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研究生:江厚志
研究生(外文):Hou-Chih Chiang
論文名稱:合併補充益生菌及含魚油之綜合營養劑對BALB/c小鼠腸道功能的影響
論文名稱(外文):The combined effects of probiotics and nutrition supplement containing fish oil on intestinal function in BALB/c Mice
指導教授:林璧鳳林璧鳳引用關係
指導教授(外文):Bi-Fong Lin
口試委員:蔡英傑江孟燦林金源李昆達
口試委員(外文):Ying-Chieh TsaiMeng-Tsan ChiangJin-Yuarn LinKung-Ta Lee
口試日期:2014-07-03
學位類別:碩士
校院名稱:國立臺灣大學
系所名稱:生化科技學系
學門:生命科學學門
學類:生物科技學類
論文種類:學術論文
論文出版年:2014
畢業學年度:102
語文別:中文
論文頁數:58
中文關鍵詞:消化酵素活性益生菌魚油比菲德氏菌乳酸菌產氣夾膜梭菌
外文關鍵詞:Intestinal digestive enzymeprobioticsfish oilBifidobacteium spp.Lactobacillus spp.Clostridium perfringens
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腸道的主要功能是將所攝入的食物進行消化與吸收,而近幾年的研究則發現,人體腸道中的共生菌所組成的腸道菌相,在人體的健康狀態上扮演了重要的角色。
  本研究以雀巢公司的益生菌粉與含有魚油的綜合營養劑來管餵小鼠,探討單獨與合併補充對腸道消化酵素活性以及腸道菌相的影響,並參考另外兩位同學所進行的免疫調節及腸道免疫的結果來評估哪種補充方式最佳。非特異性免疫小鼠實驗腸道酵素活性的部分顯示,給予補充皆可以顯著性的提高麥芽糖&;#37238;的活性,乳糖&;#37238;則是在給予單劑補充益生菌時有著顯著性的提升,白胺酸胺基酵素的活性則是有補充都會提高活性,在高劑量時有顯著性的差益,然而在特異性免疫動物實驗的時候則呈現了相反的調控方式。腸內細菌菌相的部分則顯示了,只要有補充,都可以減少腸道中產氣夾膜梭菌並增加乳酸菌的含量。單獨補充益生菌粉或中、高劑量的合併補充時有較好的效果,僅給予綜合營養劑的補充或是減半劑量的合併補充則沒有效果。
  兩批腸道酵素活性實驗的結果不一樣,可能的原因是由於特異性免疫動物實驗需要額外進行腹腔注射OVA,因而導致小鼠腸道功能的受損而造成兩次實驗的結果不一致,因此推論第一批動物實驗的酵素實驗結果較可信。綜合兩次實驗的結果,給予中或高劑量的合併補充時皆會有良好的補充效益,而在給予中劑量的合併補充即可有最好的補充效益。


The main function of the gastrointestinal function was to digest and absorb the food we eat. Recent studies have shown that microbiota which was composed by the intestinal commensal bacteria played an important role in health
  In this research, we supplied the mice with probiotics and fish oil-containing nutritional supplement through tube feeding to evaluate the effect of single dose or combination of two doses on intestinal digestive enzyme activity and microbiota. And to determine which method will have the best supplemental benefit.
  The result of intestinal enzyme activity showed that all of the supplement could enhance the activity of maltase and leucine aminopeptidase, and the single dose of probiotic supplement could enhance the activity of lactase in non-specific immune response in mice. But the regulation role of supplement was adverse in OVA-specific immune responses in mice. The microbial result showed that no matter how the supplement we feed the mice, all of them can decrease the Clostridium Perfringens and increase the Lactobacillus spp.. Supply with probiotics and median or high dose combination can increase the bifidobacterium spp. in microbiota.
  Different result in intestinal enzyme activity may due to the intestinal dysfunction in OVA-specific immune responses in mice which had been intraperitoneal injection of . OVA. Thus, the result of regulation of supplement on intestinal enzyme activity in non-specific immune responses mice may be more dependable. A summary of the result above, we suggested that the supply of the median dose of combination of probiotics and fish oil-containing nutritional supplements may have the better supplementary effect compared to that of other supply method.


總目錄
中文摘要 I
英文摘要 II
縮寫對照表 III
總目錄 IV
圖目錄 VII
表目錄 VIII
第一章 文獻回顧與研究動機 1
 文獻回顧 1
  第一節 前言 1
第二節 胃腸道系統 1
   一、胃腸道系統的構造與組成 2
   二、胃腸道功能 3
    (一)蠕動 3
    (二)分泌 3
    (三)消化與吸收 3
   三、腸道消化酵素 3
  第三節 人體微生物菌相 4
一、腸道微生物的組成 5
    二、腸道微生物與年齡 6
    三、腸道微生物與飲食的關聯 8
    四、腸道微生物與免疫系統的關聯 9
    五、腸道微生物與疾病的關聯 10
   第四節 益生菌與益菌生 11
   一、益生菌與胃腸道功能 12
   二、益生菌與免疫系統 12
   三、益生菌與疾病 13
  第五節 DHA 14
  第六節 維生素 14
   一、維生素A 14
   二、維生素D 15
   三、葉酸 16
 研究動機 17
第二章 補充綜合營養劑合併益生菌對腸道功能的影響 18
  第一節 前言 18
  第二節 管餵樣品與動物飼養 18
   一、管餵劑量轉換與製備 18
    (一) 劑量轉換 18
(二) 管餵養品配製與管餵 20
   二、動物飼養 21
   三、動物實驗流程 22
    (一) 各組管餵樣品 22
    (二) 分析項目 23
   四、致免模式 23
   五、樣品收集與分析 24
    (一) 動物犧牲 24
    (二) 糞便樣品收集 24
   六、統計分析 24
第三節 腸道酵素活性測定方法 25
    一、腸道酵素樣品的製備 25
 二、雙醣酵素活性分析 25
 三、白胺酸胺劑酵素活性分析 27
    四、脂解酵素活性分析 27
    五、統計方法 28
第四節 腸內細菌菌相分析方法 29
    一、塗盤法 29
     (一) 培養基的選擇與製備 29
      1. MRS 與 BIM-25 選擇性培養基的製備 29
      2. TSC 選擇性培養基的製備 31
     (二) 厭氧稀釋液的製備 32
     (三) 實驗方法 32
    二、以 qPCR 對腸內特定菌群進行定量 36
     (一) Genomic-DNA 樣品抽取與處理 36
     (二) 引子的選擇 36
     (三) Real-time PCR 法分析糞便中特定菌群基因的表現量 38
     (四) 計算方法 38
     (五) 統計分析方法 39
   第五節 小鼠生長情形與攝食量結果 40
   第六節 腸道酵素活性實驗結果 43
   第七節 腸內特定細菌菌群分析結果 45
第三章 綜合討論與總結 47
  第一節 塗盤培養法與 qPCR 法的優缺比較 47
   一、塗盤培養法的優缺點 47
   二、qPCR 法的優缺點 48
第二節 腸道消化酵素活性 49
  第三節 腸道細菌菌相 49
  第五節 總結 50
參考文獻 51


Baron S, editor. Medical Microbiology. 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996.
Bergstrom KS, Kissoon-Singh V, Gibson DL, Ma C, Montero M, Sham HP, Ryz N, Huang T, Velcich A, Finlay BB, Chadee K, Vallance BA. Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa. PLoS Pathog. 2010
Bouskra D, Brezillon C, Berard M, Werts C, Varona R, Boneca IG, Eberl G. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature. 2008
Brady LJ, Gallaher DD, Busta FF. The role of probiotic cultures in the prevention of colon cancer. J Nutr. 2000
Brestoff JR1, Artis D. Commensal bacteria at the interface of host metabolism and the immune system. Nat Immunol. 2013
Cassone M,Serra P,Mondello F,Girolamo A,Scafetti S,Pistella E,et al. Outbreak of Saccharomyces cerevisiae subtype boulardii fungemia in patients neighboring those treated with a probiotic preparation of the organism. J Clin Microbiol. 2003
Cho T, Nagao JI, Imayoshi R, Tanaka Y. Importance of Diversity in the Oral Microbiota including Candida Species Revealed by High-Throughput Technologies. Int J Dent. 2014
Cleland LG, James MJ, Proudman SM. Fish oil: what the prescriber needs to know. Arthritis Res Ther. 2006
Cotter PD1, Hill C, Ross RP. Bacteriocins: developing innate immunity for food. Nat Rev Microbiol. 2005
Cummings JH, Macfarlane GT. The control and consequences of bacterial fermentation
  in the human colon. J Appl Bacteriol. 1991
Darfeuille-Michaud A, Boudeau J, Bulois P, Neut C, Glasser AL, Barnich N, Bringer MA, Swidsinski A, Beaugerie L, Colombel JF. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn''s disease. Gastroenterology. 2004
Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N,
  Knight R. Delivery mode shapes the acquisition and structure of the initial
  microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A.
  2010
Drasar, BS. &; Hill, MJ. Human Intestinal Flora. Academic Press, London, U.K. 1974
Duncan SH, Louis P, Thomson JM, Flint HJ. The role of pH in determining the species composition of the human colonic microbiota. Environ Microbiol. 2009
Eastwood, ML. Colon structure.In: The Colon: Structure and Function (Busto-Ferandes, L., Acd.),pp. 1-16. Plenum Medical Book Company, London, U.K. 1982
Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, Gill SR, Nelson KE, Relman DA. Diversity of the human intestinal microbial flora. Science. 2005
Everard A, Lazarevic V, Derrien M, Girard M, Muccioli GG, Neyrinck AM, Possemiers S, Van Holle A, Francois P, de Vos WM, Delzenne NM, Schrenzel J, Cani PD. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes. 2011
Faith JJ, McNulty NP, Rey FE, Gordon JI. Predicting a human gut microbiota''s response to diet in gnotobiotic mice. Science. 2011
Flint HJ, Scott KP, Louis P, Duncan SH. The role of the gut microbiota in nutrition and health. Nat Rev Gastroenterol Hepatol. 2012
Fuller R. Probiotics in man and animals. J Appl Bacteriol. 1989
Furness JB. The enteric nervous system and neurogastroenterology. Nat Rev Gastroenterol Hepatol. 2012
Galdeano CM, Perdigon G. Role of viability of probiotic strains in their persistence in
  the gut and in mucosal immune stimulation. J Appl Microbiol. 2004
Gangopadhyay NN, Moldoveanu Z, Stephensen CB. Vitamin A deficiency has different effects on immunoglobulin A production and transport during influenza A infection in BALB/c mice. J Nutr. 1996
Garrett WS, Gallini CA, Yatsunenko T, Michaud M, DuBois A, Delaney ML, Punit S,
  Karlsson M, Bry L, Glickman JN, Gordon JI, Onderdonk AB, Glimcher LH.
  Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous
  and maternally transmitted colitis. Cell Host Microbe. 2010
Ghorbanihaghjo A, Safa J, Alizadeh S, Argani H, Rashtchizadeh N, Taghinia MV,
Abbasi MM. Protective effect of fish oil supplementation on DNA damage induced
by cigarette smoking. J Health Popul Nutr. 2013
Ghoshal U, Shukla R, Ghoshal U, Gwee K, Ng S and Quigley E. The gut microbiota
  and irritable bowel syndrome: friend or foe? Int J Inflam 2012
Gibson GR. Dietary modulation of the human gut microflora using prebiotics. Br J Nutr.
  1998
Gibson GR, Roberfroid MB. Colon Microbiota, Nutrition and Health. The Netherlands:
  Kluwer Academic Publishers, 1999
Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol. 2011
Gordon HA, Bruckner-Kardoss E, Wostmann BS. Aging in germ-free mice: life tables
  and lesions observed at natural death. J Gerontol. 1966
Guinane CM, Cotter PD. Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ. Therap Adv Gastroenterol. 2013
Haller D, Bode C, Hammes WP, Pfeifer AM, Schiffrin EJ, Blum S. Non-pathogenic
  bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte
  co-cultures. Gut. 2000
Hamada H, Hiroi T, Nishiyama Y, Takahashi H, Masunaga Y, Hachimura S, Kaminogawa S, Takahashi-Iwanaga H, Iwanaga T, Kiyono H, Yamamoto H, Ishikawa H. Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine. J Immunol. 2002
Heilig HG, Zoetendal EG, Vaughan EE, Marteau P, Akkermans AD, de Vos WM. Molecular diversity of Lactobacillus spp. and other lactic acid bacteria in the human intestine as determined by specific amplification of 16S ribosomal DNA. Appl Environ Microbiol. 2002
Hildebrandt MA, Hoffmann C, Sherrill-Mix SA, Keilbaugh SA, Hamady M, Chen YY, Knight R, Ahima RS, Bushman F, Wu GD. High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology. 2009
Hollister EB, Gao C, Versalovic J. Compositional and functional features of the gastrointestinal microbiome and their effects on human health. Gastroenterology. 2014
Iwata M, Yokota A. Retinoic acid production by intestinal dendritic cells. Vitam Horm. 2011
Jimenez E, Marin ML, Martin R, Odriozola JM, Olivares M, Xaus J, Fernandez L, Rodriguez JM. Is meconium from healthy newborns actually sterile? Res Microbiol. 2008
Johansson ME, Phillipson M, Petersson J, Velcich A, Holm L, Hansson GC. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci U S A. 2008
Jonkers D, Stockbrugger R. Review article: Probiotics in gastrointestinal and liver diseases. Aliment Pharmacol Ther. 2007
Jung K, Ahn K, Chae C. Decreased activity of brush border membrane-bound digestive enzymes in small intestines from pigs experimentally infected with porcine epidemic diarrhea virus. Res Vet Sci. 2006
Kamada N, Seo SU, Chen GY, Nunez G. Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol. 2013 May
Kato T, Hancock RL, Mohammadpour H, McGregor B, Manalo P, Khaiboullina S, Hall MR, Pardini L, Pardini RS. Influence of omega-3 fatty acids on the growth of human colon carcinoma in nude mice. Cancer Lett. 2002
Kashyap PC, Marcobal A, Ursell LK, Smits SA, Sonnenburg ED, Costello EK, Higginbottom SK, Domino SE, Holmes SP, Relman DA, Knight R, Gordon JI, Sonnenburg JL. Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota. Proc Natl Acad Sci U S A. 2013
Kengatharan M1, De Kimpe SJ, Thiemermann C. Analysis of the signal transduction in the induction of nitric oxide synthase by lipoteichoic acid in macrophages. Br J Pharmacol. 1996
Kiessling G, Schneider J, Jahreis G. Long-term consumption of fermented dairy products over 6 months increases HDL cholesterol. Eur J Clin Nutr. 2002
Koenig JE, Spor A, Scalfone N, Fricker AD, Stombaugh J, Knight R, Angenent LT, Ley RE. Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci U S A. 2011
Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med. 2013
Koropatkin NM, Cameron EA, Martens EC. How glycan metabolism shapes the human gut microbiota. Nat Rev Microbiol. 2012 Apr
Kunkel D, Basseri RJ, Makhani MD, Chong K, Chang C, Pimentel M. Methane on breath testing is associated with constipation: a systematic review and meta-analysis. Dig Dis Sci. 2011
Kunisawa J, Hashimoto E, Ishikawa I, Kiyono H. A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo. PLoS One. 2012
Lands WE. Biochemistry and physiology of n-3 fatty acids. FASEB J. 1992
Lanham-new, SA., Macdonald, IA., and Roche, HM. Nutrition and metabolism.
  2nd ed. Wiley-Blackwell, Oxford, UK. 2011
Lim GP, Calon F, Morihara T, Yang F, Teter B, Ubeda O, Salem N Jr, Frautschy SA, Cole GM. A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J Neurosci. 2005
Liu L, Yu YL, Liu C, Wang XT, Liu XD, Xie L. Insulin deficiency induces abnormal increase in intestinal disaccharidase activities and expression under diabetic states, evidences from in vivo and in vitro study. Biochem Pharmacol. 2011
Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zugel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006
Liu T, Hougen H, Vollmer AC, Hiebert SM. Gut bacteria profiles of Mus musculus at the phylum and family levels are influenced by saturation of dietary fatty acids. Anaerobe. 2012
Macfarlane S, Furrie E, Cummings JH, Macfarlane GT. Chemotaxonomic analysis of bacterial populations colonizing the rectal mucosa in patients with ulcerative colitis. Clin Infect Dis. 2004
Madan JC, Salari RC, Saxena D, Davidson L, O''Toole GA, Moore JH, Sogin ML,
  Foster JA, Edwards WH, Palumbo P, Hibberd PL. Gut microbial colonisation in
  premature neonates predicts neonatal sepsis. Arch Dis Child Fetal Neonatal Ed.
  2012
Maeda H, Fujimoto C, Haruki Y, Maeda T, Kokeguchi S, Petelin M, Arai H, Tanimoto I,   
  Nishimura F, Takashiba S. Quantitative real-time PCR using TaqMan and SYBR
  Green for Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis,
  Prevotella intermedia, tetQ gene and total bacteria. FEMS Immunol Med
  Microbiol. 2003
Manichanh C, Rigottier-Gois L, Bonnaud E, Gloux K, Pelletier E, Frangeul L, Nalin R,
  Jarrin C, Chardon P, Marteau P, Roca J, Dore J. Reduced diversity of faecal
  microbiota in Crohn''s disease revealed by a metagenomic approach. Gut. 2006
Matamoros S, Gras-Leguen C, Le Vacon F, Potel G, de La Cochetiere MF. Development
  of intestinal microbiota in infants and its impact on health. Trends Microbiol. 2013
Matsuki T, Watanabe K, Fujimoto J, Miyamoto Y, Takada T, Matsumoto K, Oyaizu H,
  Tanaka R. Development of 16S rRNA-gene-targeted group-specific primers for the
  detection and identification of predominant bacteria in human feces. Appl Environ
  Microbiol. 2002
Meer RR, Songer JG. Multiplex polymerase chain reaction assay for genotyping
  Clostridium perfringens. Am J Vet Res. 1997
Meurman JH, Stamatova I. Probiotics: contributions to oral health. Oral Dis. 2007
Mukai T, Kaneko S, Matsumoto M, Ohori H. Binding of Bifidobacterium bifidum and
  Lactobacillus reuteri to the carbohydrate moieties of intestinal glycolipids
  recognized by peanut agglutinin. Int J Food Microbiol. 2004
Pelto L, Isolauri E, Lilius EM, Nuutila J, Salminen S Probiotic bacteria down-regulate
  the milk-induced inflammatory response in milk-hypersensitive subjects but have
  an immunostimulatory effect in healthy subjects. Clin Exp Allergy. 1998
Pessi T, Sutas Y, Hurme M, Isolauri E. Interleukin-10 generation in atopic children
  following oral Lactobacillus rhamnosus GG. Clin Exp Allergy. 2000
Pomare EW, Branch WJ, Cummings JH. Carbohydrate fermentation in the human colon
  and its relation to acetate concentrations in venous blood. J Clin Invest. 1985
Provvedini DM, Tsoukas CD, Deftos LJ, Manolagas SC. 1,25-dihydroxyvitamin D3 receptors in human leukocytes. Science. 1983
Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, Nielsen T, Pons N, Levenez F, Yamada T, Mende DR, Li J, Xu J, Li S, Li D, Cao J, Wang B, Liang H, Zheng H, Xie Y, Tap J, Lepage P, Bertalan M, Batto JM, Hansen T, Le Paslier D, Linneberg A, Nielsen HB, Pelletier E, Renault P, Sicheritz-Ponten T, Turner K, Zhu H, Yu C, Li S, Jian M, Zhou Y, Li Y, Zhang X, Li S, Qin N, Yang H, Wang J, Brunak S, Dore J, Guarner F, Kristiansen K, Pedersen O, Parkhill J, Weissenbach J; MetaHIT Consortium, Bork P, Ehrlich SD, Wang J. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010
Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies
  revisited. FASEB J. 2008
Rinttila T, Kassinen A, Malinen E, Krogius L, Palva A. Development of an extensive set
  of 16S rDNA-targeted primers for quantification of pathogenic and indigenous
  bacteria in fecal samples by real-time PCR. J Appl Microbiol. 2004
Salonen A, de Vos WM. Impact of diet on human intestinal microbiota and health. Annu
  Rev Food Sci Technol. 2014
Salzman NH, Hung K, Haribhai D, Chu H, Karlsson-Sjoberg J, Amir E, Teggatz P,
  Barman M, Hayward M, Eastwood D, Stoel M, Zhou Y, Sodergren E, Weinstock
  GM, Bevins CL, Williams CB, Bos NA. Enteric defensins are essential regulators
  of intestinal microbial ecology. Nat Immunol. 2010
Scanlan PD, Marchesi JR. Micro-eukaryotic diversity of the human distal gut
  microbiota: qualitative assessment using culture-dependent and -independent
  analysis of faeces. ISME J. 2008
Schwandner R, Dziarski R, Wesche H, Rothe M, Kirschning CJ. Peptidoglycan- and
  lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol
  Chem. 1999
Scott KP1, Gratz SW, Sheridan PO, Flint HJ, Duncan SH. The influence of diet on the
  gut microbiota. Pharmacol Res. 2013
Sekirov I, Russell SL, Antunes LC, Finlay BB. Gut microbiota in health and disease.
  Physiol Rev. 2010
Servin AL. Antagonistic activities of lactobacilli and bifidobacteria against microbial  
  pathogens. FEMS Microbiol Rev. 2004
Shida K, Takahashi R, Iwadate E, Takamizawa K, Yasui H, Sato T, Habu S, Hachimura
  S, Kaminogawa S. Lactobacillus casei strain Shirota suppresses serum
  immunoglobulin E and immunoglobulin G1 responses and systemic anaphylaxis in
  a food allergy model. Clin Exp Allergy. 2002
Sindhu SC and Khetarpaul N. Effect of feeding probiotic fermented indigenous food
  mixture on serum cholesterol levels in mice. Nutr. Res. 2003
Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermudez-Humaran LG, Gratadoux JJ,
  Blugeon S, Bridonneau C, Furet JP, Corthier G, Grangette C, Vasquez N, Pochart P,
  Trugnan G, Thomas G, Blottiere HM, Dore J, Marteau P, Seksik P, Langella P.
  Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium
  identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci
  U S A. 2008
Spor A, Koren O, Ley R. Unravelling the effects of the environment and host genotype
  on the gut microbiome. Nat Rev Microbiol. 2011
Strugnell RA, Wijburg OL. The role of secretory antibodies in infection immunity. Nat
  Rev Microbiol. 2010
Grice EA, Segre JA. The human microbiome: our second genome. Annu Rev Genomics
  Hum Genet. 2012
Tabbaa M, Golubic M, Roizen MF, Bernstein AM. Docosahexaenoic acid, inflammation, and bacterial dysbiosis in relation to periodontal disease, inflammatory bowel disease, and the metabolic syndrome. Nutrients.
Tallon R, Arias S, Bressollier P, Urdaci MC. Strain- and matrix-dependent adhesion of
  Lactobacillus plantarum is mediated by proteinaceous bacterial compounds. J Appl
  Microbiol. 2007
Tao Y, Drabik KA, Waypa TS, Musch MW, Alverdy JC, Schneewind O, Chang EB,
  Petrof EO. Soluble factors from Lactobacillus GG activate MAPKs and induce
  cytoprotective heat shock proteins in intestinal epithelial cells. Am J Physiol Cell
  Physiol. 2006
Turnbaugh PJ, Ridaura VK, Faith JJ, Rey FE, Knight R, Gordon JI. The effect of diet on
  the human gut microbiome: a metagenomic analysis in humanized
  gnotobioticmice. Sci Transl Med. 2009
Vaishnava S, Behrendt CL, Ismail AS, Eckmann L, Hooper LV. Paneth cells directly
  sense gut commensals and maintain homeostasis at the intestinal host-microbial
  interface. Proc Natl Acad Sci U S A. 2008 Dec
Vismaya, Rajini PS. Oral exposure to the organophosphorus insecticide, Monocrotophos
  induces intestinal dysfunction in rats. Food Chem Toxicol. 2014
Walker AW, Duncan SH, McWilliam Leitch EC, Child MW, Flint HJ. pH and peptide
  supply can radically alter bacterial populations and short-chain fatty acid ratios
  within microbial communities from the human colon. Appl Environ Microbiol.
  2005
Walter J, Ley R. The human gut microbiome: ecology and recent evolutionary changes.
  Annu Rev Microbiol. 2011
Walter J, Hertel C, Tannock GW, Lis CM, Munro K, Hammes WP. Detection of
  Lactobacillus, Pediococcus, Leuconostoc, and Weissella species in human feces by
  using group-specific PCR primers and denaturing gradient gel electrophoresis.
  Appl Environ Microbiol. 2001
Wollowski I, Rechkemmer G, Pool-Zobel BL. Protective role of probiotics and
  prebiotics in colon cancer. Am J Clin Nutr. 2001
Yadav H, Jain S, Sinha PR. Antidiabetic effect of probiotic dahi containing
  Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats.
  Nutrition. 2007
Yan F, Polk DB. Probiotic bacterium prevents cytokine-induced apoptosis in intestinal
  epithelial cells. J Biol Chem. 2002
Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M,
  Magris M, Hidalgo G, Baldassano RN, Anokhin AP, Heath AC, Warner B, Reeder
  J, Kuczynski J, Caporaso JG, Lozupone CA, Lauber C, Clemente JC, Knights D,
  Knight R, Gordon JI. Human gut microbiome viewed across age and geography.
  Nature. 2012
Yu HN, Zhu J, Pan WS, Shen SR, Shan WG, Das UN. Effects of fish oil with a high
  content of n-3 polyunsaturated fatty acids on mouse gut microbiota. Arch Med Res.
  2014
Zhang C, Li S, Yang L, Huang P, Li W, Wang S, Zhao G, Zhang M, Pang X, Yan Z, Liu
  Y, Zhao L. Structural modulation of gut microbiota in life-long calorie-restricted
  mice. Nat Commun. 2013
Zhang C, Zhang M, Wang S, Han R, Cao Y, Hua W, Mao Y, Zhang X, Pang X, Wei C, Zhao G, Chen Y, Zhao L. Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice. ISME J. 2010


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