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研究生:張寧馨
研究生(外文):Ning-Shin Chang
論文名稱:山煙草根部化學及活性成分之研究
論文名稱(外文):Chemical and Bioactive Constituents from the Roots of Solanum erianthum
指導教授:郭昭麟郭昭麟引用關係
指導教授(外文):Chao-Lin Kuo
學位類別:碩士
校院名稱:中國醫藥大學
系所名稱:中國藥學暨中藥資源學系碩士班
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:2015
畢業學年度:103
語文別:中文
論文頁數:118
中文關鍵詞:山煙草茄科化學成分
外文關鍵詞:Solanum erianthumSolanaceaeChemical constituents
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山煙草(Solanum erianthum D. Don) 為Solanaceae (茄科)植物,是一種廣佈在台灣平地至低海拔地區的常綠性灌木,全株披星狀絨毛,原產於巴西,分佈於熱帶亞洲、美洲及澳洲。在台灣的傳統用藥中,葉子常被用作補益產婦、治療腰椎神經痛;莖及根被用來治療風濕、感冒和胃潰瘍。
近代研究顯示山煙草的甲醇萃取物在lipopolysaccharide (LPS)誘導Raw 264.7細胞下,能有效抑制Nitric Oxide (NO)的生成量。本研究經由分配分離以及管柱層析甲醇萃取物以後,得知在正己烷層己分離出的化學及活性成分,而乙酸乙酯層經評估亦具有顯著的抗發炎活性。由乙酸乙酯層分離出30個化合物:其中3個為新化物,分別為1個為醯胺類新化合物N-Methyl-N-trans-feruloyloctopamine (*15),1個木酚素類新化合物Syringaresinone (*22),1個為4,5-Dimethyldioxolanoctanoic acid (*27);及27個已知的化合物,包括固醇類2個、芳香族類4個、倍半萜類9個、醯胺類3個、木酚素類5個、木酚素醯胺類3個、其他類1個。

Solanum erianthum D. Don (Solanaceae) is a shrub or small tree with stellate tomentose. It is native to South America, widespread in tropical Asia and Oceania. In Taiwan, the leaves are used as maternal tonic and to treat lumbar neuralgia; the roots are used as folk medicine for stomachache, abdominal pain, fracture, bruises and chronic granular leukemia.
In the program of screening, the MeOH extract of the roots of S. erianthum was shown to be able to inhibit NO release without affecting the cellular viability in LPS-activated Raw 264.7 cells. The previous reported two new norsesquiterpenoids, solanerianones A and B, along with nine known compounds from the n-hexane-soluble fraction of the root of S. erianthum. Continuing investigation of the EtOAc-soluble fraction led to the isolation of a new amide, N-Methyl-N-trans-feruloyloctopamine (*15), a new lignan, Syringaresinone (*22), a new conjugated erythro-2,3-butanediol and 9- oxononanoic acid 4,5-Dimethyldioxolanoctanoic acid (*27) and twenty-seven known compounds, including two steroids, four aromatic compounds, nine sesquiterpenoids, three amides, five lignanoids, three lignanamide and one other compound. The structures of these compounds were determined by spectroscopic analysis.

目錄 I
圖目錄 III
表目錄 VII
摘要 VIII
Abstract IX
第一章 緒論 1
第一節 前言 1
第二節 山煙草之植物考察 3
第三節 茄屬植物成分之考察 6
第二章 研究動機與目的 17
第三章 結果與討論 18
第一節 化合物之萃取與分離 18
第二節 化合物結構 22
第三節 化合物之結構鑑定 25
Solafuranone (8)之結構鑑定 25
Septemlobins C (11)之結構鑑定 32
Dehydrocarissone (13)之結構鑑定 39
N-Methyl-N-trans-feruloyloctopamine (*15)之結構鑑定 46
Cannabisin F (19)之結構鑑定 54
Syringaresinone (*22)之結構鑑定 62
Buddlenol A (25)之結構鑑定 70
4,5-Dimethyldioxolanoctanoic acid (*27)之結構鑑定 78
第四章 抗發炎活性之研究 85
第五章 結論 88
第六章 實驗部分 90
第一節 儀器與材料 90
第二節 根部之抽出與分離 92
第三節 乙酸乙酯層之分離 94
第四節 各化合物之實驗數據 101
參考文獻 113

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