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研究生:李沅蓉
研究生(外文):Lee, Yuan-Jung
論文名稱:以定量式超音波骨質密度儀分析生活習慣對骨質結構的影響
論文名稱(外文):Use quantitative ultrasound to analysis the effect of lifestyle on the bone structure
指導教授:郭瓊文郭瓊文引用關係
指導教授(外文):Kuo, Chiung-Wen
學位類別:碩士
校院名稱:元培科技大學
系所名稱:醫學影像暨放射技術研究所
學門:醫藥衛生學門
學類:醫學技術及檢驗學類
論文種類:學術論文
畢業學年度:102
語文別:中文
論文頁數:71
中文關鍵詞:定量式超音波定量超音波指數音波速度頻寬衰減值
外文關鍵詞:quantitative ultrasoundquantitative ultrasound indexspeed of soundbroadband ultrasound attenuation
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本研究目的為用定量式超音波評估一般民眾的生活習慣對骨質密度的影響,以預防骨折之發生率。受檢者共為937位,男性為312位,平均年齡66.8 ± 16.9歲;女性為625位,平均年齡60.3 ± 15.3歲。全部受檢者均接受定量式超音波測量慣用腳跟骨或未受傷腳的跟骨檢測,並填寫生活狀況之問卷,將檢測出的音波速度(speed of sound, SOS, m/s)、寬頻衰減值(broadband ultrasound attenuation, BUA, dB/cm)與定量超音波指數(quantitative ultrasound index, QUI)及問卷內容作相關性分析。研究顯示男性的SOS平均值為1528.7 ± 31.8 m/s較女性(1524.3 ± 32.8 m/s)為高(p=0.049),男性的BUA平均值為69.5 ± 17.3 dB/cm;女性為63.2 ± 18.4 dB/cm (p<0.001),男性的QUI平均值為84.4 ± 19.3;女性為79.5 ± 20.4 (p<0.001),T-score男性為-1.1 ± 1.2;女性為-1.4 ± 1.3 (p=0.001)。從女性的結果中發現老年時期抽菸習慣的SOS (r=-0.141)、BUA (r=-0.131)及QUI (r=-0.150)均呈顯著的負相關(p<0.05),但在全體女性一同分析時卻沒有此相關性;而全體女性中有喝茶及咖啡習慣的SOS (r=-0.115)、BUA (r=-0.111)及QUI (r=-0.106)皆有極顯著的負相關(p<0.01),但在年齡分層中則沒有。另外在本研究中女性停經前SOS (r=-0.194)、BUA (r=-0.160)及QUI (r=-0.177)對長期性的藥物服用皆有顯著的負相關(p<0.05),這和全體女性一同分析時的結果相同,但在年齡分層的統計中則沒有顯著相關。總結來探討,骨質密度除了在性別上具有顯著的差異外,在不同的年齡層及不同的生活習慣中亦會以不同的骨質密度結果。
The purpose of this study was to assess the impact of general population living habits of bone density by quantitative ultrasound to prevent the incidence of fractures. A total of 937 examinee, 312 men, mean age 66.8 ± 16.9 years; 625 women, mean age 60.3 ± 15.3 years. All examinee were accepted quantitative ultrasound measurement of the usual or not injured calcaneus, and fill out the questionnaire of living conditions. Then, the detected speed of sound (SOS)、broadband ultrasound attenuation (BUA) and quantitative ultrasound index (QUI) and the questionnaire for correlation analysis. In this study, the SOS average for male is 1528.7 ± 31.8 m/s; for female is 1524.3 ± 32.8 m/s (p=0.049), the BUA average for male is 69.5 ± 17.3 dB/cm; for females is 63.2 ± 18.4 dB/cm (p<0.001), the QUI average for male is 84.4 ± 19.3; for females is 79.5 ± 20.4 (p<0.001), the T-score average for male is -1.1 ± 1.2; for females is -1.4 ± 1.3 (p=0.001). From the results of which can be found in older women during the smoking habits of SOS (r=-0.141), BUA (r=-0.131) and QUI (r=-0.150) showed a significant negative correlation (p<0.05), but without this correlation analysis of all women; And all the women have tea and coffee habit SOS (r=-0.115), BUA (r=-0.111) and QUI (r=-0.106) are of extreme significant negative correlation (p<0.01), but in the age-stratified are not. In addition to this study, premenopausal women SOS (r=-0.194), BUA (r=-0.160) and QUI (r=-0.177) for long-term drug use has a significant negative correlation (p<0.05), and analysis of all women with the same result, but in the age-stratified is no significant correlation. In conclusion, bone density is significant differences in genders. At different age-stratified and different living habits also have the different bone density.
中文摘要 I
Abstract II
誌謝 III
目錄 IV
圖目錄 VI
表目錄 VII

第一章 緒論 1
1.1 研究背景 1
1.1.1 骨質疏鬆症的介紹 3
1.2 研究動機 8

第二章 研究材料與方法 11
2.1 超音波原理 11
2.2 定量式超音波原理 13
2.3 問卷內容 21
2.4 參與研究受檢者 21
2.5 統計方法 22
2.6 實驗架構 23

第三章 實驗結果 25
3.1受檢者的基本資料統計 25
3.2男性受檢者的骨質結構結果 32
3.2.1 男性骨質結構結果-年齡分層 33
3.3女性受檢者的骨質結構結果 37
3.3.1 女性骨質結構結果-年齡分層 38
3.3.2 女性骨質結構結果-停經與否 42

第四章 討論 46
4.1基本資料結果討論 48
4.2男性骨質結構結果討論 50
4.3女性骨質結構結果討論 51

第五章 結論 55

參考文獻 57

附錄一 骨密問卷調查表 64

1.Kanis JA, Burlet N, Cooper C, Delmas PD, Reginster JY, Borgstrom F, Rizzoli R, European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2008;19:399-428.

2.Center JR, Nguyen TV, Schneider D, Sambrook PN, Eisman JA. Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet. 1999;353:878-882.

3.Chie WC, Yang RS, Liu JP, Tsai KS. High incidence rate of hip fracture in Taiwan: estimated from a nationwide health insurance database. Osteoporos Int. 2004;15:998-1002.

4.Kanis JA, Burlet N, Cooper C, Delmas PD, Reginster JY, Borgstrom F, Rizzoli F, European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2008;19:399-428.

5.Center JR, Nguyen TV, Schneider D, Sambrook PN, Eisman JA. Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet. 1999;353:878-882.

6.World Health Organization. Assessment of fracture risk and its application to screen for postmenopausal osteoporosis; Report of a WHO study Group; WHO technical report series 843. WHO Geneva 1994.

7.NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy, March 7-29, 2000: highlights of the conference. South Med J 2001;94:569-573

8.Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser. 1994;843:1-129.

9.Kanis JA, Gluer CC. An update on the diagnosis and assessment of osteoporosis with densitometry. Committee of Scientific Advisors, International Osteoporosis Foundation. Osteoporos Int. 2000;11:192-202.

10.Riggs BL, Melton LJ 3rd. Involutional osteoporosis. N Engl J Med. 1986;314:1676-1686.

11.Khosla S, Riggs BL. Pathophysiology of age-related bone loss and osteoporosis. Endocrinol Metab Clin North Am. 2005;34:1015-1030.

12.Duque G, Troen BR. Understanding the mechanisms of senile osteoporosis: new facts for a major geriatric syndrome. J Am Geriatr Soc. 2008;56:935-941.

13.Chie WC, Yang RS, Liu JP, Tsai KS. High incidence rate of hip fracture in Taiwan-estimated from a nationwide health insurance database. Osteoporos Int. 2004;15:998-1002.

14.Shao CJ, Hsieh YH, Tsai CH, Lai KA. A nationwide seven-year trend of hip fractures in the elderly population of Taiwan. Bone. 2009;44:125-129.

15.Looker AC, Melton LJ 3rd, Harris TB, Borrud LG, Shepherd JA. Prevalence and trends in low femur bone density among older US adults: NHANES 2005-2006 compared with NHANES III. J Bone Miner Res. 2010;25:64-71.

16.Shen SJ, Tsai KS, Yang RS, Chieng PU, Liu TK, Chou SN, Chang Lai SP, Su CT. The effect of chronological age and year since menopause on bone mineral density in normal Chinese women. Chinese J Radiology. 1994;19:39-45.

17.Lin JD, Chen JF, Chang HY, Ho C. Evaluation of bone mineral density by quantitative ultrasound of bone in 16862 subjects during routine health examination. The British Journal of Radiology. 2001;74:602-606.

18.Liu G, Peacock M, Eilam O , Dorul1a G et al., Effect of osteoarthritis in the lumbar spine and hip on bone mineral density and diagnosis of osteoporosis in elderly men and women. Osteoporosis International 1997;7:564-569.

19.Larijani B, Dabbaghmanesh MH, Aghakhani S et al, Correlation of quantitative heel ultrasounograph with central dual-energy x-ray absorptiometric bone mineral density in postmenopausal women. Journal Ultrasound Medical 2005:24:941-946.

20.Langton CM, Palmer SB, Porter RW. The measurement of broadband ultrasonic attenuation in cancellous bone. Eng Med. 1984;13:89-91.

21.Njeh CF, Boivin CM, Langton CM. The role of ultrasound in the assessment of osteoporosis: a review. Osteoporos Int. 1997;7:7-22.

22.Gluer CC. Quantitative ultrasound techniques for the assessment of osteoporosis: expert agreement on current status. The International Quantitative Ultrasound Consensus Group. J Bone Miner Res. 1997;12:1280-1288.

23.Nayak S, Olkin I, Liu H, Grabe M, Gould MK, Allen IE, Owens DK, Bravata DM. Meta-analysis: accuracy of quantitative ultrasound for identifying patients with osteoporosis. Ann Intern Med. 2006;144:832-841.

24.Hans D, Dargent-Molina P, Schott AM, Sebert JL, Cormier C, Kotzki PO, Delmas PD, Pouilles JM, Breart G, Meunier PJ. Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study. Lancet. 1996;348:511-514.

25.Bauer DC, Gluer CC, Cauley JA, Vogt TM, Ensrud KE, Genant HK, Black DM. Broadband ultrasound attenuation predict fractures strongly and independently of densitometry in older women. A prospective study. Arch Intern Med. 1997;157:629-34.

26.Bauer DC, Ewing SK, Cauley JA, Ensrud KE, Cummings SR, Orwoll ES. Quantitative ultrasound predicts hip and non-spine fracture in men: the MrOS study. Osteoporos Int. 2007;18:771-777.

27.Khaw KT, Reeve J, Luben R, Bingham S, Welch A, Wareham N, Oakes S, Day N. Prediction of total and hip fracture risk in men and women by quantitative ultrasound of the calcaneus: EPIC-Norfolk prospective population study. Lancet. 2004;363:197-202.

28.Fujiwara S, Sone T, Yamazaki K, Yoshimura N, Nakatsuka K, Masunari N, Fujita S, Kushida K, Fukunaga M. Heel bone ultrasound predicts non-spine fracture in Japanese men and women. Osteoporos Int. 2005;16:2107-2112.

29.Genant HK, Njeh CF. Update on the diagnosis of osteoporosis. Curr Orth. 1999;13:144-155.

30.Njeh CF, Fuerst T, Diessel E, Genant HK. Is quantitative ultrasound dependent on bone structure? A reflection. Osteoporos Int. 2001;12:1-15.

31.Faulkner KG, von Stetten E, Steiger P. Discrepancies in osteoporosis prevalence at different skeletal sites: impact on the WHO criteria. Bone. 1998;5:s194.

32.SAHARA Clinical Bone Sonometer.

33.Drozdzowska B, Pluskiewicz W. Quantitative ultrasound in diagnosis of metabolic bone diseases. Current Medical Imaging Reviews. 2005;1:67-74

34.Frost ML, Blake GM, Fogelman I. Can the WHO criteria for diagnosing osteoporosis be applied to calcaneal quantitative ultrasound? Osteoporos Int. 2000;11:321-330.

35.Alibasic E, Ramic E, Batic Mujanovic O, Avdibasic E, Husic D, Alic A. Assessment of osteoporosis in family medicine obtained by ultrasound densitometry. Acta Inform Med. 2013;21:274-276.

36.Frost ML, Blake GM, Fogelman I. Quantitative ultrasound and bone mineral density are equally strongly associated with risk factors for osteoporosis. J Bone Miner Res. 2001;16:406-416.

37.Larijani B, Dabbaghmanesh MH, Aghakhani S, Sedaghat M, Hamidi Z, Rahimi E. Correlation of quantitative heel ultrasonography with central dual-energy X-ray absorptiometric bone mineral density in postmenopausal women. J Ultrasound Med. 2005;24:941-946.

38.Prins SH, Jorgensen HL, Jørgensen LV, Hassager C. The role of quantitative ultrasound in the assessment of bone: a review. Clin Physiol. 1998;18:3-17.

39.Bauer DC, Gluer CC, Cauley JA, Vogt TM, Ensrud KE, Genant HK, Black DM. Broadband ultrasound attenuation predicts fractures strongly and independently of densitometry in older women. A prospective study. Study of Osteoporotic Fractures Research Group. Arch Intern Med. 1997;157:629-634.

40.Moayyeri A, Kaptoge S, Dalzell N, Bingham S, Luben RN, Wareham NJ, Reeve J, Khaw KT. Is QUS or DXA better for predicting the 10-year absolute risk of fracture ? J Bone Miner Res. 2009;24:1319-1325.

41.Koh LK, Sedrine WB, Torralba TP, Kung A, Fujiwara S, Chan SP, Huang QR,Rajatanavin R, Tsai KS, Park HM, Reginster JY; Osteoporosis Self-Assessment Tool for Asians (OSTA) Research Group. A simple tool to identify Asian women at increased risk of osteoporosis. Osteoporosis Int. 2001;12:699-705.

42.De Laet C, Kanis JA, Odén A, Johanson H, Johnell O, Delmas P, Eisman JA, Kroger H, Fujiwara S, Garnero P, McCloskey EV, Mellstrom D, Melton LJ 3rd, Meunier PJ, Pols HA, Reeve J, Silman A, Tenenhouse A. Body mass index as a predictor of fracture risk: a meta-analysis. Osteoporos Int. 2005;16:1330-1338.

43.Liu H, Paige NM, Goldzweig CL, Wong E, Zhou A, Suttorp MJ, Munjas B, Orwoll E, Shekelle P. Screening for osteoporosis in men: a systematic review for an American College of Physicians guideline. Ann Intern Med. 2008;148:685-701.

44.Papaioannou A, Kennedy CC, Cranney A, Hawker G, Brown JP, Kaiser SM, Leslie WD, O’Brien CJ, Sawka AM, Khan A, Siminoski K, Tarulli G, Webster D, McGowan J, Adachi JD. Risk factors for low BMD in healthy men age 50 years or older: a systematic review. Osteoporos Int. 2009;20:507-518.

45.Green ADH, HColón-Emeric CSH, HBastian LH, HDrake MTH, HLyles KW. Does this woman have osteoporosis? HJAMA. 2004;292:890-90.

46.Kruger MC, Todd JM, Schollum LM, Kuhn-Sherlock B, McLean DW, Wylie K. Bone health comparison in seven Asian countries using calcaneal ultrasound. BMC Musculoskelet Disord. 2013;14:81.

47.Khosla S. Update in male osteoporosis. J Clin Endocrinol Metab. 2010;95:3-10.

48.Khosla S, Amin S, Orwoll E. Osteoporosis in men. Endocr Rev. 2008;29:441-464.

49.Baim S, Binkley N, Bilezikian JP, Kendler DL, Hans DB, Lewiecki EM, Silverman S. Official Positions of the International Society for Clinical Densitometry and executive summary of the 2007 ISCD Position Development Conference. J Clin Densitom. 2008;11:75-91.

50.Turner RT. Skeletal response to alcohol. Alcohol Alcohol Clin Exp Res. 2000;24:1693-1701.

51.Hollenbach KA, Barrett-Connor E, Edelstein SL, Holbrook T. Cigarette smoking and bone mineral density in older men and women. Am J Pub Health. 1993;83:1265-1270.

52.Wong PK, Christie JJ, Wark JD. The effects of smoking on bone health. Clin Sci (Lond). 2007;113:233-241.

53.World Health Organization. Assessment of osteoporosis at the primary health care level: summary report of a WHO Scientific Group. 2007.

54.Reid IR. Anti-resorptive therapies for osteoporosis. Semin Cell Dev Biol. 2008;19:473-478.

55.Smith AM. Veganism and osteoporosis: A review of the current literature. International Journal of Nursing Practice. 2006;12:302-306.

56.Ho-Pham LT, Nguyen ND, Nguyen TV. Effect of vegetarian diets on bone mineral density: a Bayesian meta-analysis. Am J Clin Nutr. 2009;90:943-950.

57.Blake GM, Gluer CC, Fogelman I. Bone densitometry: current status and future prospects. Br J Radiol. 1997;70:S177-86.

58.Alibasic E, Ramic E, Batic Mujanovic O, Avdibasic E, Husic D, Alic A. Assessment of osteoporosis in family medicine obtained by ultrasound densitometry. Acta Inform Med. 2013;21:274-276.

59.Pye SR, Devakumar V, Boonen S, Borghs H, Vanderschueren D, Adams JE, Ward KA, Bartfai G, Casanueva FF, Finn JD, Forti G, Giwercman A, Han TS,Huhtaniemi IT, Kula K, Lean ME, Pendleton N, Punab M, Silman AJ, Wu FC, O'Neill TW; EMAS Study Group. Influence of lifestyle factors on quantitative heel ultrasound measurements in middle-aged and elderly men. Calcif Tissue Int. 2010;86:211-219.

60.Solomon ED & Davis PW. Human Anatomy and Physiology. Tokyo: CBS College Publishing. 1983.

61.Tortora GJ & Anagnostakos NP. Principles of Anatomy and Physiology. New York: Harper & Row. 1990.

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