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研究生:陳俊宏
研究生(外文):Chun-Hung Chen
論文名稱:慢性阻塞性肺疾病病患在失智症增加的風險及相關因素:以台灣全人口基礎的前瞻式世代研究
論文名稱(外文):Increased risk and related factors of dementia among chronic obstructive pulmonary disease patients: A population-based prospective cohort study in Taiwan
指導教授:洪炯宗洪炯宗引用關係
指導教授(外文):Jorng-Tzong Horng
學位類別:碩士
校院名稱:國立中央大學
系所名稱:資訊工程學系在職專班
學門:工程學門
學類:電資工程學類
論文種類:學術論文
論文出版年:2015
畢業學年度:103
語文別:英文
論文頁數:47
中文關鍵詞:慢性阻塞性肺疾病失智症阿茲海默症世代研究
外文關鍵詞:COPDdementiaAlzheimer's diseasecohort study
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慢性阻塞性肺病(COPD)是一種慢性發炎所造成的呼吸道阻塞疾病,除了本身的肺部效應外,還伴隨著顯著的肺外效應,如:營養不良、骨骼肌功能障礙、中樞神經系統損害等。近年研究顯示,慢性阻塞性肺病增加了對輕度認知障礙(MCI)的風險,而輕度認知障礙每年則約有10%至15%轉變成失智症。因此,本研究擬利用台灣全民健保研究資料庫之資料,針對50歲以上的病患探討慢性阻塞性肺病患是否比非慢性阻塞性肺病患增加失智症的風險。研究結果顯示,慢性阻塞性肺病患與非慢性阻塞性肺病患相比,慢性阻塞性肺病患有顯著增加失智症風險 (HR =2.05, 95% CI=1.88-2.22)。其中罹患阿茲海默症和非阿茲海默失智症的風險各為(HR =2.16, 95% CI=1.97-2.37)和(HR =1.64, 95% CI=1.35-1.98) ,均有顯著增加的風險。
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease caused by airway obstruction, in addition to the lungs effects itself, but also be accompanied by a significant extra-pulmonary effects, such as: malnutrition, skeletal muscle dysfunction, central nervous system damage, etc. Recent studies have shown that chronic obstructive pulmonary disease increases the risk of mild cognitive impairment (MCI), and mild cognitive impairment each year and about 10-15% into dementia. Therefore, this study intends to use the information in Taiwan National Health Insurance Research Database for patients over 50 years old to explore whether patients with chronic obstructive pulmonary increased risk of dementia than non-chronic obstructive pulmonary patients. The results showed that patients with chronic obstructive pulmonary compared with non-chronic obstructive pulmonary patients suffering from chronic obstructive pulmonary disease significantly increases the risk of dementia (HR = 2.05, 95% CI= 1.88-2.22). Where the risk of suffering from Alzheimer's disease and non-Alzheimer's dementia each (HR = 2.16, 95% CI=1.97-2.37) and (HR = 1.64, 95% CI=1.35-1.98), were significantly increased risk.
摘要 i
ABSTRACT ii
誌謝 iii
Table of Contents iv
List of Figures v
List of Tables vi
Chapter 1 Introduction 1
1.1 Background 1
1.2 Motivation 2
1.3 Research Goal 2
Chapter 2 Related Works 3
2.1 Chronic Obstructive Pulmonary Disease 3
2.2 COPD and Dementia 4
Chapter 3 Materials and Methods 6
3.1 Data Source 6
3.2 Study Design and Cohort Selection 6
3.3 Definition of disease 8
3.4 Confounding Factors 9
3.5 Statistical Analysis 10
Chapter 4 Results 12
4.1 Demographic Characteristics 12
4.2 Incidence Rate and Risk of Dementia between Two Cohorts 14
4.3 Relative Risk of Dementia among COPD Cohorts 17
4.4 Kaplan-Meier Dementia-Free Curves 25
4.5 Multiple Logistic Regression Model 28
Chapter 5 Discussion 30
Chapter 6 Conclusion 33
References 34
Appendix I Charlson-Deyo Comorbidity Index 37
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