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研究生:王彥鈞
研究生(外文):Yen-Chun Wang
論文名稱:血清中類胰島素成長因子與骨質密度之相關性分析
論文名稱(外文):The study aimed at dependency analysis of Insulin-like growth factor-1(, IGF-I) and bony density in serum.
指導教授:郭瓊文郭瓊文引用關係
指導教授(外文):Chiung-Wen Kuo
學位類別:碩士
校院名稱:元培科技大學
系所名稱:醫學影像暨放射技術研究所
學門:醫藥衛生學門
學類:醫學技術及檢驗學類
論文種類:學術論文
畢業學年度:102
語文別:中文
論文頁數:69
中文關鍵詞:類胰島素生長因子骨質疏鬆骨質密度值
外文關鍵詞:Insulin-like Growth Factor 1Osteoporosisbone mineral density
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本研究針對血清中類胰島素生長因子-Ι(Insulin-like Growth Factor 1, IGF-1)與骨質密度之相關性研究。研究起於2011年8月至2012年8月,共147位受試者,62位男性(42.2%),85位女性(57.8%),資料收集包括受試者血清中IGF-1檢驗值與骨質密度值(Bone Mineral Density, BMD),分析受試者IGF-1濃度對BMD之影響。研究中將受試者分為四個年齡層,發現IGF-1濃度會因年齡層增加,而有下降之趨勢,但無統計學上之意義。依國際衛生組織(World Health Organization, WHO)所定義之骨質疏鬆分級中發現,骨質正常之受試者IGF-1濃度為三組間最高,骨質流失組次之,骨質疏鬆症組受試者為最低,且有統計學上之意義(p<0.05),說明了IGF-1之濃度可能影響骨質密度值。利用Pearson簡單相關分析IGF-1之濃度對骨質密度之相關性發現,LS BMD(r=0.178: p<0.05)、LS T-score(r=0.164: p<0.05),LFN BMD(r=0.351: p<0.05)、LFN T-score(r=0.335: p<0.01),RFN BMD(r=0.343: p<0.05)、RFN T-score(r=0.342: p<0.01)與IGF-1皆成呈正相關,有顯著性之相關性。老年骨質疏鬆患者骨形成和骨吸收平衡失調。因此IGF- 1濃度下降,可能是老年骨質疏鬆發生的原因之一。雙能量骨質密度檢測儀是目前檢測骨質度最可靠的工具之一,透過檢測血清中IGF-1之濃度可間接瞭解骨質密度,對老年骨質疏鬆的診斷提供可靠的依據。
There were 147 cases received the study, 62 males and 85 female (42.2% and 57.8%respectively), since August 2011 to August 2012, the data had collected from those candidates, with the IGF-I serum value, and bone mineral density (BMD), to rule out which is the correlation of density.
The study was classified into 4 groups in age-layer, and found that the age regarded to the IGF-I density, the older the value declined more, but nothing revealed specific differences, statistically. According to the definition and classification of World Health Organization, WHO), the normal one within the 3 classified groups; the serum IGF-I is the highest, secondly the group who has BMD loss, and the lowest found in the Osteoporosis group with statistical significance (p<0.05), stands for the density of IGF-I in serum may cause the BMD value. Through the Pearson simple analysis of correlation, found that L-spine BMD, T-score was showed appositive relation (r=0.178: r=0.164: p<0.05), LFN BMD, T-score presented positive correlation with IGF-I (r=0.351: r=0.335 p<0.01), RFN BMD, T-score also revealed positive correlation (r=0.343: r=0.342: p<0.01), all had the significant correlations.
Currently, the Dual Energy X-ray Absorptiometry (DEXA) is one of the reliable tools for BMD, via the blood serum IGF-I can detect the density of bone mass indirectly, provides aged bony osteoporosis a way for diagnosis.

中文摘要 I
英文摘要 II
致謝 III
目錄 IV
圖目錄 VI
表目錄 VII
第一章 緒論 1
1.1 研究背景 1
1.2 研究目的 3
第二章 文獻檢閱 4
2.1 骨質疏鬆症發病之病理學機轉 4
2.1.1 骨質疏鬆症定義 4
2.1.2 臨床上骨質疏鬆症之分類 5
2.2 骨質疏鬆症之問卷及測量方法與診斷標準 6
2.3 骨質疏鬆與IGF-1相關性 8
第三章 研究材料與方法 11
3.1 研究受試者 11
3.2 研究流程圖 11
3.3 研究工具 12
3.4 骨質密度測量方法 17
3.5 類胰島素成長因子測量方法 20
3.6 研究變項 22
3.7 資料整理 22
第四章 結果 24
4.1 受試者之基本資料分布 24
4.2 受試者之骨質密度測量結果 28
4.3 受試者之骨質密度測量結果 32
4.4 受試者之BMI與BMD之分析結果 34
4.5 血清中IGF-1含量檢驗結果 37
4.6 骨質疏鬆症分級標準與血清中IGF-1濃度分析 39
4.7 性別、年齡、BMI、BMD與IGF-1之相關性 43
4.8 IGF-1血清檢驗結果之線性迴歸分析 44
第五章 討論 47
5.1 骨質疏鬆與性別、年齡、BM I 47
5.2 IGF-1與年齡 49
5.3 IGF-1與BMD 51
5.4 IGF-1對骨質密度之相關性及影響 52
第六章 結論 55
參考文獻 57


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