &; Mastral, A. M. PAH in airborne particulate matter. Carcinogenic character of PM10 samples and assessment of the energy generation impact Fuel Processing Technology 2011, 92, 176-182
17 Camatini, M., Gualtieri, M., Mantecca, P., Ovrevik, J., &; Holme, J. Seasonal and dimensional differences in pro-inflammatory potency of the atmospheric particulate matter of Milano on lung cell lines Toxicology Letters 2008, 180, S97-S97
18 Chang, S. Y., Fang, G. C., Chou, C. C. K., &; Chen, W. N. Source identifications of PM10 aerosols depending on hourly measurements of soluble components characterization among different events in Taipei Basin during spring season of 2004 Chemosphere 2006, 65, 792-801
19 Chirino, Y. I., Sanchez-Perez, Y., Osornio-Vargas, A. R., Morales-Barcenas, R., Gutierrez-Ruiz, M. C., Segura-Garcia, Y., . . . Garcia-Cuellar, C. M. PM10 impairs the antioxidant defense system and exacerbates oxidative stress driven cell death Toxicology Letters 2010, 193, 209-216
20 Choi, S. J., Oh, J. M., &; Choy, J. H. Toxicological effects of inorganic nanoparticles on human lung cancer A549 cells Journal of Inorganic Biochemistry 2009, 103, 463-471
21 Clarke, L. B. THE FATE OF TRACE-ELEMENTS DURING COAL COMBUSTION AND GASIFICATION - AN OVERVIEW Fuel 1993, 72, 731-736
22 de Kok, T. M. C. M., Driece, H. A. L., Hogervorst, J. G. F., &; Briede, J. J. Toxicological assessment of ambient and traffic-related particulate matter: A review of recent studies Mutation Research-Reviews in Mutation Research 2006, 613, 103-122
23 Delfino, R. J., Sioutas, C., &; Malik, S. Potential role of ultrafine particles in associations between airborne particle mass and cardiovascular health Environmental Health Perspectives 2005, 113, 934-946
24 Dias, J. R. Handbook of Polycyclic Hydrocarbons, Part A, Benzenoid Hydrocarbons 1987, 30A, 86-96
25 Donaldson, K., Stone, V., Borm, P. J. A., Jimenez, L. A., Gilmour, P. S., Schins, R. P. F., . . . MacNee, W. Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10) Free Radical Biology and Medicine 2003, 34, 1369-1382
26 Donaldson, K., Stone, V., Tran, C. L., Kreyling, W., &; Borm, P. J. A. Nanotoxicology Occupational and Environmental Medicine 2004, 61, 727-728
27 Donaldson, K., &; Tran, C. L. Inflammation caused by particles and fibers Inhalation Toxicology 2002, 14, 5-27
28 Dos Santos, M., Gomez, D., Dawidowski, L., Gautier, E., &; Smichowski, P. Determination of water-soluble and insoluble compounds in size classified airborne particulate matter Microchemical Journal 2009, 91, 133-139
29 Driscoll, K. E., Carter, J. M., Howard, B. W., Hassenbein, D. G., Pepelko, W., Baggs, R. B., &; Oberdorster, G. Pulmonary inflammatory, chemokine, and mutagenic responses in rats after subchronic inhalation of carbon black Toxicology and Applied Pharmacology 1996, 136, 372-380
30 Duvall, R. M., Norris, G. A., Dailey, L. A., Burke, J. M., McGee, J. K., Gilmour, M. I., . . . Devlin, R. B. Source apportionment of particulate matter in the US and associations with lung inflammatory markers Inhalation Toxicology 2008, 20, 671-683
31 Dwivedi, D., Agarwal, A. K., &; Sharma, M. Particulate emission characterization of a biodiesel vs diesel-fuelled compression ignition transport engine: A comparative study Atmospheric Environment 2006, 40, 5586-5595
32 Environmental Protection Administration EY, Taiwan. 醫療廢棄物小知識 2014.07.14,
33 Europe, World Health Organization Regional Office for Health relevance of particulate matter from various sources 2007,
34 Fang, G. C., Chang, K. F., Lu, C. S., &; Bai, H. L. Estimation of PAHs dry deposition and BaP toxic equivalency factors (TEFs) study at Urban, Industry Park and rural sampling sites in central Taiwan, Taichung Chemosphere 2004, 55, 787-796
35 Farber, J. L. THE ROLE OF CALCIUM IN LETHAL CELL INJURY Chemical Research in Toxicology 1990, 3, 503-508
36 Farber, J. L. MECHANISMS OF CELL INJURY BY ACTIVATED OXYGEN SPECIES Environmental Health Perspectives 1994, 102, 17-24
37 Fischer, H. C., &; Chan, W. C. W. Nanotoxicity: the growing need for in vivo study Current Opinion in Biotechnology 2007, 18, 565-571
38 Gildemeister, A. E., Hopke, P. K., &; Kim, E. Sources of fine urban particulate matter in Detroit, MI Chemosphere 2007, 69, 1064-1074
39 Goretski, J., Zafiriou, O. C., &; Hollocher, T. C. Steady-State Nitric-Oxide Concentrations during Denitrification Journal of Biological Chemistry 1990, 265, 11535-11538
40 Gualtieri, M., Mantecca, P., Corvaja, V., Longhin, E., Perrone, M. G., Bolzacchini, E., &; Camatini, M. Winter fine particulate matter from Milan induces morphological and functional alterations in human pulmonary epithelial cells (A549) Toxicology Letters 2009, 188, 52-62
41 Gualtieri, M., Ovrevik, J., Holme, J. A., Perrone, M. G., Bolzacchini, E., Schwarze, P. E., &; Camatini, M. Differences in cytotoxicity versus pro-inflammatory potency of different PM fractions in human epithelial lung cells Toxicology in Vitro 2010, 24, 29-39
42 Gurbani, D., Bharti, S. K., Kumar, A., Pandey, A. K., Ana, G. R. E. E., Verma, A., . . . Dhawan, A. Polycyclic aromatic hydrocarbons and their quinones modulate the metabolic profile and induce DNA damage in human alveolar and bronchiolar cells International Journal of Hygiene and Environmental Health 2013, 216, 553-565
43 Halliwell, B., &; Gutteridge, J. M. C. Free radicals in biology and medicine 1999,
44 Healy, D. A., Hellebust, S., Silvari, V., Lopez, J. M., Whittaker, A. G., Wenger, J. C., . . . Sodeau, J. R. Using a pattern recognition approach to link inorganic chemical fingerprints of ambient PM2.5-0.1 with in vitro biological effects Air Quality Atmosphere and Health 2012, 5, 125-147
45 Hirano, M., Tanaka, S., &; Asami, O. Classification of polycyclic aromatic hydrocarbons based on mutagenicity in lung tissue through DNA microarray Environ Toxicol 2011,
46 Hu, W. W., Feng, Z. H., &; Tang, M. S. Nickel (II) enhances benzo[a]pyrene diol epoxide-induced mutagenesis through inhibition of nucleotide excision repair in human cells: a possible mechanism for nickel (II)-induced carcinogenesis Carcinogenesis 2004, 25, 455-462
47 Huang, S. L., Cheng, W. L., Lee, C. T., Huang, H. C., &; Chan, C. C. Contribution of endotoxin in macrophage cytokine response to ambient particles in vitro Journal of Toxicology and Environmental Health-Part A 2002, 65, 1261-1272
48 Huang, W. J., Tsai, J. L., &; Liao, M. H. Cytotoxicity of municipal solid waste incinerator ash wastes toward mammalian kidney cell lines Chemosphere 2008, 71, 1860-1865
49 Hughes, L. S., Cass, G. R., Gone, J., Ames, M., &; Olmez, I. Physical and chemical characterization of atmospheric ultrafine particles in the Los Angeles area Environmental Science &; Technology 1998, 32, 1153-1161
50 IARC IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Polynuclear aromatic hydrocarbons 1983, 32,
51 Jalava, P. I., Salonen, R. O., Pennanen, A. S., Happo, M. S., Penttinen, P., Halinen, A. I., . . . Hirvonen, M. R. Effects of solubility of urban air fine and coarse particles on cytotoxic and inflammatory responses in RAW 264.7 macrophage cell line Toxicology and Applied Pharmacology 2008, 229, 146-160
52 Janssen, N. A. H., VanMansom, D. F. M., VanDerJagt, K., Harssema, H., &; Hoek, G. Mass concentration and elemental composition of airborne particulate matter at street and background locations Atmospheric Environment 1997, 31, 1185-1193
53 Johansson, I., &; van Bavel, B. Levels and patterns of polycyclic aromatic hydrocarbons in incineration ashes Science of the Total Environment 2003, 311, 221-231
54 Johansson, I., &; van Bavel, B. Polycyclic aromatic hydrocarbons in weathered bottom ash from incineration of municipal solid waste Chemosphere 2003, 53, 123-128
55 Karlsson, H. L., Gustafsson, J., Cronholm, P., &; Moller, L. Size-dependent toxicity of metal oxide particles-A comparison between nano- and micrometer size Toxicology Letters 2009, 188, 112-118
56 Kennedy, T., Ghio, A. J., Reed, W., Samet, J., Zagorski, J., Quay, J., . . . Devlin, R. B. Copper-dependent inflammation and nuclear factor-kappa B activation by particulate air pollution American Journal of Respiratory Cell and Molecular Biology 1998, 19, 366-378
57 Klangsin, P., &; Harding, A. K. Medical waste treatment and disposal methods used by hospitals in Oregon, Washington, and Idaho Journal of the Air &; Waste Management Association 1998, 48, 516-526
58 Knaapen, A. M., Borm, P. J. A., Albrecht, C., &; Schins, R. P. F. Inhaled particles and lung cancer. Part A: Mechanisms International Journal of Cancer 2004, 109, 799-809
59 Kriek, E., Vanschooten, F. J., Hillebrand, M. J. X., Vanleeuwen, F. E., Denengelse, L., Delooff, A. J. A., &; Dijkmans, A. P. G. DNA Adducts as a Measure of Lung-Cancer Risk in Humans Exposed to Polycyclic Aromatic-Hydrocarbons Environmental Health Perspectives 1993, 99, 71-75
60 Levendis, Y. A., Atal, A., Carlson, J. B., &; Quintana, M. D. PAH and soot emissions from burning components of medical waste: examination/surgical gloves and cotton pads Chemosphere 2001, 42, 775-783
61 Lewinski, N., Colvin, V., &; Drezek, R. Cytotoxicity of nanoparticles Small 2008, 4, 26-49
62 Li, C. K., &; Kamens, R. M. THE USE OF POLYCYCLIC AROMATIC-HYDROCARBONS AS SOURCE SIGNATURES IN RECEPTOR MODELING Atmospheric Environment Part a-General Topics 1993, 27, 523-532
63 Li, M., Xiang, J., Hu, S., Sun, L. S., Su, S., Li, P. S., &; Sun, X. X. Characterization of solid residues from municipal solid waste incinerator Fuel 2004, 83, 1397-1405
64 Li, N., Sioutas, C., Cho, A., Schmitz, D., Misra, C., Sempf, J., . . . Nel, A. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage Environmental Health Perspectives 2003, 111, 455-460
65 Li, N., Xia, T., &; Nel, A. E. The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles Free Radical Biology and Medicine 2008, 44, 1689-1699
66 Lim, M. C. H., Ayoko, G. A., Morawska, L., Ristovski, Z. D., &; Jayaratne, E. R. The effects of fuel characteristics and engine operating conditions on the elemental composition of emissions from heavy duty diesel buses Fuel 2007, 86, 1831-1839
67 Limbach, L. K., Wick, P., Manser, P., Grass, R. N., Bruinink, A., &; Stark, W. J. Exposure of engineered nanoparticles to human lung epithelial cells: Influence of chemical composition and catalytic activity on oxidative stress Environmental Science &; Technology 2007, 41, 4158-4163
68 Lin, C. C., Chen, S. J., Huang, K. L., Hwang, W. I., Chang-Chien, G. P., &; Lin, W. Y. Characteristics of metals in nano/ultrafine/fine/coarse particles collected beside a heavily trafficked road Environmental Science &; Technology 2005, 39, 8113-8122
69 Linak, W. P., &; Wendt, J. O. L. TOXIC METAL EMISSIONS FROM INCINERATION - MECHANISMS AND CONTROL Progress in Energy and Combustion Science 1993, 19, 145-185
70 Liska, D. A. J. The Detoxification Enzyme Systems Alternative Medicine Review 1998, 3, 186-198
71 Loft, S., &; Poulsen, H. E. Cancer risk and oxidative DNA damage in man Journal of Molecular Medicine-Jmm 1996, 74, 297-312
72 Longhin, E., Pezzolato, E., Mantecca, P., Holme, J. A., Franzetti, A., Camatini, M., &; Gualtieri, M. Season linked responses to fine and quasi-ultrafine Milan PM in cultured cells Toxicology in Vitro 2013, 27, 551-559
73 Manahan, S. E. Environmental Chemistry 1994,
74 Mangelson, N. F., Lewis, L., Joseph, J. M., Cui, W. X., Machir, J., Williams, N. W., . . . Jensen, D. T. The contribution of sulfate and nitrate to atmospheric fine particles during winter inversion fogs in Cache Valley, Utah Journal of the Air &; Waste Management Association 1997, 47, 167-175
75 Mantecca, P., Gualtieri, M., Longhin, E., Bestetti, G., Palestini, P., Bolzacchini, E., &; Camatini, M. Adverse Biological Effects of Milan Urban Pm Looking for Suitable Molecular Markers of Exposure Chemical Industry &; Chemical Engineering Quarterly 2012, 18, 635-641
76 Mastral, A. M., Callen, M., Mayoral, C., &; Galban, J. Polycyclic Aromatic Hydrocarbon Emissions from Fluidized-Bed Combustion of Coal Fuel 1995, 74, 1762-1766
77 Mastral, A. M., &; Callen, M. S. A review an polycyclic aromatic hydrocarbon (PAH) emissions from energy generation Environmental Science &; Technology 2000, 34, 3051-3057
78 Matsuzawa, A., &; Ichijo, H. Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling Biochimica Et Biophysica Acta-General Subjects 2008, 1780, 1325-1336
79 McDonald, J. D., Eide, I., Seagrave, J., Zielinska, B., Whitney, K., Lawson, D. R., &; Mauderly, J. L. Relationship between composition and toxicity of motor vehicle emission samples Environmental Health Perspectives 2004, 112, 1527-1538
80 Mehta, M., Chen, L. C., Gordon, T., Rom, W., &; Tang, M. S. Particulate matter inhibits DNA repair and enhances mutagenesis Mutation Research-Genetic Toxicology and Environmental Mutagenesis 2008, 657, 116-121
81 Monn, C., &; Becker, S. Cytotoxicity and induction of proinflammatory cytokines from human monocytes exposed to fine (PM2.5) and coarse particles (PM10-2.5) in outdoor and indoor air Toxicology and Applied Pharmacology 1999, 155, 245-252
82 Muir, K. IARC monographs on the evaluation of carcinogenic risks to humans, vol 62, Wood dust and formaldehyde, vol 63, Dry cleaning, some chlorinated solvents and other industrial chemicals - WHO Journal of Public Health Medicine 1996, 18, 492-492
83 Nadon, L., Siemiatycki, J., Dewar, R., Krewski, D., &; Gerin, M. Cancer Risk Due to Occupational Exposure to Polycyclic Aromatic-Hydrocarbons American Journal of Industrial Medicine 1995, 28, 303-324
84 Nel, A., Xia, T., Madler, L., &; Li, N. Toxic potential of materials at the nanolevel Science 2006, 311, 622-627
85 Nisbet, I. C. T., &; Lagoy, P. K. TOXIC EQUIVALENCY FACTORS (TEFS) FOR POLYCYCLIC AROMATIC-HYDROCARBONS (PAHS) Regulatory Toxicology and Pharmacology 1992, 16, 290-300
86 Nriagu, J. O. A GLOBAL ASSESSMENT OF NATURAL SOURCES OF ATMOSPHERIC TRACE-METALS Nature 1989, 338, 47-49
87 Oberdorster, G., Oberdorster, E., &; Oberdorster, J. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles Environmental Health Perspectives 2005, 113, 823-839
88 Oberdorster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Lunts, A., . . . Cox, C. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats Journal of Toxicology and Environmental Health-Part A 2002, 65, 1531-1543
89 Pacyna, J. M. Atmospheric Trace Elements from Natural and Anthropogenic Sources, in Nriagu, In Nriagu, J.O., Davidson, C.I. (Eds.): Toxic Metals in the Atmosphere. 1986,
90 Panouilleres, M., Boillot, C., &; Perrodin, Y. Study of the combined effects of a peracetic acid-based disinfectant and surfactants contained in hospital effluents on Daphnia magna Ecotoxicology 2007, 16, 327-340
91 Papis, E., Rossi, F., Raspanti, M., Donne, I. D., Colombo, G., Milzani, A., . . . G., Gornati Engineered cobalt oxide nanoparticles readily enter cells Toxicology Letters 2009, 189, 253-259
92 Perrone, M. G., Gualtieri, M., Ferrero, L., Lo Porto, C., Udisti, R., Bolzacchini, E., &; Camatini, M. Seasonal variations in chemical composition and in vitro biological effects of fine PM from Milan Chemosphere 2010, 78, 1368-1377
93 Polichetti, G., Cocco, S., Spinali, A., Trimarco, V., &; Nunziata, A. Effects of particulate matter (PM10, PM2.5 and PM1) on the cardiovascular system Toxicology 2009, 261, 1-8
94 Powers, K. W., Brown, S. C., Krishna, V. B., Wasdo, S. C., Moudgil, B. M., &; Roberts, S. M. Research strategies for safety evaluation of nanomaterials. Part VI. Characterization of nanoscale particles for toxicological evaluation Toxicological Sciences 2006, 90, 296-303
95 Putaud, J. P., Van Dingenen, R., Alastuey, A., Bauer, H., Birmili, W., Cyrys, J., . . . Raes, F. A European aerosol phenomenology-3: Physical and chemical characteristics of particulate matter from 60 rural, urban, and kerbside sites across Europe Atmospheric Environment 2010, 44, 1308-1320
96 Puxbaum, H. Metal Compounds in the atmosphere, in: merian, E.(eds.):metals and their compounds in the environment 1991, 257-286
97 Ravindra, K., Sokhi, R., &; Van Grieken, R. Atmospheric polycyclic aromatic hydrocarbons: Source attribution, emission factors and regulation Atmospheric Environment 2008, 42, 2895-2921
98 Remde, A., &; Conrad, R. Production of Nitric-Oxide in Nitrosomonas-Europaea by Reduction of Nitrite Archives of Microbiology 1990, 154, 187-191
99 Risom, L., Moller, P., &; Loft, S. Oxidative stress-induced DNA damage by particulate air pollution Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis 2005, 592, 119-137
100 Robert, A. E., Thomas, A. C., &; Robert, G. F. Composition of PM2.5 and PM10 Aerosols in the IMPROVE Network Journal of the Air &; Waste Management Association 1997, 47, 194-203
101 Roig, N., Sierra, J., Rovira, J., Schuhmacher, M., Domingo, J. L., &; Nadal, M. In vitro tests to assess toxic effects of airborne PM10 samples. Correlation with metals and chlorinated dioxins and furans Science of the Total Environment 2013, 443, 791-797
102 Roubicek, D. A., Gutierrez-Castillo, M. E., Sordo, M., Cebrian-Garcia, M. E., &; Ostrosky-Wegman, P. Micronuclei induced by airborne particulate matter from Mexico City Mutation Research-Genetic Toxicology and Environmental Mutagenesis 2007, 631, 9-15
103 Russell, A. G., &; Brunekreef, B. A Focus on Particulate Matter and Health Environmental Science &; Technology 2009, 43, 4620-4625
104 Satsangi, P. G., Yadav, S., Pipal, A. S., &; Kumbhar, N. Characteristics of trace metals in fine (PM2.5) and inhalable (PM10) particles and its health risk assessment along with in-silico approach in indoor environment of India Atmospheric Environment 2014, 92, 384-393
105 Schanen, B. C., Karakoti, A. S., Seal, S., Drake, D. R., Warren, W. L., &; Self, W. T. Exposure to Titanium Dioxide Nanomaterials Provokes Inflammation of an in Vitro Human Immune Construct Acs Nano 2009, 3, 2523-2532
106 Schiliro, T., Alessandria, L., Degan, R., Traversi, D., &; Gilli, G. Chemical characterisation and cytotoxic effects in A549 cells of urban-air PM10 collected in Torino, Italy Environmental Toxicology and Pharmacology 2010, 29, 150-157
107 Sharma, A. K., Jensen, K. A., Rank, J., White, P. A., Lundstedt, S., Gagne, R., . . . Wallin, H. Genotoxicity, inflammation and physico-chemical properties of fine particle samples from an incineration energy plant and urban air Mutation Research-Genetic Toxicology and Environmental Mutagenesis 2007, 633, 95-111
108 Shi, J. P., Evans, D. E., Khan, A. A., &; Harrison, R. M. Sources and concentration of nanoparticles (< 10 nm diameter) in the urban atmosphere Atmospheric Environment 2001, 35, 1193-1202
109 Singh, S. K., Agarwal, A. K., &; Sharma, M. Experimental investigations of heavy metal addition in lubricating oil and soot deposition in an EGR operated engine Applied Thermal Engineering 2006, 26, 259-266
110 Sorensen, M., Autrup, H., Hertel, O., Wallin, H., Knudsen, L. E., &; Loft, S. Personal exposure to PM2.5 and biomarkers of DNA damage Cancer Epidemiology Biomarkers &; Prevention 2003, 12, 191-196
111 Sorensen, M., Autrup, H., Moller, P., Hertel, O., Jensen, S. S., Vinzents, P., . . . Loft, S. Linking exposure to environmental pollutants with biological effects Mutation Research-Reviews in Mutation Research 2003, 544, 255-271
112 Srivastava, A., &; Jain, V. K. Size distribution and source identification of total suspended particulate matter and associated heavy metals in the urban atmosphere of Delhi Chemosphere 2007, 68, 579-589
113 Stearns, R. C., Paulauskis, J. D., &; Godleski, J. J. Endocytosis of ultrafine particles by A549 cells American Journal of Respiratory Cell and Molecular Biology 2001, 24, 108-115
114 Tao, F., Gonzalez-Flecha, B., &; Kobzik, L. Reactive oxygen species in pulmonary inflammation by ambient particulates Free Radical Biology and Medicine 2003, 35, 327-340
115 Thipse, S. S., &; Dreizin, E. L. Metal partitioning in products of incineration of municipal solid waste Chemosphere 2002, 46, 837-849
116 Ting, C. H., Chen, H. H., &; Yen, C. C. A PID ratio control for removal of HCI/SOx in flue gas from refuse municipal incinerators Control Engineering Practice 2008, 16, 286-293
117 Topinka, J., Rossner, P., Milcova, A., Schmuczerova, J., Svecova, V., &; Sram, R. J. DNA adducts and oxidative DNA damage induced by organic extracts from PM2.5 in an acellular assay Toxicology Letters 2011, 202, 186-192
118 Tsai, P. J., Shieh, H. Y., Lee, W. J., &; Lai, S. O. Health-risk assessment for workers exposed to polycyclic aromatic hydrocarbons (PAHs) in a carbon black manufacturing industry Science of the Total Environment 2001, 278, 137-150
119 Utell, M. J., &; Frampton, M. W. Acute health effects of ambient air pollution: The ultrafine particle hypothesis Journal of Aerosol Medicine-Deposition Clearance and Effects in the Lung 2000, 13, 355-359
120 Valavanidis, A., Fiotakis, K., &; Vlachogianni, T. Airborne Particulate Matter and Human Health: Toxicological Assessment and Importance of Size and Composition of Particles for Oxidative Damage and Carcinogenic Mechanisms Journal of Environmental Science and Health Part C-Environmental Carcinogenesis &; Ecotoxicology Reviews 2008, 26, 339-362
121 Valavanidis, A., Iliopoulos, N., Fiotakis, K., &; Gotsis, G. Metal leachability, heavy metals, polycyclic aromatic hydrocarbons and polychlorinated biphenyls in fly and bottom ashes of a medical waste incineration facility Waste Management &; Research 2008, 26, 247-255
122 Walgraeve, C., Demeestere, K., Dewulf, J., Zimmermann, R., &; Van Langenhove, H. Oxygenated polycyclic aromatic hydrocarbons in atmospheric particulate matter: Molecular characterization and occurrence Atmospheric Environment 2010, 44, 1831-1846
123 Walker, B. L., &; Cooper, C. D. Air-Pollution Emission Factors for Medical Waste Incinerators Journal of the Air &; Waste Management Association 1992, 42, 784-791
124 Wey, M. Y., Chao, C. Y., Wei, M. C., Yu, L. J., &; Liu, Z. S. The influence of heavy metals on partitioning of PAHs during incineration Journal of Hazardous Materials 2000, 77, 77-87
125 Xia, T., Kovochich, M., &; Nel, A. E. Impairment of mitochondrial function by particulate matter (PM) and their toxic components: implications for PM-induced cardiovascular and lung disease Frontiers in Bioscience 2007, 12, 1238-1246
126 Yates, J. R. W., Sepp, T., Matharu, B. K., Khan, J. C., Thurlby, D. A., Shahid, H., . . . Genetic Factors, A. M. D. Study G. Complement C3 variant and the risk of age-related macular degeneration New England Journal of Medicine 2007, 357, 553-561
127 Ye, R. W., Averill, B. A., &; Tiedje, J. M. Denitrification - Production and Consumption of Nitric-Oxide Applied and Environmental Microbiology 1994, 60, 1053-1058
128 Yi, S., Zhang, F., Qu, F., &; Ding, W. J. Water-Insoluble Fraction of Airborne Particulate Matter (PM10) Induces Oxidative Stress in Human Lung Epithelial A549 Cells Environmental Toxicology 2014, 29, 226-233
129 Zeuthen, J. H., Pedersen, A. J., Hansen, J., Frandsen, F. J., Livbjerg, H., Riber, C., &; Astrup, T. Combustion aerosols from municipal waste incineration - Effect of fuel feedstock and plant operation Combustion Science and Technology 2007, 179, 2171-2198
130 Zhao, L. J., Zhang, F. S., Hao, Z. P., &; Wang, H. L. Levels of polycyclic aromatic hydrocarbons in different types of hospital waste incinerator ashes Science of the Total Environment 2008, 397, 24-30
131 Zhu, Y., Hinds, W. C., Kim, S., Shen, S., &; C., Sioutas Study of ultrafine particles near a major highway with heavy-duty diesel traffic Atmospheric Environment 2002, 36, 4323–4335
132 王柏智 垃圾焚化及燃煤程序之重金屬排放特性 2006,
133 林志忠 交通源大氣奈米、超細、細及粗微粒組成特性之研究 2007,
134 曾維昌 可怕的重金屬 輔英醫訊 2008, 59,
135 楊錫賢, 簡淑美 Size Distribution of Particulate Matter and Polycyclic Aromatic Hydrocarbons from Motocycles 1995,

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