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論文名稱(外文):Occupational hand dermatosis among betel quid assemblers
指導教授(外文):How-Ran Guo
外文關鍵詞:betel quidbetel quid ingredientscontact dermatitisassemblelimeskin disorderdermatosis
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Background:According to the data of Ministry of Interior, the consumption of betel quid was preceded only by tea, cigarettes, and alcohol. Some ingredients of the betel quid have been identified as carcinogens, and many studies have shown that betel quid chewing can not only increase the risk of oral cancer, oropharyngeal cancer and liver cancer but also lead to mental disorders. Studies in Taiwan have also shown that the betel leaf can cause skin dermatitis and that those who engaged in packing betel quid reported more skin dermatitis. Associations between the ingredients of the betel quid and skin disorders are unclear, and there are few related studies. Therefore, we conduct a study to investigate which ingredients of betel quid may lead to skin disorders of betel quid assemblers and thus recommend appropriate protective measures to reduce the risk of skin damage. In addition, we assessed the prevalence of skin disorders in betel quid assemblers in southern Taiwan.
Methods:This is a cross-sectional study. We collected data on demographics, lifestyle, work-related risk factors and skin health status by using a questionnaire. In addition, we used betel leaves, white lime, red lime and areca catechu as allergens to perform skin patch test. Furthermore, we proposed appropriate protective measures to reduce betel quid assemblers’ exposure to the risk factors. Result:We obtained questionnaires from 110 assemblers and performed skin patch tests on 33. The common skin injuries include erythema (23.6%), thickened or lichenified (16.3%), itching (13.6%), pigmentation (12.7%), and eczematous (11.8%). In most cases, the skin disorders were mild. In skin patch tests, we did not identify the allergens among these workers.
Conclusions:The prevalence of skin disorders was high in betel quid assemblers, but most of them had mild hand skin damages. We results did not identify allergens in skin patch tests but found the prevalence of hand skin disorders was lower in betel quid assemblers who wore gloves.

中文摘要 I
Abstract II
致謝 IV
Table of contents V
List of tables VI
List of figures VII
Chapter 1 Introduction 1
Chapter 2 References review 3
1. The Ingredients of Betel Quids 3
2. The Distribution of Betel Quids 5
3. The Health Effects Related to the Betel Quids 5
4. Discussion on the Betel Quids Assembler's Hand Damage 8
5. Contact Dermatitis 9
6. Mechanism of Allergic Contact Dermatitis 10
Chapter 3 The Purposes and Importance of the Research 12
1. The Purposes of the Research 12
2. Importance of the Research 12
Chapter 4 Research Materials and Methods 14
1. Research Design and Framework 14
2. The Subjects and the Selection Criteria 14
3. Data Collection 14
4. Study Protocol 15
5. Statistic Analysis 16
Chapter 5 Research Results 17
1. Results of the Questionnaire Survey 17
2. Skin Patch Test Results 18
3. Skin Diseases Diagnosed among Betel Quids Assemblers 19
Chapter 6 Discussion 20
1. The Results of Questionnaire Survey on the Betel Quid assemblers' Hand Skin manifestations 20
2. The Results of Skin Patch Test 21
3. Research limitations 22
Chapter 7 Conclusions 23
References 24
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